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Ophtalmology

The clinical and basic research activity of the Ophthalmology Research Group is dedicated to finding new treatments for blindness through the development of new therapies for macular and retinal degenerative diseases, as well as for retinal vascular diseases (diabetic retinopathy and retinal vascular occlusions). Our group consists of core researchers and clinical researchers, so there is a clear clinical translation of the ongoing research in the research group.

We have a research program for the development of new therapeutic strategies based on:

  • Cell therapies
  • Formulations of ocular solutions (LUCIA PI18 and CELLUX EuroNanoMed/AC19)
  • Biological matrices
  • Gene therapy
  • Animal models
  • Retinal cell models based on stem cell-derived organoids.

In the clinical part, the research group bases its activity on clinical trials to develop new treatments for retinal diseases as well as on the ophthalmic involvement of systemic treatments, an example is the phase II trial to test mesenchymal cells (MSV) intravitreal in non-arteritic ischemic optic neuropathy (NAION), the RECOGNISED study or the PULSAR study with aflibercept.

Team

Jorge Fernandez Engroba

Jorge Fernandez Engroba

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Júlia Angrill Valls

Júlia Angrill Valls

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Maddalen Zufiaurre Seijo

Maddalen Zufiaurre Seijo

Research technician
Ophtalmology
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Marc Tort Lacambra

Marc Tort Lacambra

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Natalia Anglada Masferrer

Natalia Anglada Masferrer

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Paula García Valentin

Paula García Valentin

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Jorge Fernandez Engroba

Jorge Fernandez Engroba

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Júlia Angrill Valls

Júlia Angrill Valls

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Maddalen Zufiaurre Seijo

Maddalen Zufiaurre Seijo

Research technician
Ophtalmology
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Marc Tort Lacambra

Marc Tort Lacambra

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Natalia Anglada Masferrer

Natalia Anglada Masferrer

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Paula García Valentin

Paula García Valentin

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Publications

Prevalence of age-related macular degeneration among optometric telemedicine users in Spain: a retrospective nationwide population-based study.

PMID: 33576860
Journal: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Year: 2021
Reference: Graefes Arch Clin Exp Ophthalmol. 2021 Jul;259(7):1993-2003. doi: 10.1007/s00417-021-05093-4. Epub 2021 Feb 12.
Impact factor: 3.117
Publication type: Paper in international publication
Authors: Zapata, Miguel A, Bures, Anniken, Gallego-Pinazo, Roberto, Gutierrez-Sanchez, Estanislao, Olenik, Andrea, Pastor, Salvador, Ruiz-Medrano, Jorge, Salinas, Cecilia, Otero-Romero, Susana, Abraldes, Maximino et al.
DOI: 10.1007/s00417-021-05093-4

Bimonthly, treat-and-extend and as-needed ranibizumab in naive neovascular age-related macular degeneration patients: 12-month outcomes of a randomized study.

PMID: 32190990
Journal: ACTA OPHTHALMOLOGICA
Year: 2020
Reference: Acta Ophthalmol. 2020 Nov;98(7):e820-e829. doi: 10.1111/aos.14399. Epub 2020 Mar 19.
Impact factor: 3.362
Publication type: Paper in international publication
Authors: S Figueroa, Marta, Garcia-Layana, Alfredo, Ruiz Moreno, Jose M, Fernandez Rodriguez, Maribel, Garcia Arumi, Josep, Amat Peral, Pedro, Ascaso Puyuelo, Javier, Armada Maresca, Felix, Cervera Taulet, Enrique, Torres Imaz, Ramon et al.
DOI: 10.1111/aos.14399

ANATOMICAL AND VISUAL OUTCOMES OF INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE VERSUS INTERNAL LIMITING MEMBRANE PEELING IN MYOPIC MACULAR HOLE WITHOUT RETINAL DETACHMENT: A Preliminary Retrospective Study.

PMID: 31972792
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2020
Reference: Retina. 2020 Feb;40(2):233-240. doi: 10.1097/IAE.0000000000002368.
Impact factor: 3.649
Publication type: Paper in international publication
Authors: Bove Alvarez, Maria, Sabate, Sergi, Gomez-Resa, Maria, Garcia-Arumi, Jose et al.
DOI: 10.1097/IAE.0000000000002368

The LRRC8-mediated volume-regulated anion channel is altered in glaucoma.

PMID: 30931966
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Apr 1;9(1):5392. doi: 10.1038/s41598-019-41524-3.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Gasull, Xavier, Castany, Marta, Castellanos, Aida, Rezola, Mikel, Andres-Bilbe, Alba, Canut, Maria Isabel, Estevez, Raul, Borras, Teresa, Comes, Nuria et al.
DOI: 10.1038/s41598-019-41524-3

Efficacy of Internal Limiting Membrane Flap Techniques with Vitrectomy for Macular Detachment Associated with an Optic Disc Pit.

PMID: 30808833
Journal: OPHTHALMOLOGICA
Year: 2019
Reference: Ophthalmologica. 2019;242(1):38-48. doi: 10.1159/000495621. Epub 2019 Mar 22.
Impact factor: 1.781
Publication type: Paper in international publication
Authors: Pastor-Idoate, Salvador, Gomez-Resa, Maria, Karam, Sarah, Copete, Sergio, Kyriakou, Danai, Garcia-Arumi Fuste, Claudia, Pastora, Natalia, Nadal, Jeroni, Garcia-Arumi, Jose et al.
DOI: 10.1159/000495621

The EX-PRESS glaucoma shunt versus nonpenetrating deep sclerectomy with Esnoper implant in combined surgery for open-angle glaucoma: a prospective randomized study.

PMID: 30714336
Journal: ACTA OPHTHALMOLOGICA
Year: 2019
Reference: Acta Ophthalmol. 2019 Nov;97(7):e952-e961. doi: 10.1111/aos.14023. Epub 2019 Feb 3.
Impact factor: 3.153
Publication type: Paper in international publication
Authors: Munoz, Marcos, Anton, Alfonso, Castany, Marta, Gil, Alfonso, Martinez, Alberto, Munoz-Negrete, Francisco J, Urcelay, Jose, Moreno-Montanes, Javier et al.
DOI: 10.1111/aos.14023

Effects of Topically Administered Neuroprotective Drugs in Early Stages of Diabetic Retinopathy. Results of the EUROCONDOR Clinical Trial.

PMID: 30389750
Journal: DIABETES
Year: 2019
Reference: Diabetes. 2019 Feb;68(2):457-463. doi: 10.2337/db18-0682. Epub 2018 Nov 2.
Impact factor: 7.199
Publication type: Paper in international publication
Authors: Simo, Rafael, Hernandez, Cristina, Porta, Massimo, Bandello, Francesco, Grauslund, Jakob, Harding, Simon P, Aldington, Stephen J, Egan, Catherine, Frydkjaer-Olsen, Ulrik, Garcia-Arumi, Jose et al.
DOI: 10.2337/db18-0682

Blog

News

On January 24, a session was held to explain what these three-dimensional models are and what advantages they have, as well as to review some of their applications in research.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.

Dr. José García Arumi and Dr. Anna Duarri from the Ophthalmology research group at Vall Hebron Recerca lead the project.