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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas.

PMID: 35172160
Journal: Cell Reports
Year: 2022
Reference: Cell Rep. 2022 Feb 15;38(7):110385. doi: 10.1016/j.celrep.2022.110385.
Impact factor: 9.423
Publication type: Paper in international publication
Authors: Lazaro, Conxi, Gel, Bernat, Carrio, Meritxell, Serra, Eduard, Romagosa, Cleofe, Heyn, Holger, Raya, Angel, Mazuelas, Helena, Magallon-Lorenz, Miriam, Fernandez-Rodriguez, Juana et al.
DOI: 10.1016/j.celrep.2022.110385

Focal and segmental glomerulosclerosis associated with COVID-19 infection.

PMID: 33888348
Journal: NEFROLOGIA
Year: 2021
Reference: Nefrologia (Engl Ed). 2021 Apr 19. pii: S0211-6995(21)00058-8. doi: 10.1016/j.nefro.2021.03.002.
Impact factor: 2.033
Publication type: Letter or abstract
Authors: LeonRoman, Juan, Vergara, Ander, Agraz, Irene, Garcia-Carro, Clara, Bermejo, Sheila, Gabaldon, Alejandra, Soler, Maria Jose et al.
DOI: 10.1016/j.nefro.2021.03.002

Cytokeratin Expression in Plasmablastic Lymphoma - a Possible Diagnostic Pitfall in the Routine Work-Up of Tumors.

PMID: 33165992
Journal: HISTOPATHOLOGY
Year: 2021
Reference: Histopathology. 2021 May;78(6):831-837. doi: 10.1111/his.14300. Epub 2020 Dec 25.
Impact factor: 5.087
Publication type: Paper in international publication
Authors: Frontzek, Fabian, Goodlad, John R, Tapia, Gustavo, Rosenwald, Andreas, Klapper, Wolfram, Fend, Falko, Climent, Fina, Castellvi, Josep, Tzankov, Alexandar, Dirnhofer, Stefan et al.
DOI: 10.1111/his.14300

Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer.

PMID: 33342055
Journal: Molecular Oncology
Year: 2021
Reference: Mol Oncol. 2021 Apr;15(4):887-900. doi: 10.1002/1878-0261.12891. Epub 2021 Jan 6.
Impact factor: 6.603
Publication type: Paper in international publication
Authors: Frigola, Joan, Navarro, Alejandro, Carbonell, Caterina, Callejo, Ana, Iranzo, Patricia, Cedres, Susana, Martinez-Marti, Alex, Pardo, Nuria, Saoudi-Gonzalez, Nadia, Martinez, Debora et al.
DOI: 10.1002/1878-0261.12891

ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity.

PMID: 33807672
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Mar 5;13(5). pii: cancers13051110. doi: 10.3390/cancers13051110.
Impact factor: 6.639
Publication type: Paper in international publication
Authors: Avila, Matias A, Minguez, Beatriz, Soriano, Eduardo, Villarroya, Francesc, Berasain, Carmen, Uriarte, Iker, Santamaria, Eva, Balibrea, Jose Maria, Mirra, Serena, Gavalda-Navarro, Aleix et al.
DOI: 10.3390/cancers13051110

Assessment of Safety and Efficacy of Combined Trabectedin and Low-Dose Radiotherapy for Patients With Metastatic Soft-Tissue Sarcomas: A Nonrandomized Phase 1/2 Clinical Trial.

PMID: 32077895
Journal: JAMA Oncology
Year: 2020
Reference: JAMA Oncol. 2020 Apr 1;6(4):535-541. doi: 10.1001/jamaoncol.2019.6584.
Impact factor: 24.799
Publication type: Paper in international publication
Authors: Luna, Pablo, Alastuey, Ignacio, Redondo, Andres, Belinchon, Belen, Martinez-Serra, Jordi, Sunyach, Marie-Pierre, Coindre, Jean-Michel, Dei Tos, Angelo P, Romero, Jesus, Gronchi, Alessandro et al.
DOI: 10.1001/jamaoncol.2019.6584

Hemophagocytic syndrome following alemtuzumab treatment for multiple sclerosis: A case report.

PMID: 32028116
Journal: Multiple Sclerosis and Related Disorders
Year: 2020
Reference: Mult Scler Relat Disord. 2020 May;40:101973. doi: 10.1016/j.msard.2020.101973. Epub 2020 Jan 31.
Impact factor: 2.889
Publication type: Letter or abstract
Authors: Romero, A, Midaglia, L, Salcedo, M T, Viladomiu, L, Guillen, E, Bajana, I, Escola-Verge, L, Tintore, M, Montalban, X, Len, O et al.
DOI: 10.1016/j.msard.2020.101973

Efficacy and safety of bortezomib in refractory lupus nephritis: a single-center experience.

PMID: 31865857
Journal: LUPUS
Year: 2020
Reference: Lupus. 2020 Feb;29(2):118-125. doi: 10.1177/0961203319896018. Epub 2019 Dec 22.
Impact factor: 2.251
Publication type: Paper in international publication
Authors: Segarra, A, Arredondo, K V, Jaramillo, J, Jatem, E, Salcedo, M T, Agraz, I, Ramos, N, Carnicer, C, Valtierra, N, Ostos, E et al.
DOI: 10.1177/0961203319896018

Clinical implications of intratumor heterogeneity: challenges and opportunities.

PMID: 31970428
Journal: JOURNAL OF MOLECULAR MEDICINE-JMM
Year: 2020
Reference: J Mol Med (Berl). 2020 Feb;98(2):161-177. doi: 10.1007/s00109-020-01874-2. Epub 2020 Jan 22.
Impact factor: 4.427
Publication type: Review in international publication
Authors: Castellvi, Josep, Diaz-Cano, Salvador J, Ramon Y Cajal, Santiago, Sese, Marta, Capdevila, Claudia, Aasen, Trond, De Mattos-Arruda, Leticia, Hernandez-Losa, Javier et al.
DOI: 10.1007/s00109-020-01874-2

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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