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Physiology and Pathophysiology of the Digestive Tract

The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.

Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.

We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function. 

 

Team

Francisca Yañez Araya

Francisca Yañez Araya

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Gloria Santaliestra Vivaracho

Gloria Santaliestra Vivaracho

Research assistant
Physiology and Pathophysiology of the Digestive Tract
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Jorge Serra Pueyo

Jorge Serra Pueyo

Main researcher
Physiology and Pathophysiology of the Digestive Tract
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Josefa Mª Heredia Montiel

Josefa Mª Heredia Montiel

Administration and Management
Physiology and Pathophysiology of the Digestive Tract
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Lara Aguilera  Castro

Lara Aguilera Castro

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Laura Campderros Traver

Laura Campderros Traver

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Francisca Yañez Araya

Francisca Yañez Araya

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Gloria Santaliestra Vivaracho

Gloria Santaliestra Vivaracho

Research assistant
Physiology and Pathophysiology of the Digestive Tract
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Jorge Serra Pueyo

Jorge Serra Pueyo

Main researcher
Physiology and Pathophysiology of the Digestive Tract
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Josefa Mª Heredia Montiel

Josefa Mª Heredia Montiel

Administration and Management
Physiology and Pathophysiology of the Digestive Tract
Read more
Lara Aguilera  Castro

Lara Aguilera Castro

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
Read more
Laura Campderros Traver

Laura Campderros Traver

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
Read more

Publications

Increased gut permeability and bacterial translocation are associated with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome: implications for disease-related biomarker discovery.

PMID: 37744357
Journal: Frontiers in Immunology
Year: 2023
Reference: Front Immunol. 2023 Sep 7;14:1253121. doi: 10.3389/fimmu.2023.1253121. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre-Martin, Jose; Alegre-Martin, Jose; Almirall, Miriam; Blanco-Suarez, Manuel; Caceres, Oscar; Castro-Marrero, Jesus; Domingo, Joan Carles; Gonzalez-Castro, Ana Maria; Gonzalez-Castro, Ana Maria; Jurek, Joanna et al.
DOI: 10.3389/fimmu.2023.1253121

HLA signatures as pathophysiological discriminants of microscopic colitis subtypes.

PMID: 37768647
Journal: Journal of Crohns & Colitis
Year: 2023
Reference: J Crohns Colitis. 2023 Sep 28:jjad165. doi: 10.1093/ecco-jcc/jjad165.
Impact factor:
Publication type: Paper in international publication
Authors: Almer, Sven; Bonfiglio, Ferdinando; Bresso, Francesca; Bujanda, Luis; Camargo Tavares, Leticia; Chen, Ye; Colombel, Jean-Frederic; D'Amato, Mauro; Escudero-Hernandez, Celia; Esteve, Maria et al.
DOI: 10.1093/ecco-jcc/jjad165

Implementation of the recommendations for the psychological management of patients with spondyloarthritis and inflammatory bowel disease.

PMID: 37805255
Journal: Reumatologia clinica
Year: 2023
Reference: Reumatol Clin (Engl Ed). 2023 Oct;19(8):423-429. doi: 10.1016/j.reumae.2023.03.007.
Impact factor:
Publication type: Paper in international publication
Authors: Almirall, Miriam; Borruel, Natalia; Borruel, Natalia; Ginard, Daniel; Gonzalez-Lama, Yago; Gratacos, Jordi; Juanola, Xavier; Loza, Estibaliz; Sanz, Jesus; Urruticoechea-Arana, Ana et al.
DOI: 10.1016/j.reumae.2023.03.007

Corrigendum to "Differences between childhood- and adulthood-onset eosinophilic esophagitis: An analysis from the EoE connect registry" [Digestive and Liver Disease Volume 55, Issue 3, March 2023, Pages 350-359].

