Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
The role of MNK kinases in cellular stress resistance.
The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Team

Trond Aasen

Main researcher
Translational Molecular Pathology
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Ximena Garcia Torres

Administration and Management
Translational Molecular Pathology
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Trond Aasen

Main researcher
Translational Molecular Pathology
Read more

Ximena Garcia Torres

Administration and Management
Translational Molecular Pathology
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Projects

Implicaction of proteins associated with vascular beta-amyloid in Cerebral Amyloid Angiopathy

IP: Maria Mar Hernandez Guillamon
Collaborators: Marcel Lamana Vallverdu, Anna Bonaterra Pastra, Jessica Camacho Soriano, Olga Maisterra Santos, Olalla Pancorbo Rosal
Funding agency: Instituto de Salud Carlos III
Funding: 169400
Reference: PI20/00465
Duration: 01/01/2021 - 30/06/2025

Protuberancias intercelulares reguladas por Cx43 en cáncer: elucidación funcional, descubrimiento de objetivos, desarrollo de biomarcadores y detección de tumores

IP: Trond Aasen
Collaborators: Maria Rosa Somoza Lopez de Haro, Jordi Temprana Salvador, Teresa Moline Marimon, Marta Sese Faustino, Irene Sansano Valero, Stefan Hummer
Funding agency: Instituto de Salud Carlos III
Funding: 147620
Reference: PI21/00470
Duration: 01/01/2022 - 31/12/2024

Inmunomonitorización personalizada para estratificar los pacientes con lupus eritematoso sistémico

IP: Josefina Cortes Hernandez
Collaborators: Teresa Moline Marimon, Sheila Bermejo Garcia
Funding agency: Instituto de Salud Carlos III
Funding: 141570
Reference: PI21/00287
Duration: 01/01/2022 - 31/12/2024

Next generation personalised medicine for childhood cancers

IP: Lucas Moreno Martín-Retortillo
Collaborators: Aroa Soriano Fernández, Jessica Camacho Soriano, Raquel Hladun Alvaro, Gabriela Guillén Burrieza, Andrea Vilaplana Blanes, Paula Cabre Fernandez, Lorena Valero Arrese, Sergio Manresa Vera, Mariona Morell Daniel
Funding agency: Instituto de Salud Carlos III
Funding: 214170
Reference: PI21/01661
Duration: 01/01/2022 - 31/12/2024

Publications

Analysis of tumor infiltrating CD4+ and CD8+ CDR3 sequences reveals shared features putatively associated to the anti-tumor immune response.

PMID: 37600765
Journal: Frontiers in Immunology
Year: 2023
Reference: Front Immunol. 2023 Aug 4;14:1227766. doi: 10.3389/fimmu.2023.1227766. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Abanco, Ferran; Aran, Andrea; Cortes, Javier; Garrigos, Laia; Gion, Maria; Lazaro, Gonzalo; Marco, Vicente; Marti, Merce; Molina, Elisa; Peg, Vicente et al.
DOI: 10.3389/fimmu.2023.1227766

Repolarization parameters and ventricular arrhythmias in Takotsubo syndrome: A substudy from the RETAKO national registry.

PMID: 37645263
Journal: Heart rhythm O2
Year: 2023
Reference: Heart Rhythm O2. 2023 Jun 28;4(8):517-519. doi: 10.1016/j.hroo.2023.06.008. eCollection 2023 Aug.
Impact factor:
Publication type: Paper in international publication
Authors: Blanco-Ponce, Emilia; Corbi-Pascual, Miguel; Martinez, Eduardo; Martinez-Selles, Manuel; Nunez-Gil, Ivan J; Salamanca, Jorge; Sionis, Alessandro; Uribarri, Aitor; Vazirani, Ravi; Vedia, Oscar et al.
DOI: 10.1016/j.hroo.2023.06.008

Correlation between E-cadherin/beta-catenin, Vimentin expression, clinicopathologic features and drug resistance prediction in naive prostate cancer: A molecular and clinical study.

PMID: 37649322
Journal: GENESIS
Year: 2023
Reference: Genesis. 2023 Aug 30:e23543. doi: 10.1002/dvg.23543.
Impact factor:
Publication type: Paper in international publication
Authors: Blel, Ahlem; de Haro, Rosa Somoza Lopez; Derouiche, Amine; Hernandez-Losa, Javier; Hernandez-Losa, Javier; Moline, Teresa; Ouerhani, Slah; Rammeh, Soumaya; Said, Rahma; Zouari, Skander et al.
DOI: 10.1002/dvg.23543

Early-Stage Breast Cancer Detection in Breast Milk.

