Transfusional Medicine

We are dedicated to investigate transfusional activity, the alteration of erythrocytes during the conservation period and extracorporeal photoapheresis. We work on the molecular and serological characterization of blood group variants. In non-invasive fetal genotyping strategies due to blood group incompatibilities. We develop iPSC lines and produce in vitro erythrocytes with rare phenotypes.

We deepen in the knowledge of epidemiology and the detection of infectious agents relevant for safety of the products supplied by the Blood and Tissue Bank.

We investigate in clinical immunology and develop our own HLA and KIR typing protocols. We develop and incorporate new therapeutic applications in cell therapy including hematopoietic transplantation, cellular immunology and regenerative medicine.

We investigate the molecular mechanisms and genotype-phenotype correlation of coagulopathies, haemorrhagic diathesis and other associated congenital pathologies. We develop tools based on the new technologies of parallel massive sequencing with application to the molecular study, genetic counselling and prenatal diagnosis.

Team

Elisenda Farssac Busquets

Transfusional Medicine
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Enrich Rande, Emma

Postdoctoral researcher
Transfusional Medicine
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Julia Ayats Blanch

Predoctoral researcher
Transfusional Medicine
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Marina Rierola Carrera

Marta Guerrero Parés

Transfusional Medicine
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Martinez Raneque, Fran

Transfusional Medicine
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Elisenda Farssac Busquets

Transfusional Medicine
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Enrich Rande, Emma

Postdoctoral researcher
Transfusional Medicine
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Julia Ayats Blanch

Predoctoral researcher
Transfusional Medicine
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Marina Rierola Carrera

Marta Guerrero Parés

Transfusional Medicine
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Martinez Raneque, Fran

Transfusional Medicine
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Research lines

Immunohematology

Molecular and serological characterization of blood group variants. Non-invasive fetal genotyping strategies due to blood group incompatibilities. Development of iPSC lines and production of in vitro red blood cells with rare erythrocytic phenotypes.

PI: Muñiz Diaz, Eduardo

Researchers:

Nogués Gálvez, Núria

Canals Surís, Carme

González Santesteban, Cecilia

Miquel Serra, Eulàlia

IP: Immunohematologia

Transfusion and apheresis

Investigation in transfusional activity, the alteration of red blood cells during the conservation period and the usefulness of extracorporeal photoapheresis.

PI: Parra López, Rafael

Researchers in training

Rodríguez Aliberas, Marta

Fernández Sojo, Jesus

IP: Rafael Parra López

Projects

TISSUE ENGINEERING FOR THE IMPROVEMENT OF THE FETOSCOPIC REPAIR OF OPEN SPINAL NEURAL TUBE DEFECTS IN OVINE FETUSES (TISSUE-NTD)

IP: Nerea Maiz Elizaran
Collaborators: Ana Lain Fernandez, Margarita Codinach Creus, Silvia Arévalo Martínez, Pablo García Manau, Paula Garcia Aguilar, Susana Manrique Muñoz, Manuel López Paredes, Ester Del Barco Martínez, Erika Bonacina
Funding agency: Instituto de Salud Carlos III
Funding: 135520
Reference: PI20/00421
Duration: 01/01/2021 - 30/06/2025

Publications

Treatment of non-hypertrophic pseudoarthrosis of long bones with a Tissue Engineered Product loaded with autologous bone marrow-derived Mesenchymal Stromal Cells: Results from a phase IIa, prospective, randomized, parallel, pilot clinical trial comparing to iliac crest autograft.

PMID: 38797000
Journal: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Year: 2024
Reference: Injury. 2024 May 1;55(7):111596. doi: 10.1016/j.injury.2024.111596.
Impact factor:
Publication type: Paper in international publication
Authors: Chaverri, Daniel; Codinach, Margarita; Coll, Ruth; Gallardo-Villares, Santiago; Garcia-Lopez, Joan; Granell-Escobar, Fernando; Pinto, Javier A; Querol, Sergi; Rodriguez, Luciano; Vives, Joaquim et al.
DOI: 10.1016/j.injury.2024.111596

Correction: Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?

PMID: 38806675
Journal: BONE MARROW TRANSPLANTATION
Year: 2024
Reference: Bone Marrow Transplant. 2024 May 28. doi: 10.1038/s41409-024-02318-y.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Ancochea, Agueda; Azqueta, Carmen; Canals, Carme; Carreras, Enric; Castillo, Nerea; Codinach, Margarita; Diaz de Heredia, Cristina; Elorza, Izaskun; Fernandez-Sojo, Jesus; Ferra, Christelle et al.
DOI: 10.1038/s41409-024-02318-y

Quality and stability studies of red blood cell concentrates from umbilical cord blood compared to their adult counterparts.

PMID: 39133620
Journal: Blood Transfusion
Year: 2024
Reference: Blood Transfus. 2024 Aug 2. doi: 10.2450/BloodTransfus.761.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Eva; Aran, Gemma; Azqueta, Carmen; Codinach, Margarita; Farssac, Elisenda; Fernandez-Sojo, Jesus; Guitart, Mar; Madrigal, Alejandro; Martinez, Nuria; Martorell, Lluis et al.
DOI: 10.2450/BloodTransfus.761

Efficiency assessment of cord blood banking and compatibility with delayed cord clamping.

