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The science produced by our scientists is very important. In 2022, 1,629 papers were published in scientific journals with a global impact factor of over 15,000 points.

Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial.

PMID: 30739747
Journal: LANCET
Year: 2019
Reference: Lancet. 2019 Mar 9;393(10175):1021-1032. doi: 10.1016/S0140-6736(19)30195-3. Epub 2019 Feb 7.
Impact factor: 59.102
Publication type: Paper in international publication
Authors: Dodd, Robert, Ali, Hasan, Carhuapoma, J Ricardo, Kase, Carlos S, Lees, Kennedy R, Dawson, Jesse, Wilson, Alastair, Betz, Joshua F, Sugar, Elizabeth A, Hao, Yi et al.
DOI: 10.1016/S0140-6736(19)30195-3

Efficacy and safety of omalizumab (Xolair(R)) for cholinergic urticaria in patients unresponsive to a double dose of antihistamines: a randomized mixed double-blind and open-label placebo-controlled clinical trial.

PMID: 30654196
Journal: Journal of Allergy and Clinical Immunology-In Practice
Year: 2019
Reference: J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1599-1609.e1. doi: 10.1016/j.jaip.2018.12.025. Epub 2019 Jan 15.
Impact factor: 7.55
Publication type: Paper in international publication
Authors: Nunez-Cordoba, Jorge M, Baeza, Maria Luisa, Echechipia, Susana, Gaig, Pere, Garcia, Blanca Esther, Labrador-Horrillo, Moises, Sala-Cunill, Ana, Bresco, Marina Sabate, Beristain, Ana, Quinones, Dolores et al.
DOI: 10.1016/j.jaip.2018.12.025

Efficacy and safety of ozanimod in multiple sclerosis: Dose-blinded extension of a randomized phase II study.

PMID: 30043658
Journal: Multiple Sclerosis Journal
Year: 2019
Reference: Mult Scler. 2019 Aug;25(9):1255-1262. doi: 10.1177/1352458518789884. Epub 2018 Jul 25.
Impact factor: 5.649
Publication type: Paper in international publication
Authors: Cohen, Jeffrey A, Comi, Giancarlo, Arnold, Douglas L, Bar-Or, Amit, Selmaj, Krzysztof W, Steinman, Lawrence, Havrdova, Eva K, Cree, Bruce Ac, Montalban, Xavier, Hartung, Hans-Peter et al.
DOI: 10.1177/1352458518789884

Efficacy and safety of the combination of reduced duration prophylaxis followed by immuno-guided prophylaxis to prevent cytomegalovirus disease in lung transplant recipients (CYTOCOR STUDY): an open-label, randomised, non-inferiority clinical trial.

PMID: 31420397
Journal: BMJ Open
Year: 2019
Reference: BMJ Open. 2019 Aug 15;9(8):e030648. doi: 10.1136/bmjopen-2019-030648.
Impact factor: 2.376
Publication type: Paper in international publication
Authors: Vaquero, Jose Manuel, Paez-Vega, Aurora, Cantisan, Sara, Lobo-Acosta, Maria Angeles, Perez, Ana Belen, Alonso-Moralejo, Rodrigo, Iturbe, David, Monforte, Victor, Otero-Gonzalez, Isabel, Pastor, Amparo et al.
DOI: 10.1136/bmjopen-2019-030648

Efficacy and safety of tobramycin inhalation powder in bronchiectasis patients with P. aeruginosa infection: Design of a dose-finding study (iBEST-1).

PMID: 31433997
Journal: PULMONARY PHARMACOLOGY & THERAPEUTICS
Year: 2019
Reference: Pulm Pharmacol Ther. 2019 Oct;58:101834. doi: 10.1016/j.pupt.2019.101834. Epub 2019 Aug 18.
Impact factor: 2.669
Publication type: Paper in international publication
Authors: Loebinger, Michael R, Polverino, Eva, Blasi, Francesco, Elborn, Stuart J, Chalmers, James D, Tiddens, Harm Awm, Goossens, Herman, Tunney, Michael, Zhou, Wenchun, Angyalosi, Gerhild et al.
DOI: 10.1016/j.pupt.2019.101834

Efficacy and toxicity of sorafenib in the treatment of advanced medullary thyroid carcinoma: A systematic review and meta-analysis.