PMID: 37704212
Journal: Cancer Discovery
Year: 2023
Reference: Cancer Discov. 2023 Sep 14:OF1-OF12. doi: 10.1158/2159-8290.CD-22-1340.
Impact factor:
Publication type: Paper in international publication
Authors: Arenas, Enrique J; Arenas, Enrique J; Arevalo, Silvia; Arevalo, Silvia; Arribas, Joaquin; Balmana, Judith; Balmana, Judith; Bayo-Puxan, Neus; Carrasco, Estela; Carrasco, Estela et al.
DOI: 10.1158/2159-8290.CD-22-1340

A high-throughput screening platform identifies novel combination treatments for Malignant Peripheral Nerve Sheath Tumors.

PMID: 35511749
Journal: MOLECULAR CANCER THERAPEUTICS
Year: 2022
Reference: Mol Cancer Ther. 2022 Jul 5;21(7):1246-1258. doi: 10.1158/1535-7163.MCT-21-0947.
Impact factor: 6.261
Publication type: Paper in international publication
Authors: Salazar-Huayna, Lourdes, Fernandez-Rodriguez, Juana, Creus-Bachiller, Edgar, Zhang, Xiaohu, Martinez-Iniesta, Maria, Ortega-Bertran, Sara, Guha, Rajarshi, Thomas, Craig J, Wallace, Margaret R, Romagosa, Cleofe et al.
DOI: 10.1158/1535-7163.MCT-21-0947

Retreatment with Checkpoint inhibitors after a severe immune-related hepatitis: Results from a prospective multicenter study.

PMID: 35487453
Journal: Clinical Gastroenterology and Hepatology
Year: 2022
Reference: Clin Gastroenterol Hepatol. 2022 Apr 26. pii: S1542-3565(22)00403-7. doi: 10.1016/j.cgh.2022.03.050.
Impact factor: 11.382
Publication type: Paper in international publication
Authors: Riveiro-Barciela, Mar, Barreira-Diaz, Ana, Callejo-Perez, Ana, Munoz-Couselo, Eva, Diaz-Mejia, Nely, Diaz-Gonzalez, Alvaro, Londono, Maria-Carlota, Salcedo, Maria-Teresa, Buti, Maria et al.
DOI: 10.1016/j.cgh.2022.03.050

[Lipoblastoma-like tumor of the vulva: A case report and review of the literature].

PMID: 35483770
Journal: Revista espanola de patologia
Year: 2022
Reference: Rev Esp Patol. 2022 Apr-Jun;55(2):139-144. doi: 10.1016/j.patol.2019.10.001. Epub 2020 Jan 2.
Impact factor: 0
Publication type: Paper in national publication
Authors: Vasquez-Dongo, Carmen, Rivas, Antoni, Ferrer, Berta, Bodet, Domingo, Valverde, Claudia, Delbene, Clara, Ramon Y Cajal, Santiago, Romagosa, Cleofe et al.
DOI: 10.1016/j.patol.2019.10.001

[The Spanish Society of Pathology's policy document concerning the necessity for technical coordination in Pathology departments].

PMID: 35483767
Journal: Revista espanola de patologia
Year: 2022
Reference: Rev Esp Patol. 2022 Apr-Jun;55(2):122-124. doi: 10.1016/j.patol.2021.11.001. Epub 2022 Feb 8.
Impact factor: 0
Publication type: Letter or abstract
Authors: Garcia-Garcia, Mar, Alvarez Alegret, Ramiro, Perez-Mies, Belen, Iglesias, Mar, Ramon Y Cajal, Santiago, Matias-Guiu, Xavier, Rodriguez Peralto, Jose Luis et al.
DOI: 10.1016/j.patol.2021.11.001

Acquired hepatocerebral degeneration in a metastatic neuroendocrine tumor long-term survivor - an update on neuroendocrine neoplasm's treatment: A case report.

PMID: 34131474
Journal: World journal of hepatology
Year: 2021
Reference: World J Hepatol. 2021 May 27;13(5):611-619. doi: 10.4254/wjh.v13.i5.611.
Impact factor: 0
Publication type: Letter or abstract
Authors: Riveiro-Barciela, Mar, Mirallas, Oriol, Saoudi, Nadia, Gomez-Puerto, Diego, Landolfi, Stefania, Blanco, Laia, Garcia-Burillo, Amparo, Molero, Xavier, Salcedo-Allende, Maria Teresa, Capdevila, Jaume et al.
DOI: 10.4254/wjh.v13.i5.611

Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma.