PMID: 37230859
Journal: DIGESTIVE AND LIVER DISEASE
Year: 2023
Reference: Dig Liver Dis. 2023 May 23:S1590-8658(23)00621-7. doi: 10.1016/j.dld.2023.05.011.
Impact factor:
Publication type: Letter or abstract
Authors: Alcedo, Javier; Arias, Angel; Barrio, Jesus; Betore-Glaria, Maria Elena; Blas-Jhon, Leonardo; Carrion, Silvia; Casabona-Frances, Sergio; Dainese, Raffaella; de la Pena-Negro, Luisa; De la Riva, Susana et al.
DOI: 10.1016/j.dld.2023.05.011

A novel case of diabetes MODY1 and chronic hereditary pancreatitis: coexistence of two infrequent genetic mutations.

PMID: 35256061
Journal: Endocrinologia Diabetes y Nutricion
Year: 2022
Reference: Endocrinol Diabetes Nutr (Engl Ed). 2022 Feb;69(2):155-156. doi: 10.1016/j.endien.2022.02.004.
Impact factor: 1.417
Publication type: Letter or abstract
Authors: Cordero-Vazquez, Efrain, Filippi-Arriaga, Francesca, Hernandez, Irene Hernandez, Haman, Stephanie Solange Tasayco, Ciudin, Andreea et al.
DOI: 10.1016/j.endien.2022.02.004

The Intestinal Gas Questionnaire (IGQ): Psychometric validation of a new instrument for measuring gas-related symptoms and their impact on daily life among general population and irritable bowel syndrome.

PMID: 34145682
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2022
Reference: Neurogastroenterol Motil. 2022 Mar;34(3):e14202. doi: 10.1111/nmo.14202. Epub 2021 Jun 18.
Impact factor: 3.598
Publication type: Paper in international publication
Authors: Duracinsky, Martin, Archbold, Sharon, Lobo, Beatriz, Bessonneau, Pascal, Thonon, Frederique, Santos, Javier, Guagnozzi, Danila, Payakachat, Nalin, Coffin, Benoit, Azpiroz, Fernando et al.
DOI: 10.1111/nmo.14202

Rapidity of clinical response to adalimumab and improvement of quality of life in luminal Crohn’s disease: RAPIDA study

PMID: 34051313
Journal: Gastroenterologia y Hepatologia
Year: 2022
Reference: Gastroenterol Hepatol. 2022 Mar;45(3):165-176. doi: 10.1016/j.gastrohep.2021.04.010. Epub 2021 May 27.
Impact factor: 2.102
Publication type: Paper in national publication
Authors: Marin-Jimenez, Ignacio, de Acosta, Manuel Barreiro, Esteve, Maria, Castro-Laria, Luisa, Garcia-Lopez, Santiago, Ceballos, Daniel, Echarri, Ana, Martin-Arranz, Maria Dolores, Busquets, David, Llao, Jordina et al.
DOI: 10.1016/j.gastrohep.2021.04.010

Pancreatitis crónica para el clínico. Parte 1: Etiología y Diagnóstico. Documento de posicionamiento interdisciplinar de la Societat Catalana de Digestologia y la Societat Catalana de Pàncrees (versión castellana)

PMID: 34157366
Journal: Gastroenterologia y Hepatologia
Year: 2022
Reference: Gastroenterol Hepatol. 2022 Mar;45(3):231-248. doi: 10.1016/j.gastrohep.2021.05.017. Epub 2021 Jun 19.
Impact factor: 2.102
Publication type: Paper in national publication
Authors: Vaquero, Eva Cristina, Serrano, Teresa, Salord, Silvia, Puig-Divi, Valenti, Molero, Xavier, Ayuso, Juan Ramon, Balsells, Joaquim, Boadas, Jaume, Busquets, Juli, Casteras, Anna et al.
DOI: 10.1016/j.gastrohep.2021.05.017

Gut Microbes and Health.

