Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
The role of MNK kinases in cellular stress resistance.
The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Projects

Aquest any no hi ha projectes actius.

Publications

Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations.

PMID: 34919756
Journal: FASEB JOURNAL
Year: 2022
Reference: FASEB J. 2022 Jan;36(1):e22091. doi: 10.1096/fj.202100819RRR.
Impact factor: 5.192
Publication type: Paper in international publication
Authors: Molina-Berenguer, Miguel; Vila-Julia, Ferran; Perez-Ramos, Sandra; Salcedo-Allende, Maria Teresa; Camara, Yolanda; Torres-Torronteras, Javier; Marti, Ramon et al.
DOI: 10.1096/fj.202100819RRR

Can We Reduce Overtreatment of Cervical High-Grade Squamous Intraepithelial Lesions?

PMID: 34928250
Journal: Journal of Lower Genital Tract Disease
Year: 2022
Reference: J Low Genit Tract Dis. 2022 Jan 1;26(1):20-26. doi: 10.1097/LGT.0000000000000635.
Impact factor: 1.925
Publication type: Paper in international publication
Authors: Bradbury, Melissa; Dinares, Maria Carme; Sainz, Alex; Castellet, Cristina; Perez-Benavente, Assumpcio; Gil-Moreno, Antonio; Centeno, Cristina; Murcia, Maria Teresa; Rabasa, Jordi et al.
DOI: 10.1097/LGT.0000000000000635

Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer's disease.

PMID: 34514662
Journal: BRAIN PATHOLOGY
Year: 2022
Reference: Brain Pathol. 2022 Jan;32(1):e13016. doi: 10.1111/bpa.13016. Epub 2021 Sep 12.
Impact factor: 6.508
Publication type: Paper in international publication
Authors: Camacho, Jessica; Rabano, Alberto; Marazuela, Paula; Bonaterra-Pastra, Anna; Serna, Garazi; Moline, Teresa; Ramon Y Cajal, Santiago; Martinez-Saez, Elena; Hernandez-Guillamon, Mar et al.
DOI: 10.1111/bpa.13016

BCL2 translocation in high grade B cell lymphoma (NOS, DH/TH) is associated with reduced progression free survival.

PMID: 34510996
Journal: LEUKEMIA & LYMPHOMA
Year: 2022
Reference: Leuk Lymphoma. 2022 Jan;63(1):101-108. doi: 10.1080/10428194.2021.1975189. Epub 2021 Sep 11.
Impact factor: 3.28
Publication type: Paper in international publication
Authors: Gonzalez de Villambrosia, Sonia; Bastos, Mariana; Palanca, Javier Menarguez; Cruz, Jorge Gayoso; Navarro, Jose-Tomas; Tapia, Gustavo; Alonso, Sara Alvarez; Martin, Alejandro; Blanco, Oscar; Abrisqueta, Pau et al.
DOI: 10.1080/10428194.2021.1975189

miRNA landscape in primary tumors and matched metastases in gastrointestinal stromal tumors.

PMID: 33432846
Journal: Epigenomics
Year: 2021
Reference: Epigenomics. 2021 Mar;13(5):369-377. doi: 10.2217/epi-2020-0303. Epub 2021 Jan 12.
Impact factor:
Publication type: Paper in international publication
Authors: Angelini, Sabrina; Graziosi, Agnese; Hrelia, Patrizia; Landolfi, Stefania; Ravegnini, Gloria; Ricci, Riccardo; Serrano, Cesar; Terrenato, Irene; Valori, Giorgia; Zhang, Qianqian et al.
DOI: 10.2217/epi-2020-0303

Transarticular epithelioid hemangioma of the ankle-a case of a rare vascular neoplasm.

PMID: 33420574
Journal: SKELETAL RADIOLOGY
Year: 2021
Reference: Skeletal Radiol. 2021 Jun;50(6):1263-1270. doi: 10.1007/s00256-020-03687-3. Epub 2021 Jan 8.
Impact factor:
Publication type: Letter or abstract
Authors: Cajal, Alfredo Gimeno; de Albert, Matias; Dominguez Oronoz, Rosa; Marton, Nikolett; Ramos-Oliver, Irma et al.
DOI: 10.1007/s00256-020-03687-3

Developing indicators for quality assurance in cytopathology. Catalan Society of Cytopathology.

