About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.
Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.
We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function.
PMID: 37081523 Journal: Genome Medicine Year: 2023 Reference: Genome Med. 2023 Apr 20;15(1):27. doi: 10.1186/s13073-023-01171-w. Impact factor: Publication type: Paper in international publication Authors: Alonso, Carolina; Arenillas, Carlota; Black, James R M; Feliu, Jaime; Garcia-Carbonero, Rocio; Guillen, Carmen; Hidalgo, Manuel; Huebner, Ariana; Juez, Ignacio; Macarulla, Teresa et al. DOI: 10.1186/s13073-023-01171-w
PMID: 37889368 Journal: OBESITY SURGERY Year: 2023 Reference: Obes Surg. 2023 Oct 27. doi: 10.1007/s11695-023-06903-w. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Ariadna; Alqahtani, Aayed R; Billy, Helmuth Thorlakur; Chiappetta, Sonja; Da Silva Ribeiro, Rui Jose; Gawdat, Khaled; Ghanem, Omar M; Haddad, Ashraf; Jazi, Amir Hossein Davarpanah; Kasama, Kazunori et al. DOI: 10.1007/s11695-023-06903-w
PMID: 37923493 Journal: Enfermedades infecciosas y microbiologia clinica ( Year: 2023 Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2023 Nov;41(9):527-528. doi: 10.1016/j.eimce.2023.06.005. Impact factor: Publication type: Editorail in international publication Authors: Dimitrova, Emiliya; Elenski, Kiril; Etropolska, Zlatka; Fernandez-Polo, Aurora; Petrisor, Diana Corina; Santos, Javier et al. DOI: 10.1016/j.eimce.2023.06.005
PMID: 37936381 Journal: Therapeutic Advances in Respiratory Disease Year: 2023 Reference: Ther Adv Respir Dis. 2023 Jan-Dec;17:17534666231208630. doi: 10.1177/17534666231208630. Impact factor: Publication type: Paper in international publication Authors: Alcala Gonzalez, Luis Gerardo; Dreher, Michael; Malagelada, Carolina; Matsunaga, Kazuto; Miravitlles, Marc et al. DOI: 10.1177/17534666231208630
PMID: 31997116 Journal: Patient-Patient Centered Outcomes Research Year: 2020 Reference: Patient. 2020 Jun;13(3):317-325. doi: 10.1007/s40271-019-00407-5. Impact factor: 3.226 Publication type: Paper in international publication Authors: Novak, Kerri, Donnet, Xavier, Easton, David, Saldana, Roberto, Protze, Katja, Tzur, Eyal, Alperovich, Gabriela, Casellas, Francesc, Hart, Ailsa, Bettenworth, Dominik et al. DOI: 10.1007/s40271-019-00407-5
PMID: 31901867 Journal: EBioMedicine Year: 2020 Reference: EBioMedicine. 2020 Jan;51:102611. doi: 10.1016/j.ebiom.2019.102611. Epub 2020 Jan 2. Impact factor: 5.736 Publication type: Paper in international publication Authors: Varela, Encarna, Clark, Allison, Campos, David, Herrera, Claudia, Santiago, Alba, Machiels, Kathleen, Vermeire, Severine, Marti, Marc, Espin, Eloy, Manichanh, Chaysavanh et al. DOI: 10.1016/j.ebiom.2019.102611
PMID: 31523867 Journal: JOURNAL OF ANIMAL BREEDING AND GENETICS Year: 2020 Reference: J Anim Breed Genet. 2020 Jan;137(1):103-120. doi: 10.1111/jbg.12441. Epub 2019 Sep 16. Impact factor: 1.822 Publication type: Paper in international publication Authors: Costa, Marcio, Massacci, Francesca Romana, Clark, Allison, Ruet, Alice, Lansade, Lea, Mach, Nuria et al. DOI: 10.1111/jbg.12441
PMID: 31734402 Journal: AUTOIMMUNITY REVIEWS Year: 2020 Reference: Autoimmun Rev. 2020 Jan;19(1):102429. doi: 10.1016/j.autrev.2019.102429. Epub 2019 Nov 15. Impact factor: 7.767 Publication type: Review in international publication Authors: Ruiz de Morales, Jose Maria G, Puig, Lluis, Dauden, Esteban, Canete, Juan D, Pablos, Jose Luis, Martin, Antonio Olveira, Juanatey, Carlos Gonzalez, Adan, Alfredo, Montalban, Xavier, Borruel, Natalia et al. DOI: 10.1016/j.autrev.2019.102429
PMID: 29329392 Journal: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY Year: 2018 Reference: Int J Epidemiol. 2018 Apr 1;47(2):473-483. doi: 10.1093/ije/dyx269. Impact factor: 8.36 Publication type: Paper in international publication Authors: O'Rorke, M, Tardon, A, Gress, T, Barbera, V M, Crnogorac-Jurcevic, T, Dominguez-Munoz, E, Munoz-Bellvis, L, Balsells, J, Costello, E, Huang, J et al. DOI: 10.1093/ije/dyx269
