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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

Exploratory study of an oral screening dysplasia program for HIV-infected men who have sex with men.

PMID: 35730367
Journal: AIDS
Year: 2022
Reference: AIDS. 2022 Jun 23. pii: 00002030-990000000-00044. doi: 10.1097/QAD.0000000000003287.
Impact factor: 4.177
Publication type: Paper in international publication
Authors: Planas, Bibiana; Garcia, Jorge; Hernandez-Losa, Javier; Molina, Maria Del Mar; Dinares, Maria Carme; Callejo, Angela; Curran, Adria; Navarro, Jordi; Suanzes, Paula; Falco, Vicenc et al.
DOI: 10.1097/QAD.0000000000003287

Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology.

PMID: 35739348
Journal: Clinical & Translational Oncology
Year: 2022
Reference: Clin Transl Oncol. 2022 Jun 23. pii: 10.1007/s12094-022-02856-1. doi: 10.1007/s12094-022-02856-1.
Impact factor: 3.405
Publication type: Paper in international publication
Authors: Garcia-Castano, Almudena; Goma, Montserrat; Mesia-Nin, Ricard; Ruiz-Bravo, Elena; Soria-Rivas, Ainara; Castillo, Paola; Brana-Garcia, Irene; Alberola-Ferranti, Margarita; Garcia-Cosio, Monica; Trigo, Jose et al.
DOI: 10.1007/s12094-022-02856-1

Transforming growth factor-beta 1: A new factor reducing hepatic SHBG production in liver fibrosis.

PMID: 35762039
Journal: JOURNAL OF CELLULAR PHYSIOLOGY
Year: 2022
Reference: J Cell Physiol. 2022 Jun 27. doi: 10.1002/jcp.30818.
Impact factor: 6.384
Publication type: Paper in international publication
Authors: Selva, David M; Simo, Rafael; Hernandez, Cristina; Salcedo-Allende, Maria Teresa; Ramos-Perez, Lorena; Fuertes-Rioja, Lidia; Brianso-Llort, Laura et al.
DOI: 10.1002/jcp.30818

Secondary organising pneumonia to persistent SARS-CoV-2 infection in immunocompromised patient.

PMID: 35786522
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Jun 10. pii: S0025-7753(22)00254-8. doi: 10.1016/j.medcli.2022.04.008.
Impact factor: 1.725
Publication type: Paper in national publication
Authors: Sansano, Irene; Villar, Ana; Granados, Galo David et al.
DOI: 10.1016/j.medcli.2022.04.008

The Role of Sphingolipids Metabolism in Cancer Drug Resistance.

PMID: 35004331
Journal: Frontiers in Oncology
Year: 2021
Reference: Front Oncol. 2021 Dec 23;11:807636. doi: 10.3389/fonc.2021.807636. eCollection 2021.
Impact factor: 6.244
Publication type: Review in international publication
Authors: LLeonart, Matilde Esther, Bataller, Marina, Sanchez-Garcia, Almudena, Garcia-Mayea, Yoelsis, Mir, Cristina, Rodriguez, Isabel et al.
DOI: 10.3389/fonc.2021.807636

Epstein-Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report.

PMID: 34868006
Journal: Frontiers in Immunology
Year: 2021
Reference: Front Immunol. 2021 Nov 16;12:761798. doi: 10.3389/fimmu.2021.761798. eCollection 2021.
Impact factor: 7.561
Publication type: Paper in international publication
Authors: Marti, Merce, Cortes, Javier, Carrascal, Montserrat, Roura-Mir, Carme, Perez, Jose, Aran, Andrea, Peg, Vicente, Rabanal, Rosa Maria, Bernado, Cristina, Zamora, Esther et al.
DOI: 10.3389/fimmu.2021.761798

Evolution of the Early Spliceosomal Complex-From Constitutive to Regulated Splicing.

PMID: 34830325
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Nov 18;22(22). pii: ijms222212444. doi: 10.3390/ijms222212444.
Impact factor: 5.924
Publication type: Review in international publication
Authors: Ayte, Jose, Hummer, Stefan, Borao, Sonia et al.
DOI: 10.3390/ijms222212444

Targeting Sphingolipids for Cancer Therapy.

