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Physiology and Pathophysiology of the Digestive Tract

The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.

Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.

We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function. 

 

Team

Rodríguez López, Ana María

Rodríguez López, Ana María

Physiology and Pathophysiology of the Digestive Tract
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Teodora Pribic

Teodora Pribic

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Alejandro  Henao  Paez

Alejandro Henao Paez

Physiology and Pathophysiology of the Digestive Tract
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Ariadna Aguilar Cayuelas

Ariadna Aguilar Cayuelas

Research technician
Physiology and Pathophysiology of the Digestive Tract
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Beatriz Lobo Alvarez

Beatriz Lobo Alvarez

Main researcher
Physiology and Pathophysiology of the Digestive Tract
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Blanca Grases Pintó

Blanca Grases Pintó

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Rodríguez López, Ana María

Rodríguez López, Ana María

Physiology and Pathophysiology of the Digestive Tract
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Teodora Pribic

Teodora Pribic

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Alejandro  Henao  Paez

Alejandro Henao Paez

Physiology and Pathophysiology of the Digestive Tract
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Ariadna Aguilar Cayuelas

Ariadna Aguilar Cayuelas

Research technician
Physiology and Pathophysiology of the Digestive Tract
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Beatriz Lobo Alvarez

Beatriz Lobo Alvarez

Main researcher
Physiology and Pathophysiology of the Digestive Tract
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Blanca Grases Pintó

Blanca Grases Pintó

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Projects

Contribución de la disfunción de CFTR al desarrollo y agresividad del cáncer de páncreas. Estimulación del crecimiento tumoral y metástasis por células estrelladas carentes de CFTR.

IP: Francesc Xavier Molero Richard
Collaborators: Laura Campderros Traver, Eva Polverino
Funding agency: Instituto de Salud Carlos III
Funding: 147620
Reference: PI22/00887
Duration: 01/01/2023 - 31/12/2025

Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in IRritable bowel syndrome In Europe (DISCOvERIE)

IP: Fco Javier Santos Vicente
Collaborators: Beatriz Lobo Alvarez, Silvia Muñoz Caller, Carmen Alonso Cotoner, Ana Maria Gonzalez Castro, Elba Exposito Fernandez, Marc Pigrau Pastor, Xavier Serra Ruiz, Adoración Nieto Ruiz, Alejandro Henao Paez, Consuelo Cammarota, José Alegre Martin, Jesus Castro Marrero, Marta Ribases Haro, Natalia Llonga Tejedor, Amanda Rodríguez Urrutia
Funding agency: EUROPEAN COMMISSION
Funding: 1148684.84
Reference: DISCOVERIE_H2020-SC1-BHC2019
Duration: 01/01/2020 - 31/12/2024

EFECTO DE PROBIÓTICOS EN LA TASA DE PARTO PRETÉRMINO (< 37 semanas) EN GESTANTES DE ALTO RIESGO DE PP: GESTANTES CON AMENAZA DE PARTO PRETÉRMINO (PROPEV TRIAL)

IP: Maria del Mar Goya Canino
Collaborators: Erika Bonacina, Francisca Yañez Araya
Funding agency: Instituto de Salud Carlos III
Funding: 29645
Reference: PI19/00287
Duration: 01/01/2020 - 30/06/2024

Contribución diferencial del epitelio intestinal a la fisiopatología de la diarrea crónica en el síndrome del intestino irritable y la colitis microscópica. Perfil clínico-biológico para el diagnóstico diferencial.

IP: Maria Vicario Perez
Collaborators: Beatriz Lobo Alvarez, Merce Albert Bayo, Inés de Torres Ramirez, Ana Maria Gonzalez Castro, Marc Pigrau Pastor, Xavier Serra Ruiz
Funding agency: Instituto de Salud Carlos III
Funding: 183920
Reference: PI19/01643
Duration: 01/01/2020 - 30/06/2024

Publications

Anatomical landmarks localization for capsule endoscopy studies.

PMID: 37267757
Journal: COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
Year: 2023
Reference: Comput Med Imaging Graph. 2023 May 18;108:102243. doi: 10.1016/j.compmedimag.2023.102243.
Impact factor:
Publication type: Paper in international publication
Authors: Gilabert, Pere; Laiz, Pablo; Malagelada, Carolina; Segui, Santi; Vitria, Jordi; Watson, Angus J M; Wenzek, Hagen et al.
DOI: 10.1016/j.compmedimag.2023.102243

Work productivity and activity impairment in disorders of gut-brain interaction: Data from the Rome Foundation Global Epidemiology Study.

PMID: 37332146
Journal: United European Gastroenterology Journal
Year: 2023
Reference: United European Gastroenterol J. 2023 Jun 18. doi: 10.1002/ueg2.12425.
Impact factor:
Publication type: Paper in international publication
Authors: Andresen, Viola; Bangdiwala, Shrikant I; Benninga, Marc A; Corazziari, Enrico S; Frandemark, Asa; Fukudo, Shin; Hreinsson, Johann Pall; Mulak, Agata; Palsson, Olafur S; Santos, Javier et al.
DOI: 10.1002/ueg2.12425

Gut microbial dysbiosis in patients with Cushing's disease in long-term remission. Relationship with cardiometabolic risk.

