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The science produced by our scientists is very important. In 2022, 1,629 papers were published in scientific journals with a global impact factor of over 15,000 points.

Phase 1 dose escalation and pharmacokinetic evaluation of oral gemcitabine prodrug (LY2334737) in combination with docetaxel in patients with advanced solid tumors.

PMID: 24744161
Journal: CANCER CHEMOTH PHARM
Year: 2014
Reference: Cancer Chemother Pharmacol. 2014 Jun;73(6):1205-15. doi: 10.1007/s00280-014-2457-1. Epub 2014 Apr 18.
Impact factor: 2.571
Publication type: Paper in international publication
Authors: Salazar, Ramon, Morales, Serafin, Gil-Martin, Marta, Aguirre, Elena, Oaknin, Ana, Garcia, Margarita, Callies, Sophie, Wickremsinhe, Enaksha R, Benhadji, Karim A, Llombart, Antonio et al.
DOI: 10.1007/s00280-014-2457-1

Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.

PMID: 24652201
Journal: INVEST NEW DRUG
Year: 2014
Reference: Invest New Drugs. 2014 Aug;32(4):670-81. doi: 10.1007/s10637-014-0082-9. Epub 2014 Mar 21.
Impact factor: 2.927
Publication type: Paper in international publication
Authors: Brana, Irene, Siu, Lillian L, De Jonge, Maja J, Homji, Natasha, Mills, David, Di Tomaso, Emmanuelle, Sarr, Celine, Trandafir, Lucia, Massacesi, Cristian, Eskens, Ferry et al.
DOI: 10.1007/s10637-014-0082-9

Phase I Safety and Pharmacokinetic Study of the PI3K/mTOR Inhibitor SAR245409 (XL765) in Combination with Erlotinib in Patients with Advanced Solid Tumors.

PMID: 24496004
Journal: J THORAC ONCOL
Year: 2014
Reference: J Thorac Oncol. 2014 Mar;9(3):316-23. doi: 10.1097/JTO.0000000000000088.
Impact factor: 5.8
Publication type: Paper in international publication
Authors: Felip, Enriqueta, Martinez, Pablo, Janne, Pasi A, Cohen, Roger B, Laird, A Douglas, Mace, Sandrine, Engelman, Jeffrey A, Ruiz-Soto, Rodrigo, Rockich, Kevin, Xu, Jianbo et al.
DOI: 10.1097/JTO.0000000000000088

Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245409 (XL765), a novel, orally administered PI3K/mTOR inhibitor in patients with advanced solid tumors.

PMID: 24583798
Journal: CLIN CANCER RES
Year: 2014
Reference: Clin Cancer Res. 2014 May 1;20(9):2445-56. doi: 10.1158/1078-0432.CCR-13-2403. Epub 2014 Feb 28.
Impact factor: 8.193
Publication type: Paper in international publication
Authors: Papadopoulos, Kyriakos P, Tabernero, Josep, Markman, Ben, Patnaik, Amita, Tolcher, Anthony W, Baselga, Jose, Shi, Weiliang, Egile, Coumaran, Ruiz-Soto, Rodrigo, Laird, A Douglas et al.
DOI: 10.1158/1078-0432.CCR-13-2403

Phase I study of sunitinib in combination with gemcitabine and capecitabine for first-line treatment of metastatic or unresectable renal cell carcinoma.

PMID: 25142843
Journal: ONCOLOGIST
Year: 2014
Reference: Oncologist. 2014 Sep;19(9):917-8. doi: 10.1634/theoncologist.2014-0072. Epub 2014 Aug 20.
Impact factor: 4.54
Publication type: Paper in international publication
Authors: Suarez, Cristina, Bellmunt, Joaquim, Pons, Francesc, Bonfill, Teresa, Beltran, Marta, Moya, Irene, Galtes, Susana, Albanell, Joan, Carles, Joan, Rodon, Jordi et al.
DOI: 10.1634/theoncologist.2014-0072

Phase I trial of olaparib in combination with cisplatin for the treatment of patients with advanced breast, ovarian and other solid tumors.

