About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The group of design and pharmacodynamics of nanoparticles at the Vall d’Hebron Research Institute focuses on the synthesis, characterization, and applications of engineered inorganic nanoparticles in the field of medicine. By mastering the inorganic core (size, structure, and shape) and understanding and controlling the linking of molecules to the nanoparticle surface, we engineer nanoparticles that can interact with biological systems in a specific way. We also put particular emphasis on safety, feasibility, scale-up, applicability, and other aspects of nanoparticle design.
Our group is led by Prof. Víctor Puntes, who holds an ICREA Research Professorship. Since a great part of our work demands highly multidisciplinary expertise, we maintain several strong collaborations with biologists, immunologists, oncologists, physicists, environmentalists, and more, from all over Europe, China and the US. The work of the group has resulted in several patents and the creation of several spin-offs such as Nanotargeting and Applied nanoparticles.
IP: Victor Franco Puntes Collaborators: Ramon Gonzalez Rioja, Joana Ramis Garcia, Lena Nerea Montaña Ernst Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 40000 Reference: 2021 SGR 00878 Duration: 01/01/2022 - 30/06/2025
IP: Elena Carreras Moratonas Collaborators: Itziar Garcia Ruiz, Erika Bonacina, Joana Ramis Garcia Funding agency: Instituto de Salud Carlos III Funding: 111320 Reference: PI20/00606 Duration: 01/01/2021 - 30/06/2025
PMID: 36985887 Journal: Nanomaterials Year: 2023 Reference: Nanomaterials (Basel). 2023 Mar 9;13(6):992. doi: 10.3390/nano13060992. Impact factor: Publication type: Paper in international publication Authors: Arbiol, Jordi; Arenal, Raul; Bastus, Neus G; Genc, Aziz; Patarroyo, Javier; Puntes, Victor; Sancho-Parramon, Jordi et al. DOI: 10.3390/nano13060992
PMID: 37049267 Journal: Nanomaterials Year: 2023 Reference: Nanomaterials (Basel). 2023 Mar 25;13(7):1174. doi: 10.3390/nano13071174. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus G; Bigini, Paolo; Chakraborty, Indranath; Cui, Daxiang; Masood, Atif; Morelli, Annalisa; Parak, Wolfgang J; Pelaz, Beatriz; Puntes, Victor; Salmona, Mario et al. DOI: 10.3390/nano13071174
PMID: 37570527 Journal: Nanomaterials Year: 2023 Reference: Nanomaterials (Basel). 2023 Jul 29;13(15):2208. doi: 10.3390/nano13152208. Impact factor: Publication type: Paper in international publication Authors: Abasolo, Ibane; Bastus, Neus G; Bastus, Neus G; Boullosa, Ana Maria; Boullosa, Ana Maria; Camara, Juan Antonio; Casals, Eudald; Garcia, Ana; Gusta, Muriel F; Mondragon, Laura et al. DOI: 10.3390/nano13152208
PMID: 37762274 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2023 Reference: Int J Mol Sci. 2023 Sep 12;24(18):13971. doi: 10.3390/ijms241813971. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus G; Casonato Melo, Cristiane; Duschl, Albert; Fauerbach, Jonathan A; Fux, Alexandra C; Gessner, Isabel; Himly, Martin; Puntes, Victor; Puntes, Victor; Schlahsa, Laura et al. DOI: 10.3390/ijms241813971
PMID: 35946341 Journal: Nanoscale Year: 2022 Reference: Nanoscale. 2022 Aug 25;14(33):12048-12059. doi: 10.1039/d2nr01318e. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus G; Lisdat, Fred; Parak, Wolfgang J; Patarroyo, Javier; Puntes, Victor; Riedel, Marc; Yue, Zhao; Zhao, Shuang et al. DOI: 10.1039/d2nr01318e