PMID: 39133625
Journal: Blood Transfusion
Year: 2024
Reference: Blood Transfus. 2024 Aug 5. doi: 10.2450/BloodTransfus.767.
Impact factor:
Publication type: Paper in international publication
Authors: Azqueta, Carmen; Buendia, Ana Garcia; Busquets, Elisenda Farssac; Fernandez-Sojo, Jesus; Ferrer, Patricia; Flores, Nerea Castillo; Manchanayake, Geethika S; Palomar, Gisela; Pelegay, Maria Jose; Querol, Sergio et al.
DOI: 10.2450/BloodTransfus.767

Impact of genetic structural variants in FXI deficiency: identification, accurate characterization and inferred mechanism by long-read sequencing.

PMID: 36940803
Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Year: 2023
Reference: J Thromb Haemost. 2023 Jul;21(7):1779-1788. doi: 10.1016/j.jtha.2023.03.009. Epub 2023 Mar 20.
Impact factor:
Publication type: Paper in international publication
Authors: Bravo-Perez, Carlos; Cifuentes, Rosa; Corral, Javier; Garrido-Rodriguez, Pedro; Llamas, Maria; Lozano, Maria Luisa; Martin-Fernandez, Laura; Minano, Antonia; Morena-Barrio, Belen de la; Morena-Barrio, Maria Eugenia de la et al.
DOI: 10.1016/j.jtha.2023.03.009

VHrare study: Prevalence, clinical features and management of severe rare bleeding disorders in a large cohort.

PMID: 37206292
Journal: EJHaem
Year: 2023
Reference: EJHaem. 2023 Mar 9;4(2):476-482. doi: 10.1002/jha2.664. eCollection 2023 May.
Impact factor:
Publication type: Review in international publication
Authors: Benitez Hidalgo, Olga; Comes Fernandez, Natalia; Comes Fernandez, Natalia; Corrrales Insa, Irene; Corrrales Insa, Irene; Cortina Giner, Vicente; Cortina Giner, Vicente; Fernandez-Caballero, Mariana; Fernandez-Caballero, Mariana; Juarez Gimenez, Juan Carlos et al.
DOI: 10.1002/jha2.664

The slowdown of new infections by human retroviruses has reached a plateau in Spain.

PMID: 37212269
Journal: JOURNAL OF MEDICAL VIROLOGY
Year: 2023
Reference: J Med Virol. 2023 May;95(5):e28779. doi: 10.1002/jmv.28779.
Impact factor:
Publication type: Review in international publication
Authors: Aguilera, Antonio; Ayerdi, Oscar; Benito, Rafael; Carrizo, Paula; de Mendoza, Carmen; Encinas, Begona; Fernandez-Ruiz, Mario; Gonzalez, Rocio; Liendo, Paloma; Miro, Elisenda et al.
DOI: 10.1002/jmv.28779

Quality by Design: Development of Safe and Efficacious Full-Thickness Acellular Dermal Matrix Based on EuroGTPII Methodologies.

PMID: 37425344
Journal: Therapeutics and Clinical Risk Management
Year: 2023
Reference: Ther Clin Risk Manag. 2023 Jul 4;19:567-578. doi: 10.2147/TCRM.S410574. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Castells-Sala, Cristina; Farinas, Oscar; Lopez-Chicon, Patricia; Perez, Maria Luisa; Perez, Maria Luisa; Piteira, Ana Rita; Tabera, Jaime; Vilarrodona, Anna et al.
DOI: 10.2147/TCRM.S410574

HTLV-1/2 Infection in Blood Donors from a Non-Endemic Area (Catalonia, Spain) between 2008 and 2017: A 10-Year Experience.

PMID: 36146780
Journal: Viruses-Basel
Year: 2022
Reference: Viruses. 2022 Sep 6;14(9). pii: v14091975. doi: 10.3390/v14091975.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Caballero, Estrella; Casamitjana, Natalia; Molina, Israel; Piron, Maria; Puig, Lluis; Salvador, Fernando; Sanchez-Montalva, Adrian; Sauleda, Silvia et al.
DOI: 10.3390/v14091975

Public Cord Blood Banks as a source of starting material for clinical grade HLA-homozygous induced pluripotent stem cells.

PMID: 35962457
Journal: Stem Cell Research & Therapy
Year: 2022
Reference: Stem Cell Res Ther. 2022 Aug 12;13(1):408. doi: 10.1186/s13287-022-02961-6.
Impact factor:
Publication type: Paper in international publication
Authors: Alenda, Raquel; Alvarez-Palomo, Belen; Arbona, Cristina; Codinach, Margarita; Cuellar, Leopoldo; Fuste, Cristina; Hernandez-Maraver, Dolores; Ponce Verdugo, Laura; Querol, Sergi; Raya, Angel et al.
DOI: 10.1186/s13287-022-02961-6

Seminal Microbiota of Idiopathic Infertile Patients and Its Relationship With Sperm DNA Integrity.

