About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
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People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
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The Research Group on Status Epilepticus and Acute Seizures is a young and emerging team, consolidated in national and international clinical research and in the comprehensive and multidisciplinary approach to epilepsy. The scientific challenge of the group is based on understanding, improving and strengthening knowledge about the different fields of epilepsy and how to help solve problems related to epileptic seizures and their consequences.
Among the different projects of the group, it is worth mentioning the search for new biomarkers related to the mechanisms of epileptogenesis, obtaining tools and biomarkers to help diagnose status epilepticus and predict its prognosis, the acquisition of neuroimaging parameters and their relationship with the cognitive status of patients, and other studies to accelerate the diagnostic processes and optimize the therapeutic management of patients with drug-resistant epilepsy.
PMID: 39615423 Journal: EPILEPSY & BEHAVIOR Year: 2024 Reference: Epilepsy Behav. 2024 Nov 29;163:110158. doi: 10.1016/j.yebeh.2024.110158. Impact factor: Publication type: Paper in international publication Authors: Abraira, Laura; Campos-Fernandez, Daniel; Elosua-Bayes, Iker; Fonseca, Elena; Lallana, Sofia; Lopez-Maza, Samuel; Quintana, Manuel; Salas-Puig, Javier; Santamarina, Estevo; Toledo, Manuel et al. DOI: 10.1016/j.yebeh.2024.110158
PMID: 36692706 Journal: Neurology and Therapy Year: 2023 Reference: Neurol Ther. 2023 Apr;12(2):479-503. doi: 10.1007/s40120-023-00437-0. Epub 2023 Jan 24. Impact factor: Publication type: Paper in international publication Authors: Albanell, Albert Molins; Artal, Jesus; Bobes, Julio; Cabeza-Alvarez, Clara-Isabel; Campos, Dulce; Castillo, Ascension; Florez, Gerardo; Franco-Martin, Manuel; Garcia-Portilla, Maria Paz; Giraldez, Beatriz G et al. DOI: 10.1007/s40120-023-00437-0
PMID: 37347842 Journal: EPILEPSIA Year: 2023 Reference: Epilepsia. 2023 Jun 22. doi: 10.1111/epi.17697. Impact factor: Publication type: Paper in international publication Authors: Campos-Fernandez, Daniel; Campos-Fernandez, Daniel; Fonseca, Elena; Gomez-Dabo, Laura; Lallana, Sofia; Quintana, Manuel; Rodrigo-Gisbert, Marc; Santamarina, Estevo; Toledo, Manuel et al. DOI: 10.1111/epi.17697
PMID: 37634373 Journal: EPILEPSY & BEHAVIOR Year: 2023 Reference: Epilepsy Behav. 2023 Aug 25;147:109384. doi: 10.1016/j.yebeh.2023.109384. Impact factor: Publication type: Paper in international publication Authors: Asensio, Montserrat; Campos, Dulce; Castillo, Ascension; Chavarria, Beatriz; Escalza, Ines; Falip, Merce; Fernandez-Cabrera, Alejandro; Garces, Mercedes; Garcia-Morales, Irene; Gifreu, Ariadna et al. DOI: 10.1016/j.yebeh.2023.109384
