About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.
PMID: 35396580 Journal: NATURE Year: 2022 Reference: Nature. 2022 Apr;604(7906):502-508. doi: 10.1038/s41586-022-04434-5. Epub 2022 Apr 8. Impact factor: 49.962 Publication type: Paper in international publication Authors: Fananas, Lourdes, Richards, Alexander L, Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen et al. DOI: 10.1038/s41586-022-04434-5
PMID: 34844023 Journal: Journal of Allergy and Clinical Immunology-In Practice Year: 2022 Reference: J Allergy Clin Immunol Pract. 2022 Apr;10(4):1020-1028. doi: 10.1016/j.jaip.2021.11.018. Epub 2021 Nov 26. Impact factor: 8.861 Publication type: Paper in international publication Authors: Garcia, M G, Laffond, E, Munoz-Bellido, F J, Nunez, R, Prior, N, Sala-Cunill, A, Saenz de San Pedro, B, Prieto-Garcia, A, Escudero, E, Castro, M et al. DOI: 10.1016/j.jaip.2021.11.018
PMID: 35385104 Journal: RHEUMATOLOGY Year: 2022 Reference: Rheumatology (Oxford). 2022 Apr 6. pii: 6564238. doi: 10.1093/rheumatology/keac205. Impact factor: 7.58 Publication type: Paper in international publication Authors: Takagi, Y, Retamozo, Soledad, Kvarnstrom, Marika, Sebastian, Agata, Atzeni, Fabiola, Giacomelli, Roberto, Carsons, Steven E, Kwok, Seung-Ki, Nakamura, Hideki, Fernandes Moca Trevisani, Virginia et al. DOI: 10.1093/rheumatology/keac205
PMID: 35351135 Journal: BMC Medicine Year: 2022 Reference: BMC Med. 2022 Mar 29;20(1):129. doi: 10.1186/s12916-022-02345-w. Impact factor: 8.775 Publication type: Paper in international publication Authors: Gallo, Monica Martinez, Arrese-Munoz, Iria, Gine, Anna, Diaz-Troyano, Noelia, Gabriel-Medina, Pablo, Riveiro-Barciela, Mar, Labrador-Horrillo, Moises, Martinez-Valle, Fernando, Montalva, Adrian Sanchez, Hernandez-Gonzalez, Manuel et al. DOI: 10.1186/s12916-022-02345-w
PMID: 34247244 Journal: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE Year: 2021 Reference: QJM. 2021 Dec 20;114(10):749. doi: 10.1093/qjmed/hcab187. Impact factor: 3.21 Publication type: Letter or abstract Authors: Selva-O'Callaghan, A, Pardos-Gea, J, Marques-Soares, J R et al. DOI: 10.1093/qjmed/hcab187
PMID: 35155485 Journal: Frontiers in Medicine Year: 2021 Reference: Front Med (Lausanne). 2022 Jan 27;8:808608. doi: 10.3389/fmed.2021.808608. eCollection 2021. Impact factor: 5.093 Publication type: Paper in international publication Authors: Saez, Luis, Pallares, Lucio, Velilla, Jose, Marin, Adela, Martinez-Lostao, Luis, Simeon, Carmen Pilar, Fanlo, Patricia, Gracia, Borja Del Carmelo et al. DOI: 10.3389/fmed.2021.808608
PMID: 34965883 Journal: Allergy Asthma and Clinical Immunology Year: 2021 Reference: Allergy Asthma Clin Immunol. 2021 Dec 29;17(1):137. doi: 10.1186/s13223-021-00641-3. Impact factor: 3.406 Publication type: Paper in international publication Authors: Guilarte, Mar, Sala-Cunill, Anna, Baeza, Maria Luisa, Cabanas, Rosario, Hernandez, Maria Dolores, Ibanez, Ethel, de Larramendi, Carlos Hernando, Lleonart, Ramon, Lobera, Teofilo, Marques, Luis et al. DOI: 10.1186/s13223-021-00641-3
PMID: 34943483 Journal: Diagnostics Year: 2021 Reference: Diagnostics (Basel). 2021 Nov 30;11(12). pii: diagnostics11122246. doi: 10.3390/diagnostics11122246. Impact factor: 3.706 Publication type: Paper in international publication Authors: Mahler, Michael, Malyavantham, Kishore, Seaman, Andrea, Bentow, Chelsea, Anunciacion-Llunell, Ariadna, Sanz-Martinez, Maria Teresa, Vinas-Gimenez, Laura, Selva-O'Callaghan, Albert et al. DOI: 10.3390/diagnostics11122246