PMID: 34150764
Journal: Frontiers in Cell and Developmental Biology
Year: 2021
Reference: Front Cell Dev Biol. 2021 Jun 3;9:670185. doi: 10.3389/fcell.2021.670185. eCollection 2021.
Impact factor: 6.684
Publication type: Paper in international publication
Authors: Noguera, Rosa, Matias-Guiu, Xavier, de Alava, Enrique, Sanegre, Sabina, Eritja, Nuria, Diaz-Martin, Juan, Diaz-Lagares, Angel, Jacome, Maria Amalia, Salguero-Aranda, Carmen, Garcia Ros, David et al.
DOI: 10.3389/fcell.2021.670185

The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome.

PMID: 34121983
Journal: Frontiers in Neuroscience
Year: 2021
Reference: Front Neurosci. 2021 May 26;15:618098. doi: 10.3389/fnins.2021.618098. eCollection 2021.
Impact factor: 4.677
Publication type: Paper in international publication
Authors: Aguilera, Cinthia, Hummer, Stefan, Masanas, Marc, Gabau, Elisabeth, Guitart, Miriam, Jeyaprakash, A Arockia, Segura, Miguel F, Santamaria, Anna, Ruiz, Anna et al.
DOI: 10.3389/fnins.2021.618098

COVID-19 in CKD Patients: Lessons from 553 CKD Patients with Biopsy-Proven Kidney Disease.

PMID: 34098555
Journal: KIDNEY & BLOOD PRESSURE RESEARCH
Year: 2021
Reference: Kidney Blood Press Res. 2021;46(4):452-459. doi: 10.1159/000515714. Epub 2021 Jun 7.
Impact factor: 2.687
Publication type: Paper in international publication
Authors: Agraz, Irene, Roman, Juan Leon, Garcia-Carro, Clara, Gabaldon, Alejandra, Torres, Irina, Bury, Roxana, Baldallo, Cinthia, Seron, Daniel, Soler, Maria Jose, Vergara, Ander et al.
DOI: 10.1159/000515714

Utility of transjugular renal biopsy as an alternative to percutaneous biopsy.

PMID: 32660793
Journal: NEFROLOGIA
Year: 2020
Reference: Nefrologia. 2020 Nov - Dec;40(6):634-639. doi: 10.1016/j.nefro.2020.04.018. Epub 2020 Jul 11.
Impact factor: 1.544
Publication type: Paper in national publication
Authors: Soler, Maria Jose, Seron, Daniel, Segarra, Alfons, Perez Lafuente, Mercedes, Bolufer, Monica, Garcia-Carro, Clara, Agraz, Irene, Diez Miranda, Iratxe, Jaramillo, Juliana, Arredondo, Karla et al.
DOI: 10.1016/j.nefro.2020.04.018

KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.

PMID: 32642733
Journal: Neuro-oncology advances
Year: 2020
Reference: Neurooncol Adv. 2020 Jan 4;2(Suppl 1):i62-i74. doi: 10.1093/noajnl/vdz061. eCollection 2020 Jul.
Impact factor: 0
Publication type: Paper in international publication
Authors: Guha, Rajiv, Zhang, Xiaohu, Gel, Bernat, Romagosa, Cleofe, Ferrer, Marc, Lazaro, Conxi, Serra, Eduard, Thomas, Craig, Ramos-Oliver, Irma, Bernal, Gabriela et al.
DOI: 10.1093/noajnl/vdz061

C4-C5 fused pyrazol-3-amines: when the degree of unsaturation and electronic characteristics of the fused ring controls regioselectivity in Ullmann and acylation reactions.

PMID: 32583833
Journal: ORGANIC & BIOMOLECULAR CHEMISTRY
Year: 2020
Reference: Org Biomol Chem. 2020 Jul 15;18(27):5145-5156. doi: 10.1039/d0ob00796j.
Impact factor: 3.412
Publication type: Paper in international publication
Authors: Bou-Petit, Elisabeth, Rodriguez-Picazo, Nieves, Torres-Coll, Antoni, Puigjaner, Cristina, Font-Bardia, Merce, Teixido, Jordi, Ramon Y Cajal, Santiago, Estrada-Tejedor, Roger, Borrell, Jose I, Plans, Arnau et al.
DOI: 10.1039/d0ob00796j

Intraoperative Human Papillomavirus Test Predicts 24-Month High-Grade Squamous Intraepithelial Lesion Recurrence Saving Costs: A Prospective Cohort Study.

