About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.
PMID: 35174793 Journal: Current Opinion in Allergy and Clinical Immunology Year: 2022 Reference: Curr Opin Allergy Clin Immunol. 2022 Jun 1;22(3):175-180. doi: 10.1097/ACI.0000000000000822. Epub 2022 Feb 16. Impact factor: 3.142 Publication type: Paper in international publication Authors: Luengo, Olga, Galvan-Blasco, Paula, Cardona, Victoria et al. DOI: 10.1097/ACI.0000000000000822
PMID: 34343358 Journal: ALLERGY Year: 2022 Reference: Allergy. 2022 Feb;77(2):357-377. doi: 10.1111/all.15032. Epub 2021 Sep 1. Impact factor: 13.146 Publication type: Paper in international publication Authors: Oude Elberink, Hanneke N G, Regent, Lynne, Sanchez, Angel, Vlieg-Boerstra, Berber J, Roberts, Graham, Michaelis, Louise J, Khaleva, Ekaterina, Jensen, Britt, Halken, Susanne, Muraro, Antonella et al. DOI: 10.1111/all.15032
PMID: 34313394 Journal: Arthritis & Rheumatology Year: 2022 Reference: Arthritis Rheumatol. 2022 Feb;74(2):358-364. doi: 10.1002/art.41931. Epub 2021 Dec 26. Impact factor: 10.995 Publication type: Paper in international publication Authors: Balboni, Imelda, Pak, Katherine, Gil-Vila, Albert, Baucells, Andres, Plotz, Benjamin, Casal-Dominguez, Maria, Derfoul, Assia, Angeles Martinez, Maria, Selva-O'Callaghan, Albert, Sabbagh, Sara et al. DOI: 10.1002/art.41931
PMID: 34779868 Journal: RHEUMATOLOGY INTERNATIONAL Year: 2022 Reference: Rheumatol Int. 2022 Jan;42(1):23-29. doi: 10.1007/s00296-021-05046-4. Epub 2021 Nov 15. Impact factor: 2.631 Publication type: Paper in international publication Authors: Gracia-Ramos, Abraham Edgar, Sen, Parikshit, Gupta, Latika, Lilleker, James B, Aggarwal, Vishwesh, Kardes, Sinan, Milchert, Marcin, Gheita, Tamer, Salim, Babur, Velikova, Tsvetelina et al. DOI: 10.1007/s00296-021-05046-4
PMID: 33996816 Journal: Frontiers in Cell and Developmental Biology Year: 2021 Reference: Front Cell Dev Biol. 2021 Apr 29;9:655201. doi: 10.3389/fcell.2021.655201. eCollection 2021. Impact factor: 6.684 Publication type: Paper in international publication Authors: Garcia-Montolio, Marc, Ballare, Cecilia, Blanco, Enrique, Gutierrez, Arantxa, Aranda, Sergi, Gomez, Antonio, Kok, Chung H, Yeung, David T, Hughes, Timothy P, Vizan, Pedro et al. DOI: 10.3389/fcell.2021.655201
PMID: 33999255 Journal: SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES Year: 2021 Reference: Surg Endosc. 2021 Jul;35(7):3233-3243. doi: 10.1007/s00464-021-08524-9. Epub 2021 May 17. Impact factor: 4.584 Publication type: Paper in international publication Authors: Antoniou, Stavros A, Mavridis, Dimitris, Kontouli, Katerina Maria, Drakopoulos, Vasileios, Gorter-Stam, Marguerite, Eriksson, Sture, Leone, Marc, Perez-Bocanegra, Maria Carmen, Smart, Neil J, Milone, Marco et al. DOI: 10.1007/s00464-021-08524-9
