About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The main objectives are to improve the diagnosis of immunodeficiencies and autoimmune diseases, addressing also their heterogeneity and mechanisms in close collaboration with the pediatrics, thyroid and systemic disease groups, being internationally recognized in both areas. The group participates in numerous research projects at the Vall d'Hebron Barcelona Hospital Campus that use immunological tests developed for specific projects led by the kidney transplantation, intensive care medicine, internal medicine, allergy and rheumatology groups. During the COVID pandemic the group made contributions in improving the immunogenetic and immunological risk profiles and in the evaluation of the immune response to vaccination and natural infection, collaborating with national and international networks. The group has also generated a biobank of more than 8.000 samples from patients with COVID-19 that have been incorporated into the VHIR biobank.
The group works as a coordinator of the "Focis" Center of Excellence (Federation of Clinical Immunology Societies) of Barcelona.
PMID: 38194689 Journal: BLOOD Year: 2024 Reference: Blood. 2024 Jan 9:blood.2023022098. doi: 10.1182/blood.2023022098. Impact factor: Publication type: Paper in international publication Authors: Abbott, Jordan; Abers, Michael S; Abolhassani, Hassan; Barlogis, Vincent; Barmettler, Sara; Campbell, Nicholas; Chapdelaine, Hugo; Church, Joseph A; Cros, Guilhem; Deordieva, Ekaterina et al. DOI: 10.1182/blood.2023022098
PMID: 37879817 Journal: Revista espanola de patologia Year: 2023 Reference: Rev Esp Patol. 2023 Oct-Dec;56(4):217-218. doi: 10.1016/j.patol.2023.09.001. Impact factor: Publication type: Editorial in national publication Authors: Acuna Perez, Maria Jose; Agueras, Cajal; Calavia, Olga; Colobran, Roger; Garcia Ramos, Maite; Garcia-Aznar, Jose Maria; Maneiro Pampin, Emilia; Minguell Domingo, Laura; Novoa Bolivar, Erika M; Ocejo Vinyals, Javier Gonzalo et al. DOI: 10.1016/j.patol.2023.09.001
PMID: 38057242 Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia H Year: 2023 Reference: Farm Hosp. 2023 Dec 5:S1130-6343(23)00890-5. doi: 10.1016/j.farma.2023.09.009. Impact factor: Publication type: Paper in international publication Authors: Climente, Monica; Escolano, Angel; Manrique-Rodriguez, Silvia; Miarons, Marta; Parra, Alba Pau; Perurena-Prieto, Janire; Quintanilla, Laura Garcia; Ramos, Natalia et al. DOI: 10.1016/j.farma.2023.09.009
PMID: 38066348 Journal: Techniques in Coloproctology Year: 2023 Reference: Tech Coloproctol. 2023 Dec 8;28(1):2. doi: 10.1007/s10151-023-02888-x. Impact factor: Publication type: Paper in international publication Authors: Celentano, V; Climente, Monica; Damani, A; Escolano, Angel; Kennedy, N; Lee, Y J; Manrique-Rodriguez, Silvia; Manzo, C A; Miarons, Marta; Parra, Alba Pau et al. DOI: 10.1007/s10151-023-02888-x
PMID: 38123718 Journal: Nature Metabolism Year: 2023 Reference: Nat Metab. 2023 Dec;5(12):2094-2110. doi: 10.1038/s42255-023-00937-1. Epub 2023 Dec 20. Impact factor: Publication type: Paper in international publication Authors: Alvarez-Sierra, Daniel; Choudhury, Feroza K; Hankeova, Simona; Kamath, Binita M; Lai, Zijuan; Miro, Emilia; Mosteiro, Lluc; Nguyen, Thi Thu Thao; Piskol, Robert; Pujol-Borrell, Ricardo et al. DOI: 10.1038/s42255-023-00937-1
PMID: 35784294 Journal: Frontiers in Immunology Year: 2022 Reference: Front Immunol. 2022 Jun 17;13:897975. doi: 10.3389/fimmu.2022.897975. eCollection 2022. Impact factor: Publication type: Letter or abstract Authors: Batlle-Maso, Laura; Castells, Neus; Colobran, Roger; Dieli-Crimi, Romina; Dieli-Crimi, Romina; Franco-Jarava, Clara; Garcia-Prat, Marina; Martinez-Gallo, Monica; Riviere, Jacques G; Soler-Palacin, Pere et al. DOI: 10.3389/fimmu.2022.897975
