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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Publications

Onset of nut allergy in a pediatric cohort: clinical and molecular patterns. AFRUSEN study.

PMID: 33884956
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2021
Reference: J Investig Allergol Clin Immunol. 2021 Apr 22:0. doi: 10.18176/jiaci.0696.
Impact factor: 7.033
Publication type: Paper in international publication
Authors: Vila, L, Ibanez-Sandin, M D, Rodriguez Del Rio, P, Alvarado, M I, Garcia, B E, Garriga-Baraut, T, Reche Frutos, M, Escudero, C, Ramirez, A, Marchan-Martin, E et al.
DOI: 10.18176/jiaci.0696

Heterogeneity of the pharmacologic treatment of allergic rhinitis in Europe based on MIDAS and OTCims platforms.

PMID: 33880889
Journal: CLINICAL AND EXPERIMENTAL ALLERGY
Year: 2021
Reference: Clin Exp Allergy. 2021 Aug;51(8):1033-1045. doi: 10.1111/cea.13884. Epub 2021 May 11.
Impact factor: 5.018
Publication type: Paper in international publication
Authors: Bousquet, Jean, Schroder-Bernhardi, Detlef, Bachert, Claus, Costa, Elisio M, Czarlewski, Wienczyslawa, Devillier, Philippe, Fonseca, Joao, Klimek, Ludger, Kuna, Piotr, Lourenco, Olga et al.
DOI: 10.1111/cea.13884

Myo-Spain: Spanish Registry of Patients with Idiopathic Inflammatory Myopathy. Methodology.

PMID: 33867271
Journal: Reumatologia clinica
Year: 2021
Reference: Reumatol Clin (Engl Ed). 2021 Apr 15. pii: S1699-258X(21)00065-6. doi: 10.1016/j.reuma.2021.01.007.
Impact factor: 0
Publication type: Paper in national publication
Authors: Barbadillo, Carmen, Sivera, Francisca, Belzunegui, Joaquin, Perez Gomez, Ana, Gomez Gomez, Alejandro, Delgado-Frias, Esmeralda, Pego-Reigosa, Jose Maria, Joven, Beatriz, Ibanez, Monica, Martinez-Gonzalez, Olga et al.
DOI: 10.1016/j.reuma.2021.01.007

Nanotechnology-based approaches for treating lysosomal storage disorders, a focus on Fabry disease.

PMID: 33314628
Journal: Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
Year: 2021
Reference: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 May;13(3):e1684. doi: 10.1002/wnan.1684. Epub 2020 Dec 13.
Impact factor: 9.182
Publication type: Review in international publication
Authors: Abasolo, Ibane, Seras-Franzoso, Joaquin, Molto-Abad, Marc, Diaz-Riascos, Vanessa, Corchero, Jose Luis, Pintos-Morell, Guillem, Schwartz, Simo Jr et al.
DOI: 10.1002/wnan.1684

Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air((R)) App.

PMID: 31995656
Journal: ALLERGY
Year: 2020
Reference: Allergy. 2020 Jul;75(7):1672-1688. doi: 10.1111/all.14204. Epub 2020 Mar 22.
Impact factor: 8.706
Publication type: Paper in international publication
Authors: Fokkens, Wytske J, Bedard, Annabelle, Anto, Josep M, Fonseca, Joao A, Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Cardona, Victoria et al.
DOI: 10.1111/all.14204

Molecular diagnosis usefulness for idiopathic anaphylaxis.

PMID: 31977447
Journal: Current Opinion in Allergy and Clinical Immunology
Year: 2020
Reference: Curr Opin Allergy Clin Immunol. 2020 Jun;20(3):248-252. doi: 10.1097/ACI.0000000000000625.
Impact factor: 3.246
Publication type: Review in international publication
Authors: Cardona, Victoria, Guilarte, Mar, Labrador-Horrillo, Moises et al.
DOI: 10.1097/ACI.0000000000000625

Serodiscordant patients with systemic sclerosis: when antibody does not correspond to skin involvement.

PMID: 31969223
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2020
Reference: Clin Exp Rheumatol. 2020 May-Jun;38 Suppl 125(3):106-114. Epub 2020 Jan 14.
Impact factor: 3.319
Publication type: Paper in international publication
Authors: Iniesta Arandia, Nerea, Espinosa, Gerard, Tolosa Vilella, Carles, Guillen Del Castillo, Alfredo, Rubio Rivas, Manuel, Freire, Mayka, Vargas Hitos, Jose Antonio, Todoli Parra, Jose Antonio, Rodriguez Carballeira, Monica, Marin Ballve, Adela et al.
DOI:

Efficacy of a Multicomponent Intervention for Fibromyalgia Based on Pain Neuroscience Education, Exercise Therapy, Psychological Support, and Nature Exposure (NAT-FM): Study Protocol of a Randomized Controlled Trial.

