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Spine Research Unit

The Vall d’Hebron Spine Research Unit (VHSRU) is a growing multidisciplinary group of professionals devoted to spinal disorders with an increasing impact in terms of number of publications, associated IF and research funding. VHSRU has published 198 articles in spine field, 40% of them Q1, with a total IF of 451,9. 

Our research unit is organized in four research lines: 

  • Pediatric and adolescent deformity, 
  • Adult deformity, 
  • Spinal cord injuries,
  • Cellular therapy and new surgical techniques.

VHRSU has been involved as coordinator or collaborator in 25 funded research projects. VHRSU is currently coordinating 5 competitive projects granted by national and international institutions (Marató TV3, Eurospine, SRS, AO, GEER). One of our research projects, the European Spine Study Group (ESSG), has been very successful, with more than 60 published manuscripts and 244 podium presentations. All these projects allowed us to establish new synergies with other research centers and universities. We hope to expand this network in the future. 

Publications

Serological response and breakthrough infection after COVID-19 vaccination in patients with cirrhosis and post-liver transplant.

PMID: 37870985
Journal: Hepatology Communications
Year: 2023
Reference: Hepatol Commun. 2023 Oct 18;7(11):e0273. doi: 10.1097/HC9.0000000000000273. eCollection 2023 Nov 1.
Impact factor:
Publication type: Paper in international publication
Authors: Albillos, Agustin; Ampuero, Javier; Andrade, Raul J; Angeli, Paolo; Arroyo, Vicente; Ballester, Maria Pilar; Belli, Luca; Berenguer, Marina; Berg, Thomas; Bongiovanni, Deborah et al.
DOI: 10.1097/HC9.0000000000000273

Correction: Revision surgery following long lumbopelvic constructs for adult spinal deformity: prospective experience from two dedicated databases.

PMID: 37906292
Journal: EUROPEAN SPINE JOURNAL
Year: 2023
Reference: Eur Spine J. 2023 Oct 31. doi: 10.1007/s00586-023-07988-8.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Alanay, Ahmet; Baldinotti, Anna; Bar-Or, Amit; Barkhof, Frederik; Haddad, Sleiman; Hauser, Stephen L; Kappos, Ludwig; Kleinstuck, Frank; Koendgen, Harold; Leppert, David et al.
DOI: 10.1007/s00586-023-07988-8

EAES, SAGES, and ESCP rapid guideline: bowel preparation for minimally invasive colorectal resection.

PMID: 37903883
Journal: SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
Year: 2023
Reference: Surg Endosc. 2023 Oct 30. doi: 10.1007/s00464-023-10477-0.
Impact factor:
Publication type: Paper in international publication
Authors: Alanay, Ahmet; Antoniou, Stavros A; Balla, Andrea; Carrano, Francesco Maria; Dore, Suzanne; Haddad, Sleiman; Huo, Bright; Kaiser, Andreas M; Kleinstuck, Frank; Koraki, Eleni et al.
DOI: 10.1007/s00464-023-10477-0

Cost Benefit of Implementation of Risk Stratification Models for Adult Spinal Deformity Surgery.

PMID: 38081300
Journal: Global Spine Journal
Year: 2023
Reference: Global Spine J. 2023 Dec 11:21925682231212966. doi: 10.1177/21925682231212966.
Impact factor:
Publication type: Paper in international publication
Authors: Alanay, Ahmet; Ames, Christopher P; Bess, Shay; Burton, Douglas C; Chou, Dean; Daniels, Alan H; Gum, Jeffrey L; Gupta, Munish C; Haddad, Sleiman; Hart, Robert A et al.
DOI: 10.1177/21925682231212966

Infections after spine instrumentation: effectiveness of short antibiotic treatment in a large multicentre cohort.

