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Research Group on Status Epilepticus and Acute Seizures

The Research Group on Status Epilepticus and Acute Seizures is a young and emerging team, consolidated in national and international clinical research and in the comprehensive and multidisciplinary approach to epilepsy. The scientific challenge of the group is based on understanding, improving and strengthening knowledge about the different fields of epilepsy and how to help solve problems related to epileptic seizures and their consequences.

Among the different projects of the group, it is worth mentioning the search for new biomarkers related to the mechanisms of epileptogenesis, obtaining tools and biomarkers to help diagnose status epilepticus and predict its prognosis, the acquisition of neuroimaging parameters and their relationship with the cognitive status of patients, and other studies to accelerate the diagnostic processes and optimize the therapeutic management of patients with drug-resistant epilepsy. 

Publications

Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes.

PMID: 37034728
Journal:
Year: 2023
Reference: medRxiv. 2023 Sep 18:2023.03.27.23287713. doi: 10.1101/2023.03.27.23287713. Preprint.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Abraira, L; Ballve, A; Batzler, Anthony; Bianchi, Sevim B; Biernacka, Joanna M; Campos, D; Coombes, Brandon J; Cox, Nancy J; Davis, Lea K; Ehinmowo, Michael et al.
DOI: 10.1101/2023.03.27.23287713

The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy.

PMID: 37892809
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Oct 22;12(20):6671. doi: 10.3390/jcm12206671.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira-Del Fresno, L; Abraira-Del Fresno, L; Barone, Paolo; Campos-Fernandez, D; Campos-Fernandez, D; De Bernardo, Maddalena; De Luca, Martina; Diana, Francesco; Fonseca-Hernandez, E; Fonseca-Hernandez, E et al.
DOI: 10.3390/jcm12206671

Risk assessment of long-term epilepsy after de novo status epilepticus with clinical and electroencephalographic biomarkers: The AFTER score.

PMID: 37995538
Journal: EPILEPSY & BEHAVIOR
Year: 2023
Reference: Epilepsy Behav. 2023 Nov 22;149:109531. doi: 10.1016/j.yebeh.2023.109531.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira, Laura; Adic, Filip; Adic, Nada Cemerlic; Aurelian, Rosca; Becker, David; Benedek, Imre; Benedek, Theodora; Berry, Colin; Birtolo, Lucia Ilaria; Bosserdt, Maria et al.
DOI: 10.1016/j.yebeh.2023.109531

The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control Study.

PMID: 38001636
Journal: Cancers
Year: 2023
Reference: Cancers (Basel). 2023 Nov 12;15(22):5376. doi: 10.3390/cancers15225376.
Impact factor:
Publication type: Paper in international publication
Authors: Abadias-Granado, Isabel; Abraira, Laura; Almagro, Manuel; Almenara-Blasco, Manuel; Arias-Santiago, Salvador; Banuls, Jose; Buendia-Eisman, Agustin; Campos-Fernandez, Daniel; Campos-Fernandez, Daniel; Colmenero, Maria et al.
DOI: 10.3390/cancers15225376

Interictal brain activity changes in temporal lobe epilepsy: A quantitative electroencephalogram analysis.

PMID: 34687043
Journal: ACTA NEUROLOGICA SCANDINAVICA
Year: 2022
Reference: Acta Neurol Scand. 2022 Feb;145(2):239-248. doi: 10.1111/ane.13543. Epub 2021 Oct 22.
Impact factor: 3.209
Publication type: Paper in international publication
Authors: Fonseca, Elena; Quintana, Manuel; Seijo-Raposo, Ivan; Ortiz de Zarate, Zurine; Abraira, Laura; Santamarina, Estevo; Toledo, Manuel; Alvarez-Sabin, Jose et al.
DOI: 10.1111/ane.13543

Epileptic seizures in the emergency room: clinical and electroencephalographic findings associated with brain perfusion patterns on computed tomography.

