About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The main objectives are to improve the diagnosis of immunodeficiencies and autoimmune diseases, addressing also their heterogeneity and mechanisms in close collaboration with the pediatrics, thyroid and systemic disease groups, being internationally recognized in both areas. The group participates in numerous research projects at the Vall d'Hebron Barcelona Hospital Campus that use immunological tests developed for specific projects led by the kidney transplantation, intensive care medicine, internal medicine, allergy and rheumatology groups. During the COVID pandemic the group made contributions in improving the immunogenetic and immunological risk profiles and in the evaluation of the immune response to vaccination and natural infection, collaborating with national and international networks. The group has also generated a biobank of more than 8.000 samples from patients with COVID-19 that have been incorporated into the VHIR biobank.
The group works as a coordinator of the "Focis" Center of Excellence (Federation of Clinical Immunology Societies) of Barcelona.
PMID: 38132824 Journal: Year: 2023 Reference: Int J Neonatal Screen. 2023 Nov 21;9(4):65. doi: 10.3390/ijns9040065. Impact factor: Publication type: Paper in international publication Authors: Alvarez-Sierra, Daniel; Barben, Jurg; Castellani, Carlo; Choudhury, Feroza K; de Winter-de Groot, Karin M; Gartner, Silvia; Hankeova, Simona; Kamath, Binita M; Karadag, Bulent; Kashirskaya, Nataliya et al. DOI: 10.3390/ijns9040065
PMID: 35708626 Journal: JOURNAL OF EXPERIMENTAL MEDICINE Year: 2022 Reference: J Exp Med. 2022 Aug 1;219(8). pii: 213287. doi: 10.1084/jem.20220131. Epub 2022 Jun 16. Impact factor: Publication type: Paper in international publication Authors: Abel, Laurent; Abel, Laurent; Abolhassani, Hassan; Abolhassani, Hassan; Abou Tayoun, Ahmad; Aiuti, Alessandro; Akcan, Ozge Metin; Al-Muhsen, Saleh; Al-Mulla, Fahd; Alkan, Gulsum et al. DOI: 10.1084/jem.20220131
PMID: 34863919 Journal: CLINICAL MICROBIOLOGY AND INFECTION Year: 2022 Reference: Clin Microbiol Infect. 2022 Jun;28(6):881.e1-881.e5. doi: 10.1016/j.cmi.2021.11.021. Epub 2021 Dec 1. Impact factor: Publication type: Paper in international publication Authors: Arrese-Munoz, I; Aznar, M L; Bosch-Nicolau, P; Espinosa-Pereiro, J; Franco-Jarava, C; Molina, I; Oliveira-Souto, I; Pou, D; Roure, S; Salvador, F et al. DOI: 10.1016/j.cmi.2021.11.021
PMID: 35576468 Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Year: 2022 Reference: Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2200413119. doi: 10.1073/pnas.2200413119. Epub 2022 May 16. Impact factor: Publication type: Paper in international publication Authors: Abel, Laurent; Aiuti, Alessandro; AlKhater, Suzan; Amador-Borrero, Blanca; Anaya, Juan-Manuel; Anderson, Mark S; Andreakos, Evangelos; Anglicheau, Dany; Arias, Andres Augusto; Arrestier, Romain et al. DOI: 10.1073/pnas.2200413119
PMID: 35475363 Journal: Multiple Sclerosis Journal Year: 2022 Reference: Mult Scler. 2022 Jun;28(7):1138-1145. doi: 10.1177/13524585221089540. Epub 2022 Apr 27. Impact factor: Publication type: Paper in international publication Authors: Agraz, Irene; Alvarez, Gary; Arrambide, Georgina; Bertran, Jordina; Bonastre, Merce; Carbonell-Mirabent, Pere; Cardenas-Robledo, Simon; Castillo, Joaquin; Castillo, Mireia; Cobo-Calvo, Alvaro et al. DOI: 10.1177/13524585221089540