PMID: 37036702 Journal: JAMA Neurology Year: 2023 Reference: JAMA Neurol. 2023 Apr 10. doi: 10.1001/jamaneurol.2023.0611. Impact factor: Publication type: Paper in international publication Authors: Abraira, Laura; Alvarez-Sabin, Jose; Baumann, Christian R; Bayona-Ortiz, Hernan; Bentes, Carla; Bicciato, Giulio; Brigo, Francesco; Conrad, Julian; Dohler, Nico; Duncan, John S et al. DOI: 10.1001/jamaneurol.2023.0611
PMID: 35907324 Journal: EPILEPSY RESEARCH Year: 2022 Reference: Epilepsy Res. 2022 Sep;185:106988. doi: 10.1016/j.eplepsyres.2022.106988. Epub 2022 Jul 19. Impact factor: Publication type: Paper in international publication Authors: Abraira, Laura; Ballve, Alejandro; Campos, Daniel; Fonseca, Elena; Giffreu, Ariadna; Llaurado, Arnau; Quintana, Manuel; Santamarina, Estevo; Toledo, Manuel et al. DOI: 10.1016/j.eplepsyres.2022.106988
PMID: 35711112 Journal: ACTA NEUROLOGICA SCANDINAVICA Year: 2022 Reference: Acta Neurol Scand. 2022 Sep;146(3):265-275. doi: 10.1111/ane.13659. Epub 2022 Jun 16. Impact factor: Publication type: Paper in international publication Authors: Ben-Menachem, Elinor; Brandt, Christian; Garcia Morales, Irene; Rosenfeld, William E; Santamarina, Estevo; Serratosa, Jose M; Steinhoff, Bernhard J et al. DOI: 10.1111/ane.13659
PMID: 34427754 Journal: JOURNAL OF NEUROLOGY Year: 2022 Reference: J Neurol. 2022 Apr;269(4):1957-1977. doi: 10.1007/s00415-021-10751-y. Epub 2021 Aug 24. Impact factor: Publication type: Paper in international publication Authors: D'Souza, Wendyl; Goji, Hiroko; Kim, Dong Wook; Liguori, Claudio; McMurray, Rob; Najm, Imad; Santamarina, Estevo; Steinhoff, Bernhard J; Trinka, Eugen; Villanueva, Vicente et al. DOI: 10.1007/s00415-021-10751-y
PMID: 35152335 Journal: JOURNAL OF NEUROLOGY Year: 2022 Reference: J Neurol. 2022 Jul;269(7):3761-3769. doi: 10.1007/s00415-022-11005-1. Epub 2022 Feb 13. Impact factor: Publication type: Paper in international publication Authors: Abraira, L; Alvarez-Sabin, J; Coscojuela, P; Fonseca, E; Quintana, M; Restrepo-Vera, J L; Rovira, A; Santamarina, E; Sarria-Estrada, S; Sueiras, M et al. DOI: 10.1007/s00415-022-11005-1
PMID: 34710770 Journal: SLEEP MEDICINE REVIEWS Year: 2021 Reference: Sleep Med Rev. 2021 Dec;60:101559. doi: 10.1016/j.smrv.2021.101559. Epub 2021 Oct 8. Impact factor: Publication type: Review in international publication Authors: Kothare, Sanjeev; Liguori, Claudio; Toledo, Manuel et al. DOI: 10.1016/j.smrv.2021.101559
PMID: 34681281 Journal: Pharmaceuticals Year: 2021 Reference: Pharmaceuticals (Basel). 2021 Oct 18;14(10). pii: ph14101057. doi: 10.3390/ph14101057. Impact factor: Publication type: Review in international publication Authors: Alonso-Lana, Silvia; Boada, Merce; Cano, Amanda; de Rojas, Itziar; Ettcheto, Miren; Fonseca, Elena; Marquie, Marta; Morato, Xavier; Ruiz, Agustin; Sanchez-Lopez, Elena et al. DOI: 10.3390/ph14101057