PMID: 33652061
Journal: Gastroenterologia y Hepatologia
Year: 2021
Reference: Gastroenterol Hepatol. 2021 Aug-Sep;44(7):519-535. doi: 10.1016/j.gastrohep.2021.01.009. Epub 2021 Feb 27.
Impact factor: 2.102
Publication type: Review in national publication
Authors: Alvarez, Julia, Manuel Fernandez Real, Jose, Guarner, Francisco, Gueimonde, Miguel, Rodriguez, Juan Miguel, Saenz de Pipaon, Miguel, Sanz, Yolanda et al.
DOI: 10.1016/j.gastrohep.2021.01.009

Corrigendum to "Recomendaciones del Grupo Español de Trabajo en enfermedad de Crohn y colitis ulcerosa (GETECCU) sobre la reservoritis en la colitis ulcerosa. Parte 2: Tratamiento" [Gastroenterología y Hepatología 2020;43(10):649-658]

PMID: 33642094
Journal: Gastroenterologia y Hepatologia
Year: 2021
Reference: Gastroenterol Hepatol. 2021 Apr;44(4):320. doi: 10.1016/j.gastrohep.2021.02.001. Epub 2021 Feb 25.
Impact factor: 2.102
Publication type: Letter or abstract
Authors: Beltran, Belen, Barreiro-de Acosta, Manuel, Marin-Jimenez, Ignacio, Rodriguez-Lago, Iago, Guarner, Francisco, Espin, Eloy, Ferrer Bradley, Isabel, Gutierrez, Ana, Nos, Pilar, Gisbert, Javier P et al.
DOI: 10.1016/j.gastrohep.2021.02.001

Different responses of the blockade of the P2Y1 receptor with BPTU in human and porcine intestinal tissues and in cell cultures.

PMID: 33619847
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2021
Reference: Neurogastroenterol Motil. 2021 Jul;33(7):e14101. doi: 10.1111/nmo.14101. Epub 2021 Feb 22.
Impact factor: 3.598
Publication type: Paper in international publication
Authors: Maclnnes, Jane, Relea, Lucia, MacPherson, Lewis C, Cunningham, Margaret R, Vergara, Patri, Accarino, Anna, Kennedy, Charles, Jimenez, Marcel, Barber, Claudia, Traserra, Sara et al.
DOI: 10.1111/nmo.14101

Evaluation of an O2-Substituted (1-3)-beta-D-Glucan, Produced by Pediococcus parvulus 2.6, in ex vivo Models of Crohn's Disease.

PMID: 33613490
Journal: Frontiers in Microbiology
Year: 2021
Reference: Front Microbiol. 2021 Feb 5;12:621280. doi: 10.3389/fmicb.2021.621280. eCollection 2021.
Impact factor: 5.64
Publication type: Paper in international publication
Authors: Notararigo, Sara, Varela, Encarnacion, Otal, Anna, Cristobo, Ivan, Antolin, Maria, Guarner, Francisco, Prieto, Alicia, Lopez, Paloma et al.
DOI: 10.3389/fmicb.2021.621280

Food, Eating, and the Gastrointestinal Tract.

PMID: 32252402
Journal: Nutrients
Year: 2020
Reference: Nutrients. 2020 Apr 2;12(4). pii: nu12040986. doi: 10.3390/nu12040986.
Impact factor: 4.546
Publication type: Paper in international publication
Authors: Livovsky, Dan M, Pribic, Teorora, Azpiroz, Fernando et al.
DOI: 10.3390/nu12040986

Prevalence, features and predictive factors of liver nodules in Fontan surgery patients: The VALDIG Fonliver prospective cohort.

PMID: 31726116
Journal: JOURNAL OF HEPATOLOGY
Year: 2020
Reference: J Hepatol. 2020 Apr;72(4):702-710. doi: 10.1016/j.jhep.2019.10.027. Epub 2019 Nov 11.
Impact factor: 20.582
Publication type: Paper in international publication
Authors: Tellez, Luis, Rodriguez de Santiago, Enrique, Minguez, Beatriz, Payance, Audrey, Clemente, Ana, Baiges, Anna, Morales-Arraez, Dalia, La Mura, Vincenzo, Llop, Elba, Garrido, Elena et al.
DOI: 10.1016/j.jhep.2019.10.027

Testing the Food Experience in Healthy Human Volunteers: a Proof-of-Concept Study.

