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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor.

PMID: 35417652
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Year: 2022
Reference: J Med Chem. 2022 Apr 28;65(8):6070-6087. doi: 10.1021/acs.jmedchem.1c01941. Epub 2022 Apr 13.
Impact factor: 7.446
Publication type: Paper in international publication
Authors: Alarcon, Helena, Slobodnyuk, Konstantin, Cano-Galietero, Marta, Fuentes, Pedro, Guijarro, Pedro J, Munoz, Maria Jose, Suarez-Cabrera, Leticia, Santamaria, Anna, Estrada-Tejedor, Roger, Borrell, Jose I et al.
DOI: 10.1021/acs.jmedchem.1c01941

Next-Generation Sequencing for Confronting Virus Pandemics.

PMID: 35337007
Journal: Viruses-Basel
Year: 2022
Reference: Viruses. 2022 Mar 14;14(3). pii: v14030600. doi: 10.3390/v14030600.
Impact factor: 5.048
Publication type: Review in international publication
Authors: Anton, Andres, Quer, Josep, Colomer-Castell, Sergi, Campos, Carolina, Andres, Cristina, Pinana, Maria, Cortese, Maria Francesca, Gonzalez-Sanchez, Alejandra, Garcia-Cehic, Damir, Ibanez, Marta et al.
DOI: 10.3390/v14030600

Spectrum of Soft-Tissue Lesions of the Finger.

PMID: 35302866
Journal: RADIOGRAPHICS
Year: 2022
Reference: Radiographics. 2022 May-Jun;42(3):E96-E97. doi: 10.1148/rg.210047. Epub 2022 Mar 18.
Impact factor: 5.333
Publication type: Paper in international publication
Authors: Gimeno Cajal, Alfredo, de Albert Delas, Matias, Torrents Odin, Carme, Casas Gomila, Lourdes, Ochoa Sambrizzi, Nicolas, Ramos-Oliver, Irma, Lluch Bergada, Alex, Dominguez Oronoz, Rosa, Veintemillas Araiz, M Teresa, Anton-Jimenez, Alba et al.
DOI: 10.1148/rg.210047

BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling.

PMID: 35292711
Journal: Scientific Reports
Year: 2022
Reference: Sci Rep. 2022 Mar 15;12(1):4445. doi: 10.1038/s41598-022-08461-0.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Gil-Moreno, Antonio, Sabido, Eduard, Santamaria, Anna, Perez-Benavente, Assumpcio, Sanchez-Iglesias, Jose Luis, Castellvi, Josep, Bradbury, Melissa, Borras, Eva, Mendez, Olga et al.
DOI: 10.1038/s41598-022-08461-0

The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome.

PMID: 34121983
Journal: Frontiers in Neuroscience
Year: 2021
Reference: Front Neurosci. 2021 May 26;15:618098. doi: 10.3389/fnins.2021.618098. eCollection 2021.
Impact factor: 4.677
Publication type: Paper in international publication
Authors: Aguilera, Cinthia, Hummer, Stefan, Masanas, Marc, Gabau, Elisabeth, Guitart, Miriam, Jeyaprakash, A Arockia, Segura, Miguel F, Santamaria, Anna, Ruiz, Anna et al.
DOI: 10.3389/fnins.2021.618098

COVID-19 in CKD Patients: Lessons from 553 CKD Patients with Biopsy-Proven Kidney Disease.

PMID: 34098555
Journal: KIDNEY & BLOOD PRESSURE RESEARCH
Year: 2021
Reference: Kidney Blood Press Res. 2021;46(4):452-459. doi: 10.1159/000515714. Epub 2021 Jun 7.
Impact factor: 2.687
Publication type: Paper in international publication
Authors: Agraz, Irene, Roman, Juan Leon, Garcia-Carro, Clara, Gabaldon, Alejandra, Torres, Irina, Bury, Roxana, Baldallo, Cinthia, Seron, Daniel, Soler, Maria Jose, Vergara, Ander et al.
DOI: 10.1159/000515714

Spontaneous Cell Detachment and Reattachment in Cancer Cell Lines: An In Vitro Model of Metastasis and Malignancy.

PMID: 34066490
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 May 6;22(9). pii: ijms22094929. doi: 10.3390/ijms22094929.
Impact factor: 5.924
Publication type: Paper in international publication
Authors: Ramon Y Cajal, Santiago, Vargas-Accarino, Elena, Herrera-Montavez, Carlos, Aasen, Trond et al.
DOI: 10.3390/ijms22094929

A Specific Tubular ApoA-I Distribution Is Associated to FSGS Recurrence after Kidney Transplantation.

PMID: 34069888
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 May 18;10(10). pii: jcm10102174. doi: 10.3390/jcm10102174.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Agraz, Irene, Moreso, Francesc, Soler, Maria Jose, Seron, Daniel, Lopez-Hellin, Joan, Villena-Ortiz, Yolanda, Sellares, Joana, Vergara, Ander, Jacobs-Cacha, Conxita, Puig-Gay, Natalia et al.
DOI: 10.3390/jcm10102174

Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer.