PMID: 31963773
Journal: International Journal of Environmental Research and Public Health
Year: 2020
Reference: Int J Environ Res Public Health. 2020 Jan 19;17(2). pii: ijerph17020634. doi: 10.3390/ijerph17020634.
Impact factor: 2.849
Publication type: Paper in international publication
Authors: Serrat, Mayte, Sanabria-Mazo, Juan P, Garcia-Troiteiro, Elna, Fontcuberta, Anna, Mateo-Canedo, Corel, Almirall, Miriam, Feliu-Soler, Albert, Mendez-Ulrich, Jorge Luis, Sanz, Antoni, Luciano, Juan V et al.
DOI: 10.3390/ijerph17020634

Sclerosing Cholangitis Related to IgG4: Not Always a Curable Entity.

PMID: 31113593
Journal: Annals of Hepatology
Year: 2019
Reference: Ann Hepatol. 2019 Jan - Feb;18(1):215-219. doi: 10.5604/01.3001.0012.7916.
Impact factor: 1.895
Publication type: Paper in international publication
Authors: Martinez-Valle, Fernando, Riveiro-Barciela, Mar, Salcedo, Maria-Teresa, Merino-Casabiel, Xavier, Fernandez-Codina, Andreu, Torres, Ines de, Esteban, Rafael, Buti, Maria et al.
DOI: 10.5604/01.3001.0012.7916

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.

PMID: 30911161
Journal: NATURE GENETICS
Year: 2019
Reference: Nat Genet. 2019 Apr;51(4):659-674. doi: 10.1038/s41588-019-0364-4. Epub 2019 Mar 25.
Impact factor: 25.455
Publication type: Paper in international publication
Authors: Mahajan, Milind C, Kramer, Robin, Domenici, Enrico, Gamazon, Eric R, Purcell, Shaun, Demontis, Ditte, Borglum, Anders D, Walters, James T R, O'Donovan, Michael C, Sullivan, Patrick et al.
DOI: 10.1038/s41588-019-0364-4

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.

PMID: 31086353
Journal: NATURE GENETICS
Year: 2019
Reference: Nat Genet. 2019 Jun;51(6):1068. doi: 10.1038/s41588-019-0435-6.
Impact factor: 25.455
Publication type: Letter or abstract
Authors: Gamazon, Eric R, Huckins, Laura M, Dobbyn, Amanda, Ruderfer, Douglas M, Hoffman, Gabriel, Wang, Weiqing, Pardinas, Antonio F, Rajagopal, Veera M, Als, Thomas D, T Nguyen, Hoang et al.
DOI: 10.1038/s41588-019-0435-6

Risk of ischaemic events at giant cell arteritis diagnosis according to PET/CT findings.

PMID: 31081519
Journal: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Year: 2019
Reference: Eur J Nucl Med Mol Imaging. 2019 Jul;46(8):1626-1632. doi: 10.1007/s00259-019-04339-y. Epub 2019 May 12.
Impact factor: 7.182
Publication type: Paper in international publication
Authors: Martinez-Valle, Fernando, Navales, Ignacio, Loureiro-Amigo, Jose, Solans-Laque, Roser, Simo-Perdigo, Marc, Mestre-Torres, Jaume et al.
DOI: 10.1007/s00259-019-04339-y

Opportunistic infections in patients with idiopathic inflammatory myopathies.

PMID: 29314762
Journal: International Journal of Rheumatic Diseases
Year: 2018
Reference: Int J Rheum Dis. 2018 Feb;21(2):487-496. doi: 10.1111/1756-185X.13255. Epub 2018 Jan 5.
Impact factor: 2.423
Publication type: Paper in international publication
Authors: Redondo-Benito, Ada, Curran, Adrian, Villar-Gomez, Ana, Trallero-Araguas, Ernesto, Fernandez-Codina, Andreu, Pinal-Fernandez, Iago, Rodrigo-Pendas, Jose Angel, Selva-O'Callaghan, Albert et al.
DOI: 10.1111/1756-185X.13255

Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - Reference Site Twinning (EIP on AHA).