PMID: 37342265
Journal: Frontiers in Endocrinology
Year: 2023
Reference: Front Endocrinol (Lausanne). 2023 Jun 5;14:1074757. doi: 10.3389/fendo.2023.1074757. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Amodru, Vincent; Fernandez, Pedro Gonzalez; Gaztambide, Sonia; Manichanh, Chaysavanh; Martel-Duguech, Luciana; Puig-Domingo, Manel; Valassi, Elena; Webb, Susan M; Yanez, Francisca et al.
DOI: 10.3389/fendo.2023.1074757

Perioperative Nivolumab and Chemotherapy in Stage III Non-Small-Cell Lung Cancer.

PMID: 37379158
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2023
Reference: N Engl J Med. 2023 Jun 28. doi: 10.1056/NEJMoa2215530.
Impact factor:
Publication type: Paper in international publication
Authors: Aguado de la Rosa, Carlos; Aguilar, Andres; Barneto, Isidoro; Benitez, Raquel; Bernabe, Reyes; Bosch-Barrera, Joaquim; Calvo, Virginia; Camps, Carlos; Casal-Rubio, Joaquin; Cobo, Manuel et al.
DOI: 10.1056/NEJMoa2215530

Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations.

PMID: 35805133
Journal: Cells
Year: 2022
Reference: Cells. 2022 Jun 28;11(13). pii: cells11132046. doi: 10.3390/cells11132046.
Impact factor: 6.6
Publication type: Paper in international publication
Authors: Rodriguez-Urrutia, Amanda, Torres, Ines de, Santos-Briones, Ignacio, Azpiroz, Fernando, Lobo, Beatriz, Alonso-Cotoner, Carmen, Santos, Javier, Gonzalez-Castro, Ana M, Vicario, Maria, Guagnozzi, Danila et al.
DOI: 10.3390/cells11132046

Efficacy of pre-test questionnaires and PCR on COVID-19 detection prior to motility examinations.

PMID: 35641109
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2022
Reference: Neurogastroenterol Motil. 2022 May 31:e14413. doi: 10.1111/nmo.14413.
Impact factor: 3.598
Publication type: Letter or abstract
Authors: Serra, Jordi, Aguilar, Ariadna et al.
DOI: 10.1111/nmo.14413

Human gut metatranscriptome changes induced by a fermented milk product are associated with improved tolerance to a flatulogenic diet.

PMID: 35465165
Journal: Computational and Structural Biotechnology Journal
Year: 2022
Reference: Comput Struct Biotechnol J. 2022 Apr 5;20:1632-1641. doi: 10.1016/j.csbj.2022.04.001. eCollection 2022.
Impact factor: 7.271
Publication type: Paper in international publication
Authors: Oyarzun, Inigo, Le Neve, Boris, Yanez, Francisca, Xie, Zixuan, Pichaud, Matthieu, Serrano-Gomez, Gerard, Roca, Joaquim, Veiga, Patrick, Azpiroz, Fernando, Tap, Julien et al.
DOI: 10.1016/j.csbj.2022.04.001

Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?

PMID: 35431513
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2022
Reference: World J Gastroenterol. 2022 Mar 28;28(12):1204-1219. doi: 10.3748/wjg.v28.i12.1204.
Impact factor: 5.742
Publication type: Review in international publication
Authors: Ivashkin, Vladimir, Guarner, Francisco, Shifrin, Oleg, Svistushkin, Valery, Mamieva, Zarina, Poluektova, Elena, Sobolev, Vasily et al.
DOI: 10.3748/wjg.v28.i12.1204

Propagation patterns of jejunal motor activity measured by high-resolution water-perfused manometry.

PMID: 34378830
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2021
Reference: Neurogastroenterol Motil. 2021 Dec;33(12):e14240. doi: 10.1111/nmo.14240. Epub 2021 Aug 11.
Impact factor: 3.598
Publication type: Paper in international publication
Authors: Alcala-Gonzalez, Luis Gerardo, Malagelada, Carolina, Galan, Carmen, Nieto, Adoracion, Accarino, Anna, Azpiroz, Fernando et al.
DOI: 10.1111/nmo.14240

Effectiveness of a Telephone-Based Motivational Intervention for Smoking Cessation in Patients With Crohn Disease: A Randomized, Open-Label, Controlled Clinical Trial.