PMID: 33074593
Journal: DIAGNOSTIC CYTOPATHOLOGY
Year: 2021
Reference: Diagn Cytopathol. 2021 Feb;49(2):273-286. doi: 10.1002/dc.24639. Epub 2020 Oct 19.
Impact factor:
Publication type: Paper in international publication
Authors: Alameda, Francesc; Bosch, Ramon; CatalÃ , Isabel; Combalia, Neus; Dinares, Maria Carme; Fabra, Gemma; Gallardo, Joana; Gonzalez, Clarisa; Lloveras, Belen; Mancebo, Eva et al.
DOI: 10.1002/dc.24639

Progression of Interstitial Fibrosis and Tubular Atrophy in Low Immunological Risk Renal Transplants Monitored by Sequential Surveillance Biopsies: The Influence of TAC Exposure and Metabolism.

PMID: 33406589
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Jan 4;10(1). pii: jcm10010141. doi: 10.3390/jcm10010141.
Impact factor:
Publication type: Paper in international publication
Authors: Castella, Eva; Chamoun, Betty; Cidraque, Ignacio; Gabaldon, Alejandra; Guri, Xavier; Moreso, Francesc; Perello, Manel; Salcedo, Maite; Sellares, Joana; Seron, Daniel et al.
DOI: 10.3390/jcm10010141

Autophagy Takes Center Stage as a Possible Cancer Hallmark.

PMID: 33194736
Journal: Frontiers in Oncology
Year: 2020
Reference: Front Oncol. 2020 Oct 22;10:586069. doi: 10.3389/fonc.2020.586069. eCollection 2020.
Impact factor: 4.848
Publication type: Review in international publication
Authors: Kondoh, Hiroshi, Alvarez-Meythaler, Jose G, Garcia-Mayea, Yoelsis, Mir, Cristina, LLeonart, Matilde E et al.
DOI: 10.3389/fonc.2020.586069

TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance.

PMID: 33167355
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Nov 5;12(11). pii: cancers12113269. doi: 10.3390/cancers12113269.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Garcia-Mayea, Yoelsis, Mir, Cristina, Carballo, Laia, Castellvi, Josep, Temprana-Salvador, Jordi, Lorente, Juan, Benavente, Sergi, Garcia-Pedrero, Juana M, Allonca, Eva, Rodrigo, Juan P et al.
DOI: 10.3390/cancers12113269

#EBUSTwitter: Novel Use of Social Media for Conception, Coordination, and Completion of an International, Multicenter Pathology Study.

PMID: 31846366
Journal: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
Year: 2020
Reference: Archives of Pathology & Laboratory Medicine. 2020 Jul 1;144(7):878-82. doi: 10.5858/arpa.2019-0297-OA.
Impact factor: 4.094
Publication type: Paper in international publication
Authors: Lepe, Marcos, Oltulu, Pembe, Canepa, Mariana, Wu, Roseann I, Deeken, Amy, Alex, Deepu, Dinares, Carme, Doxtader, Erika E, Fitzhugh, Valerie A, Gibier, Jean-Baptiste et al.
DOI: 10.5858/arpa.2019-0297-OA

Multimerization of Zika Virus-NS5 Causes Ciliopathy and Forces Premature Neurogenesis.

PMID: 33147489
Journal: Cell Stem Cell
Year: 2020
Reference: Cell Stem Cell. 2020 Dec 3;27(6):920-936.e8. doi: 10.1016/j.stem.2020.10.002. Epub 2020 Nov 3.
Impact factor: 20.86
Publication type: Paper in international publication
Authors: Saade, Murielle, Ferrero, Diego S, Blanco-Ameijeiras, Jose, Gonzalez-Gobartt, Elena, Flores-Mendez, Marco, Ruiz-Arroyo, Victor M, Martinez-Saez, Elena, Ramon Y Cajal, Santiago, Akizu, Naiara, Verdaguer, Nuria et al.
DOI: 10.1016/j.stem.2020.10.002

Decompensated liver disease due to primary hepatic amyloidosis: Is liver transplantation still mandatory?