PMID: 34737957
Journal: Frontiers in Oncology
Year: 2021
Reference: Front Oncol. 2021 Oct 19;11:745092. doi: 10.3389/fonc.2021.745092. eCollection 2021.
Impact factor: 6.244
Publication type: Review in international publication
Authors: Companioni, Osmel, Mir, Cristina, Garcia-Mayea, Yoelsis, LLeonart, Matilde E et al.
DOI: 10.3389/fonc.2021.745092

Axillary staging based on molecular analysis: Results of the B-CLOSER-II study.

PMID: 32919301
Journal: PATHOLOGY RESEARCH AND PRACTICE
Year: 2020
Reference: Pathol Res Pract. 2020 Nov;216(11):153197. doi: 10.1016/j.prp.2020.153197. Epub 2020 Sep 3.
Impact factor: 2.05
Publication type: Paper in international publication
Authors: Sansano, Irene, Vieites, Begona, Sancho de Salas, Magdalena, Garcia, Carmen, Amendoeira, Isabel, Bernet, Laia, Perez-Garcia, Jose Manuel, Espinosa-Bravo, Martin, Rubio, Isabel T, Ramon Y Cajal, Santiago et al.
DOI: 10.1016/j.prp.2020.153197

New opacities in lung allograft after transbronchial cryobiopsy.

PMID: 32843174
Journal: RESPIRATORY MEDICINE
Year: 2020
Reference: Respir Med. 2020 Aug - Sep;170:106043. doi: 10.1016/j.rmed.2020.106043. Epub 2020 May 25.
Impact factor: 3.095
Publication type: Paper in international publication
Authors: Loor, Karina, Pallisa, Esther, Culebras, Mario, Deu, Maria, Alvarez, Antonio, Sansano, Irene, Berastegui, Cristina, Clofent, David, Polverino, Eva, de Gracia, Javier et al.
DOI: 10.1016/j.rmed.2020.106043

Five simple reasons to discard DIP, or why we should stop calling dolphins big fish.

PMID: 32843423
Journal: JOURNAL OF CLINICAL PATHOLOGY
Year: 2020
Reference: J Clin Pathol. 2020 Nov;73(11):762-768. doi: 10.1136/jclinpath-2020-206669. Epub 2020 Aug 25.
Impact factor: 2.46
Publication type: Review in international publication
Authors: Mukhopadhyay, Sanjay, Aesif, Scott W, Sansano, Irene et al.
DOI: 10.1136/jclinpath-2020-206669

ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells.

PMID: 32848136
Journal: Nature Communications
Year: 2020
Reference: Nat Commun. 2020 Aug 26;11(1):4261. doi: 10.1038/s41467-020-18081-9.
Impact factor: 12.121
Publication type: Paper in international publication
Authors: Fuentes, Pedro, Sese, Marta, Guijarro, Pedro J, Emperador, Marta, Sanchez-Redondo, Sara, Peinado, Hector, Hummer, Stefan, Ramon Y Cajal, Santiago et al.
DOI: 10.1038/s41467-020-18081-9

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy.

PMID: 30918495
Journal: Frontiers in Neurology
Year: 2019
Reference: Front Neurol. 2019 Mar 13;10:187. doi: 10.3389/fneur.2019.00187. eCollection 2019.
Impact factor: 2.635
Publication type: Paper in international publication
Authors: Camacho, Jessica, Moline, Teresa, Bonaterra-Pastra, Anna, Ramon Y Cajal, Santiago, Martinez-Saez, Elena, Hernandez-Guillamon, Mar et al.
DOI: 10.3389/fneur.2019.00187

Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis.

PMID: 30845770
Journal: Cancers
Year: 2019
Reference: Cancers (Basel). 2019 Mar 6;11(3). pii: cancers11030320. doi: 10.3390/cancers11030320.
Impact factor: 6.162
Publication type: Paper in international publication
Authors: Aasen, Trond, Montero, Maria Angeles, Romagosa, Cleofe, Temprana-Salvador, Jordi, Martinez-Marti, Alexandre, Moline, Teresa, Hernandez-Losa, Javier, Y Cajal, Santiago Ramon, Sansano, Irene et al.
DOI: 10.3390/cancers11030320

Expression of Bone Morphogenetic Proteins In Multiple Sclerosis Lesions.