PMID: 34269705
Journal: Gastroenterology Nursing
Year: 2021
Reference: Gastroenterol Nurs. 2021 Nov-Dec 01;44(6):418-425. doi: 10.1097/SGA.0000000000000572.
Impact factor: 0.978
Publication type: Paper in international publication
Authors: Robles Alonso, Virginia, Navarro Correal, Ester, Casellas Jorda, Francesc, Borruel Sainz, Natalia, Sanchez Garcia, Josep Maria, Vila Morte, Genoveva, Fuentelsaz Gallego, Carmen, Ibarz Casas, Arantxa, Herrera de Guise, Claudia et al.
DOI: 10.1097/SGA.0000000000000572

Acquired hepatocerebral degeneration in a metastatic neuroendocrine tumor long-term survivor - an update on neuroendocrine neoplasm's treatment: A case report.

PMID: 34131474
Journal: World journal of hepatology
Year: 2021
Reference: World J Hepatol. 2021 May 27;13(5):611-619. doi: 10.4254/wjh.v13.i5.611.
Impact factor: 0
Publication type: Letter or abstract
Authors: Riveiro-Barciela, Mar, Mirallas, Oriol, Saoudi, Nadia, Gomez-Puerto, Diego, Landolfi, Stefania, Blanco, Laia, Garcia-Burillo, Amparo, Molero, Xavier, Salcedo-Allende, Maria Teresa, Capdevila, Jaume et al.
DOI: 10.4254/wjh.v13.i5.611

The role of liver steatosis as measured with transient elastography and transaminases on hard clinical outcomes in patients with COVID-19.

PMID: 34104210
Journal: Therapeutic Advances in Gastroenterology
Year: 2021
Reference: Therap Adv Gastroenterol. 2021 May 30;14:17562848211016567. doi: 10.1177/17562848211016567. eCollection 2021.
Impact factor: 4.409
Publication type: Paper in international publication
Authors: Campos-Varela, Isabel, Villagrasa, Ares, Simon-Talero, Macarena, Riveiro-Barciela, Mar, Ventura-Cots, Meritxell, Aguilera-Castro, Lara, Alvarez-Lopez, Patricia, Nordahl, Emilie A, Rivera-Esteban, Jesus M, Romero, Alba et al.
DOI: 10.1177/17562848211016567

Recommendations of the Spanish Association of Neurogastroenterology and Motility (ASENEM) to restart the activity of gastrintestinal motility laboratories after the state of alarm called due to the Covid-19 pandemic.

PMID: 32680731
Journal: Gastroenterologia y Hepatologia
Year: 2020
Reference: Gastroenterol Hepatol. 2020 Oct;43(8):485-496. doi: 10.1016/j.gastrohep.2020.05.011. Epub 2020 Jun 18.
Impact factor: 1.581
Publication type: Paper in national publication
Authors: Mas, Pilar, Barba, Elizabeth, Suarez, Jose Francisco, Accarino, Anna, Perez de la Serna, Julio, Serra, Jordi, Alcedo, Javier et al.
DOI: 10.1016/j.gastrohep.2020.05.011

Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment.

PMID: 32600917
Journal: Gastroenterologia y Hepatologia
Year: 2020
Reference: Gastroenterol Hepatol. 2020 Dec;43(10):649-658. doi: 10.1016/j.gastrohep.2020.04.004. Epub 2020 Jun 27.
Impact factor: 1.581
Publication type: Paper in national publication
Authors: Barreiro-de Acosta, Manuel, Marin-Jimenez, Ignacio, Rodriguez-Lago, Iago, Guarner, Francisco, Espin, Eloy, Ferrer Bradley, Isabel, Gutierrez, Ana, Chaparro, Maria, Gisbert, Javier P, Nos, Pilar et al.
DOI: 10.1016/j.gastrohep.2020.04.004

European Society for Neurogastroenterology and Motility (ESNM) recommendations for conducting gastrointestinal motility and function testing in the recovery phase of the COVID-19 pandemic.

PMID: 32525249
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2020
Reference: Neurogastroenterol Motil. 2020 Jul;32(7):e13930. doi: 10.1111/nmo.13930.
Impact factor: 2.946
Publication type: Paper in international publication
Authors: Farmer, Adam, Hauser, Goran, Mulak, Agata, Novais, Luis, Edoardo Savarino, Daniel Pohl, Storonova, Olga, Zerbib, Frank, Carbone, Florencia, Geeraerts, Annelies, Enck, Paul et al.
DOI: 10.1111/nmo.13930

Sex Differences and Commonalities in the Impact of a Palatable Meal on Thalamic and Insular Connectivity.

PMID: 32492812
Journal: Nutrients
Year: 2020
Reference: Nutrients. 2020 Jun 1;12(6). pii: nu12061627. doi: 10.3390/nu12061627.
Impact factor: 4.546
Publication type: Paper in international publication
Authors: Kilpatrick, Lisa, Pribic, Teodora, Ciccantelli, Barbara, Malagelada, Carolina, Livovsky, Dan M, Accarino, Anna, Pareto, Deborah, Azpiroz, Fernando, Mayer, Emeran A et al.
DOI: 10.3390/nu12061627

Development and validation of the QUECOMIICAT questionnaire: a tool to assess disease-related knowledge in patients with inflammatory bowel disease.

