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Spine Research Unit

The Vall d’Hebron Spine Research Unit (VHSRU) is a growing multidisciplinary group of professionals devoted to spinal disorders with an increasing impact in terms of number of publications, associated IF and research funding. VHSRU has published 198 articles in spine field, 40% of them Q1, with a total IF of 451,9. 

Our research unit is organized in four research lines: 

  • Pediatric and adolescent deformity, 
  • Adult deformity, 
  • Spinal cord injuries,
  • Cellular therapy and new surgical techniques.

VHRSU has been involved as coordinator or collaborator in 25 funded research projects. VHRSU is currently coordinating 5 competitive projects granted by national and international institutions (Marató TV3, Eurospine, SRS, AO, GEER). One of our research projects, the European Spine Study Group (ESSG), has been very successful, with more than 60 published manuscripts and 244 podium presentations. All these projects allowed us to establish new synergies with other research centers and universities. We hope to expand this network in the future. 

Publications

The dynamics of satisfaction in surgical and non-surgical adult spinal deformity patients.

PMID: 33754196
Journal: EUROPEAN SPINE JOURNAL
Year: 2021
Reference: Eur Spine J. 2021 May;30(5):1235-1246. doi: 10.1007/s00586-021-06816-1. Epub 2021 Mar 22.
Impact factor: 3.134
Publication type: Paper in international publication
Authors: Nunez-Pereira, Susana, Serra-Burriel, Miquel, Vila-Casademunt, Alba, Hayashi, Kazunori, Haddad, Sleiman, Pizones, Javier, Kleinstuck, Frank, Obeid, Ibrahim, Alanay, Ahmet, Pellise, Ferran et al.
DOI: 10.1007/s00586-021-06816-1

Impact of New Motor Deficit on HRQOL after Adult Spinal Deformity Surgery: Subanalysis from Scoli Risk 1 Prospective Study.

PMID: 33290376
Journal: SPINE
Year: 2021
Reference: Spine (Phila Pa 1976). 2021 Apr 1;46(7):E450-E457. doi: 10.1097/BRS.0000000000003852.
Impact factor: 3.468
Publication type: Paper in international publication
Authors: Kelly, Michael, Dahl, Benny T, Mehdian, Hossein, Pellise, Ferran, Lewis, Stephen J, Cheung, Kenneth Mc, Shaffrey, Christopher I, Fehlings, Michael G, Lenke, Lawrence G, Ames, Christopher P et al.
DOI: 10.1097/BRS.0000000000003852

Characterization of complex vertebral transposition (gamma deformity) > 180 degrees: clinical and radiographic outcomes of halo gravity traction and vertebral column resection (VCR).

PMID: 33206355
Journal: Spine deformity
Year: 2021
Reference: Spine Deform. 2021 Mar;9(2):411-425. doi: 10.1007/s43390-020-00179-1. Epub 2020 Nov 18.
Impact factor: 0
Publication type: Paper in international publication
Authors: Ayamga, Jennifer, Sackeyfio, Arthur, Duah, Henry Ofori, Yankey, Kwadwo Poku, Akoto, Harry, Hodes, Rick, Wulff, Irene, Pellise, Ferran, Sacramento-Dominguez, Cristina, Boachie-Adjei, Oheneba et al.
DOI: 10.1007/s43390-020-00179-1

Static and dynamic sagittal lumbar apex: a new concept for the assessment of lumbar lordosis distribution in spinal deformity.

PMID: 33606102
Journal: EUROPEAN SPINE JOURNAL
Year: 2021
Reference: Eur Spine J. 2021 May;30(5):1155-1163. doi: 10.1007/s00586-021-06767-7. Epub 2021 Feb 19.
Impact factor: 3.134
Publication type: Paper in international publication
Authors: Iwai, Chizuo, Pizones, Javier, Boissiere, Louis, Jakinapally, Sreenath, Yilgor, Caglar, Larrieu, Daniel, Pellise, Ferran, Vital, Jean-Marc, Bourghli, Anouar, Obeid, Ibrahim et al.
DOI: 10.1007/s00586-021-06767-7

What level of symptoms are patients with adult spinal deformity prepared to live with? A cross-sectional analysis of the 12-month follow-up data from 1043 patients.