PMID: 35152335
Journal: JOURNAL OF NEUROLOGY
Year: 2022
Reference: J Neurol. 2022 Jul;269(7):3761-3769. doi: 10.1007/s00415-022-11005-1. Epub 2022 Feb 13.
Impact factor: 4.849
Publication type: Paper in international publication
Authors: Coscojuela, P; Fonseca, E; Quintana, M; Sarria-Estrada, S; Santamarina, E; Abraira, L; Sueiras, M; Thonon, V; Alvarez-Sabin, J; Toledo, M et al.
DOI: 10.1007/s00415-022-11005-1

'Leukodystrophy-Like' Phenotype in anti-MOG antibody-associated disorders.

PMID: 35030636
Journal: NEUROPEDIATRICS
Year: 2022
Reference: Neuropediatrics. 2022 Apr;53(2):147-148. doi: 10.1055/a-1740-9649. Epub 2022 Jan 14.
Impact factor: 1.947
Publication type: Paper in international publication
Authors: Gomez-Andres, David, Armangue, Thais, Sanchez-Montanez, Angel, Ortiz de Zarate Caballero, Zurine, Felipe-Rucian, Ana et al.
DOI: 10.1055/a-1740-9649

Expert opinion: use of valproate in girls and women of childbearing potential with epilepsy: recommendations and alternatives based on a review of the literature and clinical experience-a European perspective.

PMID: 32239268
Journal: JOURNAL OF NEUROLOGY
Year: 2021
Reference: J Neurol. 2021 Aug;268(8):2735-2748. doi: 10.1007/s00415-020-09809-0. Epub 2020 Apr 1.
Impact factor:
Publication type: Review in international publication
Authors: Biraben, Arnaud; Bosak, Magdalena; Jedrzejzak, Joanna; Mostacci, Barbara; Salas-Puig, Javier; Schmitz, Bettina; Thomas, Rhys H; Toledo, Manuel et al.
DOI: 10.1007/s00415-020-09809-0

Relationship between sleep quality and cognitive performance in patients with epilepsy.

PMID: 34147020
Journal: EPILEPSY & BEHAVIOR
Year: 2021
Reference: Epilepsy Behav. 2021 Sep;122:108127. doi: 10.1016/j.yebeh.2021.108127. Epub 2021 Jun 17.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira, Laura; Campos Blanco, Dulce M; Castro Vilanova, Maria Dolores; Centeno, Maria; Diaz de Cerio Julian, Leyre; Estevez-Maria, Jose Carlos; Falip, Merce; Fonseca, Elena; Garamendi, Inigo; Gomez-Eguilaz, Maria et al.
DOI: 10.1016/j.yebeh.2021.108127

Is Spreading Depolarization a Risk Factor for Late Epilepsy? A Prospective Study in Patients with Traumatic Brain Injury and Malignant Ischemic Stroke Undergoing Decompressive Craniectomy.

PMID: 33000378
Journal: Neurocritical Care
Year: 2021
Reference: Neurocrit Care. 2021 Jun;34(3):876-888. doi: 10.1007/s12028-020-01107-x. Epub 2020 Sep 30.
Impact factor:
Publication type: Paper in international publication
Authors: Gandara, Dario; Poca, Maria-Antonia; Quintana, Manuel; Riveiro, Marilyn; Sahuquillo, Juan; Sanchez-Guerrero, Angela; Santamarina, Estevo; Sueiras, Maria; Thonon, Vanessa et al.
DOI: 10.1007/s12028-020-01107-x

Thumb-up sign: Characterization of an undescribed seizure semiologic sign.

PMID: 34015572
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2021
Reference: Seizure. 2021 Jul;89:62-64. doi: 10.1016/j.seizure.2021.04.029. Epub 2021 May 11.
Impact factor:
Publication type: Letter whit IF
Authors: Abraira, Laura; Alvarez-Sabin, Jose; Anciones Martin, Carla; Fonseca, Elena; Gil-Nagel, Antonio; Quintana, Manuel; Santamarina, Estevo; Seijo-Raposo, Ivan; Toledo, Manuel; Vilaseca, Andreu et al.
DOI: 10.1016/j.seizure.2021.04.029

A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy.

