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Spine Research Unit

The Vall d’Hebron Spine Research Unit (VHSRU) is a growing multidisciplinary group of professionals devoted to spinal disorders with an increasing impact in terms of number of publications, associated IF and research funding. VHSRU has published 198 articles in spine field, 40% of them Q1, with a total IF of 451,9. 

Our research unit is organized in four research lines: 

  • Pediatric and adolescent deformity, 
  • Adult deformity, 
  • Spinal cord injuries,
  • Cellular therapy and new surgical techniques.

VHRSU has been involved as coordinator or collaborator in 25 funded research projects. VHRSU is currently coordinating 5 competitive projects granted by national and international institutions (Marató TV3, Eurospine, SRS, AO, GEER). One of our research projects, the European Spine Study Group (ESSG), has been very successful, with more than 60 published manuscripts and 244 podium presentations. All these projects allowed us to establish new synergies with other research centers and universities. We hope to expand this network in the future. 

Publications

Infections after spine instrumentation: effectiveness of short antibiotic treatment in a large multicentre cohort.

PMID: 33496335
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2021
Reference: J Antimicrob Chemother. 2021 Mar 12;76(4):1085-1093. doi: 10.1093/jac/dkaa548.
Impact factor: 5.79
Publication type: Paper in international publication
Authors: Pigrau, Carlos, Murillo, Oscar, Horcajada, Juan P, Gomez, Reinaldo Espindola, Riera, Melchor, Gasch, Oriol, Blanco, Silvia, Galindo, Nieves Sopena, Rabunal, Ramon, Haddad, Sleiman et al.
DOI: 10.1093/jac/dkaa548

Development and Validation of a Multi-Domain Surgical Complication Classification System for Adult Spinal Deformity.

PMID: 33156283
Journal: SPINE
Year: 2021
Reference: Spine (Phila Pa 1976). 2021 Feb 15;46(4):E267-E273. doi: 10.1097/BRS.0000000000003766.
Impact factor: 3.468
Publication type: Paper in international publication
Authors: Lafage, Renaud, Lafage, Virginie, Pellise, Ferran, Haddad, Sleiman, Yilgor, Caglar, Nunez-Pereira, Susana, Gupta, Munish, Smith, Justin S, Shaffrey, Christopher, Schwab, Frank et al.
DOI: 10.1097/BRS.0000000000003766

Mental health status and sagittal spinopelvic alignment correlate with self-image in patients with adult spinal deformity before and after corrective surgery.

PMID: 31673854
Journal: EUROPEAN SPINE JOURNAL
Year: 2020
Reference: Eur Spine J. 2020 Jan;29(1):63-72. doi: 10.1007/s00586-019-06200-0. Epub 2019 Oct 31.
Impact factor: 2.458
Publication type: Paper in international publication
Authors: Nakamura, Hiroaki, Obeid, Ibrahim, Alanay, Ahmet, Acaroglu, Emre, Perez-Grueso, Francisco Javier Sanchez, Hayashi, Kazunori, Boissiere, Louis, Guevara-Villazon, Fernando, Larrieu, Daniel, Bourghli, Anouar et al.
DOI: 10.1007/s00586-019-06200-0

Restoring the ideal Roussouly sagittal profile in adult scoliosis surgery decreases the risk of mechanical complications.

PMID: 31641904
Journal: EUROPEAN SPINE JOURNAL
Year: 2020
Reference: Eur Spine J. 2020 Jan;29(1):54-62. doi: 10.1007/s00586-019-06176-x. Epub 2019 Oct 22.
Impact factor: 2.458
Publication type: Paper in international publication
Authors: Pizones, Javier, Moreno-Manzanaro, Lucia, Sanchez Perez-Grueso, Francisco Javier, Vila-Casademunt, Alba, Yilgor, Caglar, Obeid, Ibrahim, Alanay, Ahmet, Kleinstuck, Frank, Acaroglu, Emre R, Pellise, Ferran et al.
DOI: 10.1007/s00586-019-06176-x

Opioids and analgesics use after adult spinal deformity surgery correlates with sagittal alignment and preoperative analgesic pattern.