PMID: 35770252 Journal: EClinicalMedicine Year: 2022 Reference: EClinicalMedicine. 2022 Jun 25;50:101515. doi: 10.1016/j.eclinm.2022.101515. eCollection 2022 Aug. Impact factor: Publication type: Paper in international publication Authors: Aguilera-Albesa, Sergio; Alegria, Iosune; Cantarin, Veronica; Colobran, Roger; Davalos, Veronica; Esteller, Manel; Ferrer, Gerardo; Flores-Perez, Patricia; Fumado, Victoria; Garcia-Prieto, Carlos A et al. DOI: 10.1016/j.eclinm.2022.101515
PMID: 35255492 Journal: NATURE Year: 2022 Reference: Nature. 2022 Jul;607(7917):97-103. doi: 10.1038/s41586-022-04576-6. Epub 2022 Mar 7. Impact factor: Publication type: Paper in international publication Authors: Abd Elghafar, Mohamed S; Abdel-Aziz, Mahmoud; Abdelrazik, Marwa; Abdollahi, Hamed; Abdullah, Tala; Abecasis, Goncalo R; Abecasis, Goncalo R; Abedalthagafi, Malak; Abel, Lynn; Abernathy, Caroline et al. DOI: 10.1038/s41586-022-04576-6
PMID: 35727945 Journal: BRAIN Year: 2022 Reference: Brain. 2022 Nov 21;145(11):3931-3942. doi: 10.1093/brain/awac220. Impact factor: Publication type: Paper in international publication Authors: Arrambide, Georgina; Auger, Cristina; Carbonell-Mirabent, Pere; Cardenas-Robledo, Simon; Castillo, Joaquin; Castillo, Mireia; Cobo-Calvo, Alvaro; Comabella, Manuel; Dieli-Crimi, Romina; Dieli-Crimi, Romina et al. DOI: 10.1093/brain/awac220
PMID: 34413140 Journal: Science Immunology Year: 2021 Reference: Sci Immunol. 2021 Aug 19;6(62). pii: 6/62/eabl4348. doi: 10.1126/sciimmunol.abl4348. Impact factor: Publication type: Paper in international publication Authors: Abad, Jorge; Abel, Laurent; Abel, Laurent; Abel, Laurent; Abolhassani, Hassan; Abou Tayoun, Ahmad; Accordino, Giulia; Achille, Cristian; Aguilera-Albesa, Sergio; Aguilo-Cucurull, Aina et al. DOI: 10.1126/sciimmunol.abl4348
PMID: 34294672 Journal: International journal of neonatal screening Year: 2021 Reference: Int J Neonatal Screen. 2021 Jul 20;7(3). pii: ijns7030046. doi: 10.3390/ijns7030046. Impact factor: Publication type: Paper in international publication Authors: Argudo-Ramirez, Ana; Collado, Tatiana; Colobran, Roger; Garcia-Prat, Marina; Garcia-Villoria, Judit; Gonzalez de Aledo-Castillo, Jose Manuel; Lopez-Galera, Rosa; Marin-Soria, Jose Luis; Martin-Nalda, Andrea; Martinez-Gallo, Monica et al. DOI: 10.3390/ijns7030046
PMID: 34140949 Journal: Frontiers in Immunology Year: 2021 Reference: Front Immunol. 2021 Jun 1;12:665824. doi: 10.3389/fimmu.2021.665824. eCollection 2021. Impact factor: Publication type: Letter or abstract Authors: Chiscano-Camon, Luis; Ferrer, Ricard; Garcia-de-Acilu, Marina; Hernandez-Gonzalez, Manuel; Palmada, Clara; Perez-Carrasco, Marcos; Perurena-Prieto, Janire; Plata-Menchaca, Erika; Ruiz-Rodriguez, Juan Carlos; Ruiz-Sanmartin, Adolf et al. DOI: 10.3389/fimmu.2021.665824
PMID: 34101091 Journal: JOURNAL OF CLINICAL IMMUNOLOGY Year: 2021 Reference: J Clin Immunol. 2021 Oct;41(7):1425-1442. doi: 10.1007/s10875-021-01068-6. Epub 2021 Jun 8. Impact factor: Publication type: Editorail in international publication Authors: Abel, Laurent; Aiuti, Alessandro; Arkin, Lisa M; Bastard, Paul; Bolze, Alexandre; Casanova, Jean-Laurent; Charkravorty, Samya; Cheng, Matthew P; Christodoulou, John; Cicalese, Maria-Pia et al. DOI: 10.1007/s10875-021-01068-6
