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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

Characteristics of 24 SARS-CoV-2-Sequenced Reinfection Cases in a Tertiary Hospital in Spain.

PMID: 35722299
Journal: Frontiers in Microbiology
Year: 2022
Reference: Front Microbiol. 2022 May 26;13:876409. doi: 10.3389/fmicb.2022.876409. eCollection 2022.
Impact factor: 5.64
Publication type: Paper in international publication
Authors: Codina, Maria Gema, Martin, Maria Carmen, Castillo, Carla, Garcia-Comunas, Karen, Vasquez-Mercado, Rodrigo, Martins-Martins, Reginald, Colomer-Castell, Sergi, Pumarola, Tomas, Campins, Magda, Quer, Josep et al.
DOI: 10.3389/fmicb.2022.876409

A Nine-Strain Bacterial Consortium Improves Portal Hypertension and Insulin Signaling and Delays NAFLD Progression In Vivo.

PMID: 35625927
Journal: Biomedicines
Year: 2022
Reference: Biomedicines. 2022 May 20;10(5). pii: biomedicines10051191. doi: 10.3390/biomedicines10051191.
Impact factor: 6.081
Publication type: Paper in international publication
Authors: Augustin, Salvador, Martell, Maria, Salcedo, Maria Teresa, Pinheiro, Iris, Barbera, Aurora, Raurell, Imma, Estrella, Federico, de Leeuw, Marcel, Bolca, Selin, Gottardi, Davide et al.
DOI: 10.3390/biomedicines10051191

Non-Invasive Tests of Liver Fibrosis Help in Predicting the Development of Hepatocellular Carcinoma among Patients with NAFLD.

PMID: 35566592
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Apr 27;11(9). pii: jcm11092466. doi: 10.3390/jcm11092466.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Banares, Juan, Bermudez, Maria, Vargas, Victor, Salcedo-Allende, Maria Teresa, Castells, Lluis, Augustin, Salvador, Minguez, Beatriz, Pericas, Juan M, Manzano, Ramiro, Rivera-Esteban, Jesus et al.
DOI: 10.3390/jcm11092466

Cost-effectiveness analysis of an active search to retrieve HCV patients lost to follow-up (RELINK-C strategy) and the impact of COVID-19.

PMID: 35555847
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2022
Reference: J Viral Hepat. 2022 Jul;29(7):579-583. doi: 10.1111/jvh.13686. Epub 2022 May 23.
Impact factor: 3.728
Publication type: Paper in international publication
Authors: Vargas-Accarino, Elena, Martinez-Camprecios, Joan, Dominguez-Hernandez, Raquel, Rando-Segura, Ariadna, Riveiro-Barciela, Mar, Rodriguez-Frias, Francisco, Barreira, Ana, Palom, Adriana, Casado, Miguel Angel, Esteban, Rafael et al.
DOI: 10.1111/jvh.13686

Case Report: A Case Study Documenting the Activity of Atezolizumab in a PD-L1-Negative Triple-Negative Breast Cancer.

PMID: 34616675
Journal: Frontiers in Oncology
Year: 2021
Reference: Front Oncol. 2021 Sep 20;11:710596. doi: 10.3389/fonc.2021.710596. eCollection 2021.
Impact factor: 6.244
Publication type: Letter whit IF
Authors: Sanso, Miriam, Chic, Nuria, Martinez, Debora, Gonzalez-Farre, Blanca, Sanfeliu, Esther, Ghiglione, Lucio, Carcelero, Esther, Garcia-Corbacho, Javier, Sanchez, Marcelo, Soy, Dolors et al.
DOI: 10.3389/fonc.2021.710596

Genetic evolution to tyrosine kinase inhibitory therapy in patients with EGFR-mutated non-small-cell lung cancer.

PMID: 34599295
Journal: BRITISH JOURNAL OF CANCER
Year: 2021
Reference: Br J Cancer. 2021 Nov;125(11):1561-1569. doi: 10.1038/s41416-021-01558-9. Epub 2021 Oct 1.
Impact factor: 7.64
Publication type: Paper in international publication
Authors: Martinez-Marti, Alex, Felip, Enriqueta, Mancuso, Francesco Mattia, Caratu, Ginevra, Matito, Judit, Nuciforo, Paolo, Sansano, Irene, Diaz-Mejia, Nely, Cedres, Susana, Callejo, Ana et al.
DOI: 10.1038/s41416-021-01558-9

Monocyte-to-Lymphocyte Ratio in Clot Analysis as a Marker of Cardioembolic Stroke Etiology.

PMID: 34586594
Journal: Translational Stroke Research
Year: 2021
Reference: Transl Stroke Res. 2021 Sep 29. pii: 10.1007/s12975-021-00946-w. doi: 10.1007/s12975-021-00946-w.
Impact factor: 6.829
Publication type: Paper in international publication
Authors: Ribo, Marc, Juega, Jesus, Palacio-Garcia, Carlos, Rodriguez, Maite, Deck, Matias, Rodriguez-Luna, David, Requena, Manuel, Garcia-Tornel, Alvaro, Rodriguez-Villatoro, Noelia, Rubiera, Marta et al.
DOI: 10.1007/s12975-021-00946-w

Gene expression signatures for tailoring adjuvant chemotherapy of luminal breast cancer: the pathologists' perspective.

