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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Team

Stefan Huemmer

Stefan Huemmer

Main researcher
Translational Molecular Pathology
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Trond Aasen

Trond Aasen

Main researcher
Translational Molecular Pathology
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Ximena Garcia Torres

Ximena Garcia Torres

Administration and Management
Translational Molecular Pathology
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Stefan Huemmer

Stefan Huemmer

Main researcher
Translational Molecular Pathology
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Trond Aasen

Trond Aasen

Main researcher
Translational Molecular Pathology
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Ximena Garcia Torres

Ximena Garcia Torres

Administration and Management
Translational Molecular Pathology
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Projects

Proyecto colaborativo europeo-latinoamericano y caribeño sobre medicina personalizada para el estudio de trastornos neurológicos

IP: Maria Mar Hernandez Guillamon
Collaborators: Anna Penalba Morenilla, Jessica Camacho Soriano, Anas Chaachou Charradi, Elena Antima Martinez Saez, Laia Fernandez Resano
Funding agency: Instituto de Salud Carlos III
Funding: 174845
Reference: AC22/00051
Duration: 01/01/2023 - 31/12/2025

Patologia molecular translacional

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Cleofé Romagosa Pérez-Portabell, Maria Rosa Somoza Lopez de Haro, Jordi Temprana Salvador, Teresa Moline Marimon, Jessica Camacho Soriano, Carmela Iglesias i Felip, Josep Castellví Vives, Elena Muro Blanc, Marta Cano Galietero, Elena Antima Martinez Saez, Javier Hernandez Losa, Marta Sese Faustino, Vicente Peg Camara, Irene Sansano Valero, Trond Aasen, Stefan Hummer
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 01138
Duration: 01/01/2022 - 30/06/2025

Estudio de expresión de antígenos en tejido tumoral de pacientes con Esclerosis Sistémica.

IP: Alfredo Guillen Del Castillo
Collaborators: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla, Maria Roca Herrera, Janire Perurena Prieto, Irene Sansano Valero
Funding agency: Instituto de Salud Carlos III
Funding: 75020
Reference: PI22/01804
Duration: 01/01/2023 - 31/12/2025

Enhancing CD8+ Resident Memory T cell function to control and eliminate viral reservoirs

IP: Meritxell Genesca Ferrer
Collaborators: Vicente Descalzo Jorro, Josep Castellví Vives, Laura Mañalich Barrachina
Funding agency: Instituto de Salud Carlos III
Funding: 171820
Reference: PI20/00160
Duration: 01/01/2021 - 30/06/2025

Publications

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling.

PMID: 39044100
Journal: EMBO JOURNAL
Year: 2024
Reference: EMBO J. 2024 Jul 23. doi: 10.1038/s44318-024-00177-3.
Impact factor:
Publication type: Paper in international publication
Authors: Aasen, Trond; Almeida, Jani; Carvalho, Filomena A; Catarino, Steve; Correia-Rodrigues, Ania; Cristovao, Beatriz; Domingues, Neuza; Fernandes, Fabio; Girao, Henrique; Goncalves, Teresa et al.
DOI: 10.1038/s44318-024-00177-3

Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: human ex-vivo study.

PMID: 39050750
Journal: Frontiers in Pharmacology
Year: 2024
Reference: Front Pharmacol. 2024 Jul 10;15:1384070. doi: 10.3389/fphar.2024.1384070. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Alcala-Gonzalez, Luis Gerardo; Barber, Claudia; Corsetti, Maura; Jimenez, Marcel; Landolfi, Stefania; Lange, Robert; Malagelada, Carolina; Traserra, Sara et al.
DOI: 10.3389/fphar.2024.1384070

Inferring disease course from differential exon usage in the wide titinopathy spectrum.

PMID: 39198997
Journal: Annals of Clinical and Translational Neurology
Year: 2024
Reference: Ann Clin Transl Neurol. 2024 Aug 28. doi: 10.1002/acn3.52189.
Impact factor:
Publication type: Paper in international publication
Authors: Attie-Bitach, Tania; Brady, Angela F; Camacho Soriano, Jessica; Castiglioni, Claudia; Cereda, Anna; Chabrol, Brigitte; Di Feo, Maria Francesca; Estevez Arias, Berta; Forzano, Francesca; Gautel, Mathias et al.
DOI: 10.1002/acn3.52189

[Times and conditions of storage of samples in anatomic pathology. Recommendations of the Spanish Society of Anatomic Pathology (SEAP) part 1: samples for diagnosis].