PMID: 32880997 Journal: ALLERGY Year: 2021 Reference: Allergy. 2021 May;76(5):1493-1506. doi: 10.1111/all.14580. Epub 2020 Sep 29. Impact factor: 13.146 Publication type: Review in international publication Authors: Regent, Lynne, Sanchez, Angel, Vlieg-Boerstra, Berber, Roberts, Graham, Oude Elberink, Hanneke, Michaelis, Louise J, Jensen, Britt, de Silva, Debra, Singh, Chris, Muraro, Antonella et al. DOI: 10.1111/all.14580
PMID: 33289951 Journal: ALLERGY Year: 2021 Reference: Allergy. 2021 May;76(5):1480-1492. doi: 10.1111/all.14689. Epub 2020 Dec 22. Impact factor: 13.146 Publication type: Paper in international publication Authors: Sanchez-Lopez, Jaime, Araujo, Giovanna, Cardona, Victoria, Garcia-Moral, Alba, Casas-Saucedo, Rocio, Guilarte, Mar, Jose Torres, Maria, Dona, Inmaculada, Picado, Cesar, Pascal, Mariona et al. DOI: 10.1111/all.14689
PMID: 31365334 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2020 Reference: Clin Exp Rheumatol. 2020 Jan-Feb;38(1):67-73. Epub 2019 Jul 30. Impact factor: 3.319 Publication type: Paper in international publication Authors: Dani, Lara, Holmqvist, Marie, Martinez, Maria Angeles, Trallero-Araguas, Ernesto, Dastmalchi, Maryam, Svensson, John, Labrador-Horrillo, Moises, Selva-O'Callaghan, Albert, Lundberg, Ingrid E et al. DOI:
PMID: 31203229 Journal: JOURNAL OF RHEUMATOLOGY Year: 2020 Reference: J Rheumatol. 2020 Mar;47(3):407-414. doi: 10.3899/jrheum.190065. Epub 2019 Jun 15. Impact factor: 3.35 Publication type: Paper in international publication Authors: Garcia-Vives, Eloi, Segarra-Medrano, Alfons, Martinez-Valle, Ferran, Agraz, Irene, Solans-Laque, Roser et al. DOI: 10.3899/jrheum.190065
PMID: 31230373 Journal: ALLERGY Year: 2020 Reference: Allergy. 2020 Feb;75(2):259-272. doi: 10.1111/all.13953. Epub 2019 Sep 16. Impact factor: 8.706 Publication type: Paper in international publication Authors: Blaiss, Michael S, Matricardi, Paolo Maria, Dramburg, Stephanie, Alvarez-Perea, Alberto, Antolin-Amerigo, Dario, Apfelbacher, Christian, Atanaskovic-Markovic, Marina, Berger, Uwe, Pfaar, Oliver, Pitsios, Constantinos et al. DOI: 10.1111/all.13953
PMID: 32101173 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2020 Reference: J Investig Allergol Clin Immunol. 2020;30(4):296-298. doi: 10.18176/jiaci.0498. Epub 2020 Feb 25. Impact factor: 3.488 Publication type: Paper in international publication Authors: Navas, A, Serrano, P, Espinazo, M, Labrador-Horrillo, M, Monsalve, R I, Jurado, A, Moreno-Aguilar, C, Ruiz-Leon, B et al. DOI: 10.18176/jiaci.0498
PMID: 31229481 Journal: ANNALS OF THORACIC SURGERY Year: 2019 Reference: Ann Thorac Surg. 2019 Oct;108(4):1052-1058. doi: 10.1016/j.athoracsur.2019.04.096. Epub 2019 Jun 21. Impact factor: 3.919 Publication type: Paper in international publication Authors: Loor, Karina, Culebras, Mario, Sansano, Irene, Alvarez, Antonio, Berastegui, Cristina, de Gracia, Javier et al. DOI: 10.1016/j.athoracsur.2019.04.096