PMID: 31317762
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2019
Reference: Rev Esp Enferm Dig. 2019 Aug;111(8):586-592. doi: 10.17235/reed.2019.6298/2019.
Impact factor: 1.858
Publication type: Paper in international publication
Authors: Casellas, Francesc, Navarro, Ester, Amil, Paloma, Barber, Claudia, Marin, Laura, Guardiola, Jordi, Espin, Eloy, Sainz, Empar, Aldeguer, Xavier, Gallego, Marta et al.
DOI: 10.17235/reed.2019.6298/2019

Unraveling the effects of the gut microbiota composition and function on horse endurance physiology.

PMID: 31270376
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Jul 3;9(1):9620. doi: 10.1038/s41598-019-46118-7.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Philippe, Catherine, Plancade, Sandra, Clark, Allison, Esquerre, Diane, Moyec, Laurence le, Robert, Celine, Barrey, Eric, Mach, Nuria, Moisan, Marie-Pierre, Helbling, Jean-Christophe et al.
DOI: 10.1038/s41598-019-46118-7

Perioperative management and early complications after intestinal resection with ileocolonic anastomosis in Crohn's disease: analysis from the PRACTICROHN study.

PMID: 31217980
Journal: Gastroenterology Report
Year: 2019
Reference: Gastroenterol Rep (Oxf). 2019 Jun;7(3):168-175. doi: 10.1093/gastro/goz010. Epub 2019 Apr 19.
Impact factor: 2.194
Publication type: Paper in international publication
Authors: Gutierrez, Ana, Rivero, Montserrat, Martin-Arranz, Maria Dolores, Garcia Sanchez, Valle, Castro, Manuel, Barrio, Jesus, de Francisco, Ruth, Julia, Berta, Cea-Calvo, Luis, Romero, Cristina et al.
DOI: 10.1093/gastro/goz010

Gut epithelial and vascular barrier abnormalities in patients with chronic intestinal pseudo-obstruction.

PMID: 31144425
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2019
Reference: Neurogastroenterol Motil. 2019 Aug;31(8):e13652. doi: 10.1111/nmo.13652. Epub 2019 May 29.
Impact factor: 3.803
Publication type: Paper in international publication
Authors: Giancola, Fiorella, Bianco, Francesca, Bonora, Elena, Clavenzani, Paolo, Volta, Umberto, Caio, Giacomo, Sternini, Catia, Stanghellini, Vincenzo, Azpiroz, Fernando, De Giorgio, Roberto et al.
DOI: 10.1111/nmo.13652

Probiotics in irritable bowel syndrome: Where are we?

PMID: 30460770
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2018
Reference: Neurogastroenterol Motil. 2018 Dec;30(12):e13513. doi: 10.1111/nmo.13513.
Impact factor: 3.842
Publication type: Review in national publication
Authors: Barbara, Giovanni, Cremon, Cesare, Azpiroz, Fernando et al.
DOI: 10.1111/nmo.13513

Consensus document on exclusion diets in irritable bowel syndrome (IBS).

PMID: 30421956
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2018
Reference: Rev Esp Enferm Dig. 2018 Dec;110(12):806-824. doi: 10.17235/reed.2018.5941/2018.
Impact factor: 1.632
Publication type: Paper in international publication
Authors: Vazquez Alferez, Maria Del Carmen, Casellas, Francesc, Burgos, Rosa, Marcos, Ascension, Santos, Javier, Ciriza de Los Rios, Constanza, Garcia Manzanares, Alvaro, Polanco, Isabel, Puy Portillo, Maria, Villarino, Antonio et al.
DOI: 10.17235/reed.2018.5941/2018

[Diet and microbiota. Impact on health].

PMID: 30351154
Journal: Nutricion Hospitalaria
Year: 2018
Reference: Nutr Hosp. 2018 Sep 7;35(Spec No6):11-15.
Impact factor: 0.747
Publication type: Paper in national publication
Authors: Marcos, Ascension, Alvarez-Calatayud, Guillermo, Guarner, Francisco, Requena, Teresa et al.
DOI: 10.20960/nh.2280

Post-infectious IBS: Defining its clinical features and prognosis using an internet-based survey.

PMID: 30288287
Journal: United European Gastroenterology Journal
Year: 2018
Reference: United European Gastroenterol J. 2018 Oct;6(8):1245-1253. doi: 10.1177/2050640618779923. Epub 2018 May 23.
Impact factor: 3.477
Publication type: Paper in international publication
Authors: Spiller, Robin, Marshall, John, Aziz, Qasim, Mearin, Fermin, Azpiroz, Fernando, Card, Tim, Enck, Paul, Barbara, Giovanni, Boeckxstaens, Guy Ee, Santos, Javier et al.
DOI: 10.1177/2050640618779923

Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation.