PMID: 31162772
Journal: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Year: 2019
Reference: Head Neck. 2019 Aug;41(8):2823-2829. doi: 10.1002/hed.25832. Epub 2019 Jun 4.
Impact factor: 2.442
Publication type: Review in international publication
Authors: Vuong, Huy Gia, Ho, An Thi Nhat, Tran, Thao T K, Capdevila, Jaume, Benekli, Mustafa, Nakazawa, Tadao, Katoh, Ryohei, Kondo, Tetsuo et al.
DOI: 10.1002/hed.25832

Efficacy, immunogenicity, and safety of a quadrivalent inactivated influenza vaccine in children aged 6-35months: A multi-season randomised placebo-controlled trial in the Northern and Southern Hemispheres.

PMID: 30558818
Journal: VACCINE
Year: 2019
Reference: Vaccine. 2019 Mar 22;37(13):1876-1884. doi: 10.1016/j.vaccine.2018.11.074. Epub 2018 Dec 14.
Impact factor: 3.269
Publication type: Paper in international publication
Authors: Borja-Tabora, Charissa Fay Corazon, Montellano, May, Bravo, Lulu, Santos, Jaime, de Castro, Jo-Anne, Rivera-Medina, Doris Maribel, Cutland, Clare, Ariza, Miguel, Diez-Domingo, Javier, Gonzalez, Celia Diaz et al.
DOI: 10.1016/j.vaccine.2018.11.074

Efficacy of high doses of penicillin versus amoxicillin in the treatment of uncomplicated community acquired pneumonia in adults. A non-inferiority controlled clinical trial.

PMID: 29061311
Journal: Atencion Primaria
Year: 2019
Reference: Aten Primaria. 2019 Jan;51(1):32-39. doi: 10.1016/j.aprim.2017.08.003. Epub 2017 Oct 20.
Impact factor: 1.346
Publication type: Paper in international publication
Authors: Roman-Rodriguez, Miguel, Llor, Carl, Perez, Almudena, Carandell, Eugenia, Garcia-Sangenis, Anna, Rezola, Javier, Llorente, Marian, Gestoso, Salvador, Bobe, Francesc, Cortes, Jordi et al.
DOI: 10.1016/j.aprim.2017.08.003

Efficacy of Internal Limiting Membrane Flap Techniques with Vitrectomy for Macular Detachment Associated with an Optic Disc Pit.

PMID: 30808833
Journal: OPHTHALMOLOGICA
Year: 2019
Reference: Ophthalmologica. 2019;242(1):38-48. doi: 10.1159/000495621. Epub 2019 Mar 22.
Impact factor: 1.781
Publication type: Paper in international publication
Authors: Pastor-Idoate, Salvador, Gomez-Resa, Maria, Karam, Sarah, Copete, Sergio, Kyriakou, Danai, Garcia-Arumi Fuste, Claudia, Pastora, Natalia, Nadal, Jeroni, Garcia-Arumi, Jose et al.
DOI: 10.1159/000495621

Efficacy of liposomal amphotericin B and anidulafungin using an antifungal lock technique (ALT) for catheter-related Candida albicans and Candida glabrata infections in an experimental model.

PMID: 30779771
Journal: PLoS One
Year: 2019
Reference: PLoS One. 2019 Feb 19;14(2):e0212426. doi: 10.1371/journal.pone.0212426. eCollection 2019.
Impact factor: 2.776
Publication type: Paper in international publication
Authors: Basas, Jana, Palau, Marta, Gomis, Xavier, Almirante, Benito, Gavalda, Joan et al.
DOI: 10.1371/journal.pone.0212426

Efficacy of PI3K inhibitors in advanced breast cancer.

PMID: 31859349
Journal: ANNALS OF ONCOLOGY
Year: 2019
Reference: Ann Oncol. 2019 Dec 1;30(Supplement_10):x12-x20. doi: 10.1093/annonc/mdz381.
Impact factor: 14.196
Publication type: Paper in international publication
Authors: Verret, B, Cortes, J, Bachelot, T, Andre, F, Arnedos, M et al.
DOI: 10.1093/annonc/mdz381

Efficacy of PI3K inhibitors in advanced breast cancer.

PMID: 31928690
Journal: ANNALS OF ONCOLOGY
Year: 2019
Reference: Ann Oncol. 2019 Dec;30 Suppl 10:x12-x20. doi: 10.1093/annonc/mdz381.
Impact factor: 14.196
Publication type: Review in international publication
Authors: Verret, B, Cortes, J, Bachelot, T, Andre, F, Arnedos, M et al.
DOI: 10.1093/annonc/mdz381

Efficacy of Single-Agent Chemotherapy for Patients with Advanced Invasive Lobular Carcinoma: A Pooled Analysis from Three Clinical Trials.