PMID: 32350749
Journal: CNS DRUGS
Year: 2020
Reference: CNS Drugs. 2020 Jun;34(6):661-672. doi: 10.1007/s40263-020-00726-4.
Impact factor:
Publication type: Paper in international publication
Authors: Arenas Cabrera, Carmen Maria; Ben-Menachem, Elinor; Critchley, David; Crockett, Julie; Gunning, Boudewijn; Morrison, Gilmour; Tayo, Bola; Toledo, Manuel; VanLandingham, Kevan; Wray, Louise et al.
DOI: 10.1007/s40263-020-00726-4

Vascular risk factors as independent predictors of neurocognitive impairments in patients with late-onset epilepsy who have small-vessel disease.

PMID: 31399342
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 Mar;104(Pt B):106443. doi: 10.1016/j.yebeh.2019.106443. Epub 2019 Aug 6.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira, Laura; Cazorla, Sonia; Fonseca, Elena; Quintana, Manuel; Salas-Puig, Xavier; Santamarina, Estevo; Toledo, Manuel; Turon, Marc et al.
DOI: 10.1016/j.yebeh.2019.106443

Corrigendum to "Correlation of blood biomarkers with early-onset seizures after an acute stroke event" [Epilepsy Behav 104(Pt B) (2020 Mar)].

PMID: 32248061
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 May;106:107045. doi: 10.1016/j.yebeh.2020.107045. Epub 2020 Apr 2.
Impact factor:
Publication type: Letter or abstract
Authors: Abraira, Laura; Alvarez-Sabin, Jose; Becerra, Juan Luis; Bustamante, Alejandro; Canovas, David; Cardona, Pere; Castellanos, Mar; Cazorla, Sonia; Ciurans, Jordi; Davalos, Antoni et al.
DOI: 10.1016/j.yebeh.2020.107045

Correlation of blood biomarkers with early-onset seizures after an acute stroke event.

PMID: 31677998
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 Mar;104(Pt B):106549. doi: 10.1016/j.yebeh.2019.106549. Epub 2019 Oct 31.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira, Laura; Alvarez-Sabin, Jose; Becerra, Juan Luis; Bustamante, Alejandro; Canovas, David; Cardona, Pere; Castellanos, Mar; Cazorla, Sonia; Ciurans, Jordi; Davalos, Antoni et al.
DOI: 10.1016/j.yebeh.2019.106549

Update in status epilepticus.

PMID: 30803796
Journal: MEDICINA CLINICA
Year: 2019
Reference: Med Clin (Barc). 2019 Jul 19;153(2):70-77. doi: 10.1016/j.medcli.2019.01.013. Epub 2019 Feb 23.
Impact factor:
Publication type: Review in national publication
Authors: Abraira, Laura; Santamarina, Estevo; Toledo, Manuel et al.
DOI: 10.1016/j.medcli.2019.01.013

Cerebrovascular disease burden in late-onset non-lesional focal epilepsy.

PMID: 30776698
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2019
Reference: Seizure. 2019 Mar;66:31-35. doi: 10.1016/j.seizure.2019.02.004. Epub 2019 Feb 8.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira, Laura; Gramegna, Laura Ludovica; Quintana, Manuel; Rovira, Alex; Salas-Puig, Javier; Santamarina, Estevo; Sarria, Silvana; Toledo, Manuel et al.
DOI: 10.1016/j.seizure.2019.02.004

Etiology, seizure type, and prognosis of epileptic seizures in the emergency department.

PMID: 30763767
Journal: EPILEPSY & BEHAVIOR
Year: 2019
Reference: Epilepsy Behav. 2019 Mar;92:327-331. doi: 10.1016/j.yebeh.2018.12.008. Epub 2019 Feb 11.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira Del Fresno, Laura; Alvarez-Sabin, Jose; Fonseca Hernandez, Elena; Olive-Gadea, Marta; Quintana, Manuel; Requena, Manuel; Salas-Puig, Xavier; Santamarina, Estevo; Toledo, Manuel et al.
DOI: 10.1016/j.yebeh.2018.12.008

[Progressive multifocal leukoencephalopathy and non-specific immune dysfunction].