PMID: 28966116
Journal: Stem Cell Reports
Year: 2017
Reference: Stem Cell Reports. 2017 Oct 10;9(4):1109-1123. doi: 10.1016/j.stemcr.2017.07.014. Epub 2017 Sep 28.
Impact factor: 7.338
Publication type: Paper in international publication
Authors: Serena, Carolina, Keiran, Noelia, Madeira, Ana, Maymo-Masip, Elsa, Ejarque, Miriam, Terron-Puig, Margarida, Espin, Eloy, Marti, Marc, Borruel, Natalia, Guarner, Francisco et al.
DOI: 10.1016/j.stemcr.2017.07.014

Microbiome-Based Diagnostics: Ready for Applications in Laboratory Medicine?

PMID: 28882888
Journal: CLINICAL CHEMISTRY
Year: 2017
Reference: Clin Chem. 2017 Nov;63(11):1674-1679. doi: 10.1373/clinchem.2016.264473. Epub 2017 Sep 7.
Impact factor: 8.008
Publication type: Paper in international publication
Authors: Versalovic, James, Dore, Joel, Guarner, Francisco, Luna, Ruth Ann, Ringel, Yehuda et al.
DOI: 10.1373/clinchem.2016.264473

The role of incongruence between the perceived functioning by patients and clinicians in the detection of psychological distress among functional and motor digestive disorders.

PMID: 28712415
Journal: JOURNAL OF PSYCHOSOMATIC RESEARCH
Year: 2017
Reference: J Psychosom Res. 2017 Aug;99:112-119. doi: 10.1016/j.jpsychores.2017.06.005. Epub 2017 Jun 9.
Impact factor: 2.809
Publication type: Paper in international publication
Authors: Rodriguez-Urrutia, Amanda, Eiroa-Orosa, Francisco Jose, Accarino, Anna, Malagelada, Carolina, Azpiroz, Fernando et al.
DOI: 10.1016/j.jpsychores.2017.06.005

Correction of Abdominal Distension by Biofeedback-guided Control of Abdomino-thoracic Muscular Activity in a Randomized, Placebo-Controlled Trial.

PMID: 28705783
Journal: Clinical Gastroenterology and Hepatology
Year: 2017
Reference: Clin Gastroenterol Hepatol. 2017 Dec;15(12):1922-1929. doi: 10.1016/j.cgh.2017.06.052. Epub 2017 Jul 11.
Impact factor: 7.398
Publication type: Paper in international publication
Authors: Barba, Elizabeth, Accarino, Anna, Azpiroz, Fernando et al.
DOI: 10.1016/j.cgh.2017.06.052

Impact of endoscopic ultrasonography (EUS) and EUS-guided fine-needle aspiration on the management of pancreatic cystic lesions.

PMID: 27286570
Journal: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Year: 2016
Reference: Eur J Gastroenterol Hepatol. 2016 Sep;28(9):1094-9. doi: 10.1097/MEG.0000000000000678.
Impact factor: 2.093
Publication type: Paper in international publication
Authors: Fernandez-Esparrach, Gloria, Boadas, Jaume, Busquets, Juli, Fernandez-Cruz, Laureano, Ferrer, Joana, Vaquero, Eva C, Molero, Xavier, Navarro, Salvador, Sanchez-Cabus, Santiago, Araujo, Isis K et al.
DOI: 10.1097/MEG.0000000000000678

Patient satisfaction in the management of mild-to-moderate ulcerative colitis: Results of a Delphi study among patients and physicians.

PMID: 27474198
Journal: DIGESTIVE AND LIVER DISEASE
Year: 2016
Reference: Dig Liver Dis. 2016 Oct;48(10):1172-9. doi: 10.1016/j.dld.2016.06.036. Epub 2016 Jul 14.
Impact factor: 2.719
Publication type: Paper in international publication
Authors: Casellas, Francesc, Ginard, Daniel, Riestra, Sabino et al.
DOI: 10.1016/j.dld.2016.06.036

Evidence-based Guidelines for the Management of Exocrine Pancreatic Insufficiency After Pancreatic Surgery.

PMID: 27045859
Journal: ANNALS OF SURGERY
Year: 2016
Reference: Ann Surg. 2016 Dec;264(6):949-958.
Impact factor: 8.569
Publication type: Paper in international publication
Authors: Marra-Lopez, Carlos, Sabater, Luis, Ausania, Fabio, Bakker, Olaf J, Boadas, Jaume, Dominguez-Munoz, J Enrique, Falconi, Massimo, Fernandez-Cruz, Laureano, Frulloni, Luca, Gonzalez-Sanchez, Victor et al.
DOI: 10.1097/SLA.0000000000001732

Perception of lactose intolerance impairs health-related quality of life.

PMID: 27188918
Journal: EUROPEAN JOURNAL OF CLINICAL NUTRITION
Year: 2016
Reference: Eur J Clin Nutr. 2016 Sep;70(9):1068-72. doi: 10.1038/ejcn.2016.80. Epub 2016 May 18.
Impact factor: 2.935
Publication type: Paper in international publication
Authors: Casellas, F, Aparici, A, Perez, M J, Rodriguez, P et al.
DOI: 10.1038/ejcn.2016.80

[Prebiotics: concept, properties and beneficial effects].