PMID: 30578311
Journal: ONCOLOGIST
Year: 2019
Reference: Oncologist. 2019 Aug;24(8):1041-1047. doi: 10.1634/theoncologist.2018-0182. Epub 2018 Dec 21.
Impact factor: 5.252
Publication type: Paper in international publication
Authors: Perez-Garcia, Jose, Cortes, Javier, Metzger Filho, Otto et al.
DOI: 10.1634/theoncologist.2018-0182

Efficacy of Vemurafenib in Patients With Non-Small-Cell Lung Cancer With BRAF V600 Mutation: An Open-Label, Single-Arm Cohort of the Histology-Independent VE-BASKET Study.

PMID: 32914022
Journal: JCO precision oncology
Year: 2019
Reference: JCO Precis Oncol. 2019 Jun 27;3. pii: 1800266. doi: 10.1200/PO.18.00266. eCollection 2019.
Impact factor: 0
Publication type: Paper in international publication
Authors: Subbiah, Vivek, Gervais, Radj, Riely, Gregory, Hollebecque, Antoine, Blay, Jean-Yves, Felip, Enriqueta, Schuler, Martin, Goncalves, Anthony, Italiano, Antonio, Keedy, Vicki et al.
DOI: 10.1200/PO.18.00266

EGFR detection in extracellular vesicles of breast cancer patients through immunosensor based on silica-chitosan nanoplatform.

PMID: 30609526
Journal: TALANTA
Year: 2019
Reference: Talanta. 2019 Mar 1;194:243-252. doi: 10.1016/j.talanta.2018.10.016. Epub 2018 Oct 13.
Impact factor:
Publication type: Paper in international publication
Authors: Fernandez Baldo, Martin A; Jimenez Castillo, Maria I; Lorente, Jose A; Messina, German A; Ortega, Francisco G; Piguillem, Sofia V; Raba, Julio; Rubilar, Olga; Serrano, Maria J; Tortella, Gonzalo R et al.
DOI: 10.1016/j.talanta.2018.10.016

Egg OIT in clinical practice (SEICAP II): Maintenance patterns and desensitization state after normalizing the diet.

PMID: 30414284
Journal: PEDIATRIC ALLERGY AND IMMUNOLOGY
Year: 2019
Reference: Pediatr Allergy Immunol. 2019 Mar;30(2):214-224. doi: 10.1111/pai.13002. Epub 2018 Dec 18.
Impact factor: 4.654
Publication type: Paper in international publication
Authors: Martin-Munoz, Maria Flora, Alonso Lebrero, Elena, Zapatero, Lidia, Fuentes Aparicio, Victoria, Piquer Gibert, Monica, Plaza Martin, Ana Maria, Munoz, Candelaria, Martorell-Calatayud, Cristina, Martorell-Aragones, Antonio, Blasco, Cristina et al.
DOI: 10.1111/pai.13002

Egg Oral Immunotherapy in Children (SEICAP I). Daily or Weekly Desensitization Pattern.

PMID: 30169915
Journal: PEDIATRIC ALLERGY AND IMMUNOLOGY
Year: 2019
Reference: Pediatr Allergy Immunol. 2019 Feb;30(1):81-92. doi: 10.1111/pai.12974. Epub 2018 Nov 21.
Impact factor: 4.654
Publication type: Paper in international publication
Authors: Martorell, Antonio, Martin-Munoz, Maria Flora, Belver, Maria Teresa, Alonso, Elena, Zapatero, Lidia, Fuentes, Victoria, Pique, Monica, Plaza, Ana Maria, Munoz, Candelaria, Martorell, Cristina et al.
DOI: 10.1111/pai.12974

Elaboration of consensus clinical endpoints to evaluate antimicrobial treatment efficacy in future HABP/VABP clinical trials.

PMID: 30722013
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2019
Reference: Clin Infect Dis. 2019 Nov 13;69(11):1912-1918. doi: 10.1093/cid/ciz093.
Impact factor: 9.055
Publication type: Paper in international publication
Authors: Rello, Jordi, Rex, John H, Shorr, Andrew F, Talbot, George H, Thamlikitkul, Visanu, Torres, Antoni, Wunderink, Richard G, Timsit, Jean-Francois, Prokocimer, Philippe, Poulakou, Garyphallia et al.
DOI: 10.1093/cid/ciz093

Elective and emergent laparotomy closure: The importance of protocolizing the technique.