PMID: 35837328
Journal: Frontiers in Cell and Developmental Biology
Year: 2022
Reference: Front Cell Dev Biol. 2022 Jun 28;10:937157. doi: 10.3389/fcell.2022.937157. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Benet, Jordi; Castel, Ana Belen; Closa, Laia; Del Rey, Javier; Garcia-Martinez, Iris; Garcia-Segura, Sergio; Hobeich, Carlos; Oliver-Bonet, Maria; Ribas-Maynou, Jordi; Vidal, Francisco et al.
DOI: 10.3389/fcell.2022.937157

Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations.

PMID: 35805133
Journal: Cells
Year: 2022
Reference: Cells. 2022 Jun 28;11(13). pii: cells11132046. doi: 10.3390/cells11132046.
Impact factor:
Publication type: Paper in international publication
Authors: Albert-Bayo, Merce; Alonso-Cotoner, Carmen; Azpiroz, Fernando; Exposito, Elba; Fortea, Marina; Ganda Mall, John-Peter; Gonzalez-Castro, Ana M; Guagnozzi, Danila; Lobo, Beatriz; Martinez, Cristina et al.
DOI: 10.3390/cells11132046

Type 2N VWD: Conclusions from the Spanish PCM-EVW-ES project.

PMID: 34494337
Journal: HAEMOPHILIA
Year: 2021
Reference: Haemophilia. 2021 Nov;27(6):1007-1021. doi: 10.1111/hae.14405. Epub 2021 Sep 7.
Impact factor:
Publication type: Paper in international publication
Authors: Altisent, Carmen; Batlle, Fernando; Batlle, Javier; Bonanad, Santiago; Borras, Nina; Cid, Ana Rosa; Corrales, Irene; Fontanes, Emilia; Garcia-Martinez, Iris; Herrero, Sonia et al.
DOI: 10.1111/hae.14405

Plasmapheresis for the Treatment of Acute Pancreatitis due to Severe Hypertriglyceridemia.

PMID: 33232960
Journal: BLOOD PURIFICATION
Year: 2021
Reference: Blood Purif. 2021;50(4-5):572-574. doi: 10.1159/000510647. Epub 2020 Nov 24.
Impact factor:
Publication type: Letter or abstract
Authors: Chiscano-Camon, Luis Silvestre; Ferrer, Ricard; Palmada, Clara; Pons, Veronica; Ruiz-Rodriguez, Juan Carlos et al.
DOI: 10.1159/000510647

Earth: the planet of the annexins.

PMID: 34274051
Journal: Clinica e investigacion en arteriosclerosis : publ
Year: 2021
Reference: Clin Investig Arterioscler. 2021 Jul-Aug;33(4):195-197. doi: 10.1016/j.arteri.2021.06.001.
Impact factor:
Publication type: Editorial in national publication
Authors: Corrales, Irene; Martinez-Gonzalez, Jose et al.
DOI: 10.1016/j.arteri.2021.06.001

Partial restoration of immune response in Hepatitis C patients after viral clearance by direct-acting antiviral therapy.

PMID: 34242330
Journal: PLoS One
Year: 2021
Reference: PLoS One. 2021 Jul 9;16(7):e0254243. doi: 10.1371/journal.pone.0254243. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Costafreda, Maria Isabel; Esteban, Juan Ignacio; Gabriel-Medina, Pablo; Guerrero-Murillo, Mercedes; Llorens-Revull, Meritxell; Perales, Celia; Piriz-Ruzo, Sofia; Quer, Josep; Rico, Angie et al.
DOI: 10.1371/journal.pone.0254243

Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity.

PMID: 32868394
Journal: Journal for ImmunoTherapy of Cancer
Year: 2020
Reference: J Immunother Cancer. 2020 Aug;8(2). pii: jitc-2020-001419. doi: 10.1136/jitc-2020-001419.
Impact factor:
Publication type: Paper in international publication
Authors: Camos, Mireia; Delgado, Mario; Fuster, Jose Luis; Juan, Manel; Menendez, Pablo; Querol, Sergi; Romecin, Paola Alejandra; Vinyoles, Meritxell; Zanetti, Samanta Romina et al.
DOI: 10.1136/jitc-2020-001419

RH genotyping by nonspecific quantitative next-generation sequencing.

PMID: 32871036
Journal: TRANSFUSION
Year: 2020
Reference: Transfusion. 2020 Nov;60(11):2691-2701. doi: 10.1111/trf.16034. Epub 2020 Sep 1.
Impact factor:
Publication type: Paper in international publication
Authors: Apraiz, Izaskun; Arteta, David; Fennell, Katie; Gonzalez, Cecilia; Nogues, Nuria; Ochoa-Garay, Gorka; Stef, Marianne et al.
DOI: 10.1111/trf.16034

IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8(+) T-cell responses.