PMID: 34619543 Journal: EPILEPSY & BEHAVIOR Year: 2021 Reference: Epilepsy Behav. 2021 Oct 4;124:108341. doi: 10.1016/j.yebeh.2021.108341. Impact factor: Publication type: Review in international publication Authors: Beniczky, Sandor; Eriksson, Sofia H; Nobili, Lino; Romigi, Andrea; Rosenzweig, Ivana; Ryvlin, Philippe; Toledo, Manuel et al. DOI: 10.1016/j.yebeh.2021.108341
PMID: 34509250 Journal: JOURNAL OF CLINICAL NEUROSCIENCE Year: 2021 Reference: J Clin Neurosci. 2021 Oct;92:189-190. doi: 10.1016/j.jocn.2021.08.006. Epub 2021 Aug 14. Impact factor: Publication type: Letter or abstract Authors: Lallana, Sofia; Siegler, James E et al. DOI: 10.1016/j.jocn.2021.08.006
PMID: 32857458 Journal: EPILEPSIA Year: 2020 Reference: Epilepsia. 2020 Oct;61(10):2244-2253. doi: 10.1111/epi.16648. Epub 2020 Aug 28. Impact factor: Publication type: Paper in international publication Authors: Abraira, Laura; Alvarez-Sabin, Jose; Bustamante, Alejandro; Canovas, David; Cardona, Pere; Castellanos, Mar; Cazorla, Sonia; Ciurans, Jordi; Fonseca, Elena; Gasull, Teresa et al. DOI: 10.1111/epi.16648
PMID: 32799337 Journal: ACTA NEUROLOGICA SCANDINAVICA Year: 2020 Reference: Acta Neurol Scand. 2020 Dec;142(6):545-554. doi: 10.1111/ane.13335. Epub 2020 Sep 6. Impact factor: Publication type: Paper in international publication Authors: Abraira, Laura; Fonseca, Elena; Lallana, Sofia; Quintana, Manuel; Restrepo, Juan Luis; Santamarina, Estevo; Seijo-Raposo, Ivan; Toledo, Manuel et al. DOI: 10.1111/ane.13335
PMID: 32694039 Journal: EPILEPSY & BEHAVIOR Year: 2020 Reference: Epilepsy Behav. 2020 Oct;111:107315. doi: 10.1016/j.yebeh.2020.107315. Epub 2020 Jul 18. Impact factor: Publication type: Paper in international publication Authors: Abraira, L; Ballve, A; Campos, D; Fonseca, E; Guzman, L; Llaurado, A; Olive, M; Quintana, M; Requena, M; Santamarina, E et al. DOI: 10.1016/j.yebeh.2020.107315
PMID: 32702656 Journal: EPILEPSY & BEHAVIOR Year: 2020 Reference: Epilepsy Behav. 2020 Oct;111:107291. doi: 10.1016/j.yebeh.2020.107291. Epub 2020 Jul 20. Impact factor: Publication type: Paper in international publication Authors: Abraira, Laura; Cordero, Esteban; Fonseca, Elena; Martinez-Ricarte, Francisco; Quintana, Manuel; Salas-Puig, Javier; Santamarina, Estevo; Sueiras, Maria; Thonon, Vanessa; Toledo, Manuel et al. DOI: 10.1016/j.yebeh.2020.107291
PMID: 31181429 Journal: EPILEPSY & BEHAVIOR Year: 2019 Reference: Epilepsy Behav. 2019 Aug;97:51-59. doi: 10.1016/j.yebeh.2019.05.003. Epub 2019 Jun 7. Impact factor: Publication type: Paper in international publication Authors: Alvarez, Blanca Mercedes; Baiges, Joan Josep; Bermejo, Pedro; Bertol, Vicente; Bonet, Macarena; Castro-Vilanova, M Dolores; Esteve, Patricia; Galiano, Maria Luisa; Garces, Mercedes; Giner, Pau et al. DOI: 10.1016/j.yebeh.2019.05.003
PMID: 31166616 Journal: EPILEPSIA Year: 2019 Reference: Epilepsia. 2019 Jul;60(7):1317-1324. doi: 10.1111/epi.16063. Epub 2019 Jun 5. Impact factor: Publication type: Paper in international publication Authors: Coscojuela, Pilar; Gonzalez-Cuevas, Montserrat; Guzman, Lorena; Pareto, Deborah; Quintana, Manuel; Rovira, Alex; Salas-Puig, Xavier; Santamarina, Estevo; Sarria, Silvana; Sueiras, Maria et al. DOI: 10.1111/epi.16063
