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Rheumatology

The Rheumatology Research Group (GRR) is focused on translational research in immunity-mediated inflammatory diseases (IMIDA), mainly in the area of rheumatology. The GRR is a multidisciplinary group made up of clinical specialists, biologists, bioinformaticians and laboratory technicians. The different research lines of the GRR emphasize the use of high-performance technologies for the study at the cellular and molecular level of the immununopathology of IMIDA, mainly chronic inflammatory arthritis and autoimmune systemic diseases.

At the clinical level, we have developed lines of research in very diverse areas of rheumatology, including chronic inflammatory arthritis (rheumatoid arthritis, spondyloarthropathies), systemic autoimmune diseases (lupus, myositis, Sjögren's syndrome), the study of musculoskeletal imaging, pediatric rheumatology (juvenile idiopathic arthritis, autoimmune systemic diseases, autoinflammatory syndromes), central sensitization syndromes and the study of bone metabolism. One of the main objectives of the GRR is the coordination of basic and clinical research to accelerate the transfer of knowledge to clinical practice and thus improve the quality of life of patients.

Publications

Effectiveness of an online multicomponent program (FATIGUEWALK) for chronic fatigue syndrome: A randomized controlled trial.

PMID: 38127508
Journal: HEALTH PSYCHOLOGY
Year: 2023
Reference: Health Psychol. 2023 Dec 21. doi: 10.1037/hea0001346.
Impact factor:
Publication type: Paper in international publication
Authors: Auer, William; Borras, Xavier; Feliu-Soler, Albert; Ferres, Sonia; Luciano, Juan V; Navarrete, Jaime; Neblett, Randy; Nieto, Ruben; Sanmartin-Sentanes, Ramon; Serrat, Mayte et al.
DOI: 10.1037/hea0001346

Global Lung Initiative as diagnostic criteria in Asthma-COPD overlap syndrome. Prevalence and characterization of the syndrome in a real-life asthma cohort.

PMID: 38131661
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2023
Reference: J Investig Allergol Clin Immunol. 2023 Dec 22:0. doi: 10.18176/jiaci.0966.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez Puebla, J M; Arismendi, E; Auer, William; Barranco, P; Barroso, B; Betancor, D; Bobolea, I; Borras, Xavier; Cardaba, B; Cruz, M J et al.
DOI: 10.18176/jiaci.0966

Prospective observational study to validate a next-generation sequencing blood RNA signature to predict early kidney transplant rejection.

PMID: 38152017
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2023
Reference: Am J Transplant. 2023 Nov 29:S1600-6135(23)00723-2. doi: 10.1016/j.ajt.2023.09.021.
Impact factor:
Publication type: Paper in international publication
Authors: Alberici, Federico; Ansari, Mohammed Javeed; Anton, Jordi; Augustine, Joshua; Benken, Scott; Bestard, Oriol; Bhati, Chandra; Bittermann, Violetta; Bou, Rosa; Calvo Penades, Immaculada et al.
DOI: 10.1016/j.ajt.2023.09.021

Mechanical Dispersion is Associated with Ventricular Arrhythmias and Sudden Cardiac Death in Non-ischemic Dilated Cardiomyopathy.

PMID: 38159616
Journal: JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
Year: 2023
Reference: J Am Soc Echocardiogr. 2023 Dec 28:S0894-7317(23)00700-9. doi: 10.1016/j.echo.2023.12.010.
Impact factor:
Publication type: Paper in international publication
Authors: Badia-Molins, Clara; Calvo-Barcelo, Maria; Ferreira-Gonzalez, Ignacio; Jurek, Joanna Michalina; Lozano-Torres, Jordi; Neymann, Victoria; Rodenas-Alesina, Eduard; Rodriguez-Palomares, Jose; Tobias-Castillo, Pablo Eduardo; Vila, Rosa et al.
DOI: 10.1016/j.echo.2023.12.010

Does Dietary Coenzyme Q10 plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?

PMID: 35229657
Journal: ANTIOXIDANTS & REDOX SIGNALING
Year: 2022
Reference: Antioxid Redox Signal. 2022 Apr;36(10-12):729-739. doi: 10.1089/ars.2022.0018.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre-Martin, Jose; Castro-Marrero, Jesus; Cordobilla, Begona; Domingo, Joan Carles; Ferrer, Roser; Giralt, Marina; Sanmartin-Sentanes, Ramon et al.
DOI: 10.1089/ars.2022.0018

Inspecting the Ribozyme Region of Hepatitis Delta Virus Genotype 1: Conservation and Variability.