PMID: 32176761
Journal: Journal of Gastrointestinal and Liver Diseases
Year: 2020
Reference: J Gastrointestin Liver Dis. 2020 Mar 13;29(1):65-68. doi: 10.15403/jgld-806.
Impact factor: 2.351
Publication type: Paper in international publication
Authors: Pribic, Teodora, Lopez, Quiro, Lucas, Eduardo, Livovsky, Dan M, Rovira, Alex, Accarino, Anna, Azpiroz, Fernando, Pareto, Deborah et al.
DOI: 10.15403/jgld-806

The Brain-Gut Team.

PMID: 32114574
Journal: DIGESTIVE DISEASES
Year: 2020
Reference: Dig Dis. 2020;38(4):293-298. doi: 10.1159/000505810. Epub 2020 Feb 28.
Impact factor: 2.493
Publication type: Review in international publication
Authors: Malagelada, Juan R et al.
DOI: 10.1159/000505810

Prevalence and Factors Associated with Fatigue in Patients with Inflammatory Bowel Disease: A Multicenter Study.

PMID: 30721954
Journal: Journal of Crohns & Colitis
Year: 2019
Reference: J Crohns Colitis. 2019 Aug 14;13(8):996-1002. doi: 10.1093/ecco-jcc/jjz024.
Impact factor: 7.827
Publication type: Paper in international publication
Authors: Castro-Laria, L, Martin-Arranz, M D, Martinez-Montiel, M P, Valls, M, Ferreiro-Iglesias, R, Llao, J, Moraleja-Yudego, I, Casellas, F, Antolin-Melero, B, Cortes, X et al.
DOI: 10.1093/ecco-jcc/jjz024

Microcytic anemia due to ileocolic anastomotic ulcer.

PMID: 29588085
Journal: Gastroenterologia y Hepatologia
Year: 2019
Reference: Gastroenterol Hepatol. 2019 Feb;42(2):111-112. doi: 10.1016/j.gastrohep.2018.02.004. Epub 2018 Mar 24.
Impact factor: 1.126
Publication type: Letter or abstract
Authors: Rivera Esteban, Jesus Manuel, Espin Basany, Eloy, Santos Vicente, Javier, Alonso-Cotoner, Carmen et al.
DOI: 10.1016/j.gastrohep.2018.02.004

Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches.

PMID: 30229903
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2019
Reference: Int J Cancer. 2019 Apr 1;144(7):1540-1549. doi: 10.1002/ijc.31866. Epub 2018 Oct 26.
Impact factor: 4.982
Publication type: Paper in international publication
Authors: Kleeff, Jorg, Kong, Bo, Mora, Josefina, Murray, Liam, O'Driscoll, Damian, Poves, Ignasi, Lawlor, Rita T, Ye, Weimin, Hidalgo, Manuel, Scarpa, Aldo et al.
DOI: 10.1002/ijc.31866

Meal Enjoyment and Tolerance in Women and Men.

PMID: 30626147
Journal: Nutrients
Year: 2019
Reference: Nutrients. 2019 Jan 8;11(1). pii: nu11010119. doi: 10.3390/nu11010119.
Impact factor: 4.171
Publication type: Paper in international publication
Authors: Galan, Carmen, Nieto, Adoracion, Amigo, Nuria, Accarino, Anna, Correig, Xavier, Azpiroz, Fernando, Pribic, Teodora, Monrroy, Hugo et al.
DOI: 10.3390/nu11010119

Zeb1 in stromal myofibroblasts promotes Kras-driven development of pancreatic cancer.