PMID: 32499909 Journal: Clinical and Translational Allergy Year: 2020 Reference: Clin Transl Allergy. 2020 May 27;10:16. doi: 10.1186/s13601-020-00323-0. eCollection 2020. Impact factor: 5.129 Publication type: Review in international publication Authors: Laune, Daniel, Bousquet, Jean, Anto, Josep M, Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi A, Blain, Hubert, Canonica, G Walter et al. DOI: 10.1186/s13601-020-00323-0
PMID: 32500148 Journal: RHEUMATOLOGY Year: 2020 Reference: Rheumatology (Oxford). 2020 Dec 1;59(12):3853-3857. doi: 10.1093/rheumatology/keaa180. Impact factor: 5.606 Publication type: Paper in international publication Authors: Moreno, Pedro J, Milisenda, Jose C, Selva O'Callaghan, Albert, Grau, Josep M, Padrosa, Joan, Antoniol, Maria N et al. DOI: 10.1093/rheumatology/keaa180
PMID: 32455633 Journal: Journal of Clinical Medicine Year: 2020 Reference: J Clin Med. 2020 May 21;9(5). pii: jcm9051557. doi: 10.3390/jcm9051557. Impact factor: 3.303 Publication type: Review in international publication Authors: Wang-Steverding, Xia, Bakken, Inger Johanne, Ivanovs, Andrejs, Castro-Marrero, Jesus, Nacul, Luis, Alegre, Jose, Zalewski, Pawel, Slomko, Joanna, Strand, Elin Bolle, Pheby, Derek et al. DOI: 10.3390/jcm9051557
PMID: 32424615 Journal: RHEUMATOLOGY INTERNATIONAL Year: 2020 Reference: Rheumatol Int. 2020 Sep;40(9):1473-1480. doi: 10.1007/s00296-020-04598-1. Epub 2020 May 18. Impact factor: 1.984 Publication type: Paper in international publication Authors: Marsal, Sara, Forger, Frauke, Ostensen, Monika, Julia, Antonio, Micu, Mihaela C, Pluma, Andrea et al. DOI: 10.1007/s00296-020-04598-1
PMID: 31522232 Journal: RHEUMATOLOGY INTERNATIONAL Year: 2019 Reference: Rheumatol Int. 2019 Nov;39(11):1875-1882. doi: 10.1007/s00296-019-04436-z. Epub 2019 Sep 14. Impact factor: 2.2 Publication type: Paper in international publication Authors: Castellvi, Ivan, Eguiluz, Saioa, Escudero-Contreras, Alejandro, Rios, Juan Jose, Calvo-Alen, Jaime, Callejas-Rubio, Jose Luis, De la Puente, Carlos, Simeon, Carmen Pilar, Narvaez, Francisco Javier, Espinosa, Gerard et al. DOI: 10.1007/s00296-019-04436-z
PMID: 31516692 Journal: Clinical and Translational Allergy Year: 2019 Reference: Clin Transl Allergy. 2019 Sep 9;9:44. doi: 10.1186/s13601-019-0279-2. eCollection 2019. Impact factor: 4.232 Publication type: Review in international publication Authors: Dokic, Dejand, Fonseca, Joao A, Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L T T, Larenas-Linnemann, Desiree et al. DOI: 10.1186/s13601-019-0279-2
PMID: 31486117 Journal: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Year: 2019 Reference: Br J Clin Pharmacol. 2019 Nov;85(11):2460-2463. doi: 10.1111/bcp.14089. Epub 2019 Sep 4. Impact factor: 3.867 Publication type: Paper in international publication Authors: de Mora, Fernando, Balsa, Alejandro, Cornide-Santos, Maria, Carrascosa, Jose-Manuel, Marsal, Sara, P Gisbert, Javier, Abad, Miguel-Angel, F Duarte, Rafael, Wiechmann, Michael, Martinez, Rafael et al. DOI: 10.1111/bcp.14089
PMID: 31464664 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2019 Reference: Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):97-106. Epub 2019 Aug 28. Impact factor: 3.238 Publication type: Paper in international publication Authors: Danda, Debashish, Praprotnik, Sonja, Kvarnstrom, Marika, Gerli, Roberto, Sebastian, Agata, Solans, Roser, Rischmueller, Maureen, Pasoto, Sandra G, Valim, Valeria, Nordmark, Gunnel et al. DOI:
PMID: 29732654 Journal: HAEMOPHILIA Year: 2018 Reference: Haemophilia. 2018 May;24(3):e163-e166. doi: 10.1111/hae.13499. Epub 2018 May 6. Impact factor: 2.768 Publication type: Review in international publication Authors: Pardos-Gea, J, Fernandez-Diaz, N, Parra, R, Cortina, V, Altisent, C et al. DOI: 10.1111/hae.13499
PMID: 29706127 Journal: AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS Year: 2018 Reference: Amyloid. 2018 Jun;25(2):109-114. doi: 10.1080/13506129.2018.1467313. Epub 2018 Apr 28. Impact factor: 4.048 Publication type: Paper in international publication Authors: Lorenzo-Bosquet, Carles, Mestre-Torres, Jaume, Solans-Laque, Roser, Fernandez-Codina, Andreu, Bujan-Rivas, Segundo, Castell-Conesa, Joan, Martinez-Valle, Fernando, Gironella, Mercedes, Cuberas-Borros, Gemma et al. DOI: 10.1080/13506129.2018.1467313
PMID: 29696075 Journal: Journal of Extracellular Vesicles Year: 2018 Reference: J Extracell Vesicles. 2018 Mar 22;7(1):1453730. doi: 10.1080/20013078.2018.1453730. eCollection 2018. Impact factor: 0 Publication type: Paper in international publication Authors: Zaragoza, Maria Cleofe, Martinez-Martinez, Alba, Blanco-Lopez, Maria Del Carmen, Alegre, Jose, Oliveira-Rodriguez, Myriam, Serrano-Pertierra, Esther, Castro-Marrero, Jesus et al. DOI: 10.1080/20013078.2018.1453730
PMID: 29632547 Journal: Allergy Asthma and Clinical Immunology Year: 2018 Reference: Allergy Asthma Clin Immunol. 2018 Apr 4;14:12. doi: 10.1186/s13223-018-0234-0. eCollection 2018. Impact factor: 2.051 Publication type: Review in national publication Authors: Tanno, Luciana Kase, Bierrenbach, Ana Luiza, Simons, F Estelle R, Cardona, Victoria, Thong, Bernard Yu-Hor, Molinari, Nicolas, Calderon, Moises A, Worm, Margitta, Papadopoulos, Nikolaos G, Casale, Thomas et al. DOI: 10.1186/s13223-018-0234-0
PMID: 28856836 Journal: CLINICAL AND EXPERIMENTAL ALLERGY Year: 2017 Reference: Clin Exp Allergy. 2017 Sep;47(9):1108-1114. doi: 10.1111/cea.12973. Impact factor: 5.264 Publication type: Editorail in international publication Authors: Demoly, P, Tanno, L K, Simons, F E R, Sanchez-Borges, M, Cardona, V, Moon, H-B, Calderon, M A, Sisul, J C, Muraro, A, Casale, T et al. DOI: 10.1111/cea.12973
PMID: 28814775 Journal: Scientific Reports Year: 2017 Reference: Sci Rep. 2017 Aug 16;7(1):8453. doi: 10.1038/s41598-017-09164-7. Impact factor: 4.259 Publication type: Paper in international publication Authors: Castaneda, Santos, Alegre-Sancho, Juan-Jose, Martin, Javier, Gonzalez-Escribano, Maria Francisca, Camps, Teresa, Rodriguez-Rodriguez, Luis, Rodriguez-Carballeira, Monica, Fanlo, Patricia, Burillo-Sanz, Sergio, Montes-Cano, Marco-Antonio et al. DOI: 10.1038/s41598-017-09164-7
PMID: 28793302 Journal: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY Year: 2017 Reference: Int Arch Allergy Immunol. 2017;173(3):171-177. doi: 10.1159/000477566. Epub 2017 Aug 9. Impact factor: 2.72 Publication type: Paper in international publication Authors: Cardona, Victoria, Ferre-Ybarz, Laia, Guilarte, Mar, Moreno-Perez, Nuria, Gomez-Galan, Catalina, Alcoceba-Borras, Eva, Delavalle, Maria Belen, Garriga-Baraut, Teresa et al. DOI: 10.1159/000477566
PMID: 28798744 Journal: Frontiers in Immunology Year: 2017 Reference: Front Immunol. 2017 Jul 26;8:846. doi: 10.3389/fimmu.2017.00846. eCollection 2017. Impact factor: 6.429 Publication type: Review in international publication Authors: Guilarte, Mar, Sala-Cunill, Anna, Luengo, Olga, Labrador-Horrillo, Moises, Cardona, Victoria et al. DOI: 10.3389/fimmu.2017.00846