PMID: 25659062
Journal: Nutricion Hospitalaria
Year: 2015
Reference: Nutr Hosp. 2015 Feb 7;31 Suppl 1:99-118. doi: 10.3305/nh.2015.31.sup1.8715.
Impact factor: 1.04
Publication type: Paper in national publication
Authors: Redondo-Cuenca, A, Sanz, M L, Clemente, A, Ruperez, P, Ruas-Madiedo, P, Plou, F J, Mateos-Aparicio, I, Corzo, N, Alonso, J L, Azpiroz, F et al.
DOI: 10.3305/nh.2015.31.sup1.8715

Digestive, cognitive and hedonic responses to a meal.

PMID: 25557693
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2015
Reference: Neurogastroenterol Motil. 2015 Mar;27(3):389-96. doi: 10.1111/nmo.12504. Epub 2015 Jan 3.
Impact factor: 3.587
Publication type: Paper in international publication
Authors: Malagelada, C, Accarino, A, Molne, L, Mendez, S, Campos, E, Gonzalez, A, Malagelada, J R, Azpiroz, F et al.
DOI: 10.1111/nmo.12504

Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations.

PMID: 25209656
Journal: GUT
Year: 2015
Reference: Gut. 2015 Sep;64(9):1379-88. doi: 10.1136/gutjnl-2013-306236. Epub 2014 Sep 10.
Impact factor: 13.319
Publication type: Paper in international publication
Authors: Vicario, Maria, Gonzalez-Castro, Ana M, Martinez, Cristina, Lobo, Beatriz, Pigrau, Marc, Guilarte, Mar, de Torres, Ines, Mosquera, Jose L, Fortea, Marina, Sevillano-Aguilera, Cesar et al.
DOI: 10.1136/gutjnl-2013-306236

The Intestinal Gas Questionnaire: development of a new instrument for measuring gas-related symptoms and their impact on daily life.

PMID: 25846412
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2015
Reference: Neurogastroenterol Motil. 2015 Jun;27(6):885-98. doi: 10.1111/nmo.12565. Epub 2015 Apr 6.
Impact factor: 3.587
Publication type: Paper in international publication
Authors: Chassany, O, Tugaut, B, Marrel, A, Guyonnet, D, Duracinsky, M, Whorwell, P J, Azpiroz, F, Arbuckle, R et al.
DOI: 10.1111/nmo.12565

Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic.

PMID: 24912386
Journal: NAT REV GASTRO HEPAT
Year: 2014
Reference: Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14. doi: 10.1038/nrgastro.2014.66. Epub 2014 Jun 10.
Impact factor: 10.807
Publication type: Clinical guide
Authors: Hill, Colin, Guarner, Francisco, Reid, Gregor, Gibson, Glenn R, Merenstein, Daniel J, Pot, Bruno, Morelli, Lorenzo, Canani, Roberto Berni, Flint, Harry J, Salminen, Seppo et al.
DOI: 10.1038/nrgastro.2014.66

Processing faecal samples: a step forward for standards in microbial community analysis.

PMID: 24884524
Journal: BMC MICROBIOL
Year: 2014
Reference: BMC Microbiol. 2014 May 1;14:112. doi: 10.1186/1471-2180-14-112.
Impact factor: 2.976
Publication type: Paper in international publication
Authors: Santiago, Alba, Panda, Suchita, Mengels, Griet, Martinez, Xavier, Azpiroz, Fernando, Guarner, Francisco, Manichanh, Chaysavanh, Dore, Joel et al.
DOI: 10.1186/1471-2180-14-112

Short-term effect of antibiotics on human gut microbiota.

PMID: 24748167
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Apr 18;9(4):e95476. doi: 10.1371/journal.pone.0095476. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Manichanh, Chaysavanh, Panda, Suchita, El khader, Ismail, Casellas, Francesc, Lopez Vivancos, Josefa, Garcia Cors, Montserrat, Santiago, Alba, Cuenca, Silvia, Guarner, Francisco et al.
DOI: 10.1371/journal.pone.0095476

From basic to applied research: lessons from the human microbiome projects.

PMID: 25291122
Journal: J CLIN GASTROENTEROL
Year: 2014
Reference: J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S3-4. doi: 10.1097/MCG.0000000000000242.
Impact factor: 3.186
Publication type: Paper in international publication
Authors: Guarner, Francisco, Robles-Alonso, Virginia et al.
DOI: 10.1097/MCG.0000000000000242

Dietary lipids and functional gastrointestinal disorders.

PMID: 23567355
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2013
Reference: Am J Gastroenterol. 2013 May;108(5):737-47. doi: 10.1038/ajg.2013.76. Epub 2013 Apr 9.
Impact factor: 7.553
Publication type: Review in international publication
Authors: Feinle-Bisset, Christine, Azpiroz, Fernando et al.
DOI: 10.1038/ajg.2013.76

The intestinal microbiome, probiotics and prebiotics in neurogastroenterology.