PMID: 33496335
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2021
Reference: J Antimicrob Chemother. 2021 Mar 12;76(4):1085-1093. doi: 10.1093/jac/dkaa548.
Impact factor: 5.79
Publication type: Paper in international publication
Authors: Pigrau, Carlos, Murillo, Oscar, Horcajada, Juan P, Gomez, Reinaldo Espindola, Riera, Melchor, Gasch, Oriol, Blanco, Silvia, Galindo, Nieves Sopena, Rabunal, Ramon, Haddad, Sleiman et al.
DOI: 10.1093/jac/dkaa548

Development and Validation of a Multi-Domain Surgical Complication Classification System for Adult Spinal Deformity.

PMID: 33156283
Journal: SPINE
Year: 2021
Reference: Spine (Phila Pa 1976). 2021 Feb 15;46(4):E267-E273. doi: 10.1097/BRS.0000000000003766.
Impact factor: 3.468
Publication type: Paper in international publication
Authors: Lafage, Renaud, Lafage, Virginie, Pellise, Ferran, Haddad, Sleiman, Yilgor, Caglar, Nunez-Pereira, Susana, Gupta, Munish, Smith, Justin S, Shaffrey, Christopher, Schwab, Frank et al.
DOI: 10.1097/BRS.0000000000003766

Mental health status and sagittal spinopelvic alignment correlate with self-image in patients with adult spinal deformity before and after corrective surgery.

PMID: 31673854
Journal: EUROPEAN SPINE JOURNAL
Year: 2020
Reference: Eur Spine J. 2020 Jan;29(1):63-72. doi: 10.1007/s00586-019-06200-0. Epub 2019 Oct 31.
Impact factor: 2.458
Publication type: Paper in international publication
Authors: Nakamura, Hiroaki, Obeid, Ibrahim, Alanay, Ahmet, Acaroglu, Emre, Perez-Grueso, Francisco Javier Sanchez, Hayashi, Kazunori, Boissiere, Louis, Guevara-Villazon, Fernando, Larrieu, Daniel, Bourghli, Anouar et al.
DOI: 10.1007/s00586-019-06200-0

Restoring the ideal Roussouly sagittal profile in adult scoliosis surgery decreases the risk of mechanical complications.

PMID: 31641904
Journal: EUROPEAN SPINE JOURNAL
Year: 2020
Reference: Eur Spine J. 2020 Jan;29(1):54-62. doi: 10.1007/s00586-019-06176-x. Epub 2019 Oct 22.
Impact factor: 2.458
Publication type: Paper in international publication
Authors: Pizones, Javier, Moreno-Manzanaro, Lucia, Sanchez Perez-Grueso, Francisco Javier, Vila-Casademunt, Alba, Yilgor, Caglar, Obeid, Ibrahim, Alanay, Ahmet, Kleinstuck, Frank, Acaroglu, Emre R, Pellise, Ferran et al.
DOI: 10.1007/s00586-019-06176-x

Opioids and analgesics use after adult spinal deformity surgery correlates with sagittal alignment and preoperative analgesic pattern.

PMID: 31493111
Journal: EUROPEAN SPINE JOURNAL
Year: 2020
Reference: Eur Spine J. 2020 Jan;29(1):73-84. doi: 10.1007/s00586-019-06141-8. Epub 2019 Sep 6.
Impact factor: 2.458
Publication type: Paper in international publication
Authors: Bourghli, Anouar, Boissiere, Louis, Larrieu, Daniel, Kaissar, Farah, Cawley, Derek, Fujishiro, Takashi, Kieser, David, Gille, Olivier, Vital, Jean-Marc, Alanay, Ahmet et al.
DOI: 10.1007/s00586-019-06141-8

Adult spinal deformity surgical decision-making score. Part 2: development and validation of a scoring system to guide the selection of treatment modalities for patients above 40 years with adult spinal deformity.