PMID: 31153569 Journal: EUROPEAN JOURNAL OF RADIOLOGY Year: 2019 Reference: Eur J Radiol. 2019 Jul;116:219-224. doi: 10.1016/j.ejrad.2019.05.001. Epub 2019 May 2. Impact factor: Publication type: Paper in international publication Authors: Coscojuela, Pilar; Dinia, Lavinia; Gramegna, Laura Ludovica; Hernandez, David; Melendez, Fernando; Molina, Carlos; Quintana, Manuel; Requena, Manuel; Ribo, Marc; Rovira, Alex et al. DOI: 10.1016/j.ejrad.2019.05.001
PMID: 31077960 Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY Year: 2019 Reference: Seizure. 2019 Jul;69:193-197. doi: 10.1016/j.seizure.2019.04.022. Epub 2019 May 1. Impact factor: Publication type: Paper in international publication Authors: Abraira, Laura; Alvarez-Sabin, Jose; Fonseca, Elena; Guzman, Lorena; Quintana, Manuel; Salas-Puig, Javier; Santamarina, Estevo; Sueiras, Maria; Toledo, Manuel et al. DOI: 10.1016/j.seizure.2019.04.022
PMID: 30172139 Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY Year: 2018 Reference: Seizure. 2018 Oct;61:158-163. doi: 10.1016/j.seizure.2018.08.016. Epub 2018 Aug 18. Impact factor: Publication type: Clinical guide Authors: Abraira Del Fresno, L; Alvarez Sabin, J; Fonseca Hernandez, E; Olive Gadea, M; Quintana, M; Requena Ruiz, M; Salas Puig, X; Santamarina Perez, E; Toledo, M et al. DOI: 10.1016/j.seizure.2018.08.016
PMID: 30118928 Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY Year: 2018 Reference: Seizure. 2018 Oct;61:78-82. doi: 10.1016/j.seizure.2018.08.007. Epub 2018 Aug 11. Impact factor: Publication type: Paper in international publication Authors: Abraira-Del-Fresno, Laura; Fonseca, Elena; Olive, Marta; Quintana, Manuel; Requena, Manuel; Salas-Puig, Xavier; Santamarina, Estevo; Toledo, Manuel et al. DOI: 10.1016/j.seizure.2018.08.007
PMID: 30062784 Journal: EPILEPSIA Year: 2018 Reference: Epilepsia. 2018 Sep;59(9):1740-1752. doi: 10.1111/epi.14522. Epub 2018 Jul 31. Impact factor: Publication type: Paper in international publication Authors: Baiges-Octavio, Juan J; Bertol, Vicente; Bonet, Macarena; Campos, Dulce; Carreno, Mar; Castillo, Ascension; Esteve-Belloch, Patricia; Falip, Merce; Garamendi, Inigo; Garces, Mercedes et al. DOI: 10.1111/epi.14522
PMID: 30047129 Journal: EPILEPSIA Year: 2018 Reference: Epilepsia. 2018 Sep;59(9):1727-1739. doi: 10.1111/epi.14520. Epub 2018 Jul 25. Impact factor: Publication type: Paper in international publication Authors: Ben-Menachem, Elinor; Bertol-Alegre, Vicente; Brodie, Martin J; Carpenter, Katherine J; Di Gennaro, Giancarlo; Garamendi, Inigo; Garcia-Morales, Irene; Lopez-Gonzalez, Francisco Javier; Maurousset, Aude; Menzler, Katja et al. DOI: 10.1111/epi.14520