PMID: 29490942
Journal: CANCER RESEARCH
Year: 2018
Reference: Cancer Res. 2018 May 15;78(10):2624-2637. doi: 10.1158/0008-5472.CAN-17-1882. Epub 2018 Feb 28.
Impact factor: 9.13
Publication type: Paper in international publication
Authors: Sangrador, Irene, Molero, Xavier, Campbell, Fiona, Franch-Exposito, Sebastia, Rovira-Rigau, Maria, Samper, Esther, Dominguez Fraile, Manuel, Fillat, Cristina, Castells, Antoni, Vaquero, Eva C et al.
DOI: 10.1158/0008-5472.CAN-17-1882

Managing iron deficiency and iron deficiency anemia in inflammatory bowel disease. The results of the "Gestiona hierro-EII" survey.

PMID: 29465251
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2018
Reference: Rev Esp Enferm Dig. 2018 Mar;110(3):172-178. doi: 10.17235/reed.2018.5354/2017.
Impact factor: 1.632
Publication type: Paper in international publication
Authors: Casellas Jorda, Francesc, Vera Mendoza, Isabel, Barreiro-de Acosta, Manuel, Vazquez Moron, Juan Maria, Lopez Roman, Javier, Judez Gutierrez, Javier et al.
DOI: 10.17235/reed.2018.5354/2017

Decreased TESK1-mediated cofilin 1 phosphorylation in the jejunum of IBS-D patients may explain increased female predisposition to epithelial dysfunction.

PMID: 29396473
Journal: Scientific Reports
Year: 2018
Reference: Sci Rep. 2018 Feb 2;8(1):2255. doi: 10.1038/s41598-018-20540-9.
Impact factor: 4.122
Publication type: Paper in international publication
Authors: Martinez, Cristina, Fortea, Marina, Lobo, Beatriz, Pigrau, Marc, Nieto, Adoracion, Gonzalez-Castro, Ana Maria, Salvo-Romero, Eloisa, Guagnozzi, Danila, Pardo-Camacho, Cristina, Iribarren, Cristina et al.
DOI: 10.1038/s41598-018-20540-9

Biogastronomy: Factors that determine the biological response to meal ingestion.

PMID: 29392797
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2018
Reference: Neurogastroenterol Motil. 2018 Jul;30(7):e13309. doi: 10.1111/nmo.13309. Epub 2018 Feb 2.
Impact factor: 3.842
Publication type: Review in international publication
Authors: Pribic, T, Azpiroz, F et al.
DOI: 10.1111/nmo.13309

Relation between cognitive and hedonic responses to a meal.

PMID: 28054426
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2017
Reference: Neurogastroenterol Motil. 2017 May;29(5). doi: 10.1111/nmo.13011. Epub 2017 Jan 5.
Impact factor: 3.617
Publication type: Paper in international publication
Authors: Ciccantelli, B, Pribic, T, Malagelada, C, Accarino, A, Azpiroz, F et al.
DOI: 10.1111/nmo.13011

Metabolic adaptation of colonic microbiota to galactooligosaccharides: a proof-of-concept-study.

PMID: 28078750
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2017
Reference: Aliment Pharmacol Ther. 2017 Mar;45(5):670-680. doi: 10.1111/apt.13931. Epub 2017 Jan 12.
Impact factor: 7.286
Publication type: Clinical Trials
Authors: Manichanh, C, Accarino, A, Campos, D, Pozuelo, M, Varela, E, Vulevic, J, Tzortzis, G, Gibson, G, Guarner, F, Azpiroz, F et al.
DOI: 10.1111/apt.13931

Brain networks associated with cognitive and hedonic responses to a meal.

PMID: 28116817
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2017
Reference: Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13031. Epub 2017 Jan 23.
Impact factor: 3.617
Publication type: Paper in international publication
Authors: Pribic, T, Kilpatrick, L, Ciccantelli, B, Malagelada, C, Accarino, A, Rovira, A, Pareto, D, Mayer, E, Azpiroz, F et al.
DOI: 10.1111/nmo.13031

Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome.

PMID: 28164346
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2017
Reference: Aliment Pharmacol Ther. 2017 Apr;45(7):909-922. doi: 10.1111/apt.13958. Epub 2017 Feb 6.
Impact factor: 7.286
Publication type: Clinical Trials
Authors: Cremon, C, Stanghellini, V, Barbaro, M R, Cogliandro, R F, Bellacosa, L, Santos, J, Vicario, M, Pigrau, M, Alonso Cotoner, C, Lobo, B et al.
DOI: 10.1111/apt.13958

Transcriptional interactions suggest niche segregation among microorganisms in the human gut.