PMID: 27091480 Journal: IMMUNOLOGY LETTERS Year: 2016 Reference: Immunol Lett. 2016 Jun;174:19-22. doi: 10.1016/j.imlet.2016.04.011. Epub 2016 Apr 14. Impact factor: 2.483 Publication type: Paper in international publication Authors: Franco-Jarava, Clara, Colobran, Roger, Mestre-Torres, Jaume, Vargas, Victor, Pujol-Borrell, Ricardo, Hernandez-Gonzalez, Manuel et al. DOI: 10.1016/j.imlet.2016.04.011
PMID: 26096669 Journal: NEUROLOGIA Year: 2016 Reference: Neurologia. 2016 May;31(4):231-238. doi: 10.1016/j.nrl.2015.05.002. Epub 2015 Jun 19. Impact factor: 1.79 Publication type: Paper in international publication Authors: Saez-Francas, N, Marti Andres, G, Ramirez, N, de Fabregues, O, Alvarez-Sabin, J, Hernandez-Vara, J, Casas, M et al. DOI: 10.1016/j.nrl.2015.05.002
PMID: 25978920 Journal: MEDICAL CLINICS OF NORTH AMERICA Year: 2016 Reference: Med Clin (Barc). 2016 Jan 1;146(1):8-15. doi: 10.1016/j.medcli.2015.02.026. Epub 2015 May 12. Impact factor: 2.333 Publication type: Paper in national publication Authors: Vergara-Gomez, Merce, Simeon-Aznar, Carmen Pilar, Fonollosa-Pla, Vicente, Jove-Buxeda, Esther, Oliva-Morera, Juan, Tolosa-Vilella, Carles, Amengual-Guedan, Maria Jose, Mari-Alfonso, Begona et al. DOI: 10.1016/j.medcli.2015.02.026
PMID: 26944419 Journal: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Year: 2016 Reference: Eur J Clin Pharmacol. 2016 Jun;72(6):755-64. doi: 10.1007/s00228-016-2032-2. Epub 2016 Mar 5. Impact factor: 2.71 Publication type: Paper in international publication Authors: Vidal, Xavier, Agusti, Antonia, Vallano, Antoni, Formiga, Francesc, Moyano, Antonio Fernandez, Garcia, Juana, Lopez-Soto, Alfonso, Ramirez-Duque, Nieves, Torres, Olga H, Barbe, Jose et al. DOI: 10.1007/s00228-016-2032-2
PMID: 25240785 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2015 Reference: J Allergy Clin Immunol. 2015 Apr;135(4):1031-43.e6. doi: 10.1016/j.jaci.2014.07.057. Epub 2014 Sep 18. Impact factor: 11.476 Publication type: Paper in international publication Authors: Cumin, Frederic, Sala-Cunill, Anna, Bjorkqvist, Jenny, Senter, Riccardo, Guilarte, Mar, Cardona, Victoria, Labrador, Moises, Nickel, Katrin F, Butler, Lynn, Luengo, Olga et al. DOI: 10.1016/j.jaci.2014.07.057
PMID: 25569641 Journal: MEDICINE Year: 2015 Reference: Medicine (Baltimore). 2015 Jan;94(1):e267. doi: 10.1097/MD.0000000000000267. Impact factor: 5.723 Publication type: Paper in international publication Authors: Erausquin, Celia, Rua-Figueroa, Inigo, Richi, Patricia, Lopez-Longo, Francisco Javier, Galindo, Maria, Calvo-Alen, Jaime, Olive-Marques, Alejandro, Loza-Santamaria, Estibaliz, Vicente, Sabina Perez, Bonilla, Gema et al. DOI: 10.1097/MD.0000000000000267
PMID: 25557950 Journal: GASTROENTEROLOGY Year: 2015 Reference: Gastroenterology. 2015 Apr;148(4):794-805. doi: 10.1053/j.gastro.2014.12.030. Epub 2014 Dec 31. Impact factor: 16.716 Publication type: Paper in international publication Authors: Alonso, Arnald, Domenech, Eugeni, Julia, Antonio, Panes, Julian, Garcia-Sanchez, Valle, Mateu, Pilar Nos, Gutierrez, Ana, Gomollon, Fernando, Mendoza, Juan L, Garcia-Planella, Esther et al. DOI: 10.1053/j.gastro.2014.12.030
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The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.
It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.