PMID: 34089457 Journal: JOURNAL OF CLINICAL IMMUNOLOGY Year: 2021 Reference: J Clin Immunol. 2021 Oct;41(7):1457-1462. doi: 10.1007/s10875-021-01078-4. Epub 2021 Jun 5. Impact factor: Publication type: Paper in international publication Authors: Bastard, Paul; Bogunovic, Dusan; Bush, Douglas; Carpenter, Taya; Casanova, Jean-Laurent; Colobran, Roger; Gans, Melissa; Malle, Louise; Martin-Nalda, Andrea; Patel, Roosheel et al. DOI: 10.1007/s10875-021-01078-4
PMID: 34021148 Journal: Nature Communications Year: 2021 Reference: Nat Commun. 2021 May 21;12(1):3010. doi: 10.1038/s41467-021-23333-3. Impact factor: Publication type: Paper in international publication Authors: Almirante, Benito; Alvarez-Sierra, Daniel; Andres, Cristina; Anton, Andres; Astorga-Gamaza, Antonio; Ayora, Alfonso; Burgos, Joaquin; Buzon, Maria J; Esperalba, Juliana; Falco, Anna et al. DOI: 10.1038/s41467-021-23333-3
PMID: 34016160 Journal: Biomarker Research Year: 2021 Reference: Biomark Res. 2021 May 20;9(1):37. doi: 10.1186/s40364-021-00290-z. Impact factor: Publication type: Paper in international publication Authors: Abrisqueta, Pau; Bobillo, Sabela; Bosch, Francesc; Carabia, Julia; Crespo, Marta; Esteve-Codina, Anna; Franco-Jarava, Clara; Garcia-Marco, Jose Antonio; Iacoboni, Gloria; Jimenez, Isabel et al. DOI: 10.1186/s40364-021-00290-z
PMID: 34016150 Journal: Immunity & Ageing Year: 2021 Reference: Immun Ageing. 2021 May 20;18(1):24. doi: 10.1186/s12979-021-00237-w. Impact factor: Publication type: Paper in international publication Authors: Abad-Molina, Cristina; Aguilar, Marta; Almeida, Delia; Alonso, Marta; Alvarez, Paula; Boiges, Marc; Boix, Francisco; Burillo-Sanz, Sergio; Cantenys-Molina, Sergi; Cunill, Vanesa et al. DOI: 10.1186/s12979-021-00237-w
PMID: 31799703 Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY Year: 2020 Reference: Clin Exp Immunol. 2020 Apr;200(1):61-72. doi: 10.1111/cei.13405. Epub 2020 Jan 19. Impact factor: Publication type: Paper in international publication Authors: Alonso, Laura; Arcas-Garcia, Andrea; Colobran, Roger; Drechsel, Oliver; Franco-Jarava, Clara; Garcia-Prat, Marina; Magallon-Lorenz, Miriam; Martin-Nalda, Andrea; Martinez-Gallo, Monica; Ossowski, Stephan et al. DOI: 10.1111/cei.13405
PMID: 32278790 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2020 Reference: J Allergy Clin Immunol. 2020 Oct;146(4):901-911. doi: 10.1016/j.jaci.2019.11.051. Epub 2020 Apr 9. Impact factor: Publication type: Paper in international publication Authors: Abolhassani, Hassan; Aghamohammadi, Asghar; Allen, Hana Lango; Allende, Luis M; Alosaimi, Mohammed; Alsina, Laia; Ameratunga, Rohan; Atschekzei, Faranaz; Bakhtiar, Shahrzad; Baris, Safa et al. DOI: 10.1016/j.jaci.2019.11.051
PMID: 32256498 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 Mar 17;11:455. doi: 10.3389/fimmu.2020.00455. eCollection 2020. Impact factor: Publication type: Paper in international publication Authors: Abolhassani, Hassan; Aghamohammadi, Asghar; Allende-Martinez, Luis M; Bergstrom, Sofia; Dezfouli, Mahya; Fernandez Pereira, Luis M; Ferrer Balaguer, Juana M; Franco Jarava, Clara; Friman, Vanda; Gonzalez-Granado, Luis I et al. DOI: 10.3389/fimmu.2020.00455