PMID: 31317308
Journal: EUROPEAN SPINE JOURNAL
Year: 2020
Reference: Eur Spine J. 2020 Jan;29(1):45-53. doi: 10.1007/s00586-019-06068-0. Epub 2019 Jul 17.
Impact factor: 2.458
Publication type: Paper in international publication
Authors: Fujishiro, Takashi, Boissiere, Louis, Cawley, Derek Thomas, Larrieu, Daniel, Gille, Olivier, Vital, Jean-Marc, Pellise, Ferran, Perez-Grueso, Francisco Javier Sanchez, Kleinstuck, Frank, Alanay, Ahmet et al.
DOI: 10.1007/s00586-019-06068-0

Artificial Intelligence Based Hierarchical Clustering of Patient Types and Intervention Categories in Adult Spinal Deformity Surgery: Towards a New Classification Scheme that Predicts Quality and Value.

PMID: 31205167
Journal: SPINE
Year: 2019
Reference: Spine (Phila Pa 1976). 2019 Jul 1;44(13):915-926. doi: 10.1097/BRS.0000000000002974.
Impact factor: 2.903
Publication type: Paper in international publication
Authors: Burton, Douglas, Lafage, Virginie, Schwab, Frank, Shaffrey, Christopher I Sr, Bess, Shay, Serra-Burriel, Miquel, Shaffrey, Christopher I Jr, Vila-Casademunt, Alba, Kleinstuck, Frank, Ames, Christopher P et al.
DOI: 10.1097/BRS.0000000000002974

Factors influencing patient satisfaction after adult scoliosis and spinal deformity surgery.

PMID: 31075761
Journal: JOURNAL OF NEUROSURGERY-SPINE
Year: 2019
Reference: J Neurosurg Spine. 2019 May 10;31(3):408-417. doi: 10.3171/2019.2.SPINE181486.
Impact factor: 2.998
Publication type: Paper in international publication
Authors: Boissiere, Louis, Hayashi, Kazunori, Nunez-Pereira, Susana, Bourghli, Anouar, Gille, Olivier, Vital, Jean-Marc, Pellise, Ferran, Sanchez Perez-Grueso, Francisco Javier, Kleinstuck, Frank, Acaroglu, Emre et al.
DOI: 10.3171/2019.2.SPINE181486

Validation of a Simplified SRS-Schwab Classification Using a Sagittal Modifier.

PMID: 31053317
Journal: Spine deformity
Year: 2019
Reference: Spine Deform. 2019 May;7(3):467-471. doi: 10.1016/j.jspd.2018.09.008.
Impact factor: 0
Publication type: Paper in international publication
Authors: Kieser, D C, Boissiere, L, Cawley, D T, Larrieu, D, Yilgor, C, Takemoto, M, Yoshida, G, Alanay, A, Acaroglu, E, Kleinstuck, F et al.
DOI: 10.1016/j.jspd.2018.09.008

Factors associated with having an indication for surgery in adult spinal deformity: an international european multicentre study.

PMID: 30218168
Journal: EUROPEAN SPINE JOURNAL
Year: 2019
Reference: Eur Spine J. 2019 Jan;28(1):127-137. doi: 10.1007/s00586-018-5754-2. Epub 2018 Sep 14.
Impact factor: 2.513
Publication type: Paper in international publication
Authors: Richner-Wunderlin, S, Mannion, A F, Vila-Casademunt, A, Pellise, F, Serra-Burriel, M, Seifert, B, Aghayev, E, Acaroglu, E, Alanay, A, Perez-Grueso, F J S et al.
DOI: 10.1007/s00586-018-5754-2

Team Approach: Metastatic Disease of the Spine.

PMID: 29762343
Journal: JBJS reviews
Year: 2018
Reference: JBJS Rev. 2018 May;6(5):e6. doi: 10.2106/JBJS.RVW.17.00118.
Impact factor: 0
Publication type: Review in international publication
Authors: Matamalas, Antonia, Valverde, Claudia, Benavente, Sergi, Casas-Gomila, Lourdes, Romagosa, Cleofe, Gonzalez-Tartiere, Pilar, Pellise, Ferran et al.
DOI: 10.2106/JBJS.RVW.17.00118

The impact of deep surgical site infection on surgical outcomes after posterior adult spinal deformity surgery: a matched control study.