PMID: 39393891
Journal:
Year: 2024
Reference: Rev Esp Patol. 2024 Oct-Dec;57(4):235-249. doi: 10.1016/j.patol.2024.04.004. Epub 2024 Jun 18.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre Anda, Jose Javier; Alfaro-Cervello, Clara; Alvarez Alegret, Ramiro; Aso Manso, Sonsoles; Azua Romeo, Javier; Bejar Valera, Javier; Centeno Haro, Macarena; Chappuis de Oliveira, Cesar; Dinares Fernandez, Carme; Fernandez Acenero, Maria Jesus et al.
DOI: 10.1016/j.patol.2024.04.004

Recommendations for the Clinical Approach to Immune Thrombocytopenia: Spanish ITP Working Group (GEPTI).

PMID: 37892566
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Oct 10;12(20):6422. doi: 10.3390/jcm12206422.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Alvarez-Roman, Maria Teresa; Andrade, Fernanda; Barez-Garcia, Abelardo; Bernardo-Gutierrez, Angel; Bernat-Pablo, Silvia; Bolanos-Calderon, Estefania; Butta-Coll, Nora; Caballero-Navarro, Gonzalo; Canaro Hirnyk, Mariana et al.
DOI: 10.3390/jcm12206422

Identification of two novel RRM2B variants associated with autosomal recessive progressive external ophthalmoplegia in a family with pseudodominant inheritance pattern.

PMID: 36959467
Journal: JOURNAL OF HUMAN GENETICS
Year: 2023
Reference: J Hum Genet. 2023 Aug;68(8):527-532. doi: 10.1038/s10038-023-01144-2. Epub 2023 Mar 23.
Impact factor:
Publication type: Paper in international publication
Authors: Codina-Sola, Marta; Garcia-Arumi, Elena; Juntas-Morales, Raul; Llaurado, Arnau; Marti, Ramon; Martinez-Saez, Elena; Ramon, Javier; Restrepo-Vera, Juan Luis; Rovira-Moreno, Eulalia; Salvado, Maria et al.
DOI: 10.1038/s10038-023-01144-2

Epidemiology of Immune-Mediated Glomerulopathies before and after SARS-CoV-2 Vaccination: A Tertiary Referral Hospital Experience.

PMID: 36983419
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Mar 21;12(6):2420. doi: 10.3390/jcm12062420.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Azancot, Maria Antonieta; Azancot, Maria Antonieta; Bermejo, Sheila; Gabaldon, Maria Alejandra; Leon Roman, Juan Carlos; Lopez-Martinez, Marina; Patricio Liebana, Marc; Patricio Liebana, Marc; Soler, Maria Jose et al.
DOI: 10.3390/jcm12062420

Diagnosis and outcome of patients with idiopathic pleural effusions.

PMID: 36990383
Journal: REVISTA CLINICA ESPANOLA
Year: 2023
Reference: Rev Clin Esp (Barc). 2023 May;223(5):320-324. doi: 10.1016/j.rceng.2023.03.005. Epub 2023 Mar 27.
Impact factor:
Publication type: Letter or abstract
Authors: Aleman, C; Persiva, O; Sanchez, L; Sansano, I; Simo, M; Vazquez, A et al.
DOI: 10.1016/j.rceng.2023.03.005

[Twin gestation with complete hydatidiform mole and a coexisting live fetus: A case report and review of the literature].

PMID: 36075658
Journal: Revista espanola de patologia
Year: 2022
Reference: Rev Esp Patol. 2022 Sep;55 Suppl 1:S21-S26. doi: 10.1016/j.patol.2020.06.008. Epub 2020 Sep 2.
Impact factor:
Publication type: Review in national publication
Authors: Camacho, Jessica; Garcia-Ruiz, Itziar; Garrido-Pontnou, Marta; Madureira, Joana; Moscoso, Olivier; Navarro, Alexandra; Ramon Y Cajal, Santiago; Reques, Armando et al.
DOI: 10.1016/j.patol.2020.06.008

Ultra Deep Sequencing of Circulating Cell-Free DNA as a Potential Tool for Hepatocellular Carcinoma Management.

PMID: 36010868
Journal: Cancers
Year: 2022
Reference: Cancers (Basel). 2022 Aug 11;14(16). pii: cancers14163875. doi: 10.3390/cancers14163875.
Impact factor:
Publication type: Paper in international publication
Authors: Bermudez-Ramos, Maria; Bilbao, Itxarone; Gregori, Josep; Guerrero-Murillo, Mercedes; Higuera, Monica; Martinez-Camprecios, Joan; Merino, Xavier; Minguez, Beatriz; Quer, Josep; Rodriguez-Frias, Francisco et al.
DOI: 10.3390/cancers14163875

Detection of early seeding of Richter transformation in chronic lymphocytic leukemia.