PMID: 28600902
Journal: ALLERGY
Year: 2018
Reference: Allergy. 2018 Jan;73(1):77-92. doi: 10.1111/all.13218. Epub 2017 Aug 24.
Impact factor: 6.048
Publication type: Paper in international publication
Authors: De Feo, G, Bousquet, J, Agache, I, Aliberti, M R, Angles, R, Annesi-Maesano, I, Anto, J M, Arnavielhe, S, Asayag, E, Bacci, E et al.
DOI: 10.1111/all.13218

Takayasu's arteritis relapse.

PMID: 28249725
Journal: JOINT BONE SPINE
Year: 2018
Reference: Joint Bone Spine. 2018 Jan;85(1):119. doi: 10.1016/j.jbspin.2017.02.008. Epub 2017 Feb 27.
Impact factor: 3.304
Publication type: Paper in international publication
Authors: Fernandez-Codina, Andreu, Simo, Marc, Solans-Laque, Roser, Martinez-Valle, Fernando et al.
DOI: 10.1016/j.jbspin.2017.02.008

Changes in the pattern of death of 987 patients with systemic sclerosis from 1990 to 2009 from the nationwide Spanish Scleroderma Registry (RESCLE).

PMID: 28229826
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2017
Reference: Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):40-47. Epub 2017 Feb 6.
Impact factor: 2.634
Publication type: Paper in international publication
Authors: Rubio-Rivas, Manuel, Simeon-Aznar, Carmen Pilar, Velasco, Cesar, Mari-Alfonso, Begona, Espinosa, Gerard, Corbella, Xavier, Colunga-Arguelles, Dolores, Egurbide-Arberas, Maria Victoria, Ortego-Centeno, Norberto, Freire, Mayka et al.
DOI:

Clinical characteristics and outcome of Spanish patients with ANCA-associated vasculitides: Impact of the vasculitis type, ANCA specificity, and treatment on mortality and morbidity.

PMID: 28225490
Journal: MEDICINE
Year: 2017
Reference: Medicine (Baltimore). 2017 Feb;96(8):e6083. doi: 10.1097/MD.0000000000006083.
Impact factor: 1.803
Publication type: Paper in international publication
Authors: Solans-Laque, Roser, Fraile, Guadalupe, Rodriguez-Carballeira, Monica, Caminal, Luis, Castillo, Maria J, Martinez-Valle, Ferran, Saez, Luis, Rios, Juan J, Solanich, Xavier, Oristrell, Joaquim et al.
DOI: 10.1097/MD.0000000000006083

Cardiac involvement in systemic sclerosis: differences between clinical subsets and influence on survival.

PMID: 26497313
Journal: RHEUMATOLOGY INTERNATIONAL
Year: 2017
Reference: Rheumatol Int. 2017 Jan;37(1):75-84. doi: 10.1007/s00296-015-3382-2. Epub 2015 Oct 25.
Impact factor: 1.824
Publication type: Paper in international publication
Authors: Fernandez-Codina, Andreu, Simeon-Aznar, Carmen Pilar, Pinal-Fernandez, Iago, Rodriguez-Palomares, Jose, Pizzi, Maria Nazarena, Hidalgo, Cristina Eve, Del Castillo, Alfredo Guillen, Prado-Galbarro, Francisco Javier, Sarria-Santamera, Antonio, Fonollosa-Pla, Vicent et al.
DOI: 10.1007/s00296-015-3382-2

Erratum to: Cardiac involvement in systemic sclerosis: differences between clinical subsets and influence on survival.

PMID: 27043027
Journal: RHEUMATOLOGY INTERNATIONAL
Year: 2017
Reference: Rheumatol Int. 2017 Jan;37(1):177. doi: 10.1007/s00296-016-3470-y.
Impact factor: 1.824
Publication type: Letter or abstract
Authors: Fernandez-Codina, Andreu, Simeon-Aznar, Carmen Pilar, Pinal-Fernandez, Iago, Rodriguez-Palomares, Jose, Pizzi, Maria Nazarena, Hidalgo, Cristina Eve, Guillen-Del Castillo, Alfredo, Prado-Galbarro, Francisco Javier, Sarria-Santamera, Antonio, Fonollosa-Pla, Vicent et al.
DOI: 10.1007/s00296-016-3470-y

Rheumatology assistance care in Catalonia (Spain): Year 2012.

