About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.
PMID: 35349419 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2022 Reference: Clin Exp Rheumatol. 2022 May;40 Suppl 134(5):3-11. doi: 10.55563/clinexprheumatol/d2qz38. Epub 2022 Mar 29. Impact factor: 4.473 Publication type: Review in international publication Authors: Cornet, Alain, Talarico, Rosaria, Aguilera, Silvia, Alexander, Tobias, Amoura, Zahir, Andersen, Janette, Arnaud, Laurent, Avcin, Tadej, Marsal Barril, Sara, Beretta, Lorenzo et al. DOI:
PMID: 35344295 Journal: Clinical and Translational Allergy Year: 2022 Reference: Clin Transl Allergy. 2022 Mar;12(3):e12128. doi: 10.1002/clt2.12128. Impact factor: 5.871 Publication type: Paper in international publication Authors: Klimek, Ludger, Sousa-Pinto, Bernardo, Azevedo, Luis Filipe, Sa-Sousa, Ana, Vieira, Rafael Jose, Amaral, Rita, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Desiree E et al. DOI: 10.1002/clt2.12128
PMID: 34672126 Journal: Arthritis & Rheumatology Year: 2022 Reference: Arthritis Rheumatol. 2022 Apr;74(4):692-699. doi: 10.1002/art.41999. Epub 2022 Feb 14. Impact factor: 10.995 Publication type: Paper in international publication Authors: Ionescu, Daniela, Penin-Franch, Alejandro, Mensa-Vilaro, Anna, Castillo, Paola, Hurtado-Navarro, Laura, Molina-Lopez, Cristina, Romero-Chala, Silvia, Plaza, Susana, Fabregat, Virginia, Bujan, Segundo et al. DOI: 10.1002/art.41999
PMID: 35293988 Journal: RHEUMATOLOGY Year: 2022 Reference: Rheumatology (Oxford). 2022 Mar 16. pii: 6549521. doi: 10.1093/rheumatology/keac162. Impact factor: 7.58 Publication type: Paper in international publication Authors: Di Matteo, Andrea, Cipolletta, Edoardo, Destro Castaniti, Giulia Maria, Smerilli, Gianluca, Airoldi, Carla, Aydin, Sibel Zehra, Becciolini, Andrea, Bonfiglioli, Karina, Bruns, Alessandra, Carrara, Greta et al. DOI: 10.1093/rheumatology/keac162
PMID: 34944673 Journal: Biomedicines Year: 2021 Reference: Biomedicines. 2021 Dec 7;9(12). pii: biomedicines9121857. doi: 10.3390/biomedicines9121857. Impact factor: 6.081 Publication type: Paper in international publication Authors: Domingo, Sandra, Sole, Cristina, Moline, Teresa, Ferrer, Berta, Cortes-Hernandez, Josefina et al. DOI: 10.3390/biomedicines9121857
PMID: 34936544 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2021 Reference: Clin Exp Rheumatol. 2021 Dec 16. pii: 17754. Impact factor: 4.473 Publication type: Paper in international publication Authors: Gracia Tello, Borja, Ramos Ibanez, Eduardo, Fanlo Mateo, Patricia, Saez Comet, Luis, Martinez Robles, Elena, Rios Blanco, Juan Jose, Mari Alfonso, Begona, Espinosa Garriga, Gerard, Todoli Parra, Jose, Ortego Centeno, Norberto et al. DOI:
PMID: 34932829 Journal: ALLERGY Year: 2021 Reference: Allergy. 2021 Dec 21. doi: 10.1111/all.15199. Impact factor: 13.146 Publication type: Paper in international publication Authors: Agache, Ioana, Sousa-Pinto, Bernardo, Filipe Azevedo, Luis, Jutel, Marek, Gemicioglu, Bilun, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan Carlos, Kvedariene, Violeta, Kuna, Piotr et al. DOI: 10.1111/all.15199