PMID: 31229269 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2019 Reference: J Allergy Clin Immunol. 2019 Sep;144(3):627-633. doi: 10.1016/j.jaci.2019.05.013. Epub 2019 Jun 20. Impact factor: 14.11 Publication type: Review in international publication Authors: Sanchez-Borges, Mario, Rosenwasser, Lanny J, Ansontegui, Ignacio, Ebisawa, Motohiro, Sisul, Juan Carlos, Jares, Edgardo, Gomez, Maximiliano, Agache, Ioana, Hellings, Peter, Muraro, Antonella et al. DOI: 10.1016/j.jaci.2019.05.013
PMID: 31178295 Journal: MEDICINA CLINICA Year: 2019 Reference: Med Clin (Barc). 2019 Aug 16;153(4):169-177. doi: 10.1016/j.medcli.2019.01.030. Epub 2019 Jun 6. Impact factor: 1.277 Publication type: Paper in national publication Authors: Siso-Almirall, Antonio, Solans, Rosa, Fernandez-Real, Jose Manuel, Carrion, Jose Antonio, Graupera, Isabel, Gines, Pere, Vila, Lluis, Goday, Antonio, Hernandez, Maria Rosa, Caballeria, Llorenc et al. DOI: 10.1016/j.medcli.2019.01.030
PMID: 31169597 Journal: Current Opinion in Allergy and Clinical Immunology Year: 2019 Reference: Curr Opin Allergy Clin Immunol. 2019 Oct;19(5):439-446. doi: 10.1097/ACI.0000000000000550. Impact factor: 3.014 Publication type: Paper in international publication Authors: Sala-Cunill, Anna, Luengo, Olga, Cardona, Victoria et al. DOI: 10.1097/ACI.0000000000000550
PMID: 29452298 Journal: JOINT BONE SPINE Year: 2018 Reference: Joint Bone Spine. 2018 Dec;85(6):721-726. doi: 10.1016/j.jbspin.2018.01.014. Epub 2018 Feb 13. Impact factor: 3.304 Publication type: Paper in international publication Authors: Fernandez-Codina, Andreu, Pinilla, Blanca, Pinal-Fernandez, Iago, Lopez, Cristina, Fraile-Rodriguez, Guadalupe, Fonseca-Aizpuru, Eva, Carballo, Iago, Brito-Zeron, Pilar, Feijoo-Masso, Carlos, Lopez-Dupla, Miguel et al. DOI: 10.1016/j.jbspin.2018.01.014
PMID: 29446469 Journal: ALLERGY Year: 2018 Reference: Allergy. 2018 Sep;73(9):1775-1783. doi: 10.1111/all.13429. Epub 2018 Apr 16. Impact factor: 6.048 Publication type: Review in national publication Authors: Pfaar, O, Alvaro, M, Cardona, V, Hamelmann, E, Mosges, R, Kleine-Tebbe, J et al. DOI: 10.1111/all.13429
PMID: 29149307 Journal: RHEUMATOLOGY Year: 2018 Reference: Rheumatology (Oxford). 2018 Feb 1;57(2):388-396. doi: 10.1093/rheumatology/kex413. Impact factor: 5.245 Publication type: Paper in international publication Authors: Pinal-Fernandez, Iago, Ferrer-Fabregas, Berta, Trallero-Araguas, Ernesto, Balada, Eva, Martinez, Maria Angeles, Milisenda, Jose Cesar, Aparicio-Espanol, Gloria, Labrador-Horrillo, Moises, Garcia-Patos, Vicente, Grau-Junyent, Josep M et al. DOI: 10.1093/rheumatology/kex413
PMID: 29336994 Journal: MOLECULAR GENETICS AND METABOLISM Year: 2018 Reference: Mol Genet Metab. 2018 Feb;123(2):69-75. doi: 10.1016/j.ymgme.2018.01.002. Epub 2018 Jan 5. Impact factor: 3.774 Publication type: Review in national publication Authors: Sampayo-Cordero, Miguel, Miguel-Huguet, Bernat, Pardo-Mateos, Almudena, Molto-Abad, Marc, Munoz-Delgado, Cecilia, Perez-Lopez, Jordi et al. DOI: 10.1016/j.ymgme.2018.01.002