PMID: 30561765
Journal: HEPATOLOGY
Year: 2019
Reference: Hepatology. 2019 Jun;69(6):2701-2703. doi: 10.1002/hep.30464. Epub 2019 Mar 7.
Impact factor: 14.971
Publication type: Paper in international publication
Authors: Senin, Alicia, Salcedo, Maria-Teresa, Merino-Casabiel, Xavier, Castells, Lluis, Esteban, Rafael, Buti, Maria, Martinez-Valle, Fernando, Gironella, Merche, Riveiro-Barciela, Mar et al.
DOI: 10.1002/hep.30464

The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer.

PMID: 31141692
Journal: Cell Reports
Year: 2019
Reference: Cell Rep. 2019 May 28;27(9):2690-2708.e10. doi: 10.1016/j.celrep.2019.04.098.
Impact factor: 7.815
Publication type: Paper in international publication
Authors: Maruvka, Yosef, De Mattos-Arruda, Leticia, Sammut, Stephen-John, Ross, Edith M, Bashford-Rogers, Rachael, Greenstein, Erez, Markus, Havell, Morganella, Sandro, Teng, Yvonne, Seoane, Joan et al.
DOI: 10.1016/j.celrep.2019.04.098

Sclerosing Cholangitis Related to IgG4: Not Always a Curable Entity.

PMID: 31113593
Journal: Annals of Hepatology
Year: 2019
Reference: Ann Hepatol. 2019 Jan - Feb;18(1):215-219. doi: 10.5604/01.3001.0012.7916.
Impact factor: 1.895
Publication type: Paper in international publication
Authors: Martinez-Valle, Fernando, Riveiro-Barciela, Mar, Salcedo, Maria-Teresa, Merino-Casabiel, Xavier, Fernandez-Codina, Andreu, Torres, Ines de, Esteban, Rafael, Buti, Maria et al.
DOI: 10.5604/01.3001.0012.7916

Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1.

PMID: 31114569
Journal: Frontiers in Immunology
Year: 2019
Reference: Front Immunol. 2019 Apr 30;10:825. doi: 10.3389/fimmu.2019.00825. eCollection 2019.
Impact factor: 4.716
Publication type: Paper in international publication
Authors: Arnau-Saz, Vicent, Garrido, Julio, Tarrats, Antoni, Buzon, Maria J, Martinez-Picado, Javier, Izquierdo-Useros, Nuria, Genesca, Meritxell, Tapia, Gustavo, Castellvi, Josep, Hernandez-Gallego, Alba et al.
DOI: 10.3389/fimmu.2019.00825

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.

PMID: 30377213
Journal: EMBO Molecular Medicine
Year: 2018
Reference: EMBO Mol Med. 2018 Dec;10(12). pii: emmm.201809172. doi: 10.15252/emmm.201809172.
Impact factor: 10.293
Publication type: Paper in international publication
Authors: Vidal, Marc, Peg, Vicente, Serres-Creixams, Xavier, Dellaire, Graham, Simard, Jacques, Nuciforo, Paolo, Rubio, Isabel T, Dientsmann, Rodrigo, Barrett, J Carl, Caldas, Carlos et al.
DOI: 10.15252/emmm.201809172

Thrombotic thrombocytopenic purpura relapse induced by acute hepatitis E transmitted by cryosupernatant plasma and successfully controlled with ribavirin.

PMID: 30284732
Journal: TRANSFUSION
Year: 2018
Reference: Transfusion. 2018 Nov;58(11):2501-2505. doi: 10.1111/trf.14831. Epub 2018 Oct 4.
Impact factor: 3.423
Publication type: Letter or abstract
Authors: Riveiro-Barciela, Mar, Bes, Marta, Quer, Josep, Valcarcel, David, Piriz, Sofia, Gregori, Josep, Llorens, Meritxell, Salcedo, Maria-Teresa, Piron, Maria, Esteban, Rafael et al.
DOI: 10.1111/trf.14831

p95HER2-T cell bispecific antibody for breast cancer treatment.