PMID: 35852911 Journal: BIOCONJUGATE CHEMISTRY Year: 2022 Reference: Bioconjug Chem. 2022 Aug 17;33(8):1505-1514. doi: 10.1021/acs.bioconjchem.2c00232. Epub 2022 Jul 19. Impact factor: Publication type: Paper in international publication Authors: Barbero, Francesco; Bastus, Neus G; Canals, Francesc; Duschl, Albert; F Gusta, Muriel; Horejs-Hoeck, Jutta; Martin, Luna; Michelini, Sara; Mondragon, Laura; Moriones, Oscar H et al. DOI: 10.1021/acs.bioconjchem.2c00232
PMID: 35628574 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2022 Reference: Int J Mol Sci. 2022 May 20;23(10). pii: ijms23105763. doi: 10.3390/ijms23105763. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus G; Hurkmans, Evelien G E; Kevenaar, Kirsten; Nelissen, Inge; Parak, Wolfgang J; Pelaz, Beatriz; Pennings, Jeroen L A; Puntes, Victor F; Remy, Sylvie; Soliman, Mahmoud G et al. DOI: 10.3390/ijms23105763
PMID: 35471829 Journal: LANGMUIR Year: 2022 Reference: Langmuir. 2022 May 10;38(18):5372-5380. doi: 10.1021/acs.langmuir.1c03155. Epub 2022 Apr 26. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus; Drummond-Brydson, Rik; Moriones, Oscar H; Nelson, Andrew L; Puntes, V; Sanver, Didem; Vakurov, Alex; William, Nicola et al. DOI: 10.1021/acs.langmuir.1c03155
PMID: 34474831 Journal: Materials Science & Engineering C-Materials for Biological Applications Year: 2021 Reference: Mater Sci Eng C Mater Biol Appl. 2021 Sep;128:112272. doi: 10.1016/j.msec.2021.112272. Epub 2021 Jun 24. Impact factor: Publication type: Paper in international publication Authors: Casals, Eudald; Casals, Gregori; Desai, Diti; Fernandez-Varo, Guillermo; Jimenez, Wladimiro; Karaman, Didem Sen; Li, Qihong; Parra-Robert, Marina; Peng, Jingbao; Puntes, Victor et al. DOI: 10.1016/j.msec.2021.112272
PMID: 34412401 Journal: SCIENCE OF THE TOTAL ENVIRONMENT Year: 2021 Reference: Sci Total Environ. 2021 Oct 15;791:148324. doi: 10.1016/j.scitotenv.2021.148324. Epub 2021 Jun 8. Impact factor: Publication type: Review in international publication Authors: Marcon, Lionel; Oliveras, Jana; Puntes, Victor F et al. DOI: 10.1016/j.scitotenv.2021.148324
PMID: 34394703 Journal: Nano Today Year: 2021 Reference: Nano Today. 2021 Feb;36. doi: 10.1016/j.nantod.2020.101056. Epub 2020 Dec 20. Impact factor: Publication type: Paper in international publication Authors: Astorga-Gamaza, Antonio; Bastus, Neus; Blanch-Lombarte, Oscar; Borrajo, Mireya L; Buzon, Maria J; Falco, Vicenc; Genesca, Meritxell; Jaime, Carlos; Lorente, Juan; Luque-Ballesteros, Laura et al. DOI: 10.1016/j.nantod.2020.101056
PMID: 33984104 Journal: Nanoscale Year: 2021 Reference: Nanoscale. 2021 May 14;13(18):8452-8466. doi: 10.1039/d1nr00790d. Epub 2021 Apr 14. Impact factor: Publication type: Paper in international publication Authors: Casals, Eudald; Casals, Gregori; Chen, Junhao; Desai, Diti; Fernandez-Varo, Guillermo; Guo, Dongdong; Jimenez, Wladimiro; Morales-Ruiz, Manuel; Parra-Robert, Marina; Perramon, Meritxell et al. DOI: 10.1039/d1nr00790d
PMID: NOPMID0080 Journal: Nano Today Year: 2020 Reference: Nano Today. 2020 Jun;32:100859. doi:10.1016/j.nantod.2020.100859 Impact factor: Publication type: Editorail in international publication Authors: Bastus, Neus G.; Gonzalez, Edgar E.; Puntes, Victor et al. DOI: 10.1016/j.nantod.2020.100859