PMID: 27564131
Journal: Nature Microbiology
Year: 2016
Reference: Nat Microbiol. 2016 Aug 26;1:16152. doi: 10.1038/nmicrobiol.2016.152.
Impact factor: 0
Publication type: Paper in international publication
Authors: Rettedal, Elizabeth, Plichta, Damian Rafal, Juncker, Agnieszka Sierakowska, Bertalan, Marcelo, Manichanh, Chaysavanh, Fouqueray, Charlene, Levenez, Florence, Nielsen, Trine, Dore, Joel, Machado, Ana Manuel Dantas et al.
DOI: 10.1038/nmicrobiol.2016.152

Activation of Immune and Defense Responses in the Intestinal Mucosa by Outer Membrane Vesicles of Commensal and Probiotic Escherichia coli Strains.

PMID: 27242727
Journal: Frontiers in Microbiology
Year: 2016
Reference: Front Microbiol. 2016 May 11;7:705. doi: 10.3389/fmicb.2016.00705. eCollection 2016.
Impact factor: 4.165
Publication type: Paper in international publication
Authors: Jose Fabrega, Maria, Aguilera, Laura, Gimenez, Rosa, Varela, Encarna, Alexandra Canas, Maria, Antolin, Maria, Badia, Josefa, Baldoma, Laura et al.
DOI: 10.3389/fmicb.2016.00705

Incongruence between Clinicians' Assessment and Self-Reported Functioning Is Related to Psychopathology among Patients Diagnosed with Gastrointestinal Disorders.

PMID: 27230869
Journal: PSYCHOTHERAPY AND PSYCHOSOMATICS
Year: 2016
Reference: Psychother Psychosom. 2016;85(4):244-5. doi: 10.1159/000443899. Epub 2016 May 27.
Impact factor: 7.632
Publication type: Paper in international publication
Authors: Rodriguez-Urrutia, Amanda, Eiroa-Orosa, Francisco Jose, Accarino, Anna, Malagelada, Carolina, Azpiroz, Fernando et al.
DOI: 10.1159/000443899

MetaTrans: an open-source pipeline for metatranscriptomics.

PMID: 27211518
Journal: Scientific Reports
Year: 2016
Reference: Sci Rep. 2016 May 23;6:26447. doi: 10.1038/srep26447.
Impact factor: 5.228
Publication type: Paper in international publication
Authors: Martinez, Xavier, Pozuelo, Marta, Pascal, Victoria, Campos, David, Gut, Ivo, Gut, Marta, Azpiroz, Fernando, Guarner, Francisco, Manichanh, Chaysavanh et al.
DOI: 10.1038/srep26447

[Use of probiotics and prebiotics in primary care].

PMID: 25659055
Journal: Nutricion Hospitalaria
Year: 2015
Reference: Nutr Hosp. 2015 Feb 7;31 Suppl 1:59-63. doi: 10.3305/nh.2015.31.sup1.8708.
Impact factor: 1.04
Publication type: Paper in national publication
Authors: Azpiroz, Fernando, Alvarez Calatayud, Guillermo et al.
DOI: 10.3305/nh.2015.31.sup1.8708

Increased antibody response in the intestinal mucosa of diarrhoea-prone irritable bowel syndrome in association with psychological stress and abdominal pain.

PMID: 26383484
Journal: PSYCHONEUROENDOCRINOLOGY
Year: 2015
Reference: Psychoneuroendocrinology. 2015 Nov;61:75-6. doi: 10.1016/j.psyneuen.2015.07.599. Epub 2015 Aug 8.
Impact factor: 4.944
Publication type: Paper in international publication
Authors: Gonzalez-Castro, Ana M, Pardo-Camacho, Cristina, Lobo, Beatriz, Alonso-Cotoner, Carmen, Fortea, Marina, Salvo-Romero, Eloisa, Casado-Bedmar, Maite, Rodino-Janeiro, Bruno K, Azpiroz, Fernando, Santos, Javier et al.
DOI: 10.1016/j.psyneuen.2015.07.599

Classification of functional bowel disorders by objective physiological criteria based on endoluminal image analysis.