PMID: 32569022
Journal: Journal of Lower Genital Tract Disease
Year: 2020
Reference: J Low Genit Tract Dis. 2020 Oct;24(4):367-371. doi: 10.1097/LGT.0000000000000549.
Impact factor: 1.306
Publication type: Paper in international publication
Authors: Rabasa, Jordi, Alcalde, Ana, Bradbury, Melissa, Sanchez-Iglesias, Jose Luis, Guerrero, Diana, Forcada, Cristina, Perez-Benavente, Assumpcio, Cabrera, Silvia, Ramon Y Cajal, Santiago, Hernandez, Javier et al.
DOI: 10.1097/LGT.0000000000000549

Decompensated liver disease due to primary hepatic amyloidosis: Is liver transplantation still mandatory?

PMID: 30561765
Journal: HEPATOLOGY
Year: 2019
Reference: Hepatology. 2019 Jun;69(6):2701-2703. doi: 10.1002/hep.30464. Epub 2019 Mar 7.
Impact factor: 14.971
Publication type: Paper in international publication
Authors: Senin, Alicia, Salcedo, Maria-Teresa, Merino-Casabiel, Xavier, Castells, Lluis, Esteban, Rafael, Buti, Maria, Martinez-Valle, Fernando, Gironella, Merche, Riveiro-Barciela, Mar et al.
DOI: 10.1002/hep.30464

The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer.

PMID: 31141692
Journal: Cell Reports
Year: 2019
Reference: Cell Rep. 2019 May 28;27(9):2690-2708.e10. doi: 10.1016/j.celrep.2019.04.098.
Impact factor: 7.815
Publication type: Paper in international publication
Authors: Maruvka, Yosef, De Mattos-Arruda, Leticia, Sammut, Stephen-John, Ross, Edith M, Bashford-Rogers, Rachael, Greenstein, Erez, Markus, Havell, Morganella, Sandro, Teng, Yvonne, Seoane, Joan et al.
DOI: 10.1016/j.celrep.2019.04.098

Sclerosing Cholangitis Related to IgG4: Not Always a Curable Entity.

PMID: 31113593
Journal: Annals of Hepatology
Year: 2019
Reference: Ann Hepatol. 2019 Jan - Feb;18(1):215-219. doi: 10.5604/01.3001.0012.7916.
Impact factor: 1.895
Publication type: Paper in international publication
Authors: Martinez-Valle, Fernando, Riveiro-Barciela, Mar, Salcedo, Maria-Teresa, Merino-Casabiel, Xavier, Fernandez-Codina, Andreu, Torres, Ines de, Esteban, Rafael, Buti, Maria et al.
DOI: 10.5604/01.3001.0012.7916

Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1.

PMID: 31114569
Journal: Frontiers in Immunology
Year: 2019
Reference: Front Immunol. 2019 Apr 30;10:825. doi: 10.3389/fimmu.2019.00825. eCollection 2019.
Impact factor: 4.716
Publication type: Paper in international publication
Authors: Arnau-Saz, Vicent, Garrido, Julio, Tarrats, Antoni, Buzon, Maria J, Martinez-Picado, Javier, Izquierdo-Useros, Nuria, Genesca, Meritxell, Tapia, Gustavo, Castellvi, Josep, Hernandez-Gallego, Alba et al.
DOI: 10.3389/fimmu.2019.00825

Analysis of intra-tumor heterogeneity in Neurofibromatosis Type 1 plexiform neurofibromas and neurofibromas with atypical features: Correlating histological and genomic findings.

PMID: 29774626
Journal: HUMAN MUTATION
Year: 2018
Reference: Hum Mutat. 2018 Aug;39(8):1112-1125. doi: 10.1002/humu.23552. Epub 2018 May 25.
Impact factor: 5.359
Publication type: Paper in international publication
Authors: Terribas, Ernest, Zucchiatti, Adriana Carolina, Moline, Teresa, Rosas, Inma, Teule, Alex, Ramon Y Cajal, Santiago, Lopez-Gutierrez, Juan Carlos, Blanco, Ignacio, Castellanos, Elisabeth, Lazaro, Conxi et al.
DOI: 10.1002/humu.23552

Team Approach: Metastatic Disease of the Spine.