PMID: 32923117
Journal: OncoImmunology
Year: 2020
Reference: Oncoimmunology. 2020 May 12;9(1):1758606. doi: 10.1080/2162402X.2020.1758606.
Impact factor:
Publication type: Paper in international publication
Authors: Couillin, Isabelle; Dadaglio, Gilles; Fayolle, Catherine; Leclerc, Claude; Oberkampf, Marine; Rosenbaum, Pierre; Rudilla, Francesc; Tang, Alexandre; Torheim, Eirik A et al.
DOI: 10.1080/2162402X.2020.1758606

Multi-laboratory assay for harmonization of enumeration of viable CD34+ and CD45+ cells in frozen cord blood units.

PMID: 31883947
Journal: CYTOTHERAPY
Year: 2020
Reference: Cytotherapy. 2020 Jan;22(1):44-51. doi: 10.1016/j.jcyt.2019.10.009. Epub 2019 Dec 27.
Impact factor:
Publication type: Paper in international publication
Authors: Ballerini, Lara; Codinach, Margarita; Elmoazzen, Heidi; Fournier, Diane; Halpenny, Mike; Kogler, Gesine; Lewin, Antoine; Liedtke, Stefanie; Louis, Isabelle; Molluna, Carmen Azqueta et al.
DOI: 10.1016/j.jcyt.2019.10.009

HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies: An analysis of umbilical cord blood units at the Barcelona Cord Blood Bank.

PMID: 31353832
Journal: HLA
Year: 2019
Reference: HLA. 2019 Oct;94(4):347-359. doi: 10.1111/tan.13644. Epub 2019 Aug 6.
Impact factor:
Publication type: Paper in international publication
Authors: Campos, Eva; Enrich, Emma; Herrero, Maria Jose; Martorell, Lluis; Querol, Sergi; Rudilla, Francesc; Vidal, Francisco et al.
DOI: 10.1111/tan.13644

Impact of prophylaxis on health-related quality of life of boys with hemophilia: An analysis of pooled data from 9 countries.

PMID: 31294327
Journal: Research and practice in thrombosis and haemostasi
Year: 2019
Reference: Res Pract Thromb Haemost. 2019 Apr 23;3(3):397-404. doi: 10.1002/rth2.12202. eCollection 2019 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Abad, Audrey; Altisent, Carmen; Antunes, Sandra V; Blanchette, Victor; Buchner-Daley, Loretta; Carneiro, Jorge D A; Feldman, Brian M; Fischer, Kathelijn; Grainger, John; Holzhauer, Susanne et al.
DOI: 10.1002/rth2.12202

Donor lymphocyte infusions for B-cell malignancies relapse after T-cell replete allogeneic hematopoietic cell transplantation.

PMID: 30546069
Journal: BONE MARROW TRANSPLANTATION
Year: 2019
Reference: Bone Marrow Transplant. 2019 Jul;54(7):1133-1137. doi: 10.1038/s41409-018-0422-z. Epub 2018 Dec 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Laura; Badell, Isabel; Caballero, Dolores; de Heredia, Cristina Diaz; Ferra, Christelle; Fox, Laura; Garcia-Cadenas, Irene; Jimenez, Maria Jose; Lopez, Lucia; Martino, Rodrigo et al.
DOI: 10.1038/s41409-018-0422-z

HLA-DR expression in clinical-grade bone marrow-derived multipotent mesenchymal stromal cells: a two-site study.

PMID: 31196185
Journal: Stem Cell Research & Therapy
Year: 2019
Reference: Stem Cell Res Ther. 2019 Jun 13;10(1):164. doi: 10.1186/s13287-019-1279-9.
Impact factor:
Publication type: Paper in international publication
Authors: Grau-Vorster, Marta; Laitinen, Anita; Nystedt, Johanna; Vives, Joaquim et al.
DOI: 10.1186/s13287-019-1279-9

Thrombotic thrombocytopenic purpura relapse induced by acute hepatitis E transmitted by cryosupernatant plasma and successfully controlled with ribavirin.

PMID: 30284732
Journal: TRANSFUSION
Year: 2018
Reference: Transfusion. 2018 Nov;58(11):2501-2505. doi: 10.1111/trf.14831. Epub 2018 Oct 4.
Impact factor:
Publication type: Letter or abstract
Authors: Bes, Marta; Buti, Maria; Esteban, Rafael; Gregori, Josep; Llorens, Meritxell; Piriz, Sofia; Piron, Maria; Quer, Josep; Riveiro-Barciela, Mar; Salcedo, Maria-Teresa et al.
DOI: 10.1111/trf.14831

Improvement in clinical outcomes and replacement factor VIII use in patients with haemophilia A after factor VIII pharmacokinetic-guided prophylaxis based on Bayesian models with myPKFiT((R)).

PMID: 30028549
Journal: HAEMOPHILIA
Year: 2018
Reference: Haemophilia. 2018 Sep;24(5):e338-e343. doi: 10.1111/hae.13540. Epub 2018 Jul 20.
Impact factor:
Publication type: Paper in international publication
Authors: Martorell, M; Mingot-Castellano, M E; Nunez, R; Parra, R et al.
DOI: 10.1111/hae.13540

GENOME-WIDE ASSOCIATION META-ANALYSIS OF AGE AT FIRST CANNABIS USE.

