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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

A high-throughput screening platform identifies novel combination treatments for Malignant Peripheral Nerve Sheath Tumors.

PMID: 35511749
Journal: MOLECULAR CANCER THERAPEUTICS
Year: 2022
Reference: Mol Cancer Ther. 2022 Jul 5;21(7):1246-1258. doi: 10.1158/1535-7163.MCT-21-0947.
Impact factor: 6.261
Publication type: Paper in international publication
Authors: Salazar-Huayna, Lourdes, Fernandez-Rodriguez, Juana, Creus-Bachiller, Edgar, Zhang, Xiaohu, Martinez-Iniesta, Maria, Ortega-Bertran, Sara, Guha, Rajarshi, Thomas, Craig J, Wallace, Margaret R, Romagosa, Cleofe et al.
DOI: 10.1158/1535-7163.MCT-21-0947

Retreatment with Checkpoint inhibitors after a severe immune-related hepatitis: Results from a prospective multicenter study.

PMID: 35487453
Journal: Clinical Gastroenterology and Hepatology
Year: 2022
Reference: Clin Gastroenterol Hepatol. 2022 Apr 26. pii: S1542-3565(22)00403-7. doi: 10.1016/j.cgh.2022.03.050.
Impact factor: 11.382
Publication type: Paper in international publication
Authors: Riveiro-Barciela, Mar, Barreira-Diaz, Ana, Callejo-Perez, Ana, Munoz-Couselo, Eva, Diaz-Mejia, Nely, Diaz-Gonzalez, Alvaro, Londono, Maria-Carlota, Salcedo, Maria-Teresa, Buti, Maria et al.
DOI: 10.1016/j.cgh.2022.03.050

[Lipoblastoma-like tumor of the vulva: A case report and review of the literature].

PMID: 35483770
Journal: Revista espanola de patologia
Year: 2022
Reference: Rev Esp Patol. 2022 Apr-Jun;55(2):139-144. doi: 10.1016/j.patol.2019.10.001. Epub 2020 Jan 2.
Impact factor: 0
Publication type: Paper in national publication
Authors: Vasquez-Dongo, Carmen, Rivas, Antoni, Ferrer, Berta, Bodet, Domingo, Valverde, Claudia, Delbene, Clara, Ramon Y Cajal, Santiago, Romagosa, Cleofe et al.
DOI: 10.1016/j.patol.2019.10.001

[The Spanish Society of Pathology's policy document concerning the necessity for technical coordination in Pathology departments].

PMID: 35483767
Journal: Revista espanola de patologia
Year: 2022
Reference: Rev Esp Patol. 2022 Apr-Jun;55(2):122-124. doi: 10.1016/j.patol.2021.11.001. Epub 2022 Feb 8.
Impact factor: 0
Publication type: Letter or abstract
Authors: Garcia-Garcia, Mar, Alvarez Alegret, Ramiro, Perez-Mies, Belen, Iglesias, Mar, Ramon Y Cajal, Santiago, Matias-Guiu, Xavier, Rodriguez Peralto, Jose Luis et al.
DOI: 10.1016/j.patol.2021.11.001

Host-dependent editing of SARS-CoV-2 in COVID-19 patients.

PMID: 34402744
Journal: Emerging Microbes & Infections
Year: 2021
Reference: Emerg Microbes Infect. 2021 Dec;10(1):1777-1789. doi: 10.1080/22221751.2021.1969868.
Impact factor: 7.163
Publication type: Paper in international publication
Authors: Quer, Josep, Anton, Andres, Rodriguez-Frias, Francisco, Esteban, Juan Ignacio, Gregori, Josep, Cortese, Maria Francesca, Pinana, Maria, Campos, Carolina, Garcia-Cehic, Damir, Andres, Cristina et al.
DOI: 10.1080/22221751.2021.1969868

Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies.

PMID: 34359597
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Jul 23;13(15). pii: cancers13153696. doi: 10.3390/cancers13153696.
Impact factor: 6.639
Publication type: Review in international publication
Authors: Thavaraj, Selvam, Muller-Richter, Urs, Alberola Ferranti, Margarita, Pamias Romero, Jorge, Saez Barba, Manel, de Pablo Garcia-Cuenca, Alba, Brana Garcia, Irene, Bossi, Paolo, Nuciforo, Paolo, Simonetti, Sara et al.
DOI: 10.3390/cancers13153696

Ki-67 immunoexpression and radiological assessment of necrosis improves accuracy of conventional and modified core biopsy systems in predicting the final grade assigned to adult-soft tissue sarcomas. An international collaborative study.