PMID: 30282693
Journal: Science Translational Medicine
Year: 2018
Reference: Sci Transl Med. 2018 Oct 3;10(461). pii: 10/461/eaat1445. doi: 10.1126/scitranslmed.aat1445.
Impact factor: 16.71
Publication type: Paper in international publication
Authors: Freimoser-Grundschober, Anne, Rius Ruiz, Irene, Vicario, Rocio, Morancho, Beatriz, Morales, Cristina Bernado, Arenas, Enrique J, Herter, Sylvia, Klein, Christian, Arribas, Joaquin, Saura, Cristina et al.
DOI: 10.1126/scitranslmed.aat1445

[Embolizing cardiac hibernoma and acute respiratory failure].

PMID: 30269781
Journal: Revista espanola de patologia : publicacion oficia
Year: 2018
Reference: Rev Esp Patol. 2018 Oct - Dec;51(4):267-270. doi: 10.1016/j.patol.2018.02.003. Epub 2018 Apr 5.
Impact factor: 0
Publication type: Paper in national publication
Authors: Montecino Romanini, Carolina, Reques Llanos, Armando, de Torres Ramirez, Ines, Rodriguez Morera, Jaime, Temprana Salvador, Jordi, Ramon Y Cajal, Santiago, Garcia Jimenez, Angel et al.
DOI: 10.1016/j.patol.2018.02.003

Sofosbuvir and daclatasvir in mono- and HIV-coinfected patients with recurrent hepatitis C after liver transplant.

PMID: 28051797
Journal: Annals of Hepatology
Year: 2017
Reference: Ann Hepatol. 2017 Jan-Feb 2017;16(1):86-93. doi: 10.5604/16652681.1226819.
Impact factor: 1.678
Publication type: Paper in international publication
Authors: Salcedo, Teresa, Esteban, Juan Ignacio, Esteban-Mur, Rafael, Charco, Ramon, Rodriguez-Frias, Francisco, Len, Oscar, Crespo, Manel, Castells, Lluis, Llaneras, Jordi, Campos-Varela, Isabel et al.
DOI: 10.5604/16652681.1226819

Gene expression-based classifications of fibroadenomas and phyllodes tumours of the breast.

PMID: 25687451
Journal: Molecular Oncology
Year: 2015
Reference: Mol Oncol. 2015 Jun;9(6):1081-90. doi: 10.1016/j.molonc.2015.01.003. Epub 2015 Jan 31.
Impact factor: 5.331
Publication type: Paper in international publication
Authors: Vidal, Maria, Peg, Vicente, Galvan, Patricia, Tres, Alejandro, Cortes, Javier, Ramon Y Cajal, Santiago, Rubio, Isabel T, Prat, Aleix et al.
DOI: 10.1016/j.molonc.2015.01.003

Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies.

PMID: 26075403
Journal: PLoS One
Year: 2015
Reference: PLoS One. 2015 Jun 15;10(6):e0129876. doi: 10.1371/journal.pone.0129876. eCollection 2015.
Impact factor: 3.234
Publication type: Paper in international publication
Authors: Rubio, Isabel T, Marangoni, Elisabetta, Deeds, James, Boehm, Markus, Schlegel, Robert, Tabernero, Josep, Mosher, Rebecca, Arribas, Joaquin, Nuciforo, Paolo, Cortes, Javier et al.
DOI: 10.1371/journal.pone.0129876

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

PMID: 26106142
Journal: CARCINOGENESIS
Year: 2015
Reference: Carcinogenesis. 2015 Jun;36 Suppl 1:S254-96. doi: 10.1093/carcin/bgv039.
Impact factor: 5.334
Publication type: Review in international publication
Authors: Salzberg, Anna C, Goodson, William H 3rd, Lowe, Leroy, Carpenter, David O, Gilbertson, Michael, Manaf Ali, Abdul, Lopez de Cerain Salsamendi, Adela, Lasfar, Ahmed, Carnero, Amancio, Azqueta, Amaya et al.
DOI: 10.1093/carcin/bgv039

Disruptive chemicals, senescence and immortality.