PMID: 32465574 Journal: JOURNAL OF HEART AND LUNG TRANSPLANTATION Year: 2020 Reference: J Heart Lung Transplant. 2020 Apr;39(4S):S380. doi: 10.1016/j.healun.2020.01.485. Epub 2020 Mar 30. Impact factor: Publication type: Paper in international publication Authors: Bello, I; Coll, E; Crowley, S; Deu, M; Duenas, J; Franco, C; Jauregui, A; Mazo, C; Minambres, E; Mosteiro, F et al. DOI: 10.1016/j.healun.2020.01.485
PMID: 32431704 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 May 5;11:771. doi: 10.3389/fimmu.2020.00771. eCollection 2020. Impact factor: Publication type: Paper in international publication Authors: Agudo-Jimenez, Teresa; Alvarez-Lafuente, Roberto; Comabella, Manuel; Dieli-Crimi, Romina; Dieli-Crimi, Romina; Dominguez-Mozo, Maria Inmaculada; Espino-Paisan, Laura; Garcia-Martinez, Maria Angel; Lopez-Cotarelo, Pilar; Perez-Perez, Silvia et al. DOI: 10.3389/fimmu.2020.00771
PMID: 31599728 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2020 Reference: J Investig Allergol Clin Immunol. 2020 Apr 24;30(2):143-145. doi: 10.18176/jiaci.0459. Epub 2019 Oct 10. Impact factor: Publication type: Paper in international publication Authors: Cardona, V; Carrasco Gonzalez, M D; Galvan Blasco, P; Guilarte, M; Labrador Horrillo, M; Luengo, O; Molina Molina, G J; Sala Cunill, A; Sanz Martinez, M; Vinas Gimenez, L et al. DOI: 10.18176/jiaci.0459
PMID: 32318097 Journal: Frontiers in Genetics Year: 2020 Reference: Front Genet. 2020 Apr 3;11:304. doi: 10.3389/fgene.2020.00304. eCollection 2020. Impact factor: Publication type: Letter or abstract Authors: Colobran, Roger et al. DOI: 10.3389/fgene.2020.00304
PMID: 30767873 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2019 Reference: Clin Exp Rheumatol. 2019 Jul-Aug;37 Suppl 119(4):41-48. Epub 2019 Feb 11. Impact factor: Publication type: Paper in international publication Authors: Balada, Eva; Callejas-Moraga, Eduardo Luis; Fonollosa-Pla, Vicente; Guillen-Del-Castillo, Alfredo; Marin-Sanchez, Ana Maria; Roca-Herrera, Maria; Simeon-Aznar, Carmen Pilar; Tolosa-Vilella, Carles et al. DOI:
PMID: 30738005 Journal: ALLERGY Year: 2019 Reference: Allergy. 2019 Jul;74(7):1384-1386. doi: 10.1111/all.13735. Epub 2019 Mar 14. Impact factor: Publication type: Letter whit IF Authors: Cardona, Victoria; Galvan-Blasco, Paula; Gil-Serrano, Ingrid Johana; Guilarte, Mar; Labrador-Horrillo, Moises; Luengo, Olga; Sala-Cunill, Anna et al. DOI: 10.1111/all.13735
PMID: 30721140 Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE Year: 2019 Reference: Clin Chem Lab Med. 2019 Jul 26;57(8):e179-e182. doi: 10.1515/cclm-2018-1121. Impact factor: Publication type: Letter whit IF Authors: Colobran, Roger; Dieli-Crimi, Romina; Dieli-Crimi, Romina; Franco-Jarava, Clara; Hernandez-Gonzalez, Manuel; Pujol-Borrell, Ricardo; Vila-Pijoan, Gemma et al. DOI: 10.1515/cclm-2018-1121
PMID: 30682461 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2019 Reference: J Allergy Clin Immunol. 2019 May;143(5):1952-1956.e6. doi: 10.1016/j.jaci.2018.12.1013. Epub 2019 Jan 22. Impact factor: Publication type: Paper in international publication Authors: Bucciol, Giorgia; Calvo, Pier Luigi; Cant, Andrew; de la Morena, M Teresa; Edgar, J David M; Espanol, Teresa; Ferrua, Francesca; Galicchio, Miguel; Gennery, Andrew R; Hadzic, Nedim et al. DOI: 10.1016/j.jaci.2018.12.1013
PMID: 29603375 Journal: JOURNAL OF CLINICAL LABORATORY ANALYSIS Year: 2018 Reference: Journal of Clinical Laboratory Analysis. 2018 Jul;32(6):e22420. doi: 10.1002/jcla.22420. Impact factor: 1.303 Publication type: Paper in international publication Authors: Garcia-Prat, Marina, Vila-Pijoan, Gemma, Martos Gutierrez, Susana, Gala Yerga, Guadalupe, Garcia Guantes, Esther, Martinez-Gallo, Monica, Martin-Nalda, Andrea, Soler-Palacin, Pere, Hernandez-Gonzalez, Manuel et al. DOI: 10.1002/jcla.22420