PMID: 29096133 Journal: EPILEPSY RESEARCH Year: 2017 Reference: Epilepsy Res. 2017 Dec;138:81-87. doi: 10.1016/j.eplepsyres.2017.10.018. Epub 2017 Oct 29. Impact factor: Publication type: Paper in international publication Authors: Arjona-Padillo, Antonio; Bertol-Alegre, Vicente; Estevez-Maria, Jose Carlos; Fernandez-Perez, Javier; Galvan-Espinosa, Jose; Garcia-Martinez, Alberto; Lopez-Gonzalez, Francisco Javier; Maestre-Moreno, Jose Francisco; Mauri-Llerda, Jose Angel; Molto-Jorda, Jose Manuel et al. DOI: 10.1016/j.eplepsyres.2017.10.018
PMID: 29073578 Journal: EPILEPSY RESEARCH Year: 2017 Reference: Epilepsy Res. 2017 Dec;138:53-61. doi: 10.1016/j.eplepsyres.2017.10.008. Epub 2017 Oct 10. Impact factor: Publication type: Review in national publication Authors: Beale, Rebecca; Borghs, Simon; Elmoufti, Sami; Evans, Jennifer S; Steeves, Sara; Toledo, Manuel; Townsend, Rebecca; Whitesides, John et al. DOI: 10.1016/j.eplepsyres.2017.10.008
PMID: 28906078 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2017 Reference: Eur J Neurol. 2017 Oct;24(10):e74. doi: 10.1111/ene.13384. Impact factor: Publication type: Letter or abstract Authors: Gonzalez-Cuevas, M; Guzman, L; Quintana, M; Sala, J; Salas-Puig, J; Santamarina, E; Sueiras, M; Toledo, M et al. DOI: 10.1111/ene.13384
PMID: 28419947 Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY Year: 2017 Reference: Seizure. 2017 May;48:53-56. doi: 10.1016/j.seizure.2017.04.003. Epub 2017 Apr 7. Impact factor: Publication type: Paper in international publication Authors: Camacho, J L; Castillo, A; Garces, M; Giner, P; Giraldez, B G; Gomez-Ibanez, A; Guillamon, E; Lopez-Gomariz, E; Lopez-Gonzalez, F J; Mauri, J A et al. DOI: 10.1016/j.seizure.2017.04.003
PMID: 27130867 Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY Year: 2016 Reference: Seizure. 2016 May;38:78. doi: 10.1016/j.seizure.2016.04.005. Epub 2016 Apr 26. Impact factor: Publication type: Letter or abstract Authors: Gonzalez-Cuevas, M; Sala-Padro, J; Salas-Puig, J; Santamarina, E; Sarria, S; Sueiras-Gil, M; Toledo, M et al. DOI: 10.1016/j.seizure.2016.04.005
PMID: 27415411 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2016 Reference: Eur J Neurol. 2016 Oct;23(10):1534-40. doi: 10.1111/ene.13073. Epub 2016 Jul 14. Impact factor: Publication type: Paper in international publication Authors: Gonzalez-Cuevas, M; Guzman, L; Quintana, M; Sala, J; Salas-Puig, J; Santamarina, E; Sueiras, M; Toledo, M et al. DOI: 10.1111/ene.13073
PMID: 27438183 Journal: CLINICAL NEUROPHARMACOLOGY Year: 2016 Reference: Clin Neuropharmacol. 2016 Nov/Dec;39(6):299-301. Impact factor: Publication type: Paper in international publication Authors: Gonzalez-Cuevas, Montserrat; Quintana, Manolo; Raspall-Chaure, Miquel; Sala-Padro, Jacint; Salas-Puig, Xavier; Santamarina, Estevo; Sueiras-Gil, Maria; Toledo, Manuel et al. DOI: 10.1097/WNF.0000000000000177
PMID: 27149188 Journal: REVISTA DE NEUROLOGIA Year: 2016 Reference: Rev Neurol. 2016 May 16;62(10):455-9. Impact factor: Publication type: Paper in national publication Authors: Auger, C; Cicuendez, M; Cordero, E; Martinez-Ricarte, F; Martinez-Saez, E; Radoi, A; Sahuquillo, J; Toledo, M et al. DOI: 10.33588/rn.6210.2015449