PMID: 26251472
Journal: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Year: 2015
Reference: Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G413-9. doi: 10.1152/ajpgi.00193.2015. Epub 2015 Aug 6.
Impact factor: 3.798
Publication type: Paper in international publication
Authors: Malagelada, Carolina, Drozdzal, Michal, Segui, Santi, Mendez, Sara, Vitria, Jordi, Radeva, Petia, Santos, Javier, Accarino, Anna, Malagelada, Juan-R, Azpiroz, Fernando et al.
DOI: 10.1152/ajpgi.00193.2015

Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome.

PMID: 26239401
Journal: Scientific Reports
Year: 2015
Reference: Sci Rep. 2015 Aug 4;5:12693. doi: 10.1038/srep12693.
Impact factor: 5.578
Publication type: Paper in international publication
Authors: Pozuelo, Marta, Panda, Suchita, Santiago, Alba, Mendez, Sara, Accarino, Anna, Santos, Javier, Guarner, Francisco, Azpiroz, Fernando, Manichanh, Chaysavanh et al.
DOI: 10.1038/srep12693

Gastric sensitivity and reflexes: basic mechanisms underlying clinical problems.

PMID: 24306100
Journal: J GASTROENTEROL
Year: 2014
Reference: J Gastroenterol. 2014 Feb;49(2):206-18. doi: 10.1007/s00535-013-0917-8. Epub 2013 Dec 4.
Impact factor: 4.02
Publication type: Review in international publication
Authors: Azpiroz, Fernando, Feinle-Bisset, Christine, Tack, Jan, Grundy, David et al.
DOI: 10.1007/s00535-013-0917-8

Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet.

PMID: 23766444
Journal: GUT
Year: 2014
Reference: Gut. 2014 Mar;63(3):401-8. doi: 10.1136/gutjnl-2012-303013. Epub 2013 Jun 13.
Impact factor: 13.319
Publication type: Paper in international publication
Authors: Guarner, Francisco, Azpiroz, Fernando, Malagelada, Juan-R, Santos, Javier, Accarino, Anna, Guyonnet, Denis, Manichanh, Chaysavanh, Eck, Anat, Varela, Encarna, Roca, Joaquim et al.
DOI: 10.1136/gutjnl-2012-303013

Mechanisms of postprandial abdominal bloating and distension in functional dyspepsia.

PMID: 23645627
Journal: GUT
Year: 2014
Reference: Gut. 2014 Mar;63(3):395-400. doi: 10.1136/gutjnl-2013-304574. Epub 2013 May 4.
Impact factor: 13.319
Publication type: Paper in international publication
Authors: Burri, Emanuel, Barba, Elizabeth, Huaman, Jose Walter, Cisternas, Daniel, Accarino, Anna, Soldevilla, Alfredo, Malagelada, Juan-R, Azpiroz, Fernando et al.
DOI: 10.1136/gutjnl-2013-304574

Development and testing of a new instrument to measure patient satisfaction with health care in inflammatory bowel disease: the CACHE questionnaire.

PMID: 23429448
Journal: INFLAMMATORY BOWEL DISEASES
Year: 2013
Reference: Inflamm Bowel Dis. 2013 Mar;19(3):559-68. doi: 10.1097/MIB.0b013e31827febd1.
Impact factor: 5.119
Publication type: Paper in international publication
Authors: Fernandez, R, Garrido, J, Taxonera, C, Canas, M M, Fernandez, F, Moreno, A, Ruiz, M C, Perez, J L, Lopez, P, Gonzalez, M et al.
DOI: 10.1097/MIB.0b013e31827febd1

The Spanish Pancreatic Club recommendations for the diagnosis and treatment of chronic pancreatitis: part 1 (diagnosis).