PMID: 30003630
Journal: ADDICTION
Year: 2018
Reference: Addiction. 2018 Nov;113(11):2073-2086. doi: 10.1111/add.14368. Epub 2018 Aug 19.
Impact factor:
Publication type: Paper in international publication
Authors: Abdellaoui, Abdel; Bernard, Manon; Bigdeli, Timothy B; Boks, Marco P; Boomsma, Dorret I; Branje, Susan J T; Brown, Sandra A; Casas, Miguel; Corley, Robin P; Davies, Gareth E et al.
DOI: 10.1111/add.14368

Role of multimeric analysis of von Willebrand factor (VWF) in von Willebrand disease (VWD) diagnosis: Lessons from the PCM-EVW-ES Spanish project.

PMID: 29924855
Journal: PLoS One
Year: 2018
Reference: PLoS One. 2018 Jun 20;13(6):e0197876. doi: 10.1371/journal.pone.0197876. eCollection 2018.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Carlos; Aguinaco, Reyes; Alonso, Nieves; Altisent, Carmen; Arribalzaga, Karmele; Batlle, Fernando; Batlle, Javier; Bermejo, Nuria; Berrueco, Ruben; Bonanad, Santiago et al.
DOI: 10.1371/journal.pone.0197876

[Characteristics of potentially inappropriate prescribing of drugs in elderly polypathological patients].

PMID: 27486035
Journal: Gaceta Sanitaria
Year: 2017
Reference: Gac Sanit. 2017 Jul - Aug;31(4):327-331. doi: 10.1016/j.gaceta.2016.06.013. Epub 2016 Jul 30.
Impact factor:
Publication type: Paper in national publication
Authors: Agusti, Antonia; Formiga, Francesc; Garcia, Juana; Gomez Hernandez, Mercedes; Lopez-Soto, Alfonso; Ramirez-Duque, Nieves; Rivas-Cobas, Paula Carlota; San-Jose, Antonio; Torres, Olga H; Vidal, Xavier et al.
DOI: 10.1016/j.gaceta.2016.06.013

Evaluation of Sensitivity and Specificity Performance of Elecsys HTLV-I/II Assay in a Multicenter Study in Europe and Japan.

PMID: 28468860
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2017
Reference: J Clin Microbiol. 2017 Jul;55(7):2180-2187. doi: 10.1128/JCM.00169-17. Epub 2017 May 3.
Impact factor:
Publication type: Paper in international publication
Authors: Hey, Ariann; Imdahl, Roland; Klinkicht, Markus; Laperche, Syria; Melchior, Walter; Muench, Peter; Muhlbacher, Annelies; Piron, Maria; Queiros, Lucinda; Sauleda, Silvia et al.
DOI: 10.1128/JCM.00169-17

Post-Transplantation Cyclophosphamide-Based Haploidentical Transplantation as Alternative to Matched Sibling or Unrelated Donor Transplantation for Hodgkin Lymphoma: A Registry Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation.

PMID: 28846465
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2017
Reference: J Clin Oncol. 2017 Oct 20;35(30):3425-3432. doi: 10.1200/JCO.2017.72.6869. Epub 2017 Aug 28.
Impact factor:
Publication type: Paper in international publication
Authors: Afanasyev, Boris; Bermudez, Arancha; Blaise, Didier; Bloor, Adrian; Canals, Carmen; Castagna, Luca; Corradini, Paolo; Dominietto, Alida; Dreger, Peter; Finel, Herve et al.
DOI: 10.1200/JCO.2017.72.6869

Risk Factors for the Progression from Low to High Titres in 260 Children with Severe Haemophilia A and Newly Developed Inhibitors.

PMID: 29212115
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2017
Reference: Thromb Haemost. 2017 Dec;117(12):2274-2282. doi: 10.1160/TH17-01-0059. Epub 2017 Dec 6.
Impact factor:
Publication type: Paper in international publication
Authors: Altisent, Carmen; Auerswald, Gunther; Carcao, Manuel; Chambost, Herve; Cid, Ana Rosa; Escuriola-Ettingshausen, Carmen; Fischer, Kathelijn; Kenet, Gili; Konigs, Cristoph; Kurnik, Karin et al.
DOI: 10.1160/TH17-01-0059

Protein-based classifier to predict conversion from clinically isolated syndrome to multiple sclerosis.

PMID: 26552840
Journal: MOLECULAR & CELLULAR PROTEOMICS
Year: 2016
Reference: Mol Cell Proteomics. 2016 Jan;15(1):318-28. doi: 10.1074/mcp.M115.053256. Epub 2015 Nov 9.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose Carlos; Borras, Eva; Canto, Ester; Chiva, Cristina; Choi, Meena; Comabella, Manuel; Montalban, Xavier; Sabido, Eduard; Villar, Luisa Maria; Vitek, Olga et al.
DOI: 10.1074/mcp.M115.053256

PML risk stratification using anti-JCV antibody index and L-selectin.