PMID: 24827126
Journal: ANN ONCOL
Year: 2014
Reference: Ann Oncol. 2014 Aug;25(8):1656-63. doi: 10.1093/annonc/mdu187. Epub 2014 May 14.
Impact factor: 6.578
Publication type: Paper in international publication
Authors: Balmana, J, Tung, N M, Isakoff, S J, Grana, B, Ryan, P D, Saura, C, Lowe, E S, Frewer, P, Winer, E, Baselga, J et al.
DOI: 10.1093/annonc/mdu187

Phase Ib Study of Buparlisib plus Trastuzumab in Patients with HER2-Positive Advanced or Metastatic Breast Cancer That Has Progressed on Trastuzumab-Based Therapy.

PMID: 24470511
Journal: CLIN CANCER RES
Year: 2014
Reference: Clin Cancer Res. 2014 Apr 1;20(7):1935-45. doi: 10.1158/1078-0432.CCR-13-1070. Epub 2014 Jan 27.
Impact factor: 8.193
Publication type: Clinical Trials
Authors: Di Tomaso, Emmanuelle, Saura, Cristina, Bendell, Johanna, Jerusalem, Guy, Su, Shaun, Ru, Qinhua, De Buck, Stefan, Mills, David, Ruquet, Sophie, Bosch, Ana et al.
DOI: 10.1158/1078-0432.CCR-13-1070

Phase II clinical trial of PM00104 (Zalypsis((R))) in urothelial carcinoma patients progressing after first-line platinum-based regimen.

PMID: 24570330
Journal: CANCER CHEMOTH PHARM
Year: 2014
Reference: Cancer Chemother Pharmacol. 2014 Apr;73(4):857-67. doi: 10.1007/s00280-014-2419-7. Epub 2014 Feb 26.
Impact factor: 2.571
Publication type: Paper in international publication
Authors: Siguero, Mariano, Castellano, Daniel E, Bellmunt, Joaquim, Maroto, Jose Pablo, Font-Pous, Albert, Morales-Barrera, Rafael, Ghanem, Ismael, Suarez, Cristina, Martin Lorente, Cristina, Etxaniz, Olatz et al.
DOI: 10.1007/s00280-014-2419-7

Phase II trial of the Sigma-1 receptor agonist cutamesine (SA4503) for recovery enhancement after acute ischemic stroke.

PMID: 25270629
Journal: STROKE
Year: 2014
Reference: Stroke. 2014 Nov;45(11):3304-10. doi: 10.1161/STROKEAHA.114.005835. Epub 2014 Sep 30.
Impact factor: 6.018
Publication type: Clinical Trials
Authors: Urfer, Roman, Moebius, Hans J, Skoloudik, David, Santamarina, Estevo, Sato, Wakao, Mita, Shiro, Muir, Keith W et al.
DOI: 10.1161/STROKEAHA.114.005835

Phase II trial to assess the safety and efficacy of clofarabine in combination with low-dose cytarabine in elderly patients with acute myeloid leukemia.

PMID: 24081577
Journal: ANN HEMATOL
Year: 2014
Reference: Ann Hematol. 2014 Jan;93(1):43-6. doi: 10.1007/s00277-013-1914-y. Epub 2013 Oct 1.
Impact factor: 2.396
Publication type: Clinical Trials
Authors: Martinez-Cuadron, David, Montesinos, Pau, Oriol, Albert, Salamero, Olga, Vidriales, Belen, Bergua, Juan, Herrera, Pilar, Vives, Susanna, Sanz, Jaime, Carpio, Cecilia et al.
DOI: 10.1007/s00277-013-1914-y

Phase III trial of nonpegylated liposomal doxorubicin in combination with trastuzumab and paclitaxel in HER2-positive metastatic breast cancer.