PMID: 32189123
Journal: EUROPEAN SPINE JOURNAL
Year: 2020
Reference: Eur Spine J. 2020 Jun;29(6):1340-1352. doi: 10.1007/s00586-020-06365-z. Epub 2020 Mar 18.
Impact factor: 2.458
Publication type: Paper in international publication
Authors: Mannion, A F, Vila-Casademunt, A, Richner-Wunderlin, S, Fekete, T F, Haschtmann, D, Jeszenszky, D, Pellise, F, Alanay, A, Obeid, I, Perez-Grueso, F S et al.
DOI: 10.1007/s00586-020-06365-z

Pathophysiological Response to Trauma-Induced Coagulopathy: A Comprehensive Review.

PMID: 31633501
Journal: ANESTHESIA AND ANALGESIA
Year: 2020
Reference: Anesth Analg. 2020 Mar;130(3):654-664. doi: 10.1213/ANE.0000000000004478.
Impact factor: 4.305
Publication type: Review in international publication
Authors: Duque, Patricia, Mora, Lidia, Levy, Jerrold H, Schochl, Herbert et al.
DOI: 10.1213/ANE.0000000000004478

Utilization of Predictive Modeling to Determine Episode of Care Costs and to Accurately Identify Catastrophic Cost Non-warranty Outlier Patients in Adult Spinal Deformity Surgery: A Step Toward Bundled Payments and Risk Sharing.

PMID: 31513120
Journal: SPINE
Year: 2020
Reference: Spine (Phila Pa 1976). 2020 Mar 1;45(5):E252-E265. doi: 10.1097/BRS.0000000000003242.
Impact factor: 2.646
Publication type: Paper in international publication
Authors: Ames, Christopher P, Smith, Justin S, Gum, Jeffrey L, Kelly, Michael, Vila-Casademunt, Alba, Burton, Douglas C, Hostin, Richard, Yeramaneni, Samrat, Lafage, Virginie, Schwab, Frank J et al.
DOI: 10.1097/BRS.0000000000003242

Author Correction: Precision and safety of Multilevel Cervical Transpedicular Screw Fixation with 3D Patient-Specific Guides; A Cadaveric Study.

PMID: 32024916
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Feb 6;10(1):2384. doi: 10.1038/s41598-020-59139-4.
Impact factor: 3.998
Publication type: Letter or abstract
Authors: Sallent, Andrea, Ramirez, Manuel, Catala, Jordi, Rodriguez-Baeza, Alfonso, Bago, Joan, de Albert, Matias, Velez, Roberto et al.
DOI: 10.1038/s41598-020-59139-4

The Adolescent Idiopathic Scoliosis International Disease Severity Study: Do Operative Curve Magnitude and Complications Vary by Country?

PMID: 31974994
Journal: Spine deformity
Year: 2019
Reference: Spine Deform. 2019 Nov;7(6):883-889. doi: 10.1016/j.jspd.2019.04.004. Epub 2019 Dec 30.
Impact factor: 0
Publication type: Paper in international publication
Authors: Toombs, Courtney, Lonner, Baron, Fazal, Akil, Boachie-Adjei, Oheneba, Bastrom, Tracey, Pellise, Ferran, Ramadan, Mohamed, Koptan, Wael, ElMiligui, Yasser, Zhu, Feng et al.
DOI: 10.1016/j.jspd.2019.04.004

Validation of a Simplified SRS-Schwab Classification Using a Sagittal Modifier.