PMID: 30687923
Journal: REVISTA DE NEUROLOGIA
Year: 2019
Reference: Rev Neurol. 2019 Feb 1;68(3):132-133.
Impact factor:
Publication type: Letter whit IF
Authors: Ballve-Martin, A; Campos-Fernandez, D; Llaurado-Gayete, A; Olive-Gadea, M; Rio, J; Rovira, A; Santamarina, E et al.
DOI: 10.33588/rn.6803.2018377

Intravenous lacosamide (LCM) in status epilepticus (SE): Weight-adjusted dose and efficacy.

PMID: 29758445
Journal: EPILEPSY & BEHAVIOR
Year: 2018
Reference: Epilepsy Behav. 2018 Jul;84:93-98. doi: 10.1016/j.yebeh.2018.04.025. Epub 2018 May 11.
Impact factor:
Publication type: Paper in international publication
Authors: Becerra, Juan Luis; Fernandez, Angel; Gonzalez-Cuevas, Montserrat; Jimenez, Marta; Marinas, Ainhoa; Mauri, J A; Puig, Xavier Salas; Quilez, Alex; Quintana, Manuel; Santamarina, Estevo et al.
DOI: 10.1016/j.yebeh.2018.04.025

Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study.

PMID: 29735930
Journal: Nutrients
Year: 2018
Reference: Nutrients. 2018 May 7;10(5). pii: nu10050573. doi: 10.3390/nu10050573.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Nuria; Fernandez-Bustillo, Enrique; Hernandez-Lahoz, Carlos; Huerta, Marcos; Rodrigo, Luis; Salas-Puig, Javier et al.
DOI: 10.3390/nu10050573

Lacosamide monotherapy in clinical practice: A retrospective chart review.

PMID: 29542107
Journal: ACTA NEUROLOGICA SCANDINAVICA
Year: 2018
Reference: Acta Neurol Scand. 2018 Sep;138(3):186-194. doi: 10.1111/ane.12920. Epub 2018 Mar 14.
Impact factor:
Publication type: Paper in international publication
Authors: Brunnert, M; Cumbo, E; De Backer, M; De Haan, G J; Dedeken, P; Gambardella, A; Giraldez, B G; Joeres, L; Serratosa, J; Toledo, M et al.
DOI: 10.1111/ane.12920

Effect of lacosamide on depression and anxiety symptoms in patients with focal refractory epilepsy: A prospective multicenter study.

PMID: 29253680
Journal: EPILEPSY & BEHAVIOR
Year: 2018
Reference: Epilepsy Behav. 2018 Feb;79:87-92. doi: 10.1016/j.yebeh.2017.10.032. Epub 2017 Dec 16.
Impact factor:
Publication type: Paper in international publication
Authors: Becerra, Juan-Luis; Bertol, Vicente; Carreno, Mar; Ley, Miguel; Mauri, Jose-Angel; Molins, Albert; Rocamora, Rodrigo; Sansa, Gemma; Toledo, Manuel et al.
DOI: 10.1016/j.yebeh.2017.10.032

Effects of adjunctive perampanel on sleep quality, daytime somnolence and cognition in refractory focal epilepsy: Further data. Author's response.

PMID: 28153473
Journal: EPILEPSY & BEHAVIOR
Year: 2017
Reference: Epilepsy Behav. 2017 Mar;68:238. doi: 10.1016/j.yebeh.2016.10.031. Epub 2017 Jan 31.
Impact factor:
Publication type: Letter or abstract
Authors: Toledo, Manuel et al.
DOI: 10.1016/j.yebeh.2016.10.031

Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy.

PMID: 28066710
Journal: Epilepsy & behavior case reports
Year: 2017
Reference: Epilepsy Behav Case Rep. 2016 Oct 21;7:13-15. doi: 10.1016/j.ebcr.2016.10.002. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Cambrodi, Roser; Ferrer, Alex; Gonzalez-Cuevas, Montserrat; Jurado, Maria Jose; Quintana, Manuel; Romero, Odile; Salas-Puig, Xavier; Santamarina, Estevo; Toledo, Manuel et al.
DOI: 10.1016/j.ebcr.2016.10.002