PMID: 23395564
Journal: PANCREATOLOGY
Year: 2013
Reference: Pancreatology. 2013 Jan-Feb;13(1):8-17. doi: 10.1016/j.pan.2012.11.309. Epub 2012 Nov 27.
Impact factor: 2.043
Publication type: Paper in international publication
Authors: Martinez, J, Abad-Gonzalez, A, Aparicio, J R, Aparisi, L, Boadas, J, Boix, E, Farre, A, Fernandez-Cruz, L, Gomez, L, Iglesias-Garcia, J et al.
DOI: 10.1016/j.pan.2012.11.309

Linking the gut microbiota to human health.

PMID: 23360877
Journal: BRITISH JOURNAL OF NUTRITION
Year: 2013
Reference: Br J Nutr. 2013 Jan;109 Suppl 2:S21-6. doi: 10.1017/S0007114512005235.
Impact factor: 3.302
Publication type: Review in international publication
Authors: Robles Alonso, Virginia, Guarner, Francisco et al.
DOI: 10.1017/S0007114512005235

Phylogenetic Analysis of Dysbiosis in Ulcerative Colitis During Remission.

PMID: 23385241
Journal: INFLAMMATORY BOWEL DISEASES
Year: 2013
Reference: Inflamm Bowel Dis. 2013 Mar;19(3):481-8. doi: 10.1097/MIB.0b013e31827fec6d.
Impact factor: 5.119
Publication type: Paper in international publication
Authors: Rajilic-Stojanovic, Mirjana, Shanahan, Fergus, Guarner, Francisco, de Vos, Willem M et al.
DOI: 10.1097/MIB.0b013e31827fec6d

Colonic Responses to Gas Loads in Subgroups of Patients With Abdominal Bloating.

PMID: 20179685
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2010
Reference: Am J Gastroenterol. 2010 Apr;105(4):876-82. Epub 2010 Feb 23.
Impact factor: 6.012
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.1038/ajg.2010.75

Constipation: a potential cause of pelvic floor damage?

PMID: 19761491
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2010
Reference: Neurogastroenterol Motil. 2010 Feb;22(2):150-3, e48. Epub 2009 Sep 17.
Impact factor: 3.568
Publication type: Paper in international publication
Authors: Amselem, C, Puigdollers, A, Azpiroz, F, Sala, C, Videla, S, Fernandez-Fraga, X, Whorwell, P, Malagelada, J-R et al.
DOI: 10.1111/j.1365-2982.2009.01409.x

International validation of a health-related quality of life questionnaire in patients with erosive gastro-oesophageal reflux disease.

PMID: 19183145
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2009
Reference: Aliment Pharmacol Ther. 2009 Mar 15;29(6):615-25.
Impact factor: 1.215
Publication type: Paper in international publication
Authors: Chassany, O, Devault, K R, Schmitt, H, Gebauer, U, Doerfler, H, Malagelada, J R, Holtmann, G et al.
DOI: 10.1111/j.1365-2036.2008.03922.x

Inflammatory disease processes and interactions with nutrition.

PMID: 19586558
Journal: BRITISH JOURNAL OF NUTRITION
Year: 2009
Reference: Br J Nutr. 2009 May;101 Suppl 1:S1-45.
Impact factor: 2.764
Publication type: Review in international publication
Authors: Bourdet-Sicard, R, Calder, P C, Albers, R, Antoine, J-M, Blum, S, Friedmann, P S, Frost, G S, Guarner, F, Lovik, M, Macfarlane, S et al.
DOI: 10.1017/S0007114509377867

Prebiotics, probiotics and helminths: the 'natural' solution?

PMID: 19786773
Journal: DIGESTIVE DISEASES
Year: 2009
Reference: Dig Dis. 2009;27(3):412-7.
Impact factor: 1.092
Publication type: Paper in international publication
Authors: Guarner, Francisco et al.
DOI: 10.1159/000228582

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Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.

The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.