PMID: 34329836
Journal: PATHOLOGY RESEARCH AND PRACTICE
Year: 2021
Reference: Pathol Res Pract. 2021 Sep;225:153562. doi: 10.1016/j.prp.2021.153562. Epub 2021 Jul 22.
Impact factor: 3.25
Publication type: Paper in international publication
Authors: Navarro, Samuel, Cruz, Julia, Righi, Alberto, Gambarotti, Marco, Ferrari, Cristina, Ruengwanichayakun, Poosit, Giner, Francisco, Rausell, Nuria, Lavernia, Javier, Sugita, Shintaro et al.
DOI: 10.1016/j.prp.2021.153562

Partial restoration of immune response in Hepatitis C patients after viral clearance by direct-acting antiviral therapy.

PMID: 34242330
Journal: PLoS One
Year: 2021
Reference: PLoS One. 2021 Jul 9;16(7):e0254243. doi: 10.1371/journal.pone.0254243. eCollection 2021.
Impact factor: 3.24
Publication type: Paper in international publication
Authors: Llorens-Revull, Meritxell, Costafreda, Maria Isabel, Rico, Angie, Guerrero-Murillo, Mercedes, Soria, Maria Eugenia, Piriz-Ruzo, Sofia, Vargas-Accarino, Elena, Gabriel-Medina, Pablo, Rodriguez-Frias, Francisco, Riveiro-Barciela, Mar et al.
DOI: 10.1371/journal.pone.0254243

Utility of transjugular renal biopsy as an alternative to percutaneous biopsy.

PMID: 32660793
Journal: NEFROLOGIA
Year: 2020
Reference: Nefrologia. 2020 Nov - Dec;40(6):634-639. doi: 10.1016/j.nefro.2020.04.018. Epub 2020 Jul 11.
Impact factor: 1.544
Publication type: Paper in national publication
Authors: Soler, Maria Jose, Seron, Daniel, Segarra, Alfons, Perez Lafuente, Mercedes, Bolufer, Monica, Garcia-Carro, Clara, Agraz, Irene, Diez Miranda, Iratxe, Jaramillo, Juliana, Arredondo, Karla et al.
DOI: 10.1016/j.nefro.2020.04.018

KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.

PMID: 32642733
Journal: Neuro-oncology advances
Year: 2020
Reference: Neurooncol Adv. 2020 Jan 4;2(Suppl 1):i62-i74. doi: 10.1093/noajnl/vdz061. eCollection 2020 Jul.
Impact factor: 0
Publication type: Paper in international publication
Authors: Guha, Rajiv, Zhang, Xiaohu, Gel, Bernat, Romagosa, Cleofe, Ferrer, Marc, Lazaro, Conxi, Serra, Eduard, Thomas, Craig, Ramos-Oliver, Irma, Bernal, Gabriela et al.
DOI: 10.1093/noajnl/vdz061

C4-C5 fused pyrazol-3-amines: when the degree of unsaturation and electronic characteristics of the fused ring controls regioselectivity in Ullmann and acylation reactions.

PMID: 32583833
Journal: ORGANIC & BIOMOLECULAR CHEMISTRY
Year: 2020
Reference: Org Biomol Chem. 2020 Jul 15;18(27):5145-5156. doi: 10.1039/d0ob00796j.
Impact factor: 3.412
Publication type: Paper in international publication
Authors: Bou-Petit, Elisabeth, Rodriguez-Picazo, Nieves, Torres-Coll, Antoni, Puigjaner, Cristina, Font-Bardia, Merce, Teixido, Jordi, Ramon Y Cajal, Santiago, Estrada-Tejedor, Roger, Borrell, Jose I, Plans, Arnau et al.
DOI: 10.1039/d0ob00796j

Intraoperative Human Papillomavirus Test Predicts 24-Month High-Grade Squamous Intraepithelial Lesion Recurrence Saving Costs: A Prospective Cohort Study.