PMID: 26432858
Journal: Multiple Sclerosis Journal
Year: 2016
Reference: Mult Scler. 2016 Jul;22(8):1048-60. doi: 10.1177/1352458515607651. Epub 2015 Oct 2.
Impact factor:
Publication type: Paper in international publication
Authors: Bertolotto, Antonio; Brassat, David; Breuer, Johanna; Canto, Ester; Comabella, Manuel; Du Pasquier, Renaud A; Gold, Ralf; Gorlich, Dennis; Hohlfeld, Reinhard; Jacobi, Annett et al.
DOI: 10.1177/1352458515607651

The role of hypothalamus-pituitary-adrenal genes and childhood trauma in borderline personality disorder.

PMID: 26182893
Journal: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
Year: 2016
Reference: Eur Arch Psychiatry Clin Neurosci. 2016 Jun;266(4):307-16. doi: 10.1007/s00406-015-0612-2. Epub 2015 Jul 17.
Impact factor:
Publication type: Paper in international publication
Authors: Arranz, Maria Jesus; Bauza, Joana; Calvo, Natalia; Carmona, Cristina; Elices, Matilde; Ferrer, Marc; Garcia-Martinez, Iris; Martin-Blanco, Ana; Pascual, Juan C; Perez, Victor et al.
DOI: 10.1007/s00406-015-0612-2

Clinical evolution of post-transplant diabetes mellitus.

PMID: 26538615
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2016
Reference: Nephrol Dial Transplant. 2016 Mar;31(3):495-505. doi: 10.1093/ndt/gfv368. Epub 2015 Nov 3.
Impact factor:
Publication type: Paper in international publication
Authors: Bayes-Genis, Beatriz; Benitez-Ruiz, Rocio; Delgado Mallen, Patricia I; Diaz, Jose M; Dominguez-Rollan, Rosa; Garcia, Javier; Gonzalez-Rinne, Ana; Ibernon, Meritxell; Jimenez-Sosa, Alejandro; Lampreabe, Ildefonso et al.
DOI: 10.1093/ndt/gfv368

Peripheral blood non-MAIT CD8+CD161hi cells are decreased in relapsing-remitting multiple sclerosis patients treated with interferon beta.

PMID: 26531701
Journal: J NEUROIMMUNOL
Year: 2015
Reference: J Neuroimmunol. 2015 Nov 15;288:98-101. doi: 10.1016/j.jneuroim.2015.09.007. Epub 2015 Sep 25.
Impact factor:
Publication type: Paper in international publication
Authors: Canto, Ester; Comabella, Manuel; Montalban, Xavier; Negrotto, Laura; Rio, Jordi; Tintore, Mar et al.
DOI: 10.1016/j.jneuroim.2015.09.007

Few and nonsevere adverse infusion events using an automated method for diluting and washing before unrelated single cord blood transplantation.

PMID: 25545727
Journal: BIOL BLOOD MARROW TR
Year: 2015
Reference: Biol Blood Marrow Transplant. 2015 Apr;21(4):682-7. doi: 10.1016/j.bbmt.2014.12.015. Epub 2014 Dec 27.
Impact factor:
Publication type: Paper in international publication
Authors: Azqueta, Carmen; Badell, Isabel; Barba, Pere; Canals, Carme; Castillo, Nerea; Diaz-Heredia, Cristina; Duarte, Rafael; Elorza, Izaskun; Ferra, Christelle; Garcia, Olga et al.
DOI: 10.1016/j.bbmt.2014.12.015

Dopamine receptor DRD4 gene and stressful life events in persistent attention deficit hyperactivity disorder.

PMID: 26174753
Journal: AM J MED GENET C
Year: 2015
Reference: Am J Med Genet B Neuropsychiatr Genet. 2015 Sep;168(6):480-491. doi: 10.1002/ajmg.b.32340. Epub 2015 Jul 14.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Rosa; Casas, Miguel; Cormand, Bru; Corrales, Montse; Garcia-Martinez, Iris; Pagerols, Mireia; Ramos-Quiroga, Josep Antoni; Ribases, Marta; Richarte, Vanesa; Sanchez-Mora, Cristina et al.
DOI: 10.1002/ajmg.b.32340

Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes.

PMID: 25688078
Journal: BRAIN
Year: 2015
Reference: Brain. 2015 Apr;138(Pt 4):918-31. doi: 10.1093/brain/awv017. Epub 2015 Feb 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose C; Arrambide, Georgina; Bartos, Ales; Blanco, Yolanda; Brassat, David; Canto, Ester; Comabella, Manuel; Costa, Carme; de Andres, Clara; Deisenhammer, Florian et al.
DOI: 10.1093/brain/awv017

Validation of semaphorin 7A and ala-beta-his-dipeptidase as biomarkers associated with the conversion from clinically isolated syndrome to multiple sclerosis.