PMID: 29728924
Journal: EUROPEAN SPINE JOURNAL
Year: 2018
Reference: Eur Spine J. 2018 Oct;27(10):2518-2528. doi: 10.1007/s00586-018-5583-3. Epub 2018 May 4.
Impact factor: 2.634
Publication type: Paper in international publication
Authors: Haddad, Sleiman, Nunez-Pereira, Susana, Pigrau, Carlos, Rodriguez-Pardo, Dolors, Vila-Casademunt, Alba, Alanay, Ahmet, Acaroglu, Emre R, Kleinstueck, Frank S, Obeid, Ibrahim, Perez-Grueso, Francisco Javier Sanchez et al.
DOI: 10.1007/s00586-018-5583-3

External validation of the adult spinal deformity (ASD) frailty index (ASD-FI).

PMID: 29603013
Journal: EUROPEAN SPINE JOURNAL
Year: 2018
Reference: Eur Spine J. 2018 Sep;27(9):2331-2338. doi: 10.1007/s00586-018-5575-3. Epub 2018 Mar 30.
Impact factor: 2.634
Publication type: Paper in international publication
Authors: Neuman, Brian J, Sciubba, Daniel M, Kebaish, Khaled M, Smith, Justin S, Alanay, Ahmet, Acaroglu, Emre R, Kleinstuck, Frank, Obeid, Ibrahim, Sanchez Perez-Grueso, Francisco Javier, Carreon, Leah Y et al.
DOI: 10.1007/s00586-018-5575-3

Decision-making factors in the treatment of adult spinal deformity.

PMID: 29603012
Journal: EUROPEAN SPINE JOURNAL
Year: 2018
Reference: Eur Spine J. 2018 Sep;27(9):2312-2321. doi: 10.1007/s00586-018-5572-6. Epub 2018 Mar 30.
Impact factor: 2.634
Publication type: Paper in international publication
Authors: Pellise, Ferran, Perez-Grueso, Francisco Javier Sanchez, Kleinstuck, Frank, Acaroglu, Emre, Alanay, Ahmet, Obeid, Ibrahim, Vital, Jean-Marc, Gille, Olivier, Larrieu, Daniel, Cawley, Derek Thomas et al.
DOI: 10.1007/s00586-018-5572-6

Retrospective analysis underestimates neurological deficits in complex spinal deformity surgery: a Scoli-RISK-1 Study.

PMID: 28475019
Journal: JOURNAL OF NEUROSURGERY-SPINE
Year: 2017
Reference: J Neurosurg Spine. 2017 Jul;27(1):68-73. doi: 10.3171/2016.12.SPINE161068. Epub 2017 May 5.
Impact factor: 2.696
Publication type: Paper in international publication
Authors: Pellise, Ferran, Shaffrey, Christopher I, Smith, Justin S, Lewis, Stephen J, Ames, Christopher P, Carreon, Leah Y, Fehlings, Michael G, Schwab, Frank, Shimer, Adam L, Godzik, Jakub et al.
DOI: 10.3171/2016.12.SPINE161068

Decision analysis to identify the ideal treatment for adult spinal deformity: What is the impact of complications on treatment outcomes?

PMID: 28454778
Journal: Acta Orthopaedica et Traumatologica Turcica
Year: 2017
Reference: Acta Orthop Traumatol Turc. 2017 May;51(3):181-190. doi: 10.1016/j.aott.2017.03.003. Epub 2017 Apr 25.
Impact factor: 0.599
Publication type: Paper in international publication
Authors: Acaroglu, Emre, Guler, Umit Ozgur, Cetinyurek-Yavuz, Aysun, Yuksel, Selcen, Yavuz, Yasemin, Ayhan, Selim, Domingo-Sabat, Montse, Pellise, Ferran, Alanay, Ahmet, Perez Grueso, Francesco S et al.
DOI: 10.1016/j.aott.2017.03.003

Lack of improvement in health-related quality of life (HRQOL) scores 6 months after surgery for adult spinal deformity (ASD) predicts high revision rate in the second postoperative year.