PMID: 32569022
Journal: Journal of Lower Genital Tract Disease
Year: 2020
Reference: J Low Genit Tract Dis. 2020 Oct;24(4):367-371. doi: 10.1097/LGT.0000000000000549.
Impact factor: 1.306
Publication type: Paper in international publication
Authors: Rabasa, Jordi, Alcalde, Ana, Bradbury, Melissa, Sanchez-Iglesias, Jose Luis, Guerrero, Diana, Forcada, Cristina, Perez-Benavente, Assumpcio, Cabrera, Silvia, Ramon Y Cajal, Santiago, Hernandez, Javier et al.
DOI: 10.1097/LGT.0000000000000549

The Role of Molecular Techniques for the Detection of Mycobacterium Tuberculosis Complex in Paraffin-embedded Biopsies.

PMID: 28549036
Journal: APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
Year: 2019
Reference: Appl Immunohistochem Mol Morphol. 2019 Jan;27(1):77-80. doi: 10.1097/PAI.0000000000000533.
Impact factor: 1.863
Publication type: Paper in international publication
Authors: Castellvi, Josep, Moure, Zaira, Tortola, M Teresa, Pumarola, Tomas, Sanchez-Montalva, Adrian et al.
DOI: 10.1097/PAI.0000000000000533

Restoration of A Healthy Intestinal Microbiota Normalizes Portal Hypertension In A Rat Model of Nonalcoholic Steatohepatitis.

PMID: 29113028
Journal: HEPATOLOGY
Year: 2018
Reference: Hepatology. 2018 Apr;67(4):1485-1498. doi: 10.1002/hep.29646. Epub 2018 Feb 19.
Impact factor: 14.079
Publication type: Paper in international publication
Authors: Garcia-Lezana, Teresa, Raurell, Imma, Bravo, Miren, Torres-Arauz, Manuel, Salcedo, Maria Teresa, Santiago, Alba, Schoenenberger, Andreu, Manichanh, Chaysavanh, Genesca, Joan, Martell, Maria et al.
DOI: 10.1002/hep.29646

Autoimmune disorders are common in myelodysplastic syndrome patients and confer an adverse impact on outcomes.

PMID: 29572561
Journal: ANNALS OF HEMATOLOGY
Year: 2018
Reference: Ann Hematol. 2018 Aug;97(8):1349-1356. doi: 10.1007/s00277-018-3302-0. Epub 2018 Mar 23.
Impact factor: 2.845
Publication type: Paper in international publication
Authors: Montoro, Julia, Gallur, Laura, Merchan, Brayan, Molero, Antonieta, Roldan, Elisa, Martinez-Valle, Ferran, Villacampa, Guillermo, Navarrete, Mayda, Ortega, Margarita, Castellvi, Josep et al.
DOI: 10.1007/s00277-018-3302-0

RNA Analysis as a Tool to Determine Clinically Relevant Gene Fusions and Splice Variants.

PMID: 29565207
Journal: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
Year: 2018
Reference: Arch Pathol Lab Med. 2018 Apr;142(4):474-479. doi: 10.5858/arpa.2017-0134-RA.
Impact factor: 3.658
Publication type: Paper in international publication
Authors: Rosell, Rafael, Teixido, Cristina, Gimenez-Capitan, Ana, Molina-Vila, Miguel Angel, Peg, Vicente, Karachaliou, Niki, Rodriguez-Capote, Alejandra, Castellvi, Josep et al.
DOI: 10.5858/arpa.2017-0134-RA

Activity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation.

PMID: 29529211
Journal: JNCI-Journal of the National Cancer Institute
Year: 2018
Reference: J Natl Cancer Inst. 2018 Aug 1;110(8):914-917. doi: 10.1093/jnci/djy012.
Impact factor: 11.238
Publication type: Paper in international publication
Authors: Remon, Jordin, Cedres, Susana, Felip, Enriqueta, Cruz, Cristina, Martinez de Castro, Ana, Pardo, Nuria, Navarro, Alejandro, Martinez-Marti, Alex, Llop-Guevara, Alba, Miquel, Josep M et al.
DOI: 10.1093/jnci/djy012

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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