PMID: 26491084 Journal: NEUROLOGY Year: 2015 Reference: Neurology. 2015 Nov 17;85(20):1736-43. doi: 10.1212/WNL.0000000000002125. Epub 2015 Oct 21. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Esther; Aguilera-Albesa, Sergio; Armangue, Thais; Arratibel, Izaskun; Bataller, Luis; Bosch, Beatriz; Cantarin-Extremera, Veronica; Casado-Naranjo, Ignacio; Cervera, Carlos; Conde, Carlos Enrique et al. DOI: 10.1212/WNL.0000000000002125
PMID: 26489387 Journal: CLIN NEUROL NEUROSUR Year: 2015 Reference: Clin Neurol Neurosurg. 2015 Dec;139:166-71. doi: 10.1016/j.clineuro.2015.10.002. Epub 2015 Oct 22. Impact factor: Publication type: Paper in international publication Authors: Auger, Cristina; Maldonado, Xavier; Martinez-Ricarte, Francisco; Martinez-Saez, Elena; Quintana, Manuel; Rodon, Jordi; Salas-Puig, Javier; Santamarina, Estevo; Sarria-Estrada, Silvana; Toledo, Manuel et al. DOI: 10.1016/j.clineuro.2015.10.002
PMID: 25847348 Journal: EPILEPSY RES Year: 2015 Reference: Epilepsy Res. 2015 May;112:130-6. doi: 10.1016/j.eplepsyres.2015.02.016. Epub 2015 Mar 10. Impact factor: Publication type: Paper in international publication Authors: Alvarez Sabin, J; Guzman, L; Quintana, M; Riveiro, M; Sahuquillo, J; Salas Puig, X; Santamarina, E; Sueiras, M; Toledo, M; Torne, R et al. DOI: 10.1016/j.eplepsyres.2015.02.016
PMID: 25765726 Journal: STROKE Year: 2015 Reference: Stroke. 2015 May;46(5):1187-95. doi: 10.1161/STROKEAHA.114.008311. Epub 2015 Mar 12. Impact factor: Publication type: Review in international publication Authors: Antolin-Fontes, Albert; Biteker, Murat; Bustamante, Alejandro; Castillo, Jose; Etgen, Thorleif; Fonseca, Ana Catarina; Furie, Karen; Garcia-Berrocoso, Teresa; Giannakoulas, George; Giralt, Dolors et al. DOI: 10.1161/STROKEAHA.114.008311
PMID: 24504876 Journal: REVISTA DE NEUROLOGIA Year: 2014 Reference: Rev Neurol. 2014 Feb 16;58(4):147-51. Impact factor: Publication type: Paper in national publication Authors: Alvarez-Sabin, Jose; Cambrodi-Masip, Roser; Gonzalez-Cuevas, Montserrat; Quintana, Manuel; Salas-Puig, Javier; Santamarina, Esteban; Sarria, Silvana; Sueiras-Gil, Maria; Toledo, Manuel et al. DOI: 10.33588/rn.5804.2013524
PMID: 24493378 Journal: NEURORADIOLOGY Year: 2014 Reference: Neuroradiology. 2014 Apr;56(4):283-9. doi: 10.1007/s00234-014-1330-6. Epub 2014 Feb 4. Impact factor: Publication type: Paper in international publication Authors: Auger, Cristina; Coscojuela, Pilar; Martucci, Matia; Rovira, Alex; Sarria, Silvana; Siurana, Sahyly; Toledo, Manuel; Vert, Carla et al. DOI: 10.1007/s00234-014-1330-6
PMID: 23726850 Journal: LANCET NEUROLOGY Year: 2013 Reference: Lancet Neurol. 2013 Jul;12(7):689-705. doi: 10.1016/S1474-4422(13)70055-3. Epub 2013 May 31. Impact factor: Publication type: Review in international publication Authors: Alvarez-Sabin, Jose; Kase, Carlos S; Maisterra, Olga; Santamarina, Estevo et al. DOI: 10.1016/S1474-4422(13)70055-3