PMID: 29762343
Journal: JBJS reviews
Year: 2018
Reference: JBJS Rev. 2018 May;6(5):e6. doi: 10.2106/JBJS.RVW.17.00118.
Impact factor: 0
Publication type: Review in international publication
Authors: Matamalas, Antonia, Valverde, Claudia, Benavente, Sergi, Casas-Gomila, Lourdes, Romagosa, Cleofe, Gonzalez-Tartiere, Pilar, Pellise, Ferran et al.
DOI: 10.2106/JBJS.RVW.17.00118

Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases.

PMID: 29755676
Journal: Oncotarget
Year: 2018
Reference: Oncotarget. 2018 Apr 17;9(29):20617-20630. doi: 10.18632/oncotarget.25041. eCollection 2018 Apr 17.
Impact factor: 0
Publication type: Paper in international publication
Authors: Oliveira, Mafalda, Gomez, Patricia, Teixido, Cristina, Nuciforo, Paolo, Peg, Vicente, Saura, Cristina, Ramon Y Cajal, Santiago, Casas, Francesc Tresserra, Weigelt, Britta, Cortes, Javier et al.
DOI: 10.18632/oncotarget.25041

Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease.

PMID: 29701678
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2018
Reference: Int J Mol Sci. 2018 Apr 26;19(5). pii: ijms19051296. doi: 10.3390/ijms19051296.
Impact factor: 3.687
Publication type: Review in national publication
Authors: Aasen, Trond, Johnstone, Scott, Vidal-Brime, Laia, Lynn, K Sabrina, Koval, Michael et al.
DOI: 10.3390/ijms19051296

Tacrolimus and mycophenolate regimen and subclinical tubulo-interstitial inflammation in low immunological risk renal transplants.

PMID: 28667664
Journal: TRANSPLANT INTERNATIONAL
Year: 2017
Reference: Transpl Int. 2017 Nov;30(11):1119-1131. doi: 10.1111/tri.13002. Epub 2017 Jul 27.
Impact factor: 3.079
Publication type: Paper in international publication
Authors: Garcia-Carro, Clara, Midtvedt, Karsten, Reinholt, Finn P, Scott, Helge, Castella, Eva, Salcedo, Maite, Dorje, Christina, Sellares, Joana, Azancot, Maria A, Perello, Manel et al.
DOI: 10.1111/tri.13002

Pancreatic cancer heterogeneity and response to Mek inhibition.

PMID: 28581516
Journal: ONCOGENE
Year: 2017
Reference: Oncogene. 2017 Oct 5;36(40):5639-5647. doi: 10.1038/onc.2017.174. Epub 2017 Jun 5.
Impact factor: 7.519
Publication type: Paper in international publication
Authors: Pedersen, K, Bilal, F, Bernado Morales, C, Salcedo, M T, Macarulla, T, Masso-Valles, D, Mohan, V, Vivancos, A, Carreras, M-J, Serres, X et al.
DOI: 10.1038/onc.2017.174

Angiolymphoid Hyperplasia with Eosinophilia Involving the Occipital Artery: Case Report and Review of Literature.

PMID: 28511526
Journal: Journal of clinical and diagnostic research : JCDR
Year: 2017
Reference: J Clin Diagn Res. 2017 Mar;11(3):ZD21-ZD23. doi: 10.7860/JCDR/2017/23323.9569. Epub 2017 Mar 1.
Impact factor: 0
Publication type: Review in international publication
Authors: Fite-Trepat, Laia, Martos-Fernandez, Miriam, Alberola-Ferranti, Margarita, Pablo-Garcia-Cuenca, Alba De, Bescosatin, Coro et al.
DOI: 10.7860/JCDR/2017/23323.9569

E1a is an exogenous in vivo tumour suppressor.

PMID: 28416454
Journal: CANCER LETTERS
Year: 2017
Reference: Cancer Lett. 2017 Jul 28;399:74-81. doi: 10.1016/j.canlet.2017.04.010. Epub 2017 Apr 15.
Impact factor: 6.375
Publication type: Paper in international publication
Authors: Cimas, F J, Callejas-Valera, J L, Garcia-Olmo, D C, Hernandez-Losa, J, Melgar-Rojas, P, Ruiz-Hidalgo, M J, Pascual-Serra, R, Roche, O, Marcos, P, Garcia-Gil, E et al.
DOI: 10.1016/j.canlet.2017.04.010

Myositis ossificans of the masseter muscle: A rare location. Report of a case and review of literature.