PMID: 33010592 Journal: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Year: 2020 Reference: Ecotoxicol Environ Saf. 2020 Dec 15;206:111405. doi: 10.1016/j.ecoenv.2020.111405. Epub 2020 Sep 30. Impact factor: Publication type: Paper in international publication Authors: Baccaro, M; Busquets-Fite, M; Cornelis, G; Goncalves, S F; Green Etxabe, A; Henriques, I; Khodaparast, Z; Lahive, E; Loureiro, S; Lynch, I et al. DOI: 10.1016/j.ecoenv.2020.111405
PMID: 32692793 Journal: Nanoscale Year: 2020 Reference: Nanoscale. 2020 Aug 7;12(29):15832-15844. doi: 10.1039/d0nr02379e. Epub 2020 Jul 21. Impact factor: Publication type: Paper in international publication Authors: Canals, Francesc; Casals, Eudald; Colome, Nuria; Puntes, Victor; Vitali, Michele et al. DOI: 10.1039/d0nr02379e
PMID: 32363795 Journal: Small Year: 2020 Reference: Small. 2020 May;16(21):e2000598. doi: 10.1002/smll.202000598. Epub 2020 May 4. Impact factor: Publication type: Review in international publication Authors: Alijagic, Andi; Auguste, Manon; Barbero, Francesco; Bastus, Neus G; Boraschi, Diana; Canesi, Laura; Drobne, Damjana; Duschl, Albert; Ewart, Marie-Ann; Ferrari, Eleonora et al. DOI: 10.1002/smll.202000598
PMID: NOPMID0061 Journal: CHEMISTRY OF MATERIALS Year: 2019 Reference: Chemistry of Materials. 2019 Oct 8;31(19):7922-32. doi:10.1021/acs.chemmater.9b02005 Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; Franco Puntes, Victor et al. DOI: 10.1021/acs.chemmater.9b02005
PMID: 31621309 Journal: BIOCONJUGATE CHEMISTRY Year: 2019 Reference: Bioconjug Chem. 2019 Nov 20;30(11):2917-2930. doi: 10.1021/acs.bioconjchem.9b00624. Epub 2019 Nov 4. Impact factor: Publication type: Paper in international publication Authors: Barbero, Francesco; Bastus, Neus G; Moriones, Oscar H; Puntes, Victor et al. DOI: 10.1021/acs.bioconjchem.9b00624
PMID: 31508939 Journal: BIOCHEMISTRY Year: 2019 Reference: Biochemistry. 2019 Nov 26;58(47):4761-4773. doi: 10.1021/acs.biochem.9b00390. Epub 2019 Sep 24. Impact factor: Publication type: Paper in international publication Authors: Arribas Perez, Marcos; Bastus, Neus G; Beales, Paul Andrew; Moriones, Oscar; Nelson, Andrew L; Puntes, Victor et al. DOI: 10.1021/acs.biochem.9b00390
PMID: 31492960 Journal: Scientific Reports Year: 2019 Reference: Sci Rep. 2019 Sep 6;9(1):12848. doi: 10.1038/s41598-019-49262-2. Impact factor: Publication type: Paper in international publication Authors: Carvajal, Silvia; Casals, Eudald; Casals, Gregori; Fernandez-Varo, Guillermo; Gonzalez de la Presa, Bernardino; Jimenez, Wladimiro; Morales-Ruiz, Manuel; Oro, Denise; Parra, Marina; Pastor, Oscar et al. DOI: 10.1038/s41598-019-49262-2
PMID: NOPMID004 Journal: Journal of Materials Chemistry A Year: 2017 Reference: 10.1039/C7TA03006A Impact factor: Publication type: Paper in international publication Authors: Abo Markeb, A; Alonso, A; Bastus, N; Font, X; Franco Puntes, V; Garzón-Tovar, L; Imaz, I; Maspoch, D; Moral-Vico, J; Patarroyo, J et al. DOI: 10.1039/c7ta03006a
PMID: NOPMID005 Journal: NanoImpact Year: 2017 Reference: doi.org/10.1016/j.impact.2017.11.001 Impact factor: Publication type: Review in international publication Authors: Andreozzi, Patricia; Bastús, Neus G; Escobar, Ane; Franco Puntes, V; Moya, Sergio E.; Murray, Richard A. et al. DOI: 10.1016/j.impact.2017.11.001
PMID: NOPMID006 Journal: Nanophotonics Year: 2017 Reference: 10.1515/nanoph-2016-0124 Impact factor: Publication type: Paper in international publication Authors: Arbiol, J; Bastú, N.G; Franco Puntes, V; Genç, A; Patarroyo, J; Sancho Parramons, J et al. DOI: 10.1515/nanoph-2016-0124