PMID: 31493111
Journal: EUROPEAN SPINE JOURNAL
Year: 2020
Reference: Eur Spine J. 2020 Jan;29(1):73-84. doi: 10.1007/s00586-019-06141-8. Epub 2019 Sep 6.
Impact factor: 2.458
Publication type: Paper in international publication
Authors: Bourghli, Anouar, Boissiere, Louis, Larrieu, Daniel, Kaissar, Farah, Cawley, Derek, Fujishiro, Takashi, Kieser, David, Gille, Olivier, Vital, Jean-Marc, Alanay, Ahmet et al.
DOI: 10.1007/s00586-019-06141-8

Adult spinal deformity surgical decision-making score. Part 2: development and validation of a scoring system to guide the selection of treatment modalities for patients above 40 years with adult spinal deformity.

PMID: 31317308
Journal: EUROPEAN SPINE JOURNAL
Year: 2020
Reference: Eur Spine J. 2020 Jan;29(1):45-53. doi: 10.1007/s00586-019-06068-0. Epub 2019 Jul 17.
Impact factor: 2.458
Publication type: Paper in international publication
Authors: Fujishiro, Takashi, Boissiere, Louis, Cawley, Derek Thomas, Larrieu, Daniel, Gille, Olivier, Vital, Jean-Marc, Pellise, Ferran, Perez-Grueso, Francisco Javier Sanchez, Kleinstuck, Frank, Alanay, Ahmet et al.
DOI: 10.1007/s00586-019-06068-0

Precision and safety of Multilevel Cervical Transpedicular Screw Fixation with 3D Patient-Specific Guides; A Cadaveric Study.

PMID: 31666550
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Oct 30;9(1):15686. doi: 10.1038/s41598-019-51936-w.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Sallent, Andrea, Ramirez, Manuel, Catala, Jordi, Rodriguez-Baeza, Alfonso, Bago, Joan, de Albert, Matias, Velez, Roberto et al.
DOI: 10.1038/s41598-019-51936-w

Adult Spinal Deformity Over 70 Years of Age: A 2-Year Follow-Up Study.

PMID: 31531283
Journal: International journal of spine surgery
Year: 2019
Reference: Int J Spine Surg. 2019 Aug 31;13(4):336-344. doi: 10.14444/6046. eCollection 2019 Aug.
Impact factor: 0
Publication type: Paper in international publication
Authors: Karabulut, Cem, Ayhan, Selim, Yuksel, Selcen, Nabiyev, Vugar, Vila-Casademunt, Alba, Pellise, Ferran, Alanay, Ahmet, Perez-Grueso, Francisco Javier Sanchez, Kleinstuck, Frank, Obeid, Ibrahim et al.
DOI: 10.14444/6046

Clinical photography in severe idiopathic scoliosis candidate for surgery: is it a useful tool to differentiate among Lenke patterns?

PMID: 31396690
Journal: EUROPEAN SPINE JOURNAL
Year: 2019
Reference: Eur Spine J. 2019 Dec;28(12):3018-3025. doi: 10.1007/s00586-019-06096-w. Epub 2019 Aug 8.
Impact factor: 2.513
Publication type: Paper in international publication
Authors: Matamalas, Antonia, Bago, Juan, Pizones, Javier, D'Agata, Elisa et al.
DOI: 10.1007/s00586-019-06096-w

Development of predictive models for all individual questions of SRS-22R after adult spinal deformity surgery: a step toward individualized medicine.

PMID: 31325052
Journal: EUROPEAN SPINE JOURNAL
Year: 2019
Reference: Eur Spine J. 2019 Sep;28(9):1998-2011. doi: 10.1007/s00586-019-06079-x. Epub 2019 Jul 19.
Impact factor: 2.513
Publication type: Paper in international publication
Authors: Ames, Christopher P, Smith, Justin S, Pellise, Ferran, Kelly, Michael, Gum, Jeffrey L, Alanay, Ahmet, Acaroglu, Emre, Perez-Grueso, Francisco Javier Sanchez, Kleinstuck, Frank S, Obeid, Ibrahim et al.
DOI: 10.1007/s00586-019-06079-x

Impact of iliac instrumentation on the quality of life of patients with adult spine deformity.

PMID: 29095408
Journal: SPINE
Year: 2018
Reference: Spine (Phila Pa 1976). 2018 Jul 1;43(13):913-918. doi: 10.1097/BRS.0000000000002476.
Impact factor: 2.792
Publication type: Paper in international publication
Authors: Pellise, Ferran, Acaroglu, Emre R, Kleinstuck, Frank, Alanay, Ahmet, Obeid, Ibrahim, Martin-Buitrago, Mar Perez, Pizones, Javier, Sanchez Perez-Grueso, Francisco Javier, Diaz Almiron, Mariana, Vila-Casademunt, Alba et al.
DOI: 10.1097/BRS.0000000000002476

An Analysis of the Incidence and Outcomes of Major Versus Minor Neurological Decline After Complex Adult Spinal Deformity Surgery: A Subanalysis of Scoli-RISK-1 Study.