PMID: 23202796
Journal: Gut Microbes
Year: 2013
Reference: Gut Microbes. 2013 Jan-Feb;4(1):17-27. doi: 10.4161/gmic.22973. Epub 2012 Nov 30.
Impact factor:
Publication type: Letter or abstract
Authors: Saulnier, Delphine M, Ringel, Yehuda, Heyman, Melvin B, Foster, Jane A, Bercik, Premysl, Shulman, Robert J, Versalovic, James, Verdu, Elena F, Dinan, Ted G, Hecht, Gail et al.
DOI: 10.4161/gmic.22973

Richness of human gut microbiome correlates with metabolic markers.

PMID: 23985870
Journal: NATURE
Year: 2013
Reference: Nature. 2013 Aug 29;500(7464):541-6. doi: 10.1038/nature12506.
Impact factor: 38.597
Publication type: Paper in international publication
Authors: Juste, Catherine, Tims, Sebastian, Zoetendal, Erwin G, Brunak, Soren, Clement, Karine, Dore, Joel, Kleerebezem, Michiel, Kristiansen, Karsten, Renault, Pierre, Sicheritz-Ponten, Thomas et al.
DOI: 10.1038/nature12506

Optimizing treatment for patients with irritable bowel syndrome with constipation.

PMID: 23859753
Journal: Expert Review of Gastroenterology & Hepatology
Year: 2013
Reference: Expert Rev Gastroenterol Hepatol. 2013 Jul;7(5 Suppl 1):1-2. doi: 10.1586/17474124.2013.820048.
Impact factor: 2.221
Publication type: Paper in international publication
Authors: Malagelada, Juan-Ramon et al.
DOI: 10.1586/17474124.2013.820048

World gastroenterology organisation global guidelines: probiotics and prebiotics october 2011.

PMID: 22688142
Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY
Year: 2012
Reference: J Clin Gastroenterol. 2012 Jul;46(6):468-81.
Impact factor: 3.159
Publication type: Paper in international publication
Authors: de Paula, Juan Andres, Guarner, Francisco, Khan, Aamir G, Garisch, James, Eliakim, Rami, Gangl, Alfred, Thomson, Alan, Krabshuis, Justus, Lemair, Ton, Kaufmann, Pedro et al.
DOI: 10.1097/MCG.0b013e3182549092

Acute experimental stress evokes a differential gender-determined increase in human intestinal macromolecular permeability.

PMID: 22625665
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2012
Reference: Neurogastroenterol Motil. 2012 Aug;24(8):740-6, e348-9. doi: 10.1111/j.1365-2982.2012.01928.x. Epub 2012 May 24.
Impact factor: 3.414
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1365-2982.2012.01928.x

Mucosal healing restores normal health and quality of life in patients with inflammatory bowel disease.

PMID: 22517240
Journal: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Year: 2012
Reference: Eur J Gastroenterol Hepatol. 2012 Jul;24(7):762-9.
Impact factor: 1.757
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1097/MEG.0b013e32835414b2

Accommodation of the abdomen to its content: integrated abdomino-thoracic response.

PMID: 22188369
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2012
Reference: Neurogastroenterol Motil. 2012 Apr;24(4):312-e162. doi: 10.1111/j.1365-2982.2011.01846.x. Epub 2011 Dec 21.
Impact factor: 3.414
Publication type: Paper in international publication
Authors: , , , , , , et al.
DOI: 10.1111/j.1365-2982.2011.01846.x

Human gut microbiota and its relationship to health and disease.

PMID: 21729093
Journal: NUTRITION REVIEWS
Year: 2011
Reference: Nutr Rev. 2011 Jul;69(7):392-403. doi: 10.1111/j.1753-4887.2011.00402.x. Epub 2011 Jun 30.
Impact factor: 4.077
Publication type: Review in international publication
Authors: , , , , , , et al.
DOI: 10.1111/j.1753-4887.2011.00402.x

Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients.

PMID: 21722149
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2011
Reference: Aliment Pharmacol Ther. 2011 Sep;34(5):544-54. doi: 10.1111/j.1365-2036.2011.04756.x. Epub 2011 Jul 3.
Impact factor: 3.861
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1365-2036.2011.04756.x

Effectiveness of Combined Pharmacologic and Ligation Therapy in High-Risk Patients With Acute Esophageal Variceal Bleeding.

PMID: 21625271
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2011
Reference: Am J Gastroenterol. 2011 Oct;106(10):1787-95. doi: 10.1038/ajg.2011.173. Epub 2011 May 31.
Impact factor: 6.882
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1038/ajg.2011.173

Nursing resources and responsibilities according to hospital organizational model for management of inflammatory bowel disease in Spain.