PMID: 35215809
Journal: Viruses-Basel
Year: 2022
Reference: Viruses. 2022 Jan 22;14(2). pii: v14020215. doi: 10.3390/v14020215.
Impact factor:
Publication type: Paper in international publication
Authors: Aldama, Unai; Buti, Maria; Casillas, Rosario; Cortese, Maria Francesca; Galan, Anna; Garcia-Garcia, Selene; Gonzalez-Aseguinolaza, Gloria; Gregori, Josep; Najarro, Adrian; Pacin-Ruiz, Beatriz et al.
DOI: 10.3390/v14020215

The impact of the Eurofever criteria and the new InFevers MEFV classification in real life: Results from a large international FMF cohort.

PMID: 35042149
Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM
Year: 2022
Reference: Semin Arthritis Rheum. 2022 Feb;52:151957. doi: 10.1016/j.semarthrit.2022.151957. Epub 2022 Jan 10.
Impact factor:
Publication type: Paper in international publication
Authors: Alessio, Maria; Amaryan, Gayane; Anton, Jordi; Aviel, Yonatan Butbul; Batu, Ezgi Deniz; Brogan, Paul; Bustaffa, Marta; Cantarini, Luca; Carrabba, Maria; Gallizzi, Romina et al.
DOI: 10.1016/j.semarthrit.2022.151957

Interobserver reliability of Masei index validation by a multicenter collaborative group of rheumatologists.

PMID: 33146762
Journal: RHEUMATOLOGY INTERNATIONAL
Year: 2022
Reference: Rheumatol Int. 2022 Mar;42(3):441-448. doi: 10.1007/s00296-020-04733-y. Epub 2020 Nov 4.
Impact factor:
Publication type: Paper in international publication
Authors: Aparicio Espinar, Maria; Armengol Perez, Eulalia; Busquets Perez, Noemi; Carmona, Loreto; Casado Burgos, Enrique; Clavaguera Poch, Teresa; Corominas Macias, Hector; Cuervo Aguilera, Andrea; de Agustin de Oro, Juan Jose; De Miguel Mendieta, Eugenio et al.
DOI: 10.1007/s00296-020-04733-y

The ovarian reserve as measured by the anti-Mullerian hormone is not diminished in patients with rheumatoid arthritis compared to the healthy population.

PMID: 32896242
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 Mar-Apr;39(2):337-343. Epub 2020 Sep 3.
Impact factor:
Publication type: Paper in international publication
Authors: Barcelo, Mireia; De Agustin, Juan Jose; Ferrer, Roser; Julia, Antonio; Lopez-Corbeto, Mireia; Lopez-Lasanta, Maria; Marsal, Sara; Martinez-Mateu, Sergio; Pluma, Andrea et al.
DOI:

Emerging therapy options for IgG4-related disease.

PMID: 33689549
Journal: Expert Review of Clinical Immunology
Year: 2021
Reference: Expert Rev Clin Immunol. 2021 May;17(5):471-483. doi: 10.1080/1744666X.2021.1902310. Epub 2021 Mar 25.
Impact factor:
Publication type: Review in international publication
Authors: Culver, Emma; Della-Torre, Emanuel; Ebbo, Mikael; Fernandez-Codina, Andreu; Lanzillotta, Marco; Martinez-Valle, Fernando; Schleinitz, Nicolas et al.
DOI: 10.1080/1744666X.2021.1902310

Anti-carbamylated protein antibodies are associated with early abatacept response in rheumatoid arthritis. Comment on: Anti-carbamylated protein antibodies as a clinical response predictor in rheumatoid arthritis patients treated with abatacept.

PMID: 33666163
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 Sep-Oct;39(5):1142-1143. Epub 2021 Mar 3.
Impact factor:
Publication type: Letter or abstract
Authors: Castellanos-Moreira, Raul; Gomez, Antonio; Haro, Isabel; Marsal, Sara; Ruiz-Esquide, Virginia; Sanmarti, Raimon et al.
DOI:

Response to Treatment in IgG4-Related Disease Assessed by Quantitative PET/CT Scan.

PMID: 33630792
Journal: CLINICAL NUCLEAR MEDICINE
Year: 2021
Reference: Clin Nucl Med. 2021 Jun 1;46(6):e307-e311. doi: 10.1097/RLU.0000000000003537.
Impact factor:
Publication type: Paper in international publication
Authors: Fernandez-Codina, Andreu; Martinez-Valle, Fernando; Orozco-Galvez, Olimpia; Pinal-Fernandez, Iago; Simo-Perdigo, Marc et al.
DOI: 10.1097/RLU.0000000000003537

Anti-transcriptional intermediary factor 1 gamma antibodies in cancer-associated myositis: a longitudinal study.