PMID: 34919044 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2021 Reference: Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):166-174. Epub 2021 Dec 16. Impact factor: 4.473 Publication type: Paper in international publication Authors: Sandhya, Pulukool, Retamozo, Soledad, Acar-Denizli, Nihan, Horvath, Ildiko Fanny, Ng, Wan-Fai, Rasmussen, Astrid, Dong, Xu, Li, Xiaomei, Baldini, Chiara, Olsson, Peter et al. DOI:
PMID: 32425260 Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM Year: 2020 Reference: Semin Arthritis Rheum. 2020 May 16. doi: 10.1016/j.semarthrit.2020.05.001. Impact factor: 4.751 Publication type: Paper in international publication Authors: Moreno, EstefanÃa, Michelena, Xabier, Borrell, Helena, López-Corbeto, Mireia, López-Lasanta, MarÃa, Serrat, Mayte, Espartal, Esther, Antón, Susana, Añez, Gustavo Adolfo, Caparrós-Ruiz, Raquel et al. DOI: 10.1016/j.semarthrit.2020.05.001
PMID: 32393363 Journal: GENOME BIOLOGY Year: 2020 Reference: Genome Biol. 2020 May 11;21(1):112. doi: 10.1186/s13059-020-02032-0. Impact factor: 10.806 Publication type: Paper in international publication Authors: Moutinho, Catia, Kulis, Marta, Palau, Nuria, Marchese, Domenica, Rodriguez-Ubreva, Javier, Ballestar, Esteban, Rodriguez-Esteban, Gustavo, Marsal, Sara, Aymerich, Marta, Colomer, Dolors et al. DOI: 10.1186/s13059-020-02032-0
PMID: 32376394 Journal: AUTOIMMUNITY REVIEWS Year: 2020 Reference: Autoimmun Rev. 2020 Jul;19(7):102569. doi: 10.1016/j.autrev.2020.102569. Epub 2020 May 3. Impact factor: 7.767 Publication type: Review in international publication Authors: Alijotas-Reig, Jaume, Esteve-Valverde, Enrique, Belizna, Cristina, Selva-O'Callaghan, Albert, Pardos-Gea, Josep, Quintana, Angela, Mekinian, Arsene, Anunciacion-Lunell, Ariadna, Miro-Mur, Francesc et al. DOI: 10.1016/j.autrev.2020.102569
PMID: 31584692 Journal: ALLERGY Year: 2020 Reference: Allergy. 2020 Apr;75(4):901-910. doi: 10.1111/all.14069. Epub 2019 Oct 21. Impact factor: 8.706 Publication type: Paper in international publication Authors: Kraft, M, Knop, M, Renaudin, J M, Scherer Hofmeier, K, Pfohler, C, Bilo, M B, Lang, R, Treudler, R, Wagner, N, Spindler, T et al. DOI: 10.1111/all.14069
PMID: 31443138 Journal: Revista Alergia Mexico Year: 2019 Reference: Rev Alerg Mex. 2019;66 Suppl 2:1-39. doi: 10.29262/ram.v66i6.588. Impact factor: 0 Publication type: Paper in international publication Authors: Fernandez-Rivas, Montserrat, Gangoiti, Iker, Guardia-Martinez, Pedro, Herranz-Sanz, Miguel Angel, Julia-Benito, Juan Carlos, Lobera-Labairu, Teofilo, Praena-Crespo, Manuel, Prieto-Romo, Jose Ignacio, Sanchez-Salguero, Carlos, Sanchez-Gonzalez, Jose Ignacio et al. DOI: 10.29262/ram.v66i6.588
PMID: 31445223 Journal: Journal of Allergy and Clinical Immunology-In Practice Year: 2019 Reference: J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2511-2523. doi: 10.1016/j.jaip.2019.07.044. Epub 2019 Aug 21. Impact factor: 7.55 Publication type: Paper in international publication Authors: Bousquet, Jean, Ansotegui, Ignacio J, Anto, Josep M, Arnavielhe, Sylvie, Bachert, Claus, Basagana, Xavier, Bedard, Annabelle, Bedbrook, Anna, Bonini, Matteo, Bosnic-Anticevich, Sinthia et al. DOI: 10.1016/j.jaip.2019.07.044
PMID: 31434690 Journal: NEUROLOGY Year: 2019 Reference: Neurology. 2019 Sep 17;93(12):e1193-e1204. doi: 10.1212/WNL.0000000000008128. Epub 2019 Aug 21. Impact factor: 8.689 Publication type: Paper in international publication Authors: Paik, Julie, Albayda, Jemima, Christopher-Stine, Lisa, Lloyd, Thomas E, Corse, Andrea M, Mammen, Andrew L, Selva-O'Callaghan, Albert, Grau-Junyent, Josep M, Milisenda, Jose C, Miller, Frederick W et al. DOI: 10.1212/WNL.0000000000008128