PMID: 26106138
Journal: CARCINOGENESIS
Year: 2015
Reference: Carcinogenesis. 2015 Jun;36 Suppl 1:S19-37. doi: 10.1093/carcin/bgv029.
Impact factor: 5.334
Publication type: Review in international publication
Authors: Singh, Neetu, Hamid, Roslida A, Ryan, Elizabeth P, Brown, Dustin G, Wise, John Pierce Sr, Wise, Sandra S, Yasaei, Hemad, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K et al.
DOI: 10.1093/carcin/bgv029

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression.

PMID: 24684754
Journal: MOL CANCER
Year: 2014
Reference: Mol Cancer. 2014 Mar 31;13:74. doi: 10.1186/1476-4598-13-74.
Impact factor: 5.397
Publication type: Paper in international publication
Authors: Alana, Lide, Sese, Marta, Canovas, Veronica, Punyal, Yolanda, Fernandez, Yolanda, Abasolo, Ibane, de Torres, Ines, Ruiz, Cristina, Espinosa, Lluis, Bigas, Anna et al.
DOI: 10.1186/1476-4598-13-74

Capturing Intra-Tumor Genetic Heterogeneity by De Novo Mutation Profiling of Circulating Cell-Free Tumor DNA: A Proof-of-Principle.

PMID: 25009010
Journal: ANN ONCOL
Year: 2014
Reference: Ann Oncol. 2014 Sep;25(9):1729-35. doi: 10.1093/annonc/mdu239. Epub 2014 Jul 9.
Impact factor: 6.578
Publication type: Paper in international publication
Authors: Won, H H, Ng, C K Y, Nuciforo, P, Bidard, F-C, Aura, C, Saura, C, Peg, V, Piscuoglio, S, Oliveira, M, Smolders, Y et al.
DOI: 10.1093/annonc/mdu239

Schwannomas, benign tumors with a senescent phenotype.

PMID: 24217963
Journal: HISTOL HISTOPATHOL
Year: 2014
Reference: Histol Histopathol. 2014 Jun;29(6):721-30. Epub 2013 Nov 12.
Impact factor: 2.236
Publication type: Paper in international publication
Authors: Romagosa, C, Simonetti, S, Serrano, C, Hernandez-Losa, C, Bague, S, Orellana, R, Valverde, C, Lleonart, M E, Aizpurua, M, Carles, J et al.
DOI:

RPLP1, a Crucial Ribosomal Protein for Embryonic Development of the Nervous System.

PMID: 24959908
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Jun 24;9(6):e99956. doi: 10.1371/journal.pone.0099956. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Perucho, Laura, Artero-Castro, Ana, Guerrero, Sergi, Ramon Y Cajal, Santiago, LLeonart, Matilde E, Wang, Zhao-Qi et al.
DOI: 10.1371/journal.pone.0099956

Extensive nodal involvement increases the positivity of blue nodes in the axillary reverse mapping procedure in patients with breast cancer.

PMID: 22258666
Journal: JOURNAL OF SURGICAL ONCOLOGY
Year: 2012
Reference: J Surg Oncol. 2012 Jul 1;106(1):89-93. doi: 10.1002/jso.23048. Epub 2012 Jan 18.
Impact factor: 2.1
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.1002/jso.23048

Preoperative thyrotropin serum concentrations gradually increase from benign thyroid nodules to papillary thyroid microcarcinomas then to papillary thyroid cancers of larger size.

PMID: 21860806
Journal: Journal of thyroid research
Year: 2012
Reference: J Thyroid Res. 2012;2012:530721. Epub 2011 Jul 19.
Impact factor:
Publication type: Letter or abstract
Authors: Zafon, Carles, Obiols, Gabriel, Baena, Juan Antonio, Castellvi, Josep, Dalama, Belen, Mesa, Jordi et al.
DOI: 10.1155/2012/530721

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