PMID: 29894429
Journal: SPINE
Year: 2018
Reference: Spine (Phila Pa 1976). 2018 Jul 1;43(13):905-912. doi: 10.1097/BRS.0000000000002486.
Impact factor: 2.792
Publication type: Paper in international publication
Authors: Boachie-Adjei, Oheneba, Kebaish, Khaled M, Ames, Christopher P, Qiu, Yong, Matsuyama, Yukihiro, Dahl, Benny T, Mehdian, Hossein, Pellise, Ferran, Berven, Sigurd H, Schwab, Frank J et al.
DOI: 10.1097/BRS.0000000000002486

Responsiveness of Image Perception Outcome Scales After Surgical Treatment of Idiopathic Scoliosis: A Comparison Between the Trunk Appearance Perception Scale (TAPS) and Scoliosis Research Society-22 (SRS-22) Questionnaire.

PMID: 29886913
Journal: Spine deformity
Year: 2018
Reference: Spine Deform. 2018 Jul - Aug;6(4):417-423. doi: 10.1016/j.jspd.2017.12.010.
Impact factor: 0
Publication type: Paper in international publication
Authors: Perez-Grueso, Francisco J S, Pellise, Ferran, Sanchez-Raya, Judith, Matamalas, Antonia, Bago, Juan et al.
DOI: 10.1016/j.jspd.2017.12.010

Impact of early unanticipated revision surgery on health-related quality of life after adult spinal deformity.

PMID: 29037974
Journal: Spine Journal
Year: 2018
Reference: Spine J. 2018 Jun;18(6):926-934. doi: 10.1016/j.spinee.2017.09.017. Epub 2017 Oct 13.
Impact factor: 3.119
Publication type: Paper in international publication
Authors: Nunez-Pereira, Susana, Vila-Casademunt, Alba, Domingo-Sabat, Montse, Bago, Juan, Acaroglu, Emre R, Alanay, Ahmet, Obeid, Ibrahim, Perez-Grueso, Francisco Javier Sanchez, Kleinstuck, Frank, Pellise, Ferran et al.
DOI: 10.1016/j.spinee.2017.09.017

Retrospective analysis underestimates neurological deficits in complex spinal deformity surgery: a Scoli-RISK-1 Study.

PMID: 28475019
Journal: JOURNAL OF NEUROSURGERY-SPINE
Year: 2017
Reference: J Neurosurg Spine. 2017 Jul;27(1):68-73. doi: 10.3171/2016.12.SPINE161068. Epub 2017 May 5.
Impact factor: 2.696
Publication type: Paper in international publication
Authors: Pellise, Ferran, Shaffrey, Christopher I, Smith, Justin S, Lewis, Stephen J, Ames, Christopher P, Carreon, Leah Y, Fehlings, Michael G, Schwab, Frank, Shimer, Adam L, Godzik, Jakub et al.
DOI: 10.3171/2016.12.SPINE161068

Decision analysis to identify the ideal treatment for adult spinal deformity: What is the impact of complications on treatment outcomes?

PMID: 28454778
Journal: Acta Orthopaedica et Traumatologica Turcica
Year: 2017
Reference: Acta Orthop Traumatol Turc. 2017 May;51(3):181-190. doi: 10.1016/j.aott.2017.03.003. Epub 2017 Apr 25.
Impact factor: 0.599
Publication type: Paper in international publication
Authors: Acaroglu, Emre, Guler, Umit Ozgur, Cetinyurek-Yavuz, Aysun, Yuksel, Selcen, Yavuz, Yasemin, Ayhan, Selim, Domingo-Sabat, Montse, Pellise, Ferran, Alanay, Ahmet, Perez Grueso, Francesco S et al.
DOI: 10.1016/j.aott.2017.03.003

Lack of improvement in health-related quality of life (HRQOL) scores 6 months after surgery for adult spinal deformity (ASD) predicts high revision rate in the second postoperative year.