PMID: 24252627
Journal: Reumatología clinica
Year: 2014
Reference: Reumatol Clin. 2014 Mar-Apr;10(2):85-8. doi: 10.1016/j.reuma.2013.05.012. Epub 2013 Nov 17.
Impact factor:
Publication type: Letter or abstract
Authors: Grados, Dolors, Marsal, Sara, Olive, Alejandro et al.
DOI: 10.1016/j.reuma.2013.05.012

[Current therapeutic indications of thalidomide and lenalidomide.]

PMID: 23830554
Journal: MED CLIN-BARCELONA
Year: 2014
Reference: Med Clin (Barc). 2014 Apr 22;142(8):360-4. doi: 10.1016/j.medcli.2013.04.038. Epub 2013 Jul 3.
Impact factor: 1.252
Publication type: Paper in national publication
Authors: Ordi-Ros, Josep, Cosiglio, Francisco Javier et al.
DOI: 10.1016/j.medcli.2013.04.038

Results from a multicentre international registry of familial Mediterranean fever: impact of environment on the expression of a monogenic disease in children.

PMID: 23463692
Journal: ANN RHEUM DIS
Year: 2014
Reference: Ann Rheum Dis. 2014 Apr;73(4):662-7. doi: 10.1136/annrheumdis-2012-202708. Epub 2013 Mar 5.
Impact factor: 9.27
Publication type: Paper in international publication
Authors: Ozen, Seza, Demirkaya, Erkan, Amaryan, Gayane, Kone-Paut, Isabelle, Polat, Adem, Woo, Pat, Uziel, Yosef, Modesto, Consuelo, Finetti, Martina, Quartier, Pierre et al.
DOI: 10.1136/annrheumdis-2012-202708

Early- versus Late-Onset Systemic Sclerosis: Differences in Clinical Presentation and Outcome in 1037 Patients.

PMID: 24646463
Journal: MEDICINE
Year: 2014
Reference: Medicine (Baltimore). 2014 Mar;93(2):73-81. doi: 10.1097/MD.0000000000000018.
Impact factor: 4.867
Publication type: Paper in national publication
Authors: Alba, Marco A, Velasco, Cesar, Simeon, Carmen Pilar, Fonollosa, Vicent, Trapiella, Luis, Egurbide, Maria Victoria, Saez, Luis, Castillo, Maria Jesus, Callejas, Jose Luis, Camps, Maria Teresa et al.
DOI: 10.1097/MD.0000000000000018

Anti-TIF1gamma antibodies (anti-p155) in adult patients with dermatomyositis: comparison of different diagnostic assays.

PMID: 22294626
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2012
Reference: Ann Rheum Dis. 2012 Jun;71(6):993-6. doi: 10.1136/annrheumdis-2011-200871. Epub 2012 Jan 30.
Impact factor: 8.727
Publication type: Paper in international publication
Authors: , , , , , , et al.
DOI: 10.1136/annrheumdis-2011-200871

Circulating Cell-Derived Microparticles in Severe Preeclampsia and in Fetal Growth Restriction.

PMID: 21992597
Journal: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Year: 2012
Reference: Am J Reprod Immunol. 2012 Feb;67(2):140-151. doi: 10.1111/j.1600-0897.2011.01072.x. Epub 2011 Oct 13.
Impact factor: 3.05
Publication type: Paper in international publication
Authors: , , , , , et al.
DOI: 10.1111/j.1600-0897.2011.01072.x

Polymorphisms in the Interleukin 4, Interleukin 13, and Corresponding Receptor Genes Are Not Associated with Systemic Sclerosis and Do Not Influence Gene Expression.

PMID: 22045834
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2012
Reference: J Rheumatol. 2012 Jan;39(1):112-118. Epub 2011 Nov 1.
Impact factor: 3.695
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.3899/jrheum.110235

Analysis of Class II human leucocyte antigens in Italian and Spanish systemic sclerosis.

PMID: 22087014
Journal: RHEUMATOLOGY
Year: 2012
Reference: Rheumatology (Oxford). 2012 Jan;51(1):52-9. Epub 2011 Nov 15.
Impact factor: 4.058
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1093/rheumatology/ker335

Blog

News

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.

The study showing how thrombocytopenia increases the risk of thrombosis in patients with antiphospholipid syndrome has been considered the best paper published in 2021.

Job offers

Grup de Recerca en Teràpia Gènica i Cel•lular-Personal investigador
Start date:
30/04/2013
End date:
06/05/2013
Grup de Recerca en Malalties Sistèmiques-Data Manager
Start date:
30/04/2013
End date:
06/05/2013
Grup de Recerca en Malalties Sistèmiques-Bioinformàtic/a
Start date:
05/04/2013
End date:
11/04/2013