PMID: 30553833
Journal: AMERICAN JOURNAL OF PATHOLOGY
Year: 2019
Reference: Am J Pathol. 2019 Mar;189(3):665-676. doi: 10.1016/j.ajpath.2018.11.007. Epub 2018 Dec 13.
Impact factor: 3.762
Publication type: Paper in international publication
Authors: Ortega-Aznar, Arantxa, Ramon Y Cajal, Santiago, Montalban, Xavier, Espejo, Carmen, Castro, Zoraida, Calucho, Maite, Calvo-Barreiro, Laura, Martinez-Saez, Elena, Costa, Carme, Eixarch, Herena et al.
DOI: 10.1016/j.ajpath.2018.11.007

Impact of human papilloma virus in patients with oral and oropharyngeal squamous cell carcinomas.

PMID: 30777194
Journal: MEDICINA CLINICA
Year: 2019
Reference: Med Clin (Barc). 2019 Mar 1;152(5):174-180. doi: 10.1016/j.medcli.2018.05.015. Epub 2018 Jul 7.
Impact factor: 1.277
Publication type: Paper in national publication
Authors: Valls-Ontanon, Adaia, Hernandez-Losa, Javier, Somoza Lopez de Haro, Rosa, Bellosillo-Paricio, Beatriz, Ramon Y Cajal, Santiago, Bescos-Atin, Coro, Munill-Ferrer, Montserrat, Alberola-Ferranti, Margarita et al.
DOI: 10.1016/j.medcli.2018.05.015

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis.

PMID: 29892069
Journal: NATURE MEDICINE
Year: 2018
Reference: Nat Med. 2018 Jul;24(7):1024-1035. doi: 10.1038/s41591-018-0044-4. Epub 2018 Jun 11.
Impact factor: 32.621
Publication type: Paper in international publication
Authors: Priego, Neibla, Zhu, Lucia, Monteiro, Catia, Mulders, Manon, Wasilewski, David, Bindeman, Wendy, Doglio, Laura, Martinez, Liliana, Martinez-Saez, Elena, Cajal, Santiago Ramon Y et al.
DOI: 10.1038/s41591-018-0044-4

Analysis of intra-tumor heterogeneity in Neurofibromatosis Type 1 plexiform neurofibromas and neurofibromas with atypical features: Correlating histological and genomic findings.

PMID: 29774626
Journal: HUMAN MUTATION
Year: 2018
Reference: Hum Mutat. 2018 Aug;39(8):1112-1125. doi: 10.1002/humu.23552. Epub 2018 May 25.
Impact factor: 5.359
Publication type: Paper in international publication
Authors: Terribas, Ernest, Zucchiatti, Adriana Carolina, Moline, Teresa, Rosas, Inma, Teule, Alex, Ramon Y Cajal, Santiago, Lopez-Gutierrez, Juan Carlos, Blanco, Ignacio, Castellanos, Elisabeth, Lazaro, Conxi et al.
DOI: 10.1002/humu.23552

Team Approach: Metastatic Disease of the Spine.

PMID: 29762343
Journal: JBJS reviews
Year: 2018
Reference: JBJS Rev. 2018 May;6(5):e6. doi: 10.2106/JBJS.RVW.17.00118.
Impact factor: 0
Publication type: Review in international publication
Authors: Matamalas, Antonia, Valverde, Claudia, Benavente, Sergi, Casas-Gomila, Lourdes, Romagosa, Cleofe, Gonzalez-Tartiere, Pilar, Pellise, Ferran et al.
DOI: 10.2106/JBJS.RVW.17.00118

Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases.

PMID: 29755676
Journal: Oncotarget
Year: 2018
Reference: Oncotarget. 2018 Apr 17;9(29):20617-20630. doi: 10.18632/oncotarget.25041. eCollection 2018 Apr 17.
Impact factor: 0
Publication type: Paper in international publication
Authors: Oliveira, Mafalda, Gomez, Patricia, Teixido, Cristina, Nuciforo, Paolo, Peg, Vicente, Saura, Cristina, Ramon Y Cajal, Santiago, Casas, Francesc Tresserra, Weigelt, Britta, Cortes, Javier et al.
DOI: 10.18632/oncotarget.25041

Epidemiology and diagnosis of tuberculous lymphadenitis in a tuberculosis low-burden country.