PMID: 34461263
Journal: ANNALS OF ONCOLOGY
Year: 2021
Reference: Ann Oncol. 2021 Nov;32(11):1316-1321. doi: 10.1016/j.annonc.2021.08.1993. Epub 2021 Aug 28.
Impact factor: 32.976
Publication type: Editorail in international publication
Authors: Salgado, R, Peg, V, Ruschoff, J, Vincent-Salomon, A, Castellano, I, Perner, S, Van de Vijver, K, Quinn, C M, Varga, Z et al.
DOI: 10.1016/j.annonc.2021.08.1993

Steatosis as main determinant of portal hypertension through a restriction of hepatic sinusoidal area in a dietary rat nash model.

PMID: 32770818
Journal: LIVER INTERNATIONAL
Year: 2020
Reference: Liver Int. 2020 Nov;40(11):2732-2743. doi: 10.1111/liv.14632. Epub 2020 Oct 13.
Impact factor: 5.175
Publication type: Paper in international publication
Authors: Barbera, Aurora, Raurell, Imma, Garcia-Lezana, Teresa, Torres-Arauz, Manuel, Bravo, Miren, Hide, Diana, Gil, Mar, Salcedo, Maria Teresa, Genesca, Joan, Martell, Maria et al.
DOI: 10.1111/liv.14632

Sequential immunohistochemistry and virtual image reconstruction using a single slide for quantitative KI67 measurement in breast cancer.

PMID: 32707454
Journal: BREAST
Year: 2020
Reference: Breast. 2020 Oct;53:102-110. doi: 10.1016/j.breast.2020.07.002. Epub 2020 Jul 13.
Impact factor: 3.754
Publication type: Paper in international publication
Authors: Serna, Garazi, Simonetti, Sara, Fasani, Roberta, Pagliuca, Francesca, Guardia, Xavier, Gallego, Paqui, Jimenez, Jose, Peg, Vicente, Saura, Cristina, Eppenberger-Castori, Serenella et al.
DOI: 10.1016/j.breast.2020.07.002

Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition.

PMID: 32691208
Journal: JOURNAL OF NEURO-ONCOLOGY
Year: 2020
Reference: J Neurooncol. 2020 Aug;149(1):13-25. doi: 10.1007/s11060-020-03580-y. Epub 2020 Jul 20.
Impact factor: 3.267
Publication type: Paper in international publication
Authors: Purroy, Noelia, Jimenez, Isabel, Carabia, Julia, Bobillo, Sabela, Palacio, Carles, Abrisqueta, Pau, Pages, Carlota, Nieto, Juan C, Castellvi, Josep, Martinez-Ricarte, Francisco et al.
DOI: 10.1007/s11060-020-03580-y

Lung cancer biomarker testing: perspective from Europe.

PMID: 32676354
Journal: Translational Lung Cancer Research
Year: 2020
Reference: Transl Lung Cancer Res. 2020 Jun;9(3):887-897. doi: 10.21037/tlcr.2020.04.07.
Impact factor: 5.132
Publication type: Review in international publication
Authors: Eri, Zivka, Haragan, Alex, Leonte, Diana, Carvallo, Lina, Prince, Spasenja Savic, Nicholson, Siobhan, Sansano, Irene, Ryska, Ales, Dale, Vibeke G, Perner, Sven et al.
DOI: 10.21037/tlcr.2020.04.07

ONE-STEP NUCLEIC ACID AMPLIFICATION FOR INTRAOPERATIVE ANALYSIS OF SENTINEL LYMPH NODE IN PAPILLARY THYROID CARCINOMA.

PMID: 30400049
Journal: EUROPEAN JOURNAL OF ENDOCRINOLOGY
Year: 2019
Reference: Eur J Endocrinol. 2019 Jan 1;180(1):21-29. doi: 10.1530/EJE-18-0624.
Impact factor: 5.107
Publication type: Paper in international publication
Authors: Fort, Jose M, Pujol-Borrell, Ricardo, Ramon Y Cajal, Santiago, Gonzalez, Oscar, Castell, Joan, Mesa, Jordi, Roca, Isabel, Caubet, Enric, Iglesias Felip, Carmela, Zafon, Carles et al.
DOI: 10.1530/EJE-18-0624

Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer.