PMID: 27034763
Journal: Journal of clinical and experimental dentistry
Year: 2016
Reference: J Clin Exp Dent. 2016 Apr 1;8(2):e210-3. doi: 10.4317/jced.52888. eCollection 2016 Apr.
Impact factor: 0
Publication type: Paper in international publication
Authors: Fite-Trepat, Laia, Martos-Fernandez, Miriam, Alberola-Ferranti, Margarita, Romanini-Montecino, Carolina, Saez-Barba, Manel, Bescos-Atin, Coro et al.
DOI: 10.4317/jced.52888

Disruption of the ribosomal P complex leads to stress-induced autophagy.

PMID: 26176264
Journal: Autophagy
Year: 2015
Reference: Autophagy. 2015;11(9):1499-519. doi: 10.1080/15548627.2015.1063764.
Impact factor: 11.753
Publication type: Paper in international publication
Authors: Leal, Jose A, Genestar, Monica, Castellvi, Josep, Peg, Vicente, Ramon Y Cajal, Santiago, LLeonart, Matilde E, Feliciano, Andrea, Perez-Alea, Mileidys, Artero-Castro, Ana et al.
DOI: 10.1080/15548627.2015.1063764

Fusion events lead to truncation of FOS in epithelioid hemangioma of bone.

PMID: 26173738
Journal: GENES & GENETIC SYSTEMS
Year: 2015
Reference: Genes Chromosomes Cancer. 2015 Sep;54(9):565-74. doi: 10.1002/gcc.22269. Epub 2015 Jul 14.
Impact factor: 0.93
Publication type: Paper in international publication
Authors: van IJzendoorn, David G P, de Jong, Danielle, Romagosa, Cleofe, Picci, Piero, Benassi, Maria Serena, Gambarotti, Marco, Daugaard, Soeren, van de Sande, Michiel, Szuhai, Karoly, Bovee, Judith V M G et al.
DOI: 10.1002/gcc.22269

Myo5b knockout mice as a model of microvillus inclusion disease.

PMID: 26201991
Journal: Scientific Reports
Year: 2015
Reference: Sci Rep. 2015 Jul 23;5:12312. doi: 10.1038/srep12312.
Impact factor: 5.578
Publication type: Paper in international publication
Authors: Carton-Garcia, Fernando, Overeem, Arend W, Nieto, Rocio, Bazzocco, Sarah, Dopeso, Higinio, Macaya, Irati, Bilic, Josipa, Landolfi, Stefania, Hernandez-Losa, Javier, Schwartz, Simo et al.
DOI: 10.1038/srep12312

ERRATUM: Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity.

PMID: 25670223
Journal: Scientific Reports
Year: 2015
Reference: Sci Rep. 2015 Feb 11;5:8179. doi: 10.1038/srep08179.
Impact factor: 5.578
Publication type: Paper in international publication
Authors: Prat, Aleix, Adamo, Barbara, Fan, Cheng, Peg, Vicente, Vidal, Maria, Galvan, Patricia, Vivancos, Ana, Nuciforo, Paolo, Palmer, Hector G, Dawood, Shaheenah et al.
DOI: 10.1038/srep08179

The intra-tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets.

PMID: 25060567
Journal: CLIN TRANSL ONCOL
Year: 2014
Reference: Clin Transl Oncol. 2014 Nov;16(11):937-41. doi: 10.1007/s12094-014-1203-9. Epub 2014 Jul 25.
Impact factor: 1.6
Publication type: Paper in international publication
Authors: Ramon Y Cajal, S, De Mattos-Arruda, L, Sonenberg, N, Cortes, J, Peg, V et al.
DOI: 10.1007/s12094-014-1203-9

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.

PMID: 25329316
Journal: PLoS Genetics
Year: 2014
Reference: PLoS Genet. 2014 Oct 16;10(10):e1004721. doi: 10.1371/journal.pgen.1004721. eCollection 2014 Oct.
Impact factor: 8.167
Publication type: Paper in international publication
Authors: Canals, Francesc, Ferrer, Berta, Cortes, Javier, Bastian, Boris, Ramon Y Cajal, Santiago, Martin-Caballero, Juan, Flores, Juana Maria, Vivancos, Ana, Garcia-Patos, Vicenc, Recio, Juan Angel et al.
DOI: 10.1371/journal.pgen.1004721

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.

