About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The main objectives are to improve the diagnosis of immunodeficiencies and autoimmune diseases, addressing also their heterogeneity and mechanisms in close collaboration with the pediatrics, thyroid and systemic disease groups, being internationally recognized in both areas. The group participates in numerous research projects at the Vall d'Hebron Barcelona Hospital Campus that use immunological tests developed for specific projects led by the kidney transplantation, intensive care medicine, internal medicine, allergy and rheumatology groups. During the COVID pandemic the group made contributions in improving the immunogenetic and immunological risk profiles and in the evaluation of the immune response to vaccination and natural infection, collaborating with national and international networks. The group has also generated a biobank of more than 8.000 samples from patients with COVID-19 that have been incorporated into the VHIR biobank.
The group works as a coordinator of the "Focis" Center of Excellence (Federation of Clinical Immunology Societies) of Barcelona.
PMID: 35403441 Journal: THYROID Year: 2022 Reference: Thyroid. 2022 Jun;32(6):682-693. doi: 10.1089/thy.2021.0694. Epub 2022 May 25. Impact factor: Publication type: Paper in international publication Authors: Alvarez de la Sierra, Daniel; Bello, Irene; Caubet, Enric; Gomez-Brey, Aroa; Gonzalez, Oscar; Iglesias, Carmela; Marin-Sanchez, Ana; Moreno-Llorente, Pablo; Petit, Anna; Pujol-Borrell, Ricardo et al. DOI: 10.1089/thy.2021.0694
PMID: 35351135 Journal: BMC Medicine Year: 2022 Reference: BMC Med. 2022 Mar 29;20(1):129. doi: 10.1186/s12916-022-02345-w. Impact factor: Publication type: Paper in international publication Authors: Arrese-Munoz, Iria; Borrell, Ricardo Pujol; Diaz-Troyano, Noelia; Ferrer, Roser; Gabriel-Medina, Pablo; Gallo, Monica Martinez; Gine, Anna; Hernandez-Gonzalez, Manuel; Labrador-Horrillo, Moises; Martinez-Valle, Fernando et al. DOI: 10.1186/s12916-022-02345-w
PMID: 34668539 Journal: RHEUMATOLOGY Year: 2022 Reference: Rheumatology (Oxford). 2022 Mar 2;61(3):e69-e71. doi: 10.1093/rheumatology/keab782. Impact factor: Publication type: Letter or abstract Authors: Bellaubi-Pallares, Naya; Colobran, Roger; Ferras, Patricia; Gimenez, Teresa; Pamies, Anna; Raventos, Antoni et al. DOI: 10.1093/rheumatology/keab782
PMID: 35177626 Journal: Nature Communications Year: 2022 Reference: Nat Commun. 2022 Feb 17;13(1):915. doi: 10.1038/s41467-022-28621-0. Impact factor: Publication type: Paper in international publication Authors: Alofs, Tessa M; Alvarez-Sierra, Daniel; Brouwers-Haspels, Inge; Castro Eiro, Melisa D; de Wit, Harm; Grashof, Dwin G B; Hernandez-Gonzalez, Manuel; Jaimes, Maria C; Katsikis, Peter D; Kiernan, Caoimhe H et al. DOI: 10.1038/s41467-022-28621-0
PMID: 33868243 Journal: Frontiers in Immunology Year: 2021 Reference: Front Immunol. 2021 Mar 31;12:625591. doi: 10.3389/fimmu.2021.625591. eCollection 2021. Impact factor: Publication type: Letter whit IF Authors: Boluda-Navarro, Mireia; Carreras, Carmen; Cervera, Jose Vicente; Colobran, Roger; Franco-Jarava, Clara; Ibanez, Mariam; Liquori, Alessandro; Martinez-Gallo, Monica; Rodriguez-Vega, Hector; Such, Esperanza et al. DOI: 10.3389/fimmu.2021.625591
PMID: 33867313 Journal: EBioMedicine Year: 2021 Reference: EBioMedicine. 2021 Apr;66:103339. doi: 10.1016/j.ebiom.2021.103339. Epub 2021 Apr 15. Impact factor: Publication type: Paper in international publication Authors: Aguilera-Albesa, Sergio; Albu, Sergiu; Alvarez-Errico, Damiana; Arranz, Maria J; Arribas, Carles; Casasnovas, Carlos; Castro de Moura, Manuel; Colobran, Roger; Dalmau, David; Davalos, Veronica et al. DOI: 10.1016/j.ebiom.2021.103339
PMID: 33742673 Journal: RHEUMATOLOGY Year: 2021 Reference: Rheumatology (Oxford). 2021 Dec 24;61(1):154-162. doi: 10.1093/rheumatology/keab279. Impact factor: Publication type: Paper in international publication Authors: Bellocchi, Chiara; Beretta, Lorenzo; Callejas-Moraga, Authors' Names Eduardo Luis; Del-Castillo, Alfredo Guillen-; Fonollosa-Pla, Vicente; Lorite-Gomez, Karen; Mahler, Michael; Perurena-Prieto, Janire; Sanz-Martinez, Maria Teresa; Severino, Adriana et al. DOI: 10.1093/rheumatology/keab279