PMID: 30373788
Journal: MOLECULAR & CELLULAR PROTEOMICS
Year: 2019
Reference: Mol Cell Proteomics. 2019 Feb;18(2):231-244. doi: 10.1074/mcp.RA118.001102. Epub 2018 Oct 29.
Impact factor: 4.828
Publication type: Paper in international publication
Authors: Abad, Etna, Garcia-Mayea, Yoelsis, Mir, Cristina, Sebastian, David, Zorzano, Antonio, Potesil, David, Zdrahal, Zbynek, Lyakhovich, Alex, Lleonart, Matilde et al.
DOI: 10.1074/mcp.RA118.001102

Integrating clinical, molecular, proteomic and histopathological data within the tissue context: Tissunomics.

PMID: 30667539
Journal: HISTOPATHOLOGY
Year: 2019
Reference: Histopathology. 2019 Jul;75(1):4-19. doi: 10.1111/his.13828. Epub 2019 May 14.
Impact factor: 3.294
Publication type: Editorail in international publication
Authors: Ramon Y Cajal, S, Hummer, S, Peg, V, Matias Guiu, X, De Torres, I, Castellvi, J, Martinez-Saez, E, Hernandez-Losa, J et al.
DOI: 10.1111/his.13828

Polymorphisms in MDM2 and TP53 Genes and Risk of Developing Therapy-Related Myeloid Neoplasms.

PMID: 30655613
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Jan 17;9(1):150. doi: 10.1038/s41598-018-36931-x.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Manubens, Marta, Alvarez, Yolanda, Barquinero, Joan Francesc, Ramon Y Cajal, Santiago, Ortega, Margarita, Blanco, Adoracion, Caballin, Maria Rosa, Armengol, Gemma, Alonso, Cintia, Garcia-Quevedo, Lydia et al.
DOI: 10.1038/s41598-018-36931-x

Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease.

PMID: 29701678
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2018
Reference: Int J Mol Sci. 2018 Apr 26;19(5). pii: ijms19051296. doi: 10.3390/ijms19051296.
Impact factor: 3.687
Publication type: Review in national publication
Authors: Aasen, Trond, Johnstone, Scott, Vidal-Brime, Laia, Lynn, K Sabrina, Koval, Michael et al.
DOI: 10.3390/ijms19051296

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR.

PMID: 29691292
Journal: CLINICAL CANCER RESEARCH
Year: 2018
Reference: Clin Cancer Res. 2018 Aug 1;24(15):3767-3780. doi: 10.1158/1078-0432.CCR-18-0177. Epub 2018 Apr 24.
Impact factor: 10.199
Publication type: Paper in international publication
Authors: Veiga, Sonia Rosa, Ge, Xuemei, Mercer, Carol A, Hernandez-Alvarez, Maria Isabel, Thomas, Hala Elnakat, Hernandez-Losa, Javier, Ramon Y Cajal, Santiago, Zorzano, Antonio, Thomas, George, Kozma, Sara C et al.
DOI: 10.1158/1078-0432.CCR-18-0177

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells.

PMID: 29669853
Journal: Science Translational Medicine
Year: 2018
Reference: Sci Transl Med. 2018 Apr 18;10(437). pii: 10/437/eaar6759. doi: 10.1126/scitranslmed.aar6759.
Impact factor: 16.71
Publication type: Paper in international publication
Authors: King, Colin T, Vemula, Sai, Cox, Kara, Wan, Yanmin, Li, Qingsheng, Mounzer, Karam, Kostman, Jay, Frank, Ian, Paiardini, Mirko, Hazuda, Daria et al.
DOI: 10.1126/scitranslmed.aar6759

Molecular diagnosis of diffuse gliomas through sequencing of cell-free circulating tumour DNA from cerebrospinal fluid.

PMID: 29615461
Journal: CLINICAL CANCER RESEARCH
Year: 2018
Reference: Clin Cancer Res. 2018 Jun 15;24(12):2812-2819. doi: 10.1158/1078-0432.CCR-17-3800. Epub 2018 Apr 3.
Impact factor: 10.199
Publication type: Paper in international publication
Authors: Poca, Maria A, Martinez-Ricarte, Francisco, Mayor, Regina, Martinez-Saez, Elena, Rubio-Perez, Carlota, Pineda, Estela, Cordero, Esteban, Cicuendez, Marta, Vieito, Maria, Carles, Joan et al.
DOI: 10.1158/1078-0432.CCR-17-3800

HAVCR/KIM-1 activates the IL-6/STAT-3 Pathway in ccRCC and Determines Tumor Progression and Patient Outcome.

PMID: 24390735
Journal: CANCER RES
Year: 2014
Reference: Cancer Res. 2014 Mar 1;74(5):1416-28. doi: 10.1158/0008-5472.CAN-13-1671. Epub 2014 Jan 3.
Impact factor: 9.284
Publication type: Paper in international publication
Authors: Cuadros, Thais, Trilla, Enric, Sarro, Eduard, Vila, Maya R, Vilardell, Jordi, de Torres, Ines, Salcedo, Mayte, Lopez-Hellin, Joan, Sanchez, Alex, Ramon Y Cajal, Santiago et al.
DOI: 10.1158/0008-5472.CAN-13-1671

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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