PMID: 28361369
Journal: EUROPEAN SPINE JOURNAL
Year: 2017
Reference: Eur Spine J. 2017 Aug;26(8):2160-2166. doi: 10.1007/s00586-017-5068-9. Epub 2017 Mar 30.
Impact factor: 2.563
Publication type: Paper in international publication
Authors: Bourghli, Anouar, Boissiere, Louis, Larrieu, Daniel, Vital, Jean-Marc, Yilgor, Caglar, Pellise, Ferran, Alanay, Ahmet, Acaroglu, Emre, Perez-Grueso, Francisco-Javier, Kleinstuck, Franck et al.
DOI: 10.1007/s00586-017-5068-9

Thoracic wall reconstruction with bioabsorbable plates in pediatric malignant thoracic wall tumors.

PMID: 27653461
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2017
Reference: J Pediatr Surg. 2017 Mar;52(3):377-381. doi: 10.1016/j.jpedsurg.2016.08.018. Epub 2016 Aug 31.
Impact factor: 1.976
Publication type: Paper in international publication
Authors: Guillen, G, Garcia, L, Marhuenda, C, Pellise, F, Molino, J A, Fontecha, C G, Lopez, S, Lloret, J et al.
DOI: 10.1016/j.jpedsurg.2016.08.018

Global tilt: a single parameter incorporating spinal and pelvic sagittal parameters and least affected by patient positioning.

PMID: 27323962
Journal: EUROPEAN SPINE JOURNAL
Year: 2016
Reference: Eur Spine J. 2016 Nov;25(11):3644-3649. doi: 10.1007/s00586-016-4649-3. Epub 2016 Jun 20.
Impact factor: 2.132
Publication type: Paper in international publication
Authors: Obeid, I, Boissiere, L, Acaroglu, E, Larrieu, D, Pellise, F, Alanay, A, Perez-Grueso, F J, Kleinstuck, F, Yilgor, C, Vital, J M et al.
DOI: 10.1007/s00586-016-4649-3

De novo degenerative lumbar scoliosis: a systematic review of prognostic factors for curve progression.

PMID: 27220970
Journal: EUROPEAN SPINE JOURNAL
Year: 2016
Reference: Eur Spine J. 2016 Aug;25(8):2347-58. doi: 10.1007/s00586-016-4619-9. Epub 2016 May 24.
Impact factor: 2.132
Publication type: Paper in international publication
Authors: Faraj, Sayf S A, van Hooff, Miranda L, de Kleuver, Marinus, Pellise, Ferran, Haanstra, Tsjitske M, Holewijn, Roderick M et al.
DOI: 10.1007/s00586-016-4619-9

Sagittal malalignment has a significant association with postoperative leg pain in adult spinal deformity patients.

PMID: 27225901
Journal: EUROPEAN SPINE JOURNAL
Year: 2016
Reference: Eur Spine J. 2016 Aug;25(8):2442-51. doi: 10.1007/s00586-016-4616-z. Epub 2016 May 25.
Impact factor: 2.132
Publication type: Paper in international publication
Authors: Obeid, Ibrahim, Obeid, Ibrahim, Alanay, Ahmet, Acaroglu, Emre R, Kleinstuck, Frank, Takemoto, Mitsuru, Boissiere, Louis, Novoa, Felipe, Vital, Jean-Marc, Pellise, Ferran et al.
DOI: 10.1007/s00586-016-4616-z

Validity and reliability of photographic measures to evaluate waistline asymmetry in idiopathic scoliosis.

