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Research Group on Status Epilepticus and Acute Seizures

The Research Group on Status Epilepticus and Acute Seizures is a young and emerging team, consolidated in national and international clinical research and in the comprehensive and multidisciplinary approach to epilepsy. The scientific challenge of the group is based on understanding, improving and strengthening knowledge about the different fields of epilepsy and how to help solve problems related to epileptic seizures and their consequences.

Among the different projects of the group, it is worth mentioning the search for new biomarkers related to the mechanisms of epileptogenesis, obtaining tools and biomarkers to help diagnose status epilepticus and predict its prognosis, the acquisition of neuroimaging parameters and their relationship with the cognitive status of patients, and other studies to accelerate the diagnostic processes and optimize the therapeutic management of patients with drug-resistant epilepsy. 

Publications

First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial.

PMID: 38049622
Journal: NATURE MEDICINE
Year: 2023
Reference: Nat Med. 2023 Dec 4. doi: 10.1038/s41591-023-02704-x.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira, Laura; Agarwal, Neeraj; Azad, Arun A; Bentes, Carla; Brigo, Francesco; Carles, Joan; De Giorgi, Ugo; Di Santo, Nicola; Dunshee, Curtis; Ekdahl, Christine T et al.
DOI: 10.1038/s41591-023-02704-x

Type I error rates and power of two randomization test procedures for the changing criterion design.

PMID: 38082114
Journal: Behavior Research Methods
Year: 2023
Reference: Behav Res Methods. 2023 Dec 11. doi: 10.3758/s13428-023-02303-1.
Impact factor:
Publication type: Paper in international publication
Authors: Aixut, Sonia; Chirife Chaparro, Oscar; de Dios Lascuevas, Marta; Dinia, Lavinia; Gonzalez, Alejandro; Gramegna, Laura Ludovica; Hernandez, David; Luttich, Alex; Manolov, Rumen; Moreu, Manuel et al.
DOI: 10.3758/s13428-023-02303-1

Posterior reversible encephalopathy syndrome (PRES) associated with COVID-19.

PMID: 33992168
Journal: JOURNAL OF CLINICAL NEUROSCIENCE
Year: 2021
Reference: J Clin Neurosci. 2021 Jun;88:108-112. doi: 10.1016/j.jocn.2021.03.028. Epub 2021 Mar 23.
Impact factor:
Publication type: Paper in international publication
Authors: Chen, Austin; Lallana, Sofia; Muchada, Marian; Requena, Manuel; Rubiera, Marta; Sanchez, Anna; Siegler, James E et al.
DOI: 10.1016/j.jocn.2021.03.028

Status epilepticus without impairment of consciousness: Long-term outcomes according to duration.

PMID: 33992961
Journal: EPILEPSY & BEHAVIOR
Year: 2021
Reference: Epilepsy Behav. 2021 Jul;120:108007. doi: 10.1016/j.yebeh.2021.108007. Epub 2021 May 13.
Impact factor:
Publication type: Paper in international publication
Authors: Abarrategui, B; Abraira, L; Fonseca, E; Garcia-Morales, I; Gutierrez-Viedma, A; Parejo-Carbonell, B; Quintana, M; Salas-Puig, X; Santamarina, E; Seijo, I et al.
DOI: 10.1016/j.yebeh.2021.108007

A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures.

PMID: 33998885
Journal: Cannabis and Cannabinoid Research
Year: 2021
Reference: Cannabis Cannabinoid Res. 2021 Dec;6(6):528-536. doi: 10.1089/can.2020.0075. Epub 2021 Feb 15.
Impact factor:
Publication type: Paper in international publication
Authors: Altman, Anna; Bagary, Manny; Banach, Marta; Brodie, Martin J; Czapinski, Piotr; Falip, Merce; Fule, Kalman; Horvath, Agnes; Kelemen, Anna; Komoly, Samuel et al.
DOI: 10.1089/can.2020.0075

Medium-term effects of COVID-19 pandemic on epilepsy: A follow-up study.

PMID: 33905117
Journal: ACTA NEUROLOGICA SCANDINAVICA
Year: 2021
Reference: Acta Neurol Scand. 2021 Jul;144(1):99-108. doi: 10.1111/ane.13439. Epub 2021 Apr 27.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira, Laura; Alvarez-Sabin, Jose; Fonseca, Elena; Lallana, Sofia; Quintana, Manuel; Restrepo, Juan Luis; Santamarina, Estevo; Seijo-Raposo, Ivan; Toledo, Manuel et al.
DOI: 10.1111/ane.13439

Efficacy, retention, and safety of brivaracetam in adult patients with genetic generalized epilepsy.

PMID: 31731108
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 Jan;102:106657. doi: 10.1016/j.yebeh.2019.106657. Epub 2019 Nov 12.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira, Laura; Fonseca, Elena; Guzman, Lorena; Quintana, Manuel; Salas-Puig, Xavier; Santamarina, Estevo; Toledo, Manuel et al.
DOI: 10.1016/j.yebeh.2019.106657

Change in neuron specific enolase levels in out-of-hospital cardiopulmonary arrest survivors as a simple and useful tool to predict neurological prognosis.