PMID: 31974838
Journal: Spine deformity
Year: 2019
Reference: Spine Deform. 2019 May;7(3):467-471. doi: 10.1016/j.jspd.2018.09.008. Epub 2019 Dec 30.
Impact factor: 0
Publication type: Paper in international publication
Authors: Yoshida, G, Kieser, D C, Boissiere, L, Cawley, D T, Larrieu, D, Yilgor, C, Takemoto, M, Kleinstu, F, Pellise, F, Perez-Grueso, F J S et al.
DOI: 10.1016/j.jspd.2018.09.008

Erratum to Incidence and Risk Factors for Major Surgical Complications in Patients With Complex Spinal Deformity: A Report From an SRS GOP Site [Spine Deformity 3 (2015) 57-64].

PMID: 31981157
Journal: Spine deformity
Year: 2019
Reference: Spine Deform. 2019 Mar;7(2):377. doi: 10.1016/j.jspd.2018.11.011.
Impact factor: 0
Publication type: Letter or abstract
Authors: Kim, Han Jo, Boachie-Adjei, Oheneba, Yagi, Mitsuru, Nemani, Venu M, Sacramento-Dominguez, Cristina, Akoto, Harry, Cunningham, Matthew E, Gupta, Munish, Hess, William F, Lonner, Baron S et al.
DOI: 10.1016/j.jspd.2018.11.011

The Adolescent Idiopathic Scoliosis International Disease Severity Study: Do Operative Curve Magnitude and Complications Vary by Country?

PMID: 31731998
Journal: Spine deformity
Year: 2019
Reference: Spine Deform. 2019 Nov;7(6):883-889. doi: 10.1016/j.jspd.2019.04.004.
Impact factor: 0
Publication type: Paper in international publication
Authors: Bastrom, Tracey, Pellise, Ferran, Ramadan, Mohamed, Koptan, Wael, ElMiligui, Yasser, Zhu, Feng, Qiu, Yong, Shufflebarger, Harry, Boachie-Adjei, Oheneba, Fazal, Akil et al.
DOI: 10.1016/j.jspd.2019.04.004

The Influence of Diagnosis, Age, and Gender on Surgical Outcomes in Patients With Adult Spinal Deformity.

PMID: 30560031
Journal: Global spine journal
Year: 2018
Reference: Global Spine J. 2018 Dec;8(8):803-809. doi: 10.1177/2192568218772568. Epub 2018 Apr 29.
Impact factor: 0
Publication type: Paper in international publication
Authors: Ayhan, Selim, Yuksel, Selcen, Nabiyev, Vugar, Adhikari, Prashant, Villa-Casademunt, Alba, Pellise, Ferran, Perez-Grueso, Francisco Sanchez, Alanay, Ahmet, Obeid, Ibrahim, Kleinstueck, Frank et al.
DOI: 10.1177/2192568218772568

Radiographic Axial Malalignment is Associated With Pretreatment Patient-Reported Health-Related Quality of Life Measures in Adult Degenerative Scoliosis: Implementation of a Novel Radiographic Software Tool.

PMID: 30348354
Journal: Spine deformity
Year: 2018
Reference: Spine Deform. 2018 Nov - Dec;6(6):745-752. doi: 10.1016/j.jspd.2018.03.011.
Impact factor: 0
Publication type: Paper in international publication
Authors: Faraj, Sayf S A, Boselie, Toon F M, Vila-Casademunt, Alba, de Kleuver, Marinus, Holewijn, Roderick M, Obeid, Ibrahim, Acaroglu, Emre, Alanay, Ahmet, Kleinstuck, Frank, Perez-Grueso, Francisco S et al.
DOI: 10.1016/j.jspd.2018.03.011

What are the risk factors for surgical site infection after spinal fusion? A meta-analysis.

PMID: 30128761
Journal: EUROPEAN SPINE JOURNAL
Year: 2018
Reference: Eur Spine J. 2018 Oct;27(10):2469-2480. doi: 10.1007/s00586-018-5733-7. Epub 2018 Aug 20.
Impact factor: 2.634
Publication type: Paper in international publication
Authors: Pesenti, Sebastien, Pannu, Tejbir, Andres-Bergos, Jessica, Lafage, Renaud, Smith, Justin S, Glassman, Steve, de Kleuver, Marinus, Pellise, Ferran, Schwab, Frank, Lafage, Virginie et al.
DOI: 10.1007/s00586-018-5733-7

Native vertebral osteomyelitis in aged patients: distinctive features. An observational cohort study.