PMID: 33647767 Journal: EBioMedicine Year: 2021 Reference: EBioMedicine. 2021 Mar;65:103246. doi: 10.1016/j.ebiom.2021.103246. Epub 2021 Feb 26. Impact factor: Publication type: Paper in international publication Authors: Amitrano, Sara; Baldassarri, Margherita; Benetti, Elisa; Bruttini, Mirella; Castagna, Maria Grazia; Colobran, Roger; Crawley, Francis P; Croci, Susanna; Daga, Sergio; Doddato, Gabriella et al. DOI: 10.1016/j.ebiom.2021.103246
PMID: 31701864 Journal: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Year: 2020 Reference: Am J Trop Med Hyg. 2020 Jan;102(1):159-163. doi: 10.4269/ajtmh.19-0550. Impact factor: Publication type: Paper in international publication Authors: Bosch-Nicolau, Pau; Franco-Jarava, Clara; Martinez-Gallo, Monica; Molina, Israel; Moure, Zaira; Salvador, Fernando; Sanchez-Montalva, Adrian; Sao Aviles, Augusto; Silgado, Aroa; Sulleiro, Elena et al. DOI: 10.4269/ajtmh.19-0550
PMID: 33328136 Journal: Year: 2020 Reference: Arch Bronconeumol (Engl Ed). 2020 Nov 9:S0300-2896(20)30397-5. doi: 10.1016/j.arbres.2020.10.014. Impact factor: Publication type: Other (letters to the editor, abstracts, corrigendum, etc.) Authors: Alvarez, Antoni; Assante, Giulio; Chang-Macchiu, Patricia; Clofent Alarcon, David; Martinez-Gallo, Monica; Polverino, Eva; Romero Mesones, Christian Eduardo; Traversi, Letizia; Tur-Torres, Jordi et al. DOI: 10.1016/j.arbres.2020.10.014
PMID: 33613568 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2021 Feb 1;11:625896. doi: 10.3389/fimmu.2020.625896. eCollection 2020. Impact factor: 5.085 Publication type: Paper in international publication Authors: Mariscal, Anais, Milan, Milena, Baucells, Andres, Martinez, Maria Angeles, Guillen, Andrea Garcia, Trallero-Araguas, Ernesto, Alvarado-Cardenas, Marcelo, Martinez-Martinez, Laura, Alserawan, Leticia, Franco-Leyva, Teresa et al. DOI: 10.3389/fimmu.2020.625896
PMID: 33146036 Journal: CEPHALALGIA Year: 2020 Reference: Cephalalgia. 2020 Nov;40(13):1410-1421. doi: 10.1177/0333102420965157. Impact factor: 4.868 Publication type: Paper in international publication Authors: Caronna, Edoardo, Ballve, Alejandro, Llaurado, Arnau, Gallardo, Victor Jose, Maria Ariton, Diana, Lallana, Sofia, Maza, Samuel Lopez, Gadea, Marta Olive, Quibus, Laura, Restrepo, Juan Luis et al. DOI: 10.1177/0333102420965157
PMID: 30721140 Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE Year: 2019 Reference: Clin Chem Lab Med. 2019 Jul 26;57(8):e179-e182. doi: 10.1515/cclm-2018-1121. Impact factor: 3.638 Publication type: Letter whit IF Authors: Franco-Jarava, Clara, Dieli-Crimi, Romina, Vila-Pijoan, Gemma, Pujol-Borrell, Ricardo, Hernandez-Gonzalez, Manuel, Colobran, Roger et al. DOI: 10.1515/cclm-2018-1121
PMID: 30682461 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2019 Reference: J Allergy Clin Immunol. 2019 May;143(5):1952-1956.e6. doi: 10.1016/j.jaci.2018.12.1013. Epub 2019 Jan 22. Impact factor: 14.11 Publication type: Paper in international publication Authors: Bucciol, Giorgia, Nicholas, Sarah K, Calvo, Pier Luigi, Cant, Andrew, Edgar, J David M, Espanol, Teresa, Ferrua, Francesca, Galicchio, Miguel, Gennery, Andrew R, Hadzic, Nedim et al. DOI: 10.1016/j.jaci.2018.12.1013
PMID: 30273710 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2019 Reference: J Allergy Clin Immunol. 2019 Jan;143(1):359-368. doi: 10.1016/j.jaci.2018.09.009. Epub 2018 Sep 29. Impact factor: 14.11 Publication type: Paper in international publication Authors: Balderrama-Rodriguez, Angelica, Ramos, Eduardo, Modesto, Consuelo, Mesa-Del-Castillo, Pablo, Ortego-Centeno, Norberto, Clemente, Daniel, Souto, Alejandro, Palmou, Natalia, Remesal, Agustin, Leslie, Kieron S et al. DOI: 10.1016/j.jaci.2018.09.009
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
A study from the Vall d’Hebron Campus demonstrates that the Ex Vivo C5b-9 deposition test is useful for monitoring the activity of the complement system (CS) in patients with aHUS or transplant-associated TMA.
The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.