PMID: 24401928
Journal: ANN ONCOL
Year: 2014
Reference: Ann Oncol. 2014 Mar;25(3):592-8. doi: 10.1093/annonc/mdt543. Epub 2014 Jan 8.
Impact factor: 6.578
Publication type: Clinical Trials
Authors: Baselga, J, Manikhas, A, Cortes, J, Llombart, A, Roman, L, Semiglazov, V F, Byakhov, M, Lokanatha, D, Forenza, S, Goldfarb, R H et al.
DOI: 10.1093/annonc/mdt543

Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors.

PMID: 25193991
Journal: ANN ONCOL
Year: 2014
Reference: Ann Oncol. 2014 Nov;25(11):2244-51. doi: 10.1093/annonc/mdu390. Epub 2014 Sep 5.
Impact factor: 6.578
Publication type: Clinical Trials
Authors: Robert, R, D'Incalci, M, Zucchetti, M, Camboni, M G, Tabernero, J, Saba, C, Dubois, F, Allen, A, Litten, J, Soria, J-C et al.
DOI: 10.1093/annonc/mdu390

Phase IV open-label study of the efficacy and safety of deferasirox after allogeneic stem cell transplantation.

PMID: 24997153
Journal: HAEMATOLOGICA
Year: 2014
Reference: Haematologica. 2014 Oct;99(10):1632-7. doi: 10.3324/haematol.2014.105908. Epub 2014 Jul 4.
Impact factor: 5.868
Publication type: Clinical guide
Authors: Valcarcel, David, Jarque, Isidro, Jimenez, Santiago, Rovira, Montserrat, Lopez, Javier, Hernandez, Dolores, Vallejo, Carlos, Batlle, Montserrat, Vazquez, Lourdes, Solano, Carlos et al.
DOI: 10.3324/haematol.2014.105908

Physical counter-pressure manoeuvres in preventing syncopal recurrence in patients older than 40 years with recurrent neurally mediated syncope: a controlled study from the Third International Study on Syncope of Uncertain Etiology (ISSUE-3)dagger.

PMID: 24906609
Journal: EUROPACE
Year: 2014
Reference: Europace. 2014 Oct;16(10):1515-20. doi: 10.1093/europace/euu125. Epub 2014 Jun 6.
Impact factor: 3.05
Publication type: Paper in international publication
Authors: Moya, Angel, van Dijk, Nynke, Giuli, Silvia, D'Ippolito, Giorgia, Gentili, Alessandra, Sutton, Richard, Kus, Teresa, Vitale, Elena, Romeo, Cristina, Tomaino, Marco et al.
DOI: 10.1093/europace/euu125

Physical exercise and health.

PMID: 25172071
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2014
Reference: Rev Esp Cardiol (Engl Ed). 2014 Sep;67(9):748-53. doi: 10.1016/j.rec.2014.04.005. Epub 2014 Jul 4.
Impact factor: 3.342
Publication type: Paper in international publication
Authors: Cordero, Alberto, Masia, M Dolores, Galve, Enrique et al.
DOI: 10.1016/j.rec.2014.04.005

Physical well-being in postoperative period: a survey in patients, nurses and physicians.

PMID: 24720578
Journal: J CLIN NURS
Year: 2014
Reference: J Clin Nurs. 2014 May;23(9-10):1421-9. doi: 10.1111/jocn.12446. Epub 2013 Dec 20.
Impact factor: 1.233
Publication type: Paper in international publication
Authors: Andion, Oscar, Canellas, Montserrat, Banos, Josep-E et al.
DOI: 10.1111/jocn.12446

Placebo-controlled trial of oral laquinimod in multiple sclerosis: MRI evidence of an effect on brain tissue damage.