PMID: 25406498
Journal: Journal of Neuroinflammation
Year: 2014
Reference: J Neuroinflammation. 2014 Nov 13;11(1):181. doi: 10.1186/s12974-014-0181-8.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose Carlos; Borras, Eva; Canto, Ester; Chiva, Cristina; Comabella, Manuel; Montalban, Xavier; Rovira, Alex; Sabido, Eduard; Tintore, Mar; Villar, Luisa Maria et al.
DOI: 10.1186/s12974-014-0181-8

Levels of soluble TNF-RII are increased in serum of patients with primary progressive multiple sclerosis.

PMID: 24794503
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2014
Reference: J Neuroimmunol. 2014 Jun 15;271(1-2):56-9. doi: 10.1016/j.jneuroim.2014.04.001. Epub 2014 Apr 16.
Impact factor:
Publication type: Paper in international publication
Authors: Canto, Ester; Castillo, Joaquin; Comabella, Manuel; Fissolo, Nicolas; Montalban, Xavier; Vidal-Jordana, Angela et al.
DOI: 10.1016/j.jneuroim.2014.04.001

Identification of host and viral factors involved in a dissimilar resolution of a hepatitis C virus infection.

PMID: 24134179
Journal: LIVER INTERNATIONAL
Year: 2014
Reference: Liver Int. 2014 Jul;34(6):896-906. doi: 10.1111/liv.12362. Epub 2013 Nov 20.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Casillas, Rosario; Cubero, Maria; Domingo, Esteban; Esteban, Juan I; Esteban, Rafael; Garcia-Cehic, Damir; Gregori, Josep; Guardia, Jaume; Ortega, Israel et al.
DOI: 10.1111/liv.12362

Early predictors of antiviral treatment response in liver transplant recipients with recurrent hepatitis C genotype 1.

PMID: 24620835
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2014
Reference: J Viral Hepat. 2014 Oct;21(10):e118-28. doi: 10.1111/jvh.12246. Epub 2014 Mar 12.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, H; Bes, M; Campos-Varela, I; Caralt, M; Castells, L; Charco, R; Esteban, J I; Esteban, R; Guardia, J; Rodriguez-Frias, F et al.
DOI: 10.1111/jvh.12246

Circulating levels of soluble apoptosis-related molecules in patients with multiple sclerosis.

PMID: 23932896
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2013
Reference: J Neuroimmunol. 2013 Oct 15;263(1-2):152-4. doi: 10.1016/j.jneuroim.2013.07.013. Epub 2013 Jul 26.
Impact factor:
Publication type: Paper in international publication
Authors: Canto, Ester; Castillo, Joaquin; Comabella, Manuel; Montalban, Xavier; Moreno, Montserrat; Negrotto, Laura; Saenz-Cuesta, Matias; Vidal-Jordana, Angela et al.
DOI: 10.1016/j.jneuroim.2013.07.013

[Absence of xenotropic murine leukaemia virus-related virus sequences in healthy blood donors and chronic fatigue syndrome patients in Catalonia, Spain.]

PMID: 23332972
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2013
Reference: Enferm Infecc Microbiol Clin. 2013 Aug-Sep;31(7):491-2. doi: 10.1016/j.eimc.2012.11.016. Epub 2013 Jan 17.
Impact factor:
Publication type: Letter whit IF
Authors: Alegre, Jose; Piron, Maria; Ribera, Esteban; Sauleda, Silvia et al.
DOI: 10.1016/j.eimc.2012.11.016

Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study.

PMID: 23553768
Journal: BLOOD
Year: 2013
Reference: Blood. 2013 May 16;121(20):4046-55. doi: 10.1182/blood-2012-09-457036. Epub 2013 Apr 3.
Impact factor: 9.06
Publication type: Paper in international publication
Authors: Chambost, Herve, Kurnik, Karin, Liesner, Ri, Petrini, Pia, Platokouki, Helen, Altisent, Carmen, Oldenburg, Johannes, Nolan, Beatrice, Garrido, Rosario Perez, Mancuso, M Elisa et al.
DOI: 10.1182/blood-2012-09-457036

GPI-anchor and GPI-anchored protein expression in PMM2-CDG patients.

PMID: 24139637
Journal: Orphanet Journal of Rare Diseases
Year: 2013
Reference: Orphanet J Rare Dis. 2013 Oct 20;8:170. doi: 10.1186/1750-1172-8-170.
Impact factor: 4.315
Publication type: Paper in international publication
Authors: de la Morena-Barrio, Maria E, Hernandez-Caselles, Trinidad, Corral, Javier, Garcia-Lopez, Roberto, Martinez-Martinez, Irene, Perez-Duenas, Belen, Altisent, Carmen, Sevivas, Teresa, Kristensen, Soren R, Guillen-Navarro, Encarna et al.
DOI: 10.1186/1750-1172-8-170

Notch signals contribute to preserve the multipotentiality of human CD34(+)CD38(-)CD45RA(-)CD90(+) hematopoietic progenitors by maintaining T cell lineage differentiation potential.