PMID: 31365334
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2020
Reference: Clin Exp Rheumatol. 2020 Jan-Feb;38(1):67-73. Epub 2019 Jul 30.
Impact factor:
Publication type: Paper in international publication
Authors: Dani, Lara; Dastmalchi, Maryam; Holmqvist, Marie; Labrador-Horrillo, Moises; Lundberg, Ingrid E; Martinez, Maria Angeles; Selva-O'Callaghan, Albert; Svensson, John; Trallero-Araguas, Ernesto et al.
DOI:

Expert panel consensus recommendations for diagnosis and treatment of secondary osteoporosis in children.

PMID: 32093703
Journal: Pediatric Rheumatology
Year: 2020
Reference: Pediatr Rheumatol Online J. 2020 Feb 24;18(1):20. doi: 10.1186/s12969-020-0411-9.
Impact factor:
Publication type: Paper in international publication
Authors: Alcaniz-Rodriguez, Paula; Bou-Torrent, Rosa; Galindo-Zavala, Rocio; Gonzalez-Fernandez, M feminine Isabel; Grana-Gil, Jenaro; Lopez-Corbeto, Mireia; Magallares-Lopez, Berta; Medrano-San Ildefonso, Marta; Mir-Perello, Concepcion; Nieto-Gonzalez, Juan Carlos et al.
DOI: 10.1186/s12969-020-0411-9

The Urinary Exosomal miRNA Expression Profile is Predictive of Clinical Response in Lupus Nephritis.

PMID: 32085620
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2020
Reference: Int J Mol Sci. 2020 Feb 18;21(4). pii: ijms21041372. doi: 10.3390/ijms21041372.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Cortes-Hernandez, Josefina; Garcia-Vives, Eloi; Moline, Teresa; Ordi-Ros, Josep; Sole, Cristina; Vidal, Marta et al.
DOI: 10.3390/ijms21041372

A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease.

PMID: 32024964
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Feb 5;10(1):1862. doi: 10.1038/s41598-020-58741-w.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Ma Angeles; Airo, Paolo; Alegre-Sancho, Juan Jose; Andreu, Jose Luis; Arnett, Frank C; Assassi, Shervin; Balsa, Alejandro; Bellocchi, Chiara; Beltran, Emma; Beretta, Lorenzo et al.
DOI: 10.1038/s41598-020-58741-w

Discoidin domain receptor 1 gene variants are associated with decreased white matter fractional anisotropy and decreased processing speed in schizophrenia.

PMID: 30597424
Journal: JOURNAL OF PSYCHIATRIC RESEARCH
Year: 2019
Reference: J Psychiatr Res. 2019 Mar;110:74-82. doi: 10.1016/j.jpsychires.2018.12.021. Epub 2018 Dec 24.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Nerea; Aleman-Gomez, Yasser; Canales-Rodriguez, Erick Jorge; Cortes, Maria Jose; Costas, Javier; Gas, Cinta; Guitart, Miriam; Julia, Toni; Marsal, Sara; Martorell, Lourdes et al.
DOI: 10.1016/j.jpsychires.2018.12.021

MicroRNA expression profiling identifies miR-31 and miR-485-3p as regulators in the pathogenesis of Discoid Cutaneous Lupus.

PMID: 30130620
Journal: JOURNAL OF INVESTIGATIVE DERMATOLOGY
Year: 2019
Reference: J Invest Dermatol. 2019 Jan;139(1):51-61. doi: 10.1016/j.jid.2018.07.026. Epub 2018 Aug 18.
Impact factor:
Publication type: Paper in international publication
Authors: Cortes-Hernandez, Josefina; Domingo, Sandra; Ferrer, Berta; Moline, Teresa; Ordi-Ros, Josep; Sole, Cristina et al.
DOI: 10.1016/j.jid.2018.07.026

Blog

News

Funded by the European Union, this project coordinated by the Vall d'Hebron Research Institute (VHIR) seeks to develop more effective therapies by creating new combinations of existing drugs

The head of the Rheumatology Service at Vall d'Hebron University Hospital and of the Rheumatology research group at VHIR is a highly accomplished rheumatologist with a distinguished career in the field.

It is the first international multi-centre clinical trial to analyse the safety and effect of this treatment for an autoimmune disease.