PMID: 25634205
Journal: MEDICINE
Year: 2015
Reference: Medicine (Baltimore). 2015 Jan;94(4):e509. doi: 10.1097/MD.0000000000000509.
Impact factor: 4.867
Publication type: Paper in international publication
Authors: Salvador, Fernando, Los-Arcos, Ibai, Sanchez-Montalva, Adrian, Tortola, Teresa, Curran, Adrian, Villar, Ana, Saborit, Nuria, Castellvi, Josep, Molina, Israel et al.
DOI: 10.1097/MD.0000000000000509

Updated guidelines for biomarker testing in colorectal carcinoma: a national consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology.

PMID: 25373533
Journal: Clinical & Translational Oncology
Year: 2015
Reference: Clin Transl Oncol. 2015 Apr;17(4):264-73. doi: 10.1007/s12094-014-1252-0. Epub 2014 Nov 6.
Impact factor: 2.077
Publication type: Paper in international publication
Authors: Navarro, S, Ramon Y Cajal, S, Landolfi, S, Garcia-Alfonso, P, Garcia-Foncillas, J, Salazar, R, Perez-Segura, P, Garcia-Carbonero, R, Musulen-Palet, E, Cuatrecasas, M et al.
DOI: 10.1007/s12094-014-1252-0

Targeting the proliferative and chemoresistant compartment in chronic lymphocytic leukemia by inhibiting survivin protein.

PMID: 24618734
Journal: LEUKEMIA
Year: 2014
Reference: Leukemia. 2014 Oct;28(10):1993-2004. doi: 10.1038/leu.2014.96. Epub 2014 Mar 12.
Impact factor: 9.379
Publication type: Paper in international publication
Authors: Purroy, N, Abrisqueta, P, Carabia, J, Carpio, C, Calpe, E, Palacio, C, Castellvi, J, Crespo, M, Bosch, F et al.
DOI: 10.1038/leu.2014.96

[Value of soluble urokinase receptor serum levels in the differential diagnosis between idiopathic and secondary focal segmental glomerulosclerosis].

PMID: 24463863
Journal: NEFROLOGIA
Year: 2014
Reference: Nefrologia. 2014;34(1):53-61. doi: 10.3265/Nefrologia.pre2013.Oct.12272.
Impact factor: 1.442
Publication type: Paper in national publication
Authors: Segarra, Alfons, Jatem, Elias, Quiles, M Teresa, Arbos, M Antonia, Ostos, Helena, Valtierra, Naiara, Carnicer, Clara, Salcedo, M Teresa et al.
DOI: 10.3265/Nefrologia.pre2013.Oct.12272

[Diagnostic value of soluble urokinase-type plasminogen activator receptor serum levels in adults with idiopathic nephrotic syndrome].

PMID: 24463862
Journal: NEFROLOGIA
Year: 2014
Reference: Nefrologia. 2014;34(1):46-52. doi: 10.3265/Nefrologia.pre2013.Oct.12256.
Impact factor: 1.442
Publication type: Paper in national publication
Authors: Agraz, Irene, Segarra, Alfons, Jatem, Elias, Quiles, M Teresa, Arbos, M Antonia, Ostos, Helena, Valtierra, Naiara, Carnicer, Clara, Salcedo, M Teresa et al.
DOI: 10.3265/Nefrologia.pre2013.Oct.12256

Association of BRCA1 germline mutations in young onset triple-negative breast cancer (TNBC).

PMID: 23982851
Journal: CLIN TRANSL ONCOL
Year: 2014
Reference: Clin Transl Oncol. 2014 Mar;16(3):280-4. doi: 10.1007/s12094-013-1070-9. Epub 2013 Aug 27.
Impact factor: 1.6
Publication type: Paper in international publication
Authors: Robles, L, Andres, R, Pajares, I, Balmana, J, Llort, G, Ramon Y Cajal, T, Chirivella, I, Aguirre, E, Bosch, N, Yague, C et al.
DOI: 10.1007/s12094-013-1070-9

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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