PMID: 28385573 Journal: RESPIRATORY MEDICINE Year: 2017 Reference: Respir Med. 2017 Nov;132:265-266. doi: 10.1016/j.rmed.2017.03.028. Epub 2017 Mar 31. Impact factor: 3.217 Publication type: Letter or abstract Authors: Selva-O'Callaghan, Albert, Cavagna, Lorenzo, Gonzalez-Gay, Miguel A, Scire, Carlo Alberto et al. DOI: 10.1016/j.rmed.2017.03.028
PMID: 28328347 Journal: NEW ENGLAND JOURNAL OF MEDICINE Year: 2017 Reference: N Engl J Med. 2017 Mar 23;376(12):1131-1140. doi: 10.1056/NEJMoa1613627. Impact factor: 72.406 Publication type: Paper in international publication Authors: Longhurst, Hilary, Cicardi, Marco, Craig, Timothy, Bork, Konrad, Grattan, Clive, Baker, James, Li, Huamin H, Reshef, Avner, Bonner, James, Bernstein, Jonathan A et al. DOI: 10.1056/NEJMoa1613627
PMID: 28285170 Journal: AUTOIMMUNITY REVIEWS Year: 2017 Reference: Autoimmun Rev. 2017 May;16(5):461-468. doi: 10.1016/j.autrev.2017.03.012. Epub 2017 Mar 8. Impact factor: 8.961 Publication type: Review in national publication Authors: Simeon-Aznar, Carmen Pilar, Fonollosa-Pla, Vicent, Bernal-Bello, David, de Tena, Jaime Garcia, Guillen-Del Castillo, Alfredo, Selva-O'Callaghan, Albert, Callejas-Moraga, Eduardo L, Marin-Sanchez, Ana Maria et al. DOI: 10.1016/j.autrev.2017.03.012
PMID: 28283766 Journal: CLINICAL RHEUMATOLOGY Year: 2017 Reference: Clin Rheumatol. 2017 Jun;36(6):1401-1406. doi: 10.1007/s10067-017-3594-9. Epub 2017 Mar 10. Impact factor: 2.365 Publication type: Paper in international publication Authors: Pardos-Gea, Jose, Cortes-Hernandez, Josefina, Castro-Marrero, Jesus, Balada, Eva, Ordi-Ros, Jose et al. DOI: 10.1007/s10067-017-3594-9
PMID: 26972571 Journal: BRITISH JOURNAL OF DERMATOLOGY Year: 2016 Reference: Br J Dermatol. 2016 Aug;175(2):302-13. doi: 10.1111/bjd.14539. Epub 2016 May 29. Impact factor: 4.317 Publication type: Paper in international publication Authors: Sole, C, Gimenez-Barcons, M, Ferrer, B, Ordi-Ros, J, Cortes-Hernandez, J et al. DOI: 10.1111/bjd.14539
PMID: 26743605 Journal: JOURNAL OF INVESTIGATIVE DERMATOLOGY Year: 2016 Reference: J Invest Dermatol. 2016 Mar;136(3):593-602. doi: 10.1016/j.jid.2015.11.026. Epub 2015 Dec 29. Impact factor: 6.915 Publication type: Paper in international publication Authors: Aterido, Adria, Julia, Antonio, Ferrandiz, Carlos, Puig, Lluis, Fonseca, Eduardo, Fernandez-Lopez, Emilia, Dauden, Esteban, Sanchez-Carazo, Jose Luis, Lopez-Estebaranz, Jose Luis, Moreno-Ramirez, David et al. DOI: 10.1016/j.jid.2015.11.026
PMID: 26871199 Journal: PHARMACOGENOMICS Year: 2016 Reference: Pharmacogenomics. 2016 Mar;17(4):323-6. doi: 10.2217/pgs.15.168. Epub 2016 Feb 12. Impact factor: 2.71 Publication type: Review in international publication Authors: Julia, Antonio, Marsal, Sara et al. DOI:
PMID: 26815016 Journal: Ophthalmic Surgery Lasers & Imaging Retina Year: 2016 Reference: Arthritis Rheumatol. 2016 Jun;68(6):1384-91. doi: 10.1002/art.39591. Impact factor: 1.212 Publication type: Paper in international publication Authors: Bertranpetit, Jaume, Absher, Devin, Myers, Richard M, Tornero, Jesus, Marsal, Sara, Garcia-Montero, Andres C, Lluis Gelpi, Josep, Tortosa, Raul, Julia, Antonio, Blanco, Francisco et al. DOI: 10.1002/art.39591
PMID: 25812543 Journal: ACTAS ESPANOLAS DE PSIQUIATRIA Year: 2015 Reference: Actas Esp Psiquiatr. 2015 Mar-Apr;43(2):58-65. Epub 2015 Mar 1. Impact factor: 1.2 Publication type: Paper in national publication Authors: Saez-Francas, Naia, Valero, Sergi, Alegre, Jose, Casas, Miguel, Calvo, Natalia et al. DOI:
PMID: 26005883 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2015 Reference: Clin Exp Rheumatol. 2015 Nov-Dec;33(6 Suppl 94):S36-9. Epub 2015 May 25. Impact factor: 2.724 Publication type: Paper in international publication Authors: Espinosa, Gerard, Ortiz-Fernandez, Lourdes, Garcia-Lozano, Jose Raul, Montes-Cano, Marco Antonio, Conde-Jaldon, Marta, Ortego-Centeno, Norberto, Garcia-Hernandez, Francisco Jose, Julia, Maria Rosa, Blanco, Ricardo, Barnosi-Marin, Ana Celia et al. DOI:
PMID: 26040904 Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION Year: 2015 Reference: Nephrol Dial Transplant. 2015 Sep;30(9):1488-96. doi: 10.1093/ndt/gfv128. Epub 2015 Jun 3. Impact factor: 3.577 Publication type: Paper in international publication Authors: Sole, Cristina, Cortes-Hernandez, Josefina, Felip, Maria L, Vidal, Marta, Ordi-Ros, Josep et al. DOI: 10.1093/ndt/gfv128
PMID: 25433783 Journal: MEDICINA CLINICA Year: 2015 Reference: Med Clin (Barc). 2015 Mar 9;144(5):216-22. doi: 10.1016/j.medcli.2014.08.009. Epub 2014 Nov 26. Impact factor: 1.417 Publication type: Paper in national publication Authors: Cardona, Victoria, Garriga, Teresa et al. DOI: 10.1016/j.medcli.2014.08.009
PMID: 25182205 Journal: AUTOIMMUN REV Year: 2014 Reference: Autoimmun Rev. 2014 Oct;13(10):1008-12. doi: 10.1016/j.autrev.2014.08.038. Epub 2014 Aug 27. Impact factor: 7.095 Publication type: Paper in international publication Authors: Labrador-Horrillo, Moises, Martinez, Maria Angeles, Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Grau-Junyent, Josep M, Vilardell-Tarres, Miquel, Juarez, Candido et al. DOI: 10.1016/j.autrev.2014.08.038
PMID: 25118052 Journal: LUPUS Year: 2014 Reference: Lupus. 2014 Sep;23(10):1073-8. doi: 10.1177/0961203314534303. Epub 2014 May 15. Impact factor: 2.481 Publication type: Paper in international publication Authors: Guillen-Del Castillo, A, Alonso, J, Martinez-Valle, F, Alonso-Vila, S, Garrido-Castro, A C, Vilardell-Tarres, M, Rovira, A, Ordi-Ros, J et al. DOI: 10.1177/0961203314534303
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Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.
It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.
The study showing how thrombocytopenia increases the risk of thrombosis in patients with antiphospholipid syndrome has been considered the best paper published in 2021.