PMID: 21575883
Journal: Journal of Crohns & Colitis
Year: 2011
Reference: J Crohns Colitis. 2011 Jun;5(3):211-7. Epub 2011 Feb 11.
Impact factor: 2.628
Publication type: Paper in international publication
Authors: Garcia-Sanchez, Valle, Lazaro, Pablo, Alfaro, Noelia, Casellas, Francesc, Marin, Laura, Torrejon, Antonio, Oltra, Lorena, Seoane, Montserrat, Hernandez-Sampelayo, Paloma, Vera, Maria Isabel et al.
DOI: 10.1016/j.crohns.2011.01.001

[Recommendations for diagnosis, staging and treatment of pancreatic cancer (Part I). Grupo Espanol de Consenso en Cancer de Pancreas]

PMID: 20346471
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 May 15;134(14):643-55. Epub 2010 Mar 26.
Impact factor: 1.231
Publication type: Editorial in national publication
Authors: Arguello, Lidia, Barranco, Luis, Cardenas, Andres, Conill, Carlos, Cuatrecasas, Miriam, de Madaria, Enrique, Delgado, Fructuoso, Diaz, Roberto, Dominguez, Enrique, Fabregat, Joan et al.
DOI: 10.1016/j.medcli.2009.12.014

Validation of the Spanish version of a questionnaire to measure quality of care through the eyes of patients with inflammatory bowel disease (QUOTE-IBD).

PMID: 19918968
Journal: INFLAMMATORY BOWEL DISEASES
Year: 2010
Reference: Inflamm Bowel Dis. 2010 Jun;16(6):982-92.
Impact factor: 4.643
Publication type: Paper in international publication
Authors: Masachs, Miquel, Casellas, Francesc, Borruel, Natalia, Torrejon, Antonio, Castells, Isabel, Malagelada, Juan Ramon et al.
DOI: 10.1002/ibd.21156

Reshaping the gut microbiome with bacterial transplantation and antibiotic intake.

PMID: 20736229
Journal: GENOME RESEARCH
Year: 2010
Reference: Genome Res. 2010 Oct;20(10):1411-9. Epub 2010 Aug 24.
Impact factor: 11.342
Publication type: Paper in international publication
Authors: Guarner, Francisco, Knight, Rob, Guigo, Roderic, Llopis, Marta, Manichanh, Chaysavanh, Reeder, Jens, Gibert, Prudence, Varela, Encarna, Antolin, Maria et al.
DOI: 10.1101/gr.107987.110

Prebiotic effects: metabolic and health benefits.

PMID: 20920376
Journal: BRITISH JOURNAL OF NUTRITION
Year: 2010
Reference: Br J Nutr. 2010 Aug;104 Suppl 2:S1-63.
Impact factor: 3.446
Publication type: Paper in international publication
Authors: Roberfroid, Marcel, Gibson, Glenn R, Hoyles, Lesley, McCartney, Anne L, Rastall, Robert, Rowland, Ian, Wolvers, Danielle, Watzl, Bernhard, Szajewska, Hania, Stahl, Bernd et al.
DOI: 10.1017/S0007114510003363

Infliximab maintenance therapy is associated with decreases in direct resource use in patients with luminal or fistulizing Crohn's disease.

PMID: 19448569
Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY
Year: 2009
Reference: J Clin Gastroenterol. 2009 Nov-Dec;43(10):950-6.
Impact factor: 2.775
Publication type: Paper in international publication
Authors: Roman, Antonio Lopez-San, Morales, Jose M, Casado, Miguel A, Gisbert, Javier P, Ricart, Elena, Martinez-Montiel, Pilar, Ponce, Marta, Taxonera, Carlos, Rodrigo, Luis, Casellas, Francesc et al.
DOI: 10.1097/MCG.0b013e3181986917

Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa.

PMID: 18839424
Journal: INFLAMMATORY BOWEL DISEASES
Year: 2009
Reference: Inflamm Bowel Dis. 2009 Feb;15(2):275-83.
Impact factor: 4.975
Publication type: Paper in international publication
Authors: Llopis, Marta, Antolin, Maria, Carol, Monica, Borruel, Natalia, Casellas, Francesc, Martinez, Cristina, Espin-Basany, Eloy, Guarner, Francisco, Malagelada, Juan-R et al.
DOI: 10.1002/ibd.20736

Faecal DNA and calprotectin as biomarkers of acute intestinal toxicity in patients undergoing pelvic radiotherapy.

PMID: 19392859
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2009
Reference: Aliment Pharmacol Ther. 2009 Jul 1;30(2):175-85.
Impact factor: 1.215
Publication type: Paper in international publication
Authors: Varela, E, Antolin, M, Guarner, F, Verges, R, Giralt, J, Malagelada, J-R et al.
DOI: 10.1111/j.1365-2036.2009.04019.x

Development, validation, and applicability of a symptoms questionnaire for lactose malabsorption screening.

PMID: 18716868
Journal: DIGESTIVE DISEASES AND SCIENCES
Year: 2009
Reference: Dig Dis Sci. 2009 May;54(5):1059-65.
Impact factor: 1.583
Publication type: Paper in international publication
Authors: Casellas, Francesc, Varela, E, Aparici, A, Casaus, M, Rodriguez, P et al.
DOI: 10.1007/s10620-008-0443-3

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Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.

The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.

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