PMID: 22981934
Journal: EXPERIMENTAL HEMATOLOGY
Year: 2012
Reference: Exp Hematol. 2012 Dec;40(12):983-993.e4. doi: 10.1016/j.exphem.2012.08.009. Epub 2012 Sep 11.
Impact factor:
Publication type: Paper in international publication
Authors: Azqueta, Carmen; Barquinero, Jordi; Gimeno, Ramon; Gomez, Alba; Pereira-Mendez, Sonia; Querol, Sergi; Sanchez-Dominguez, Rebeca; Torrabadella, Marta et al.
DOI: 10.1016/j.exphem.2012.08.009

T cell responses and viral variability in blood donation candidates with occult hepatitis B infection.

PMID: 22173156
Journal: JOURNAL OF HEPATOLOGY
Year: 2012
Reference: J Hepatol. 2012 Apr;56(4):765-74. Epub 2011 Dec 13.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Casamitjana, Natalia; Esteban, Juan Ignacio; Guardia, Jaime; Pinacho, Asuncion; Piron, Maria; Puig, Lluis; Quer, Josep; Sauleda, Silvia; Vargas, Victor et al.
DOI: 10.1016/j.jhep.2011.11.011

Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis.

PMID: 22183936
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 Jul;18(7):983-90. Epub 2011 Dec 19.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458511433063

Acquired haemophilia A. First line treatment with calcineurin inhibitors and steroid pulses: a 10-year follow-up study.

PMID: 22429259
Journal: HAEMOPHILIA
Year: 2012
Reference: Haemophilia. 2012 Sep;18(5):789-93. doi: 10.1111/j.1365-2516.2012.02772.x. Epub 2012 Mar 19.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI: 10.1111/j.1365-2516.2012.02772.x

The optimal mode of delivery for the haemophilia carrier expecting an affected infant: further considerations.

PMID: 21371199
Journal: HAEMOPHILIA
Year: 2011
Reference: Haemophilia. 2011 Sep;17(5):818-9. doi: 10.1111/j.1365-2516.2011.02505.x. Epub 2011 Mar 4.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; et al.
DOI: 10.1111/j.1365-2516.2011.02505.x

The study of the effect of splicing mutations in von Willebrand factor using RNA isolated from patients' platelets and leukocytes.

PMID: 21251206
Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Year: 2011
Reference: J Thromb Haemost. 2011 Apr;9(4):679-88. doi: 10.1111/j.1538-7836.2011.04204.x.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI: 10.1111/j.1538-7836.2011.04204.x

The optimal mode of delivery for the haemophilia carrier expecting an affected infant: further considerations.

PMID: 21371199
Journal: HAEMOPHILIA
Year: 2011
Reference: Haemophilia. 2011 Sep;17(5):818-9. doi: 10.1111/j.1365-2516.2011.02505.x. Epub 2011 Mar 4.
Impact factor: 2.364
Publication type: Letter or abstract
Authors: , , , , et al.
DOI: 10.1111/j.1365-2516.2011.02505.x

The study of the effect of splicing mutations in von Willebrand factor using RNA isolated from patients' platelets and leukocytes.

PMID: 21251206
Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Year: 2011
Reference: J Thromb Haemost. 2011 Apr;9(4):679-88. doi: 10.1111/j.1538-7836.2011.04204.x.
Impact factor: 5.439
Publication type: Paper in international publication
Authors: , , , , et al.
DOI: 10.1111/j.1538-7836.2011.04204.x

Allogeneic unrelated cord blood banking worldwide: An update.

PMID: 20395178
Journal: TRANSFUSION AND APHERESIS SCIENCE
Year: 2010
Reference: Transfus Apher Sci. 2010 Jun;42(3):257-63. Epub 2010 Apr 14.
Impact factor:
Publication type: Paper in international publication
Authors: et al.
DOI: 10.1016/j.transci.2010.03.010

Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis.

PMID: 20237129
Journal: BRAIN
Year: 2010
Reference: Brain. 2010 Apr;133(Pt 4):1082-93. Epub 2010 Mar 17.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1093/brain/awq035

The 'royal disease' mutation in a Spanish patient.

PMID: 20626617
Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Year: 2010
Reference: J Thromb Haemost. 2010 Oct;8(10):2316-7. doi: 10.1111/j.1538-7836.2010.03977.x.
Impact factor: 6.069
Publication type: Letter or abstract
Authors: Ramirez, L, Altisent, C, Parra, R, Vidal, F et al.
DOI: 10.1111/j.1538-7836.2010.03977.x

Integration of molecular and clinical data of 40 unrelated VWD families in a Spanish locus-specific mutation database. First release including 58 mutations.

PMID: 20801902
Journal: Haematologica-The Hematology Journal
Year: 2010
Reference: Haematologica. 2010 Nov;95(11):1982-4. Epub 2010 Aug 26.
Impact factor: 6.416
Publication type: Letter or abstract
Authors: , , , , , et al.
DOI: 10.3324/haematol.2010.028977

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A study suggests that wild boars could transmit hepatitis

Over time, wild boars have approached the city of Barcelona and surrounding areas. As carriers of the hepatitis E virus, they are linked to a study identifying them as a potential source of transmission of this disease.