PMID: 28361369
Journal: EUROPEAN SPINE JOURNAL
Year: 2017
Reference: Eur Spine J. 2017 Aug;26(8):2160-2166. doi: 10.1007/s00586-017-5068-9. Epub 2017 Mar 30.
Impact factor: 2.563
Publication type: Paper in international publication
Authors: Bourghli, Anouar, Boissiere, Louis, Larrieu, Daniel, Vital, Jean-Marc, Yilgor, Caglar, Pellise, Ferran, Alanay, Ahmet, Acaroglu, Emre, Perez-Grueso, Francisco-Javier, Kleinstuck, Franck et al.
DOI: 10.1007/s00586-017-5068-9

Thoracic wall reconstruction with bioabsorbable plates in pediatric malignant thoracic wall tumors.

PMID: 27653461
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2017
Reference: J Pediatr Surg. 2017 Mar;52(3):377-381. doi: 10.1016/j.jpedsurg.2016.08.018. Epub 2016 Aug 31.
Impact factor: 1.976
Publication type: Paper in international publication
Authors: Guillen, G, Garcia, L, Marhuenda, C, Pellise, F, Molino, J A, Fontecha, C G, Lopez, S, Lloret, J et al.
DOI: 10.1016/j.jpedsurg.2016.08.018

Sagittal malalignment has a significant association with postoperative leg pain in adult spinal deformity patients.

PMID: 27225901
Journal: EUROPEAN SPINE JOURNAL
Year: 2016
Reference: Eur Spine J. 2016 Aug;25(8):2442-51. doi: 10.1007/s00586-016-4616-z. Epub 2016 May 25.
Impact factor: 2.132
Publication type: Paper in international publication
Authors: Obeid, Ibrahim, Obeid, Ibrahim, Alanay, Ahmet, Acaroglu, Emre R, Kleinstuck, Frank, Takemoto, Mitsuru, Boissiere, Louis, Novoa, Felipe, Vital, Jean-Marc, Pellise, Ferran et al.
DOI: 10.1007/s00586-016-4616-z

Validity and reliability of photographic measures to evaluate waistline asymmetry in idiopathic scoliosis.

PMID: 26975856
Journal: EUROPEAN SPINE JOURNAL
Year: 2016
Reference: Eur Spine J. 2016 Oct;25(10):3170-3179. doi: 10.1007/s00586-016-4509-1. Epub 2016 Mar 14.
Impact factor: 2.132
Publication type: Paper in international publication
Authors: Matamalas, Antonia, Bago, Juan, D Agata, Elisabetta, Pellise, Ferran et al.
DOI: 10.1007/s00586-016-4509-1

Adult spinal deformity: a very heterogeneous population of patients with different needs.

PMID: 26854050
Journal: Acta Orthopaedica et Traumatologica Turcica
Year: 2016
Reference: Acta Orthop Traumatol Turc. 2016;50(1):57-62. doi: 10.3944/AOTT.2016.14.0421.
Impact factor: 0.398
Publication type: Paper in international publication
Authors: Acaroglu, Rifat Emre, Dede, Ozgur, Pellise, Ferran, Guler, Umit O, Domingo-Sabat, Montse, Alanay, Ahmet, Perez-Grueso, Francisco Sanchez et al.
DOI: 10.3944/AOTT.2016.14.0421

A decision analysis to identify the ideal treatment for adult spinal deformity: is surgery better than non-surgical treatment in improving health-related quality of life and decreasing the disease burden?

PMID: 26821143
Journal: EUROPEAN SPINE JOURNAL
Year: 2016
Reference: Eur Spine J. 2016 Aug;25(8):2390-400. doi: 10.1007/s00586-016-4413-8. Epub 2016 Jan 28.
Impact factor: 2.132
Publication type: Paper in international publication
Authors: Perez Grueso, Francesco Sanchez, Kleinstuck, Frank, Obeid, Ibrahim, Alanay, Ahmet, Pellise, Ferran, Yavuz, Yasemin, Acaroglu, Emre, Yavuz, Aysun Cetinyurek, Guler, Umit Ozgur, Yuksel, Selcen et al.
DOI: 10.1007/s00586-016-4413-8

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The work improves accuracy in predicting complications at the boundary between the instrumented spine area and the area that is left free when spinal deformity corrective surgery is performed.

Entre els projectes es troben 12 investigacions on participen investigadors i investigadores de Vall d’Hebron.

The Scoliosis Research Society (SRS) has awarded with this prestigious recognition Dr. Pellisé's team for the study on the similarity of the adverse effects of surgeries both in elderly patients and in the general adult population.