PMID: 30545642
Journal: CIRUGIA ESPANOLA
Year: 2019
Reference: Cir Esp. 2019 Feb;97(2):97-102. doi: 10.1016/j.ciresp.2018.09.011. Epub 2018 Dec 10.
Impact factor: 0.835
Publication type: Paper in national publication
Authors: Valverde, Silvia, SanchezLuis, Jose Luis, Pereira, Jose Antonio, Armengol, Manel, Lopez-Cano, Manuel et al.
DOI: 10.1016/j.ciresp.2018.09.011

Elevated WBP2 expression in HER2-positive breast cancers correlates with sensitivity to trastuzumab-based neo-adjuvant therapy:A Retrospective and Multicentric Study.

PMID: 30593516
Journal: CLINICAL CANCER RESEARCH
Year: 2019
Reference: Clin Cancer Res. 2019 Apr 15;25(8):2588-2600. doi: 10.1158/1078-0432.CCR-18-3228. Epub 2018 Dec 28.
Impact factor: 8.911
Publication type: Paper in international publication
Authors: Kang, Shin-Ae, Guan, Jye Swei, Tan, Hock Jin, Chu, Tinghine, Thike, Aye Aye, Bernado Morales, Cristina, Arribas, Joaquin, Wong, Chow Yin, Tan, Puay Hoon, Gudi, Mihir et al.
DOI: 10.1158/1078-0432.CCR-18-3228

Elicited and pre-existing anti-Neu5Gc antibodies differentially affect human endothelial cells transcriptome.

PMID: 31293002
Journal: XENOTRANSPLANTATION
Year: 2019
Reference: Xenotransplantation. 2019 Nov;26(6):e12535. doi: 10.1111/xen.12535. Epub 2019 Jul 10.
Impact factor: 3.484
Publication type: Paper in international publication
Authors: Le Berre, Ludmilla, Danger, Richard, Mai, Hoa L, Amon, Ron, Leviatan Ben-Arye, Shani, Bruneau, Sarah, Senage, Thomas, Perreault, Helene, Teraiya, Milan, Nguyen, Thi Van Ha et al.
DOI: 10.1111/xen.12535

Elimination of hepatitis C. Positioning document of the Spanish Association for the Study of the Liver (AEEH).

PMID: 31594683
Journal: Gastroenterologia y Hepatologia
Year: 2019
Reference: Gastroenterol Hepatol. 2019 Nov;42(9):579-592. doi: 10.1016/j.gastrohep.2019.09.002. Epub 2019 Oct 5.
Impact factor: 1.126
Publication type: Paper in international publication
Authors: Molero, Jose Maria, Molina, Esther, Perez Escanilla, Fernando, Pineda, Juan A, Rodriguez, Manuel, Romero, Manuel, Roncero, Carlos, Saiz de la Hoya, Pablo, Sanchez Antolin, Gloria, Lazarus, Jeffrey et al.
DOI: 10.1016/j.gastrohep.2019.09.002

Elimination of hepatitis C. Positioning document of the Spanish Association for the Study of the Liver (AEEH).

PMID: 31657609
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2019
Reference: Rev Esp Enferm Dig. 2019 Nov;111(11):862-873. doi: 10.17235/reed.2019.6700/2019.
Impact factor: 1.858
Publication type: Paper in international publication
Authors: Romero, Manuel, Buti, Maria, Calleja, Jose Luis, Garcia Samaniego, Javier, Hernandez Guerra, Manuel, Serrano, Trinidad, Turnes, Juan, Acin, Enrique, Berenguer, Juan, Berenguer, Marina et al.
DOI: 10.17235/reed.2019.6700/2019

Emergence of NDM-producing Klebsiella pneumoniae and Escherichia coli in Spain: phylogeny, resistome, virulence and plasmids encoding blaNDM-like genes as determined by WGS.

PMID: 31504589
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2019
Reference: J Antimicrob Chemother. 2019 Dec 1;74(12):3489-3496. doi: 10.1093/jac/dkz366.
Impact factor: 5.113
Publication type: Paper in international publication
Authors: Aracil, Belen, Saez, David, Lara, Noelia, Fernandez, Sara, Gonzalez-Lopez, Juan Jose, Campos, Jose, Kingsley, Robert A, Dougan, Gordon, Oteo-Iglesias, Jesus, Rodrigo, Cristina Herrera et al.
DOI: 10.1093/jac/dkz366