PMID: 30003490
Journal: INFECTION
Year: 2018
Reference: Infection. 2018 Oct;46(5):679-686. doi: 10.1007/s15010-018-1177-6. Epub 2018 Jul 12.
Impact factor: 2.773
Publication type: Paper in international publication
Authors: Aguilar-Company, Juan, Pigrau, Carles, Fernandez-Hidalgo, Nuria, Rodriguez-Pardo, Dolors, Falco, Vicenc, Lung, Mayli, Pellise, Ferran, Almirante, Benito et al.
DOI: 10.1007/s15010-018-1177-6

Introversion, the prevalent trait of adolescents with idiopathic scoliosis: an observational study.

PMID: 29152590
Journal: Scoliosis and spinal disorders
Year: 2017
Reference: Scoliosis Spinal Disord. 2017 Nov 8;12:27. doi: 10.1186/s13013-017-0136-9. eCollection 2017.
Impact factor: 0
Publication type: Paper in international publication
Authors: D'Agata, Elisabetta, Sanchez-Raya, Judith, Bago, Juan et al.
DOI: 10.1186/s13013-017-0136-9

Global Alignment and Proportion (GAP) Score: Development and Validation of a New Method of Analyzing Spinopelvic Alignment to Predict Mechanical Complications After Adult Spinal Deformity Surgery.

PMID: 28976431
Journal: JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
Year: 2017
Reference: J Bone Joint Surg Am. 2017 Oct 4;99(19):1661-1672. doi: 10.2106/JBJS.16.01594.
Impact factor: 4.84
Publication type: Paper in international publication
Authors: Yilgor, Caglar, Sogunmez, Nuray, Boissiere, Louis, Yavuz, Yasemin, Obeid, Ibrahim, Kleinstuck, Frank, Perez-Grueso, Francisco Javier Sanchez, Acaroglu, Emre, Haddad, Sleiman, Mannion, Anne F et al.
DOI: 10.2106/JBJS.16.01594

Avulsion of the Femoral Attachment of the Medial Collateral Ligament of the Knee Associated to Complete Tear of the Posterior Cruciate Ligament: A Case Report.

PMID: 28825018
Journal: Surgery journal (New York, N.Y.)
Year: 2017
Reference: Surg J (N Y). 2017 Mar 20;3(1):e38-e41. doi: 10.1055/s-0037-1599256. eCollection 2017 Jan.
Impact factor: 0
Publication type: Paper in international publication
Authors: Haddad, Sleiman, Sallent, Andrea, Minguell, Joan, Castellet, Enric et al.
DOI: 10.1055/s-0037-1599256

The changing epidemiology of spinal tuberculosis: the influence of international immigration in Catalonia, 1993-2014.

PMID: 28516818
Journal: EPIDEMIOLOGY AND INFECTION
Year: 2017
Reference: Epidemiol Infect. 2017 Jul;145(10):2152-2160. doi: 10.1017/S0950268817000863. Epub 2017 May 18.
Impact factor: 2.075
Publication type: Paper in international publication
Authors: Peghin, M, Rodriguez-Pardo, D, Sanchez-Montalva, A, Pellise, F, Rivas, A, Tortola, T, Aguilar, J, Almirante, B, Pigrau, C et al.
DOI: 10.1017/S0950268817000863

Trunk appearance perception scale for physicians (TAPS-Phy) - a valid and reliable tool to rate trunk deformity in idiopathic scoliosis.

PMID: 27579446
Journal: Scoliosis and spinal disorders
Year: 2016
Reference: Scoliosis Spinal Disord. 2016 Aug 17;11:24. doi: 10.1186/s13013-016-0085-8. eCollection 2016.
Impact factor: 0
Publication type: Letter or abstract
Authors: Matamalas, Antonia, D'Agata, Elisabetta, Sanchez-Raya, Judith, Bago, Juan et al.
DOI: 10.1186/s13013-016-0085-8

Safety and efficacy of osteotomies in adult spinal deformity: what happens in the first year?