PMID: 31406567 Journal: Clinical and Translational Allergy Year: 2019 Reference: Clin Transl Allergy. 2019 Aug 6;9:39. doi: 10.1186/s13601-019-0276-5. eCollection 2019. Impact factor: 4.232 Publication type: Paper in international publication Authors: Ana, Beristain, Montoro, Javier, Moreno, Carmen, Moya, Carmen, Pamies, Rafael, Perez-Pastor, Laura, Quinones, Dolores, Raducan, Isabella, Rodriguez, Fernando, Rodriguez-Pacheco, Ramon et al. DOI: 10.1186/s13601-019-0276-5
PMID: 29635517 Journal: RHEUMATOLOGY Year: 2018 Reference: Rheumatology. 2018 Jul 1;57(7):1299-304. doi: 10.1093/rheumatology/key090. Impact factor: 5.245 Publication type: Paper in international publication Authors: Votta, Bart J, Wang, Lin, Rose, Carlos D, Foley, Kevin P, Anton, Jordi, Bader-Meunier, Brigitte, Brissaud, Philippe, Chedeville, Gaelle, Cimaz, Rolando, Fernandez-Martin, Jorge et al. DOI: 10.1093/rheumatology/key090
PMID: 29602570 Journal: OPHTHALMOLOGY Year: 2018 Reference: Ophthalmology. 2018 Sep;125(9):1444-1451. doi: 10.1016/j.ophtha.2018.02.020. Epub 2018 Mar 27. Impact factor: 7.479 Publication type: Paper in international publication Authors: Pato, Esperanza, Aurrecoechea, Elena, Caracuel, Miguel A, Gamero, Fernando, Minguez, Enrique, Carrasco-Cubero, Carmen, Olive, Alejandro, Vazquez, Julio, Ruiz-Moreno, Oscar, Manero, Javier et al. DOI: 10.1016/j.ophtha.2018.02.020
PMID: 29183646 Journal: Journal of Cardiology Year: 2018 Reference: J Cardiol. 2018 May;71(5):505-512. doi: 10.1016/j.jjcc.2017.10.019. Epub 2017 Nov 26. Impact factor: 2.918 Publication type: Paper in international publication Authors: Perez-Rodon, Jordi, Galve, Enrique, Perez-Bocanegra, Carmen, Soriano-Sanchez, Teresa, Recio-Iglesias, Jesus, Domingo-Baldrich, Eva, Alzola-Guevara, Mila, Ferreira-Gonzalez, Ignacio, Marsal, Josep Ramon, Ribera-Sole, Aida et al. DOI: 10.1016/j.jjcc.2017.10.019
PMID: 29572561 Journal: ANNALS OF HEMATOLOGY Year: 2018 Reference: Ann Hematol. 2018 Aug;97(8):1349-1356. doi: 10.1007/s00277-018-3302-0. Epub 2018 Mar 23. Impact factor: 2.845 Publication type: Paper in international publication Authors: Montoro, Julia, Gallur, Laura, Merchan, Brayan, Molero, Antonieta, Roldan, Elisa, Martinez-Valle, Ferran, Villacampa, Guillermo, Navarrete, Mayda, Ortega, Margarita, Castellvi, Josep et al. DOI: 10.1007/s00277-018-3302-0
PMID: 28779496 Journal: PEDIATRIC ALLERGY AND IMMUNOLOGY Year: 2017 Reference: Pediatr Allergy Immunol. 2017 Nov;28(7):628-640. doi: 10.1111/pai.12762. Epub 2017 Oct 10. Impact factor: 3.775 Publication type: Review in national publication Authors: Storsaeter, Jann, Nilsson, Lennart, Brockow, Knut, Alm, Johan, Cardona, Victoria, Caubet, Jean-Christoph, Gomes, Eva, Jenmalm, Maria C, Lau, Susanne, Netterlid, Eva et al. DOI: 10.1111/pai.12762
PMID: 28738907 Journal: ARTHRITIS RESEARCH & THERAPY Year: 2017 Reference: Arthritis Res Ther. 2017 Jul 24;19(1):174. doi: 10.1186/s13075-017-1383-0. Impact factor: 4.121 Publication type: Paper in international publication Authors: Suarez-Calvet, Xavier, Gallardo, Eduard, Pinal-Fernandez, Iago, De Luna, Noemi, Lleixa, Cinta, Diaz-Manera, Jordi, Rojas-Garcia, Ricardo, Castellvi, Ivan, Martinez, M Angeles, Grau, Josep M et al. DOI: 10.1186/s13075-017-1383-0