PMID: 32206630 Journal: Pediatric gastroenterology, hepatology & nutrition Year: 2020 Reference: Pediatr Gastroenterol Hepatol Nutr. 2020 Mar;23(2):174-179. doi: 10.5223/pghn.2020.23.2.174. Epub 2020 Mar 4. Impact factor: Publication type: Letter or abstract Authors: Charco, Ramon; Collado-Hilly, Mauricette; Gonzales, Emmanuel; Juamperez, Javier; Julio, Ecaterina; Marin-Sanchez, Ana; Mercadal-Hally, Maria; Quintero, Jesus et al. DOI: 10.5223/pghn.2020.23.2.174
PMID: 30273710 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2019 Reference: J Allergy Clin Immunol. 2019 Jan;143(1):359-368. doi: 10.1016/j.jaci.2018.09.009. Epub 2018 Sep 29. Impact factor: Publication type: Paper in international publication Authors: Allende, Luis M; Alsina, Laia; Arostegui, Juan I; Balderrama-Rodriguez, Angelica; Bejaoui, Mohamed; Bloomfield, Marketa; Bosque, Maria Teresa; Bravo Gallego, Luz Yadira; Campistol, Josep Maria; Canellas, Jeronima et al. DOI: 10.1016/j.jaci.2018.09.009
PMID: 30577994 Journal: REVISTA CLINICA ESPANOLA Year: 2019 Reference: Rev Clin Esp. 2019 Dec;219(9):505-513. doi: 10.1016/j.rce.2018.10.006. Epub 2018 Dec 19. Impact factor: 1.043 Publication type: Review in national publication Authors: Moga Naranjo, E, Hernandez Gonzalez, M, Lopez-Trascasa, M, Villar Guimerans, L M, Mariscal-Rodriguez, A et al. DOI: 10.1016/j.rce.2018.10.006
PMID: 31681265 Journal: Frontiers in Immunology Year: 2019 Reference: Front Immunol. 2019 Oct 1;10:2325. doi: 10.3389/fimmu.2019.02325. eCollection 2019. Impact factor: 4.716 Publication type: Paper in international publication Authors: Rudilla, Francesc, Franco-Jarava, Clara, Martinez-Gallo, Monica, Garcia-Prat, Marina, Martin-Nalda, Andrea, Riviere, Jacques, Aguilo-Cucurull, Aina, Mongay, Laura, Vidal, Francisco, Solanich, Xavier et al. DOI: 10.3389/fimmu.2019.02325
PMID: 31379878 Journal: Frontiers in Immunology Year: 2019 Reference: Front Immunol. 2019 Jul 18;10:1695. doi: 10.3389/fimmu.2019.01695. eCollection 2019. Impact factor: 4.716 Publication type: Paper in international publication Authors: Marin-Sanchez, Ana, Alvarez-Sierra, Daniel, Gonzalez, Oscar, Lucas-Martin, Ana, Selles-Sanchez, Alicia, Rudilla, Francesc, Enrich, Emma, Colobran, Roger, Pujol-Borrell, Ricardo et al. DOI: 10.3389/fimmu.2019.01695
PMID: 19633526 Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL Year: 2009 Reference: Pediatr Infect Dis J. 2009 Aug;28(8):753-4. Impact factor: 3.176 Publication type: Paper in international publication Authors: Martin, Andrea, Marques, Laura, Soler-Palacin, Pere, Caragol, Isabel, Hernandez, Manuel, Figueras, Concepcion, Espanol, Teresa et al. DOI: 10.1097/INF.0b013e31819c6f3a
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
A study from the Vall d’Hebron Campus demonstrates that the Ex Vivo C5b-9 deposition test is useful for monitoring the activity of the complement system (CS) in patients with aHUS or transplant-associated TMA.
The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.