PMID: NOPMID007 Journal: ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS Year: 2017 Reference: J. Mater. Chem. A, 2017,5, 11917-11929 Impact factor: Publication type: Paper in international publication Authors: Arbiol, J; Bastús, N.G.; Franco Puntes, V; Merkoci, F; Piella, J et al. DOI: 10.1039/C7TA01328K
PMID: NO PMID Journal: ACS Photonics Year: 2016 Reference: ACS Photonics, 2016, 3 (5), pp 770–779 Impact factor: Publication type: Paper in international publication Authors: Aziz Genç; Edgar E. Gonzalez; Javier Patarroyo; Jordi Arbiol; Jordi Sancho-Parramon; Luc Henrard; Martial Duchamp; Neus G Bastus; Rafael E. Dunin-Borkowski; Raul Arenal et al. DOI: 10.1021/acsphotonics.5b00667
PMID: NOPMID4 Journal: Catalysis Science & Technology Year: 2016 Reference: Catal. Sci. Technol., 2016,6, 8388-8391 Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; Victor Franco Puntes et al. DOI: 10.1039/c6cy02071b
PMID: 27670583 Journal: ACS Applied Materials & Interfaces Year: 2016 Reference: ACS Appl Mater Interfaces. 2016 Oct 26;8(42):28437-28447. doi: 10.1021/acsami.6b06278. Epub 2016 Oct 13. Impact factor: Publication type: Paper in international publication Authors: Baggerman, Geert; Boraschi, Diana; Casals, Eudald; Italiani, Paola; Li, Yang; Mertens, Inge; Nelissen, Inge; Puntes, Victor F; Valkenborg, Dirk et al. DOI: 10.1021/acsami.6b06278
PMID: 27550382 Journal: Nanotoxicology Year: 2016 Reference: Nanotoxicology. 2016 Dec;10(10):1395-1403. doi: 10.1080/17435390.2016.1221476. Epub 2016 Sep 3. Impact factor: Publication type: Paper in international publication Authors: Bare, Birgit; Dawson, Kenneth; Deville, Sarah; Hoet, Peter; Monopoli, Marco; Nelissen, Inge; Piella, Jordi; Puntes, Victor F; Tirez, Kristof et al. DOI: 10.1080/17435390.2016.1221476
PMID: 22058075 Journal: Small Year: 2011 Reference: Small. 2011 Dec 16;7(24):3479-86. doi: 10.1002/smll.201101511. Epub 2011 Nov 7. Impact factor: Publication type: Paper in international publication Authors: Casals, Eudald; Duschl, Albert; Oostingh, Gertie J; Pfaller, Tobias; Puntes, Victor F et al. DOI: 10.1002/smll.201101511
PMID: 21728302 Journal: LANGMUIR Year: 2011 Reference: Langmuir. 2011 Sep 6;27(17):11098-105. doi: 10.1021/la201938u. Epub 2011 Jul 29. Impact factor: Publication type: Paper in international publication Authors: Bastus, Neus G; Comenge, Joan; Puntes, Victor et al. DOI: 10.1021/la201938u
PMID: 21529607 Journal: JOURNAL OF CONTROLLED RELEASE Year: 2010 Reference: J Control Release. 2010 Nov 20;148(1):e31-2. doi: 10.1016/j.jconrel.2010.07.041. Impact factor: Publication type: Paper in international publication Authors: Comenge, Joan; Dominguez, Fernando; Puntes, Victor; Romero, Francisco M; Sotelo, Carmen et al. DOI: 10.1016/j.jconrel.2010.07.041
PMID: 20832170 Journal: JOURNAL OF HAZARDOUS MATERIALS Year: 2010 Reference: J Hazard Mater. 2010 Dec 15;184(1-3):425-31. doi: 10.1016/j.jhazmat.2010.08.052. Epub 2010 Aug 21. Impact factor: Publication type: Paper in international publication Authors: Casals, Eudald; Colon, Joan; Font, Xavier; Gonzalez, Edgar; Puntes, Victor; Recillas, Sonia; Sanchez, Antoni et al. DOI: 10.1016/j.jhazmat.2010.08.052
PMID: 20973573 Journal: Annual Review of Biophysics Year: 2010 Reference: ACS Nano. 2010 Oct 26;4(10):5527-31. doi: 10.1021/nn1025687. Impact factor: Publication type: Paper in international publication Authors: Elder, Alison; Oberdorster, Gunter; Parak, Wolfgang J; Puntes, Victor; Rivera Gil, Pilar et al. DOI: 10.1021/nn1025687