PMID: 28658137 Journal: MEDICINE Year: 2017 Reference: Medicine (Baltimore). 2017 Jun;96(26):e7308. doi: 10.1097/MD.0000000000007308. Impact factor: 1.803 Publication type: Paper in international publication Authors: Blanco, Francisco, Fernandez-Gutierrez, Benjamin, Perrotti, Pedro P, Gisbert, Javier P, Domenech, Eugeni, Fernandez-Nebro, Antonio, Canete, Juan D, Ferrandiz, Carlos, Tornero, Jesus, Garcia-Sanchez, Valle et al. DOI: 10.1097/MD.0000000000007308
PMID: 28658725 Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexi Year: 2017 Reference: Rev Alerg Mex. 2017 Apr-Jun;64(2):171-177. Impact factor: 0 Publication type: Paper in national publication Authors: Cardona, Victoria, Alvarez-Perea, Alberto, Ansotegui, Ignacio J, Arias-Cruz, Alfredo, Gonzalez-Diaz, Sandra Nora, Latour-Staffeld, Patricia, Ivancevich, Juan Carlos, Sanchez-Borges, Mario, Serrano, Carlos, Sole, Dirceu et al. DOI:
PMID: 26190206 Journal: Reumatologia clinica Year: 2016 Reference: Reumatol Clin. 2016 Mar-Apr;12(2):72-77. doi: 10.1016/j.reuma.2015.05.007. Epub 2015 Jul 17. Impact factor: 0 Publication type: Paper in national publication Authors: Faro, Monica, Saez-Francas, Naia, Castro-Marrero, Jesus, Aliste, Luisa, Fernandez de Sevilla, Tomas, Alegre, Jose et al. DOI: 10.1016/j.reuma.2015.05.007
PMID: 27033432 Journal: MEDICAL CLINICS OF NORTH AMERICA Year: 2016 Reference: Med Clin (Barc). 2016 Oct 7;147(7):313-5. doi: 10.1016/j.medcli.2016.02.024. Epub 2016 Mar 28. Impact factor: 2.333 Publication type: Paper in international publication Authors: Cardellach, Francesc, Vilardell, Miquel, Pujol, Ramon et al. DOI: 10.1016/j.medcli.2016.02.024
PMID: 27007234 Journal: JAMA Psychiatry Year: 2016 Reference: JAMA Psychiatry. 2016 May 1;73(5):497-505. doi: 10.1001/jamapsychiatry.2016.0129. Impact factor: 14.417 Publication type: Paper in international publication Authors: Georgieva, Lyudmila, McGrath, John J, Mills, Melinda C, Wray, Naomi R, Lee, S Hong, Andreassen, Ole A, Bramon, Elvira, Bruggeman, Richard, Buxbaum, Joseph D, Cairns, Murray J et al. DOI: 10.1001/jamapsychiatry.2016.0129
PMID: 26983453 Journal: RHEUMATOLOGY Year: 2016 Reference: Rheumatology (Oxford). 2016 Jun;55(6):1106-11. doi: 10.1093/rheumatology/kew035. Epub 2016 Mar 15. Impact factor: 4.524 Publication type: Paper in international publication Authors: Julia, Antonio, Gonzalez, Isidoro, Fernandez-Nebro, Antonio, Blanco, Francisco, Rodriguez, Luis, Gonzalez, Antonio, Canete, Juan D, Maymo, Joan, Alperi-Lopez, Mercedes, Olive, Alejandro et al. DOI: 10.1093/rheumatology/kew035
PMID: 25712812 Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM Year: 2015 Reference: Semin Arthritis Rheum. 2015 Jun;44(6):672-9. doi: 10.1016/j.semarthrit.2015.01.006. Epub 2015 Jan 23. Impact factor: 3.925 Publication type: Paper in international publication Authors: Vilardell-Tarres, Miquel, Ordi-Ros, Josep, Egri, Natalia, Cortes-Hernandez, Josefina et al. DOI: 10.1016/j.semarthrit.2015.01.006
PMID: 25812543 Journal: ACTAS ESPANOLAS DE PSIQUIATRIA Year: 2015 Reference: Actas Esp Psiquiatr. 2015 Mar-Apr;43(2):58-65. Epub 2015 Mar 1. Impact factor: 1.2 Publication type: Paper in national publication Authors: Saez-Francas, Naia, Valero, Sergi, Alegre, Jose, Casas, Miguel, Calvo, Natalia et al. DOI:
PMID: 26005883 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2015 Reference: Clin Exp Rheumatol. 2015 Nov-Dec;33(6 Suppl 94):S36-9. Epub 2015 May 25. Impact factor: 2.724 Publication type: Paper in international publication Authors: Espinosa, Gerard, Ortiz-Fernandez, Lourdes, Garcia-Lozano, Jose Raul, Montes-Cano, Marco Antonio, Conde-Jaldon, Marta, Ortego-Centeno, Norberto, Garcia-Hernandez, Francisco Jose, Julia, Maria Rosa, Blanco, Ricardo, Barnosi-Marin, Ana Celia et al. DOI:
PMID: 26040904 Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION Year: 2015 Reference: Nephrol Dial Transplant. 2015 Sep;30(9):1488-96. doi: 10.1093/ndt/gfv128. Epub 2015 Jun 3. Impact factor: 3.577 Publication type: Paper in international publication Authors: Sole, Cristina, Cortes-Hernandez, Josefina, Felip, Maria L, Vidal, Marta, Ordi-Ros, Josep et al. DOI: 10.1093/ndt/gfv128
PMID: 24582949 Journal: PAIN Year: 2014 Reference: Pain. 2014 Jun;155(6):1102-9. doi: 10.1016/j.pain.2014.02.016. Epub 2014 Feb 26. Impact factor: 5.836 Publication type: Paper in international publication Authors: Docampo, Elisa, Escaramis, Georgia, Gratacos, Monica, Villatoro, Sergi, Puig, Anna, Kogevinas, Manolis, Carbonell, Jordi, Rivera, Javier, Vidal, Javier, Alegre, Jose et al. DOI: 10.1016/j.pain.2014.02.016
PMID: 24826505 Journal: Applied neuropsychology. Adult Year: 2014 Reference: Appl Neuropsychol Adult. 2014;21(2):120-7. doi: 10.1080/09084282.2013.771264. Epub 2013 Aug 13. Impact factor: 0.275 Publication type: Paper in international publication Authors: Santamarina-Perez, Pilar, Eiroa-Orosa, Francisco Jose, Rodriguez-Urrutia, Amanda, Qureshi, Adil, Alegre, Jose et al. DOI: 10.1080/09084282.2013.771264
PMID: 25196202 Journal: EUR J CLIN PHARMACOL Year: 2014 Reference: Eur J Clin Pharmacol. 2014 Nov;70(11):1385-93. doi: 10.1007/s00228-014-1746-2. Epub 2014 Sep 9. Impact factor: 2.697 Publication type: Paper in international publication Authors: Danes, I, Agusti, A, Vallano, A, Alerany, C, Martinez, J, Bosch, J A, Ferrer, A, Gratacos, L, Perez, A, Olmo, M et al. DOI: 10.1007/s00228-014-1746-2
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PMID: 22653399 Journal: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY Year: 2012 Reference: Int Arch Allergy Immunol. 2012;159(2):143-6. doi: 10.1159/000336388. Epub 2012 May 30. Impact factor: 2.403 Publication type: Paper in international publication Authors: , , , , , et al. DOI: 10.1159/000336388
PMID: 22658662 Journal: Reumatologia clinica Year: 2012 Reference: Reumatol Clin. 2012 Sep-Oct;8(5):259-62. Epub 2012 May 31. Impact factor: Publication type: Letter or abstract Authors: , , , , , et al. DOI: 10.1016/j.reuma.2012.03.007
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PMID: 22012429 Journal: GENES AND IMMUNITY Year: 2012 Reference: Genes Immun. 2012 Feb;13(2):191-6. doi: 10.1038/gene.2011.72. Epub 2011 Oct 20. Impact factor: 3.872 Publication type: Paper in international publication Authors: Carmona, F D, Broen, J C A, Simeon, C P, Vonk, M C, Carreira, P, Rios-Fernandez, R, Espinosa, G, Vicente-Rabaneda, E, Tolosa, C, Garcia-Hernandez, F J et al. DOI: 10.1038/gene.2011.72
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.
It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.