PMID: 32268485
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Apr 6;12(4). pii: cancers12040886. doi: 10.3390/cancers12040886.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Barber, Marta, Parrilla, Alfonso, Morote, Juan, Sanchez, Jose Luis, Perez-Benavente, Asuncion, Segura, Miguel F, Gil-Moreno, Antonio, Santamaria, Anna, Castellvi, Josep, Majem, Blanca et al.
DOI: 10.3390/cancers12040886

Is the involvement of the hepatic artery lymph node a poor prognostic factor in pancreatic adenocarcinoma?

PMID: 31839175
Journal: CIRUGIA ESPANOLA
Year: 2020
Reference: Cir Esp. 2020 Apr;98(4):204-211. doi: 10.1016/j.ciresp.2019.09.015. Epub 2019 Dec 13.
Impact factor: 1.323
Publication type: Paper in national publication
Authors: Charco, Ramon, Rodrigues, Victor, Dopazo, Cristina, Pando, Elizabeth, Blanco, Laia, Caralt, Mireia, Gomez-Gavara, Concepcion, Bilbao, Itxarone, Salcedo, Maria Teresa, Balsells, Joaquim et al.
DOI: 10.1016/j.ciresp.2019.09.015

External validation of a prognostic model based on total tumor load of sentinel lymph node for early breast cancer patients.

PMID: 32253684
Journal: BREAST CANCER RESEARCH AND TREATMENT
Year: 2020
Reference: Breast Cancer Res Treat. 2020 Jun;181(2):339-345. doi: 10.1007/s10549-020-05623-4. Epub 2020 Apr 6.
Impact factor: 3.831
Publication type: Paper in international publication
Authors: Pinero-Madrona, Antonio, Ripoll-Orts, Francisco, Sanchez-Mendez, Jose Ignacio, Chaves-Benito, Asuncion, Gomez-de la Barcena, Maximiliano Rodrigo, Calatrava-Fons, Ana, Menjon-Beltran, Salomon, Peg-Camara, Vicente et al.
DOI: 10.1007/s10549-020-05623-4

Analysis of the nuclear expression of pSer727-STAT3 as a prognostic factor in patients with clear cell renal carcinoma.

PMID: 32247519
Journal: Actas Urologicas Espanolas
Year: 2020
Reference: Actas Urol Esp. 2020 May;44(4):245-250. doi: 10.1016/j.acuro.2019.11.006. Epub 2020 Apr 1.
Impact factor: 0.873
Publication type: Paper in national publication
Authors: Lorente, D, Arevalo, J, Salcedo, M T, Trilla, E, de Torres, I, Meseguer, A, Morote, J et al.
DOI: 10.1016/j.acuro.2019.11.006

Promising activity of selinexor in the treatment of a patient with refractory diffuse large B-cell lymphoma and central nervous system involvement.

PMID: 29242296
Journal: HAEMATOLOGICA
Year: 2018
Reference: Haematologica. 2018 Feb;103(2):e92-e93. doi: 10.3324/haematol.2017.181636. Epub 2017 Dec 14.
Impact factor: 9.09
Publication type: Paper in international publication
Authors: Raheja, Priyanka, Bobillo, Sabela, Abrisqueta, Pau, Carpio, Cecilia, Bosch, Francesc, Crespo, Marta, Castellvi, Josep et al.
DOI: 10.3324/haematol.2017.181636

Intraoperative Ultrasound-Guided Excision of Axillary Clip in Patients with Node-Positive Breast Cancer Treated with Neoadjuvant Therapy (ILINA Trial) : A New Tool to Guide the Excision of the Clipped Node After Neoadjuvant Treatment.

PMID: 29197044
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2018
Reference: Ann Surg Oncol. 2018 Mar;25(3):784-791. doi: 10.1245/s10434-017-6270-z. Epub 2017 Dec 1.
Impact factor: 3.857
Publication type: Paper in international publication
Authors: Siso, Christian, de Torres, Juan, Esgueva-Colmenarejo, Antonio, Espinosa-Bravo, Martin, Rus, Neus, Cordoba, Octavi, Rodriguez, Roberto, Peg, Vicente, Rubio, Isabel T et al.
DOI: 10.1245/s10434-017-6270-z

Advances in endometrial cancer protein biomarkers for use in the clinic.

PMID: 29183259
Journal: Expert Review of Proteomics
Year: 2018
Reference: Expert Rev Proteomics. 2018 Jan;15(1):81-99. doi: 10.1080/14789450.2018.1410061. Epub 2017 Nov 30.
Impact factor: 3.489
Publication type: Paper in international publication
Authors: Martinez-Garcia, Elena, Lopez-Gil, Carlos, Campoy, Irene, Vallve, Julia, Coll, Eva, Cabrera, Silvia, Ramon Y Cajal, Santiago, Matias-Guiu, Xavier, van Oostrum, Jan, Reventos, Jaume et al.
DOI: 10.1080/14789450.2018.1410061

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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