PMID: 28082316 Journal: GUT Year: 2017 Reference: Gut. 2017 Sep;66(9):1537-1538. doi: 10.1136/gutjnl-2016-311477. Epub 2017 Jan 12. Impact factor: 16.658 Publication type: Paper in international publication Authors: Martinez, Cristina, Rodino-Janeiro, Bruno K, Lobo, Beatriz, Stanifer, Megan L, Klaus, Bernd, Granzow, Martin, Gonzalez-Castro, Ana M, Salvo-Romero, Eloisa, Alonso-Cotoner, Carmen, Pigrau, Marc et al. DOI: 10.1136/gutjnl-2016-311477
PMID: 26628509 Journal: GUT Year: 2017 Reference: Gut. 2017 Feb;66(2):314-322. doi: 10.1136/gutjnl-2015-310442. Epub 2015 Dec 1. Impact factor: 16.658 Publication type: Paper in international publication Authors: Marquez, Mirari, Sharp, Linda, Hidalgo, Manuel, Carrato, Alfredo, Ilzarbe, Lucas, Michalski, Christoph, Molero, Xavier, Farre, Antoni, Perea, Jose, Greenhalf, William et al. DOI: 10.1136/gutjnl-2015-310442
PMID: 27087165 Journal: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Year: 2017 Reference: J Gastroenterol Hepatol. 2017 Jan;32(1):53-63. doi: 10.1111/jgh.13417. Impact factor: 3.452 Publication type: Paper in international publication Authors: Gonzalez-Castro, Ana M, Martinez, Cristina, Salvo-Romero, Eloisa, Fortea, Marina, Pardo-Camacho, Cristina, Perez-Berezo, Teresa, Alonso-Cotoner, Carmen, Santos, Javier, Vicario, Maria et al. DOI: 10.1111/jgh.13417
PMID: 26603881 Journal: EUROPEAN JOURNAL OF CLINICAL NUTRITION Year: 2016 Reference: Eur J Clin Nutr. 2016 Feb;70(2):170-4. doi: 10.1038/ejcn.2015.192. Epub 2015 Nov 25. Impact factor: 2.935 Publication type: Paper in international publication Authors: Hernandez, M, Garcia-Peris, P, Velasco, C, de la Cuerda, C, Breton, I, Camblor, M, Guarner, F, Paron, L, Lozano, M A et al. DOI: 10.1038/ejcn.2015.192
PMID: 26874350 Journal: Journal of Crohns & Colitis Year: 2016 Reference: J Crohns Colitis. 2016 Jul;10(7):850-9. doi: 10.1093/ecco-jcc/jjw042. Epub 2016 Feb 13. Impact factor: 6.585 Publication type: Paper in international publication Authors: Perez-Torras, Sandra, Iglesias, Ingrid, Llopis, Marta, Lozano, Juan J, Antolin, Maria, Guarner, Francisco, Pastor-Anglada, Marcal et al. DOI: 10.1093/ecco-jcc/jjw042
PMID: 26848957 Journal: PLoS Neglected Tropical Diseases Year: 2016 Reference: PLoS Negl Trop Dis. 2016 Feb 5;10(2):e0004416. doi: 10.1371/journal.pntd.0004416. eCollection 2016 Feb. Impact factor: 3.948 Publication type: Paper in international publication Authors: Moris, Maria, Sanchez-Montalva, Adrian, Accarino, Anna, Ramirez, Kathleen, Azpiroz, Fernando, Ruiz-de-Leon, Antonio, Molina, Israel, Salvador, Fernando, Mego, Marianela et al. DOI: 10.1371/journal.pntd.0004416
PMID: 26643877 Journal: DIABETOLOGIA Year: 2016 Reference: Diabetologia. 2016 Mar;59(3):404-8. doi: 10.1007/s00125-015-3831-1. Epub 2015 Dec 7. Impact factor: 6.206 Publication type: Paper in international publication Authors: Azpiroz, Fernando, Malagelada, Carolina et al. DOI: 10.1007/s00125-015-3831-1
PMID: 24768808 Journal: Clinical Gastroenterology and Hepatology Year: 2015 Reference: Clin Gastroenterol Hepatol. 2015 Jan;13(1):100-6.e1. doi: 10.1016/j.cgh.2014.04.018. Epub 2014 Apr 24. Impact factor: 7.896 Publication type: Paper in international publication Authors: Barba, Elizabeth, Burri, Emanuel, Accarino, Anna, Malagelada, Carolina, Rodriguez-Urrutia, Amanda, Soldevilla, Alfredo, Malagelada, Juan-R, Azpiroz, Fernando et al. DOI: 10.1016/j.cgh.2014.04.018
PMID: 25304690 Journal: Beneficial Microbes Year: 2015 Reference: Benef Microbes. 2015 Mar;6(1):3-17. doi: 10.3920/BM2014.0079. Impact factor: 2.614 Publication type: Paper in international publication Authors: Van den Nieuwboer, M, Brummer, R J, Guarner, F, Morelli, L, Cabana, M, Claassen, E et al. DOI: 10.3920/BM2014.0079
Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.
The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.
Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.