PMID: 35953718
Journal: NATURE MEDICINE
Year: 2022
Reference: Nat Med. 2022 Aug;28(8):1662-1671. doi: 10.1038/s41591-022-01927-8. Epub 2022 Aug 11.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Alcoceba, Miguel; Aymerich, Marta; Baumann, Tycho; Bea, Silvia; Bosch, Francesc; Campbell, Peter J; Campo, Elias; Capella-Gutierrez, Salvador; Castellvi, Josep et al.
DOI: 10.1038/s41591-022-01927-8

ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology.

PMID: 35884568
Journal: Cancers
Year: 2022
Reference: Cancers (Basel). 2022 Jul 19;14(14). pii: cancers14143509. doi: 10.3390/cancers14143509.
Impact factor:
Publication type: Paper in international publication
Authors: Arconada-Luque, Elena; Belandia, Borja; Cimas, Francisco J; Del Peso, Luis; Esparis-Ogando, Azucena; Fernandez-Aroca, Diego M; Fliquete, German; Garcia-Flores, Natalia; Garnes-Garcia, Cristina; Hernandez-Losa, Javier et al.
DOI: 10.3390/cancers14143509

Naive hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study.

PMID: 34497439
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2021
Reference: World J Gastroenterol. 2021 Aug 14;27(30):5112-5125. doi: 10.3748/wjg.v27.i30.5112.
Impact factor:
Publication type: Paper in international publication
Authors: Bronte, Fabrizio; Buti, Maria; Craxi, Antonio; Esteban, Rafael; Marcos-Fosch, Cristina; Martinez-Valle, Fernando; Orozco, Olimpia; Petta, Salvatore; Riveiro-Barciela, Mar; Salcedo, Maria-Teresa et al.
DOI: 10.3748/wjg.v27.i30.5112

Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma.

PMID: 34465776
Journal: Nature Communications
Year: 2021
Reference: Nat Commun. 2021 Aug 31;12(1):5183. doi: 10.1038/s41467-021-25405-w.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Aldamiz, Teresa; Anagnostopoulos, Ioannis; Baptista, Maria Joao; Berning, Philipp; Bonzheim, Irina; Borgmann, Vanessa; Castellvi, Josep; Chapuy, Bjorn; Climent, Fina et al.
DOI: 10.1038/s41467-021-25405-w

Gene expression signatures for tailoring adjuvant chemotherapy of luminal breast cancer: the pathologists' perspective.

PMID: 34461263
Journal: ANNALS OF ONCOLOGY
Year: 2021
Reference: Ann Oncol. 2021 Nov;32(11):1316-1321. doi: 10.1016/j.annonc.2021.08.1993. Epub 2021 Aug 28.
Impact factor:
Publication type: Editorail in international publication
Authors: Castellano, I; Peg, V; Perner, S; Quinn, C M; Ruschoff, J; Salgado, R; Van de Vijver, K; Varga, Z; Vincent-Salomon, A et al.
DOI: 10.1016/j.annonc.2021.08.1993

Shrinkage by the third month predicts long-term response of macroprolactinoma after cabergoline.

PMID: 34374649
Journal: EUROPEAN JOURNAL OF ENDOCRINOLOGY
Year: 2021
Reference: Eur J Endocrinol. 2021 Sep 1;185(4):587-595. doi: 10.1530/EJE-21-0561.
Impact factor:
Publication type: Paper in international publication
Authors: Biagetti, Betina; Casteras, Anna; Cordero Asanza, Esteban; Giralt-Arnaiz, Marina; Hernandez, Irene; Martinez-Saez, Elena; Ng-Wong, Yiken Karelys; Sarria-Estrada, Silvana; Simo, Rafael et al.
DOI: 10.1530/EJE-21-0561

Steatosis as main determinant of portal hypertension through a restriction of hepatic sinusoidal area in a dietary rat nash model.

PMID: 32770818
Journal: LIVER INTERNATIONAL
Year: 2020
Reference: Liver Int. 2020 Nov;40(11):2732-2743. doi: 10.1111/liv.14632. Epub 2020 Oct 13.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Barbera, Aurora; Bravo, Miren; Garcia-Lezana, Teresa; Genesca, Joan; Gil, Mar; Hide, Diana; Martell, Maria; Raurell, Imma; Salcedo, Maria Teresa et al.
DOI: 10.1111/liv.14632

CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models.