PMID: 29473763 Journal: Expert Review of Clinical Immunology Year: 2018 Reference: Expert Rev Clin Immunol. 2018 Mar;14(3):215-224. doi: 10.1080/1744666X.2018.1440206. Epub 2018 Feb 23. Impact factor: 3.436 Publication type: Paper in international publication Authors: Grau-Junyent, Josep Maria, Selva-O'Callaghan, Albert, Alvarado-Cardenas, Marcelo, Pinal-Fernandez, Iago, Trallero-Araguas, Ernesto, Milisenda, Jose Cesar, Martinez, Maria Angeles, Marin, Ana, Labrador-Horrillo, Moises, Juarez, Candido et al. DOI: 10.1080/1744666X.2018.1440206
PMID: 27026170 Journal: JOURNAL OF CLINICAL IMMUNOLOGY Year: 2016 Reference: J Clin Immunol. 2016 May;36(4):388-96. doi: 10.1007/s10875-016-0275-4. Epub 2016 Mar 30. Impact factor: 3.094 Publication type: Paper in international publication Authors: Colobran, Roger, Franco-Jarava, Clara, Martin-Nalda, Andrea, Baena, Neus, Gabau, Elisabeth, Padilla, Natalia, de la Cruz, Xavier, Pujol-Borrell, Ricardo, Comas, David, Soler-Palacin, Pere et al. DOI: 10.1007/s10875-016-0275-4
PMID: 24315417 Journal: AN PEDIATR Year: 2014 Reference: An Pediatr (Barc). 2014 Aug;81(2):130-1. doi: 10.1016/j.anpedi.2013.10.045. Epub 2013 Dec 4. Impact factor: 0.867 Publication type: Letter whit IF Authors: Hernandez-Gonzalez, M, Rius Gordillo, N, Fernandez-San Jose, C, Martin-Nalda, A, Moraga-Llop, F A, Soler-Palacin, P et al. DOI: 10.1016/j.anpedi.2013.10.045
PMID: 20159255 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2010 Reference: J Allergy Clin Immunol. 2010 Feb;125(2):424-432.e8. Impact factor: 9.165 Publication type: Paper in international publication Authors: , , , , , , , , , et al. DOI: 10.1016/j.jaci.2009.10.059
PMID: 19381301 Journal: PLoS One Year: 2009 Reference: PLoS One. 2009;4(4):e5234. Impact factor: Publication type: Letter or abstract Authors: van den Berg, J Merlijn, van Koppen, Elsbeth, Ahlin, Anders, Belohradsky, Bernd H, Bernatowska, Ewa, Corbeel, Lucien, Espanol, Teresa, Fischer, Alain, Kurenko-Deptuch, Magdalena, Mouy, Richard et al. DOI: 10.1371/journal.pone.0005234
PMID: 19307326 Journal: JOURNAL OF EXPERIMENTAL MEDICINE Year: 2009 Reference: J Exp Med. 2009 Apr 13;206(4):735-42. Impact factor: 15.219 Publication type: Paper in international publication Authors: Draghici, Elena, Marangoni, Francesco, Bosticardo, Marita, Catucci, Marco, Aiuti, Alessandro, Cancrini, Caterina, Marodi, Laszlo, Espanol, Teresa, Bredius, Robbert G M, Thrasher, Adrian J et al. DOI: 10.1084/jem.20081773
PMID: 18798799 Journal: PEDIATRIC ALLERGY AND IMMUNOLOGY Year: 2009 Reference: Pediatr Allergy Immunol. 2009 Mar;20(2):113-8. Impact factor: 2.723 Publication type: Paper in international publication Authors: Llobet, M Pilar, Soler-Palacin, Pere, Detkova, Drahomira, Hernandez, Manuel, Caragol, Isabel, Espanol, Teresa et al. DOI: 10.1111/j.1399-3038.2008.00744.x
PMID: 19779048 Journal: BLOOD Year: 2009 Reference: Blood. 2009 Sep 24;114(13):2846-8. Impact factor: 10.432 Publication type: Letter or abstract Authors: Detkova, Drahomira, Arostegui, Juan I, Alvarez, Antonio, Soler-Palacin, Pere, Vidaller, Antonio, Espanol, Teresa, Sampalo, Almudena, de Gracia, Javier, Hernandez, Manuel, Yague, Jordi et al. DOI: 10.1182/blood-2009-05-213025
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
A study from the Vall d’Hebron Campus demonstrates that the Ex Vivo C5b-9 deposition test is useful for monitoring the activity of the complement system (CS) in patients with aHUS or transplant-associated TMA.
The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.