PMID: 30935900
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2020
Reference: Rev Esp Cardiol (Engl Ed). 2020 Mar;73(3):232-240. doi: 10.1016/j.rec.2019.01.007. Epub 2019 Mar 30.
Impact factor:
Publication type: Paper in national publication
Authors: Baneras, Jordi; Barrabes, Jose A; Gaig, Carles; Garcia-Dorado, David; Garcia-Garcia, Cosme; Lidon, Rosa-Maria; Mila, Laia; Ortiz-Perez, Jose T; Rafecas, Agnes; Rueda-Sobella, Ferran et al.
DOI: 10.1016/j.rec.2019.01.007

From theory to practice: Critical points in the 2017 ILAE classification of epileptic seizures and epilepsies.

PMID: 32073153
Journal: EPILEPSIA
Year: 2020
Reference: Epilepsia. 2020 Feb;61(2):350-353. doi: 10.1111/epi.16426.
Impact factor:
Publication type: Paper in international publication
Authors: Akamatsu, Naoki; Bast, Thomas; Bauer, Sebastian; Baumgartner, Christoph; Benbadis, Selim; Bermeo-Ovalle, Adriana; Beyenburg, Stefan; Bleasel, Andrew; Bozorgi, Alireza; Brazdil, Milan et al.
DOI: 10.1111/epi.16426

Hippocampal microstructural architecture and surgical outcome: Hippocampal diffusivity could predict seizure relapse.

PMID: 32044692
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2020
Reference: Seizure. 2020 Jan 26;76:84-88. doi: 10.1016/j.seizure.2020.01.006.
Impact factor:
Publication type: Paper in international publication
Authors: Camara, Estela; Falip, Merce; Miro, Julia; Plans, Gerard; Quintana, Manuel; Rodriguez-Fornells, Antoni; Sala-Padro, Jacint; Santurino, Mila; Vidal, Noemi et al.
DOI: 10.1016/j.seizure.2020.01.006

Accidental injuries in patients with generalized tonic-clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study).

PMID: 30658321
Journal: EPILEPSY & BEHAVIOR
Year: 2019
Reference: Epilepsy Behav. 2019 Mar;92:135-139. doi: 10.1016/j.yebeh.2018.10.043. Epub 2019 Jan 15.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira, Laura; Iniesta, Marc; Puig, Josep; Salas-Puig, Xavier et al.
DOI: 10.1016/j.yebeh.2018.10.043

Perampanel for treatment of status epilepticus in Austria, Finland, Germany and Spain.

PMID: 30613951
Journal: ACTA NEUROLOGICA SCANDINAVICA
Year: 2019
Reference: Acta Neurol Scand. 2019 Apr;139(4):369-376. doi: 10.1111/ane.13061. Epub 2019 Jan 20.
Impact factor:
Publication type: Paper in international publication
Authors: Kalviainen, Reetta; Knake, Susanne; Rohracher, Alexandra; Rosenow, Felix; Santamarina, Estevo; Strzelczyk, Adam; Toledo, Manuel; Trinka, Eugen; Willig, Sophia et al.
DOI: 10.1111/ane.13061

Prognosis of status epilepticus in elderly patients.

PMID: 29168175
Journal: ACTA NEUROLOGICA SCANDINAVICA
Year: 2018
Reference: Acta Neurol Scand. 2018 Mar;137(3):321-328. doi: 10.1111/ane.12867. Epub 2017 Nov 22.
Impact factor:
Publication type: Paper in international publication
Authors: Gonzalez Cuevas, M; Guzman, L; Quintana Luque, M; Salas Puig, J; Santamarina Perez, E; Sueiras Gil, M; Toledo, M; Vilella, L et al.
DOI: 10.1111/ane.12867

A retrospective, multicentre study of perampanel given as monotherapy in routine clinical care in people with epilepsy.

PMID: 29288911
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2018
Reference: Seizure. 2018 Jan;54:61-66. doi: 10.1016/j.seizure.2017.10.015. Epub 2017 Oct 18.
Impact factor:
Publication type: Paper in international publication
Authors: Burd, Sergey; Gil-Nagel, Antonio; Laurenza, Antonio; Lebedeva, Anna; Patten, Anna; Sander, Josemir W; Toledo, Manuel et al.
DOI: 10.1016/j.seizure.2017.10.015

Rufinamide for the treatment of Lennox-Gastaut syndrome: evidence from clinical trials and clinical practice.

PMID: 29313492
Journal: EPILEPTIC DISORDERS
Year: 2018
Reference: Epileptic Disord. 2018 Feb 1;20(1):13-29. doi: 10.1684/epd.2017.0950.
Impact factor:
Publication type: Paper in international publication
Authors: Falip, Merce; McMurray, Rob; Santamarina, Estevo; Striano, Pasquale et al.
DOI: 10.1684/epd.2017.0950

Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration.

PMID: 29029261
Journal: TOXICOLOGICAL SCIENCES
Year: 2018
Reference: Toxicol Sci. 2018 Jan 1;161(1):103-114. doi: 10.1093/toxsci/kfx201.
Impact factor:
Publication type: Paper in international publication
Authors: Cabrera-Garcia, David; Fernandez-Sanchez, Maria Teresa; Marini, Ann M; Novelli, Antonello; Perez-Gomez, Anabel; Salas Puig, Javier; Warm, Davide et al.
DOI: 10.1093/toxsci/kfx201