PMID: 26975856
Journal: EUROPEAN SPINE JOURNAL
Year: 2016
Reference: Eur Spine J. 2016 Oct;25(10):3170-3179. doi: 10.1007/s00586-016-4509-1. Epub 2016 Mar 14.
Impact factor: 2.132
Publication type: Paper in international publication
Authors: Matamalas, Antonia, Bago, Juan, D Agata, Elisabetta, Pellise, Ferran et al.
DOI: 10.1007/s00586-016-4509-1

Poor outcomes and satisfaction in adolescent idiopathic scoliosis surgery: the relevance of the body mass index and self-image.

PMID: 25077944
Journal: EUROPEAN SPINE JOURNAL
Year: 2015
Reference: Eur Spine J. 2015 Feb;24(2):276-80. doi: 10.1007/s00586-014-3486-5. Epub 2014 Jul 31.
Impact factor: 2.066
Publication type: Paper in international publication
Authors: Perez-Prieto, Daniel, Sanchez-Soler, Juan Francisco, Martinez-Llorens, Juana, Mojal, Sergi, Bago, Joan, Caceres, Enric, Ramirez, Manuel et al.
DOI: 10.1007/s00586-014-3486-5

Postoperative urinary tract infection and surgical site infection in instrumented spinal surgery: is there a link?

PMID: 24422787
Journal: CLIN MICROBIOL INFEC
Year: 2014
Reference: Clin Microbiol Infect. 2014 Aug;20(8):768-73. doi: 10.1111/1469-0691.12527. Epub 2014 Feb 20.
Impact factor: 5.197
Publication type: Paper in international publication
Authors: Bago, J, Nunez-Pereira, S, Rodriguez-Pardo, D, Pellise, F, Pigrau, C, Caceres, E, Villanueva, C et al.
DOI: 10.1111/1469-0691.12527

Outcome instruments to assess scoliosis surgery.

PMID: 22576158
Journal: EUROPEAN SPINE JOURNAL
Year: 2013
Reference: Eur Spine J. 2013 Mar;22 Suppl 2:S195-202. doi: 10.1007/s00586-012-2352-6. Epub 2012 May 11.
Impact factor: 2.133
Publication type: Review in international publication
Authors: , , , et al.
DOI: 10.1007/s00586-012-2352-6

The evidence on surgical interventions for low back disorders, an overview of systematic reviews.

PMID: 23681497
Journal: EUROPEAN SPINE JOURNAL
Year: 2013
Reference: Eur Spine J. 2013 Sep;22(9):1936-49. doi: 10.1007/s00586-013-2823-4. Epub 2013 May 17.
Impact factor: 2.133
Publication type: Paper in international publication
Authors: Rubinstein, Sidney M, Willems, Paul C, Moojen, Wouter A, Pellise, Ferran, Oner, Cumhur F, Peul, Wilco C, van Tulder, Maurits W, Jacobs, Wilco C H et al.
DOI: 10.1007/s00586-013-2823-4

Body composition in adolescent idiopathic scoliosis.

PMID: 22886589
Journal: EUROPEAN SPINE JOURNAL
Year: 2013
Reference: Eur Spine J. 2013 Feb;22(2):324-9. doi: 10.1007/s00586-012-2465-y. Epub 2012 Aug 12.
Impact factor: 2.133
Publication type: Paper in international publication
Authors: Ramirez, Manuel, Martinez-Llorens, Juana, Sanchez, Juan Francisco, Bago, Joan, Molina, Antoni, Gea, Joaquim, Caceres, Enric et al.
DOI: 10.1007/s00586-012-2465-y

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News

The work improves accuracy in predicting complications at the boundary between the instrumented spine area and the area that is left free when spinal deformity corrective surgery is performed.

Entre els projectes es troben 12 investigacions on participen investigadors i investigadores de Vall d’Hebron.

The Scoliosis Research Society (SRS) has awarded with this prestigious recognition Dr. Pellisé's team for the study on the similarity of the adverse effects of surgeries both in elderly patients and in the general adult population.