PMID: 25947614
Journal: EUROPEAN SPINE JOURNAL
Year: 2016
Reference: Eur Spine J. 2016 Aug;25(8):2471-9. doi: 10.1007/s00586-015-3981-3. Epub 2015 May 7.
Impact factor: 2.132
Publication type: Paper in international publication
Authors: Aykac, Bilal, Yuksel, Selcen, Guler, Umit Ozgur, Pellise, Ferran, Alanay, Ahmet, Perez-Grueso, Francisco Javier Sanchez, Acaroglu, Emre, Ayhan, Selim et al.
DOI: 10.1007/s00586-015-3981-3

Global tilt: a single parameter incorporating spinal and pelvic sagittal parameters and least affected by patient positioning.

PMID: 27323962
Journal: EUROPEAN SPINE JOURNAL
Year: 2016
Reference: Eur Spine J. 2016 Nov;25(11):3644-3649. doi: 10.1007/s00586-016-4649-3. Epub 2016 Jun 20.
Impact factor: 2.132
Publication type: Paper in international publication
Authors: Obeid, I, Boissiere, L, Acaroglu, E, Larrieu, D, Pellise, F, Alanay, A, Perez-Grueso, F J, Kleinstuck, F, Yilgor, C, Vital, J M et al.
DOI: 10.1007/s00586-016-4649-3

De novo degenerative lumbar scoliosis: a systematic review of prognostic factors for curve progression.

PMID: 27220970
Journal: EUROPEAN SPINE JOURNAL
Year: 2016
Reference: Eur Spine J. 2016 Aug;25(8):2347-58. doi: 10.1007/s00586-016-4619-9. Epub 2016 May 24.
Impact factor: 2.132
Publication type: Paper in international publication
Authors: Faraj, Sayf S A, van Hooff, Miranda L, de Kleuver, Marinus, Pellise, Ferran, Haanstra, Tsjitske M, Holewijn, Roderick M et al.
DOI: 10.1007/s00586-016-4619-9

Poor outcomes and satisfaction in adolescent idiopathic scoliosis surgery: the relevance of the body mass index and self-image.

PMID: 25077944
Journal: EUROPEAN SPINE JOURNAL
Year: 2015
Reference: Eur Spine J. 2015 Feb;24(2):276-80. doi: 10.1007/s00586-014-3486-5. Epub 2014 Jul 31.
Impact factor: 2.066
Publication type: Paper in international publication
Authors: Perez-Prieto, Daniel, Sanchez-Soler, Juan Francisco, Martinez-Llorens, Juana, Mojal, Sergi, Bago, Joan, Caceres, Enric, Ramirez, Manuel et al.
DOI: 10.1007/s00586-014-3486-5

Body composition in adolescent idiopathic scoliosis.

PMID: 22886589
Journal: EUROPEAN SPINE JOURNAL
Year: 2013
Reference: Eur Spine J. 2013 Feb;22(2):324-9. doi: 10.1007/s00586-012-2465-y. Epub 2012 Aug 12.
Impact factor: 2.133
Publication type: Paper in international publication
Authors: Ramirez, Manuel, Martinez-Llorens, Juana, Sanchez, Juan Francisco, Bago, Joan, Molina, Antoni, Gea, Joaquim, Caceres, Enric et al.
DOI: 10.1007/s00586-012-2465-y

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News

The work improves accuracy in predicting complications at the boundary between the instrumented spine area and the area that is left free when spinal deformity corrective surgery is performed.

Entre els projectes es troben 12 investigacions on participen investigadors i investigadores de Vall d’Hebron.

The Scoliosis Research Society (SRS) has awarded with this prestigious recognition Dr. Pellisé's team for the study on the similarity of the adverse effects of surgeries both in elderly patients and in the general adult population.