PMID: 24029546
Journal: J NEUROL NEUROSUR PS
Year: 2014
Reference: J Neurol Neurosurg Psychiatry. 2014 Aug;85(8):851-8. doi: 10.1136/jnnp-2013-306132. Epub 2013 Sep 12.
Impact factor: 5.58
Publication type: Clinical Trials
Authors: Taba, P, Filippi, Massimo, Rocca, Maria A, Galay, N, Weber, J, Franta, C, Lampi, C, Shotekov, P, Bozhinov, S, Deleva, N et al.
DOI: 10.1136/jnnp-2013-306132

Plasma ST2 Predicts Mortality in Patients With Acute Respiratory Distress Syndrome.

PMID: 24638340
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):174A. doi: 10.1378/chest.1822406.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Garcia de Acilu, Marina, Roca, Oriol, Masclans, Joan Ramon, Ruano, Laura, Rello, Jordi et al.
DOI: 10.1378/chest.1822406

Pneumonia and lung ultrasound in the intensive care unit.

PMID: 24638338
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):171A. doi: 10.1378/chest.1806646.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Parra, Ana, Perez, Purificacion, Serra, Joaquim, Roca, Oriol, Masclans, Joan Ramon, Rello, Jordi et al.
DOI: 10.1378/chest.1806646

Pneumonia in inmunocompetent patients: combination antibiotic therapy.

PMID: 24122034
Journal: MINERVA ANESTESIOL
Year: 2014
Reference: Minerva Anestesiol. 2014 Apr;80(4):495-503. Epub 2013 Oct 11.
Impact factor: 2.272
Publication type: Paper in international publication
Authors: Salva, S, Borgatta, B, Rello, J et al.
DOI:

PNPLA3 rs738409 causes steatosis according to viral & IL28B genotypes in hepatitis C.

PMID: 24927606
Journal: ANN HEPATOL
Year: 2014
Reference: Ann Hepatol. 2014 Jul-Aug;13(4):356-63.
Impact factor: 2.193
Publication type: Paper in international publication
Authors: Ampuero, Javier, Del Campo, Jose A, Rojas, Lourdes, Garcia-Lozano, Jose R, Sola, Ricard, Andrade, Raul, Pons, Jose A, Navarro, Jose M, Calleja, Jose L, Buti, Maria et al.
DOI:

Polypharmacy in patients hospitalised for acute exacerbation of COPD.

PMID: 24833769
Journal: EUR RESPIR J
Year: 2014
Reference: Eur Respir J. 2014 Sep;44(3):791-4. doi: 10.1183/09031936.00014814. Epub 2014 May 15.
Impact factor: 7.125
Publication type: Letter or abstract
Authors: Diez-Manglano, Jesus, Barquero-Romero, Jose, Mena, Pedro Almagro, Recio-Iglesias, Jesus, Cabrera-Aguilar, Javier, Viu, Ramon Boixeda, Soriano, Joan B, Lopez-Garcia, Francisco et al.
DOI: 10.1183/09031936.00014814

Population pharmacokinetic and covariate analysis of pertuzumab, a HER2-targeted monoclonal antibody, and evaluation of a fixed, non-weight-based dose in patients with a variety of solid tumors.

PMID: 25119184
Journal: CANCER CHEMOTH PHARM
Year: 2014
Reference: Cancer Chemother Pharmacol. 2014 Oct;74(4):819-29. doi: 10.1007/s00280-014-2560-3. Epub 2014 Aug 14.
Impact factor: 2.571
Publication type: Paper in international publication
Authors: Wada, D Russell, Li, Hanbin, Cortes, Javier, McNally, Virginia, Ross, Graham, Visich, Jennifer, Lum, Bert, Jin, Jin, Li, Jing, Garg, Amit et al.
DOI: 10.1007/s00280-014-2560-3

Posaconazole versus benznidazole for chronic Chagas' disease.

PMID: 25184871
Journal: NEW ENGL J MED
Year: 2014
Reference: N Engl J Med. 2014 Sep 4;371(10):966. doi: 10.1056/NEJMc1407914.
Impact factor: 54.42
Publication type: Letter or abstract
Authors: Molina, Israel, Salvador, Fernando, Sanchez-Montalva, Adrian et al.
DOI: 10.1056/NEJMc1407914