PMID: 32708733
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Jul 16;12(7). pii: cancers12071922. doi: 10.3390/cancers12071922.
Impact factor:
Publication type: Paper in international publication
Authors: Antonelli, Roberta; Bove, Jordi; Gallego, Soledad; Hooker, Jacob M; Jimenez, Carlos; Martinez-Saez, Elena; Martini, Maurizio; Moreno, Lucas; Riccardi, Riccardo; Riley, Misha et al.
DOI: 10.3390/cancers12071922

Sequential immunohistochemistry and virtual image reconstruction using a single slide for quantitative KI67 measurement in breast cancer.

PMID: 32707454
Journal: BREAST
Year: 2020
Reference: Breast. 2020 Oct;53:102-110. doi: 10.1016/j.breast.2020.07.002. Epub 2020 Jul 13.
Impact factor:
Publication type: Paper in international publication
Authors: Eppenberger-Castori, Serenella; Fasani, Roberta; Gallego, Paqui; Guardia, Xavier; Jimenez, Jose; Nuciforo, Paolo; Pagliuca, Francesca; Peg, Vicente; Ramon Y Cajal, Santiago; Saura, Cristina et al.
DOI: 10.1016/j.breast.2020.07.002

Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition.

PMID: 32691208
Journal: JOURNAL OF NEURO-ONCOLOGY
Year: 2020
Reference: J Neurooncol. 2020 Aug;149(1):13-25. doi: 10.1007/s11060-020-03580-y. Epub 2020 Jul 20.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Bobillo, Sabela; Boix, Joan; Bosch, Francesc; Carabia, Julia; Castellvi, Josep; Cespedes Torrez, Dennis H; Crespo, Marta; Escoda, Lourdes; Jimenez, Isabel et al.
DOI: 10.1007/s11060-020-03580-y

Assessment of a New ROS1 Immunohistochemistry Clone (SP384) for the Identification of ROS1 Rearrangements in Non-Small Cell Lung Carcinoma Patients: the ROSING Study.

PMID: 31349061
Journal: Journal of Thoracic Oncology
Year: 2019
Reference: J Thorac Oncol. 2019 Dec;14(12):2120-2132. doi: 10.1016/j.jtho.2019.07.005. Epub 2019 Jul 23.
Impact factor:
Publication type: Paper in international publication
Authors: Abdulkader, Ihab; Aguiar, David; Alvarez, Ramiro; Angulo, Barbara; Aranda, Ignacio; Arriola, Edurne; Arriola-Arellano, Esperanza; Artal, Angel; Atienza-Cuevas, Lidia; Azkona, Eider et al.
DOI: 10.1016/j.jtho.2019.07.005

Analysis of different levels of positive end-expiratory pressure during lung retrieval for transplantation: an experimental study.

PMID: 31314854
Journal: BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
Year: 2019
Reference: Braz J Med Biol Res. 2019;52(7):e8585. doi: 10.1590/1414-431X20198585. Epub 2019 Jul 15.
Impact factor:
Publication type: Paper in international publication
Authors: Aragon, D C; Fabro, A T; Goncalves-Ferri, W A; Jauregui, A; Martins-Celini, F P; Ochoa, J M; Sacramento, E M F; Sansano, I et al.
DOI: 10.1590/1414-431X20198585

The role of clonal communication and heterogeneity in breast cancer.

PMID: 31277602
Journal: BMC CANCER
Year: 2019
Reference: BMC Cancer. 2019 Jul 5;19(1):666. doi: 10.1186/s12885-019-5883-y.
Impact factor:
Publication type: Paper in international publication
Authors: Bande Vargas, Gemma; Bejar Serrano, Eva; Bribian, Ana; Castellvi, Josep; Diaz-Lagares, Angel; Guijarro, Pedro J; Hummer, Stefan; Hurtado Blanco, Pablo; Lluch-Senar, Maria; Lopez-Lopez, Rafael et al.
DOI: 10.1186/s12885-019-5883-y

MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways.

PMID: 31278368
Journal: ONCOGENE
Year: 2019
Reference: Oncogene. 2019 Aug;38(32):6035-6050. doi: 10.1038/s41388-019-0860-0. Epub 2019 Jul 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alameda, Francesc; Barber, Marta; Castellvi, Josep; Esteller, Manel; Gil-Moreno, Antonio; Jimenez, Carlos; Majem, Blanca; Marin, Andrea; Matias-Guiu, Xavier; Moran, Sebastian et al.
DOI: 10.1038/s41388-019-0860-0

Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients.