PMID: 25413277
Journal: NAT COMMUN
Year: 2014
Reference: Nat Commun. 2014 Nov 21;5:5458. doi: 10.1038/ncomms6458.
Impact factor: 10.742
Publication type: Paper in international publication
Authors: Mateo-Lozano, Silvia, Rodrigues, Paulo, Macaya, Irati, Bazzocco, Sarah, Mazzolini, Rocco, Andretta, Elena, Dopeso, Higinio, Nieto, Rocio, Suarez-Lopez, Lucia, Afonso, Elsa et al.
DOI: 10.1038/ncomms6458

Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: retrospective testing of specimens from the EURTAC trial.

PMID: 24586842
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Feb 25;9(2):e89518. doi: 10.1371/journal.pone.0089518. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Benlloch, Susana, Botero, Maria Luisa, Beltran-Alamillo, Jordi, Mayo, Clara, Gimenez-Capitan, Ana, de Aguirre, Itziar, Queralt, Cristina, Ramirez, Jose Luis, Cajal, Santiago Ramon Y, Klughammer, Barbara et al.
DOI: 10.1371/journal.pone.0089518

Determining the profiles and parameters for gene amplification testing of growth factor receptors in lung cancer.

PMID: 23400671
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2013
Reference: Int J Cancer. 2013 Aug 15;133(4):898-907. doi: 10.1002/ijc.28090. Epub 2013 Mar 9.
Impact factor: 6.198
Publication type: Paper in international publication
Authors: Pros, Eva, Lantuejoul, Sylvie, Sanchez-Verde, Lydia, Castillo, Sandra D, Bonastre, Ester, Suarez-Gauthier, Ana, Conde, Esther, Cigudosa, Juan C, Lopez-Rios, Fernando, Torres-Lanzas, Juan et al.
DOI: 10.1002/ijc.28090

Fluorescence in situ hybridization and immunohistochemistry as diagnostic methods for ALK positive non-small cell lung cancer patients.

PMID: 23359795
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013;8(1):e52261. doi: 10.1371/journal.pone.0052261. Epub 2013 Jan 24.
Impact factor: 3.73
Publication type: Paper in international publication
Authors: Montero, Ma Angeles, Cedres, Susana, Castellvi, Josep, Martinez-Marti, Alex, Tallada, Natalia, Murtra-Garrell, Nuria, Navarro-Mendivill, Alejandro, Rodriguez-Freixinos, Victor, Canela, Mercedes, Ramon y Cajal, Santiago et al.
DOI: 10.1371/journal.pone.0052261

Epithelial-mesenchymal transition markers and HER3 expression are predictors of elisidepsin treatment response in breast and pancreatic cancer cell lines.

PMID: 23320098
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013;8(1):e53645. doi: 10.1371/journal.pone.0053645. Epub 2013 Jan 8.
Impact factor: 3.73
Publication type: Paper in international publication
Authors: Ramon y Cajal, Santiago, Hernandez-Losa, Javier, Aracil, Miguel, Mares, Roso, Teixido, Cristina et al.
DOI: 10.1371/journal.pone.0053645

Hepatitis A virus cellular receptor 1/kidney injury molecule-1 is a susceptibility gene for clear cell renal cell carcinoma and hepatitis A virus cellular receptor/kidney injury molecule-1 ectodomain shedding a predictive biomarker of tumour progression.

PMID: 23352434
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2013
Reference: Eur J Cancer. 2013 May;49(8):2034-47. doi: 10.1016/j.ejca.2012.12.020. Epub 2013 Jan 23.
Impact factor: 5.061
Publication type: Paper in international publication
Authors: Meseguer, Anna, Morote, Juan, Itarte, Emilio, Ramon Y Cajal, Santiago, Trilla, Enric, Vila, Maria Rosa, de Torres, Ines, Vilardell, Jordi, Messaoud, Nabil Ben, Salcedo, Mayte et al.
DOI: 10.1016/j.ejca.2012.12.020

Exploratory analysis of activation of PTEN-PI3K pathway and downstream proteins in malignant pleural mesothelioma (MPM).

PMID: 22459204
Journal: LUNG CANCER
Year: 2012
Reference: Lung Cancer. 2012 Jul;77(1):192-8. Epub 2012 Mar 27.
Impact factor: 3.434
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.lungcan.2012.02.022

Generation and characterization of orthotopic murine models for endometrial cancer.

