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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Publications

Response to Treatment in IgG4-Related Disease Assessed by Quantitative PET/CT Scan.

PMID: 33630792
Journal: CLINICAL NUCLEAR MEDICINE
Year: 2021
Reference: Clin Nucl Med. 2021 Jun 1;46(6):e307-e311. doi: 10.1097/RLU.0000000000003537.
Impact factor: 7.794
Publication type: Paper in international publication
Authors: Orozco-Galvez, Olimpia, Fernandez-Codina, Andreu, Simo-Perdigo, Marc, Pinal-Fernandez, Iago, Martinez-Valle, Fernando et al.
DOI: 10.1097/RLU.0000000000003537

Utility of lymphocyte phenotype profile to differentiate primary Sjogren syndrome from Sicca syndrome.

PMID: 33620072
Journal: RHEUMATOLOGY
Year: 2021
Reference: Rheumatology (Oxford). 2021 Dec 1;60(12):5647-5658. doi: 10.1093/rheumatology/keab170.
Impact factor: 7.58
Publication type: Paper in international publication
Authors: Loureiro-Amigo, Jose, Martinez-Gallo, Monica, Martinez-Valle, Fernando, Ramentol-Sintas, Marc, Solans-Laque, Roser, Palacio-Garcia, Carlos et al.
DOI: 10.1093/rheumatology/keab170

A Systematic Review and Meta-Analysis to Inform Cancer Screening Guidelines in Idiopathic Inflammatory Myopathies.

PMID: 33599244
Journal: RHEUMATOLOGY
Year: 2021
Reference: Rheumatology (Oxford). 2021 Jun 18;60(6):2615-2628. doi: 10.1093/rheumatology/keab166.
Impact factor: 7.58
Publication type: Review in international publication
Authors: Tansley, Sarah, Vleugels, Ruth Ann, Werth, Victoria P, Aggarwal, Rohit, Schmidt, Jens, Selva-O'Callaghan, Albert, McHugh, Neil J, Oldroyd, Alexander G S, Allard, Andrew B, Callen, Jeffrey P et al.
DOI: 10.1093/rheumatology/keab166

The incidence rate of pulmonary arterial hypertension and scleroderma renal crisis in systemic sclerosis patients with digital ulcers on endothelin antagonist receptors (ERAs) and phosphodiesterase-5 inhibitors (PDE5i).

PMID: 32844220
Journal: RHEUMATOLOGY
Year: 2021
Reference: Rheumatology (Oxford). 2021 Feb 1;60(2):872-880. doi: 10.1093/rheumatology/keaa401.
Impact factor: 7.58
Publication type: Paper in international publication
Authors: Pestana-Fernandez, Melani, Rubio-Rivas, Manuel, Tolosa-Vilella, Carles, Guillen-Del-Castillo, Alfredo, Colunga-Arguelles, Dolores, Argibay, Ana, Mari-Alfonso, Begona, Marin-Ballve, Adela, Pla-Salas, Xavier, Chamorro, Antonio-J et al.
DOI: 10.1093/rheumatology/keaa401

Delayed drug hypersensitivity to bortezomib: desensitization and tolerance to its analogue carfilzomib.

PMID: 30738005
Journal: ALLERGY
Year: 2019
Reference: Allergy. 2019 Jul;74(7):1384-1386. doi: 10.1111/all.13735. Epub 2019 Mar 14.
Impact factor: 6.771
Publication type: Letter whit IF
Authors: Gil-Serrano, Ingrid Johana, Galvan-Blasco, Paula, Guilarte, Mar, Cardona, Victoria, Labrador-Horrillo, Moises, Sala-Cunill, Anna, Luengo, Olga et al.
DOI: 10.1111/all.13735

Discoidin domain receptor 1 gene variants are associated with decreased white matter fractional anisotropy and decreased processing speed in schizophrenia.

PMID: 30597424
Journal: JOURNAL OF PSYCHIATRIC RESEARCH
Year: 2019
Reference: J Psychiatr Res. 2019 Mar;110:74-82. doi: 10.1016/j.jpsychires.2018.12.021. Epub 2018 Dec 24.
Impact factor: 3.917
Publication type: Paper in international publication
Authors: Gas, Cinta, Canales-Rodriguez, Erick Jorge, Radua, Joaquim, Abasolo, Nerea, Cortes, Maria Jose, Salvado, Ester, Muntane, Gerard, Aleman-Gomez, Yasser, Julia, Toni, Marsal, Sara et al.
DOI: 10.1016/j.jpsychires.2018.12.021

Psychometric properties of the Spanish version of the once-daily Urticaria Activity Score (UAS) in patients with chronic spontaneous urticaria managed in clinical practice (the EVALUAS study).

PMID: 30704532
Journal: Health and Quality of Life Outcomes
Year: 2019
Reference: Health Qual Life Outcomes. 2019 Jan 31;17(1):23. doi: 10.1186/s12955-019-1087-z.
Impact factor: 2.318
Publication type: Paper in international publication
Authors: Ferrer, Marta, Jauregui, Ignacio, Gimenez-Arnau, Ana, Bartra, Joan, Labrador-Horrillo, Moises, de Frutos, Javier Ortiz, Silvestre, Juan Francisco, Sastre, Joaquin, Velasco, Manuel, Valero, Antonio et al.
DOI: 10.1186/s12955-019-1087-z

IgE-mediated sensitization to galactose-alpha-1,3-galactose (alpha-gal) in urticaria and anaphylaxis in Spain: geographical variations and risk factors.

PMID: 30676319
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2019
Reference: J Investig Allergol Clin Immunol. 2019;29(6):436-443. doi: 10.18176/jiaci.0373. Epub 2019 Jan 24.
Impact factor: 3.802
Publication type: Paper in international publication
Authors: Mateo-Borrega, M B, Garcia, B, Hernando Larramendi, C, Azofra, J, Gonzalez-Mancebo, E, Alvarado, M I, Nunez-Orjales, R, Dieguez, M C, Guilarte, M, Soriano-Galarraga, A M et al.
DOI: 10.18176/jiaci.0373

Blog

News

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.

The study showing how thrombocytopenia increases the risk of thrombosis in patients with antiphospholipid syndrome has been considered the best paper published in 2021.