PMID: 22198674
Journal: CLINICAL & EXPERIMENTAL METASTASIS
Year: 2012
Reference: Clin Exp Metastasis. 2012 Mar;29(3):217-27. Epub 2011 Dec 25.
Impact factor: 3.524
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1007/s10585-011-9444-2

USP15 stabilizes TGF-beta receptor I and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma.

PMID: 22344298
Journal: NATURE MEDICINE
Year: 2012
Reference: Nat Med. 2012 Feb 19;18(3):429-35. doi: 10.1038/nm.2619.
Impact factor: 22.462
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1038/nm.2619

Brush border Myosin Ia has tumor suppressor activity in the intestine.

PMID: 22307608
Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Year: 2012
Reference: Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1530-5. Epub 2012 Jan 18.
Impact factor: 9.681
Publication type: Paper in international publication
Authors: Arango, Diego, Mazzolini, Rocco, Dopeso, Higinio, Mateo-Lozano, Silvia, Chang, Wakam, Rodrigues, Paulo, Bazzocco, Sarah, Alazzouzi, Hafid, Landolfi, Stefania, Hernandez-Losa, Javier et al.
DOI: 10.1073/pnas.1108411109

Lipoma of the uterine corpus: exceptional eventuality combined with an ovarian thecoma.

PMID: 19718431
Journal: Case Report Med
Year: 2009
Reference: Case Report Med. 2009;2009:340603.
Impact factor:
Publication type: Letter or abstract
Authors: Y Cajal, S Ramon, Armengol, M, Fort, J M, Castellvi, J, Garcia, A, Vilallonga, R et al.
DOI: 10.1155/2009/340603

Subtractive proteomic approach to the endometrial carcinoma invasion front.

PMID: 19691290
Journal: JOURNAL OF PROTEOME RESEARCH
Year: 2009
Reference: J Proteome Res. 2009 Oct;8(10):4676-84.
Impact factor: 5.684
Publication type: Paper in international publication
Authors: Matias-Guiu, Xavier, Monge, Marta, Doll, Andreas, Colas, Eva, Gil-Moreno, Antonio, Castellvi, Josep, Garcia, Angel, Colome, Nuria, Perez-Benavente, Asummpcio, Pedrola, Nuria et al.
DOI: 10.1021/pr900390t

Epstein-Barr virus-associated lymphoma in patients with dermatomyositis. Be aware of double immunosuppression.

PMID: 19696063
Journal: RHEUMATOLOGY
Year: 2009
Reference: Rheumatology (Oxford). 2009 Nov;48(11):1462-3.
Impact factor: 4.136
Publication type: Letter or abstract
Authors: Selva-O'Callaghan, Albert, Palacios, Andres, Solans-Laque, Roser, Labirua, Anne, Salcedo-Allende, Teresa, Vilardell-Tarres, Miquel et al.
DOI: 10.1093/rheumatology/kep247

Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress.

PMID: 19443906
Journal: CARCINOGENESIS
Year: 2009
Reference: Carcinogenesis. 2009 Aug;30(8):1288-97.
Impact factor: 4.93
Publication type: Paper in international publication
Authors: Gil-Moreno, Antonio, Castellvi, Josep, Diaz, Berta, Gonzalez, Marta, Lopez-Lopez, Rafael, Xercavins, Jordi, Carreras, Ramon, Alameda, Francesc, Canals, Francesc, Gabrielli, Franco et al.
DOI: 10.1093/carcin/bgp119

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Translational research in cancer to improve the survival and quality of life of patients

On World Cancer Research Day, we highlight the oncology research model of the Vall d'Hebron Campus that allows laboratory results to be transferred as quickly as possible to clinical practice.

L’experiència del pacient i els últims avenços en recerca i innovació protagonitzen la Jornada del Dia Mundial contra el C

Vall d’Hebron ha celebrat avui la Jornada del Dia Mundial contra el Càncer, una malaltia cada cop més freqüent que patiran al llarg de la vida un de cada dos homes i una de cada tres dones del nostre entorn.

L'equip multidisciplinari que ha elaborat el treball premiat

Vall d'Hebron study awarded by the Spanish Society of Endocrinology and Nutrition

The multidisciplinary paper on papillary thyroid cancer has been considered the best original article of 2021 in the journal Endocrinología, Diabetes y Nutrición