PMID: 30250996
Journal: MOLECULAR BIOLOGY REPORTS
Year: 2018
Reference: Mol Biol Rep. 2018 Dec;45(6):2345-2358. doi: 10.1007/s11033-018-4399-x. Epub 2018 Sep 24.
Impact factor:
Publication type: Paper in international publication
Authors: Ati, Nidhal; Blel, Ahlem; Chebil, Mohamed; Derouiche, Amine; Garcia-Mayea, Yoelsis; Hernandez-Losa, Javier; LLeonart, Matilde E; Mir, Cristina; Ouerhani, Slah; Paciucci, Rosanna et al.
DOI: 10.1007/s11033-018-4399-x

Computer-based intensity measurement assists pathologists in scoring PTEN immunohistochemistry - Clinical associations in NSCLC patients of the ETOP Lungscape cohort.

PMID: 30240851
Journal: Journal of Thoracic Oncology
Year: 2018
Reference: J Thorac Oncol. 2018 Dec;13(12):1851-1863. doi: 10.1016/j.jtho.2018.08.2034. Epub 2018 Sep 18.
Impact factor:
Publication type: Paper in international publication
Authors: Bubendorf, Lukas; Casanova, Ruben; Cheney, Richard; Ciftlik, Ata Tuna; Dafni, Urania; Deml, Karl-Friedrich; Finn, Stephen P; Geiger, Thomas; Gendreau, Steven; Haberecker, Martina et al.
DOI: 10.1016/j.jtho.2018.08.2034

The Effectiveness of Trichloroacetic Acid vs Electrocautery Ablation for the Treatment of anal High-grade squamous intraepithelial lesion in HIV-infected patients.

PMID: 30179983
Journal: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Year: 2018
Reference: J Acquir Immune Defic Syndr. 2018 Dec 15;79(5):612-616. doi: 10.1097/QAI.0000000000001847.
Impact factor:
Publication type: Paper in international publication
Authors: Burgos, J; Curran, A; Dinares, M femininec; Falco, V; Landolfi, S; Martin-Castillo, M; Navarro, J; Ribera, E; Villar, J et al.
DOI: 10.1097/QAI.0000000000001847

Non traumatic giant aneurysm of middle meningeal artery. Case report and review of the literature.

PMID: 29292165
Journal: NEUROCIRUGIA
Year: 2018
Reference: Neurocirugia (Astur). 2018 Sep - Oct;29(5):250-254. doi: 10.1016/j.neucir.2017.11.003. Epub 2017 Dec 29.
Impact factor:
Publication type: Paper in national publication
Authors: Arikan, Fuat; Gandara, Dario; Martinez-Ricarte, Francisco; Martinez-Saez, Elena A; Vilalta, Jordi et al.
DOI: 10.1016/j.neucir.2017.11.003

The role of oncogenic HPV determination for diagnosis of high-grade anal intraepithelial neoplasia in HIV-infected MSM.

PMID: 28723712
Journal: AIDS
Year: 2017
Reference: AIDS. 2017 Oct 23;31(16):2227-2233. doi: 10.1097/QAD.0000000000001605.
Impact factor:
Publication type: Paper in international publication
Authors: Burgos, Joaquin; Curran, A; Dinares, M femininec; Falco, V; Guelar, A; Hernandez-Losa, J; Landolfi, S; Navarro, J; Ribera, E; Villar, J et al.
DOI: 10.1097/QAD.0000000000001605

Microcephaly with simplified gyral pattern, epilepsy and permanent neonatal diabetes syndrome (MEDS). A new patient and review of the literature.

PMID: 28711742
Journal: European Journal of Medical Genetics
Year: 2017
Reference: Eur J Med Genet. 2017 Oct;60(10):517-520. doi: 10.1016/j.ejmg.2017.07.007. Epub 2017 Jul 12.
Impact factor:
Publication type: Paper in international publication
Authors: Boronat, Susana; Carrascosa, Antonio; Clemente, Maria; Macaya, Alfons; Martinez-Saez, Elena; Munell, Francina; Sanchez-Montanez, Angel; Valenzuela, Irene et al.
DOI: 10.1016/j.ejmg.2017.07.007

A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4+ T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients.

PMID: 28698276
Journal: mBio
Year: 2017
Reference: MBio. 2017 Jul 11;8(4). pii: e00876-17. doi: 10.1128/mBio.00876-17.
Impact factor:
Publication type: Paper in international publication
Authors: Badia, Rosa; Burgos, Joaquin; Buzon, Maria J; Castellvi, Josep; Crespo, Manuel; Curran, Adria; Falco, Vicenc; Grau-Exposito, Judith; Miguel, Lucia; Navarro, Jordi et al.
DOI: 10.1128/mBio.00876-17

Overexpression of Yes Associated Protein 1, an Independent Prognostic Marker in Patients With Pancreatic Ductal Adenocarcinoma, Correlated With Liver Metastasis and Poor Prognosis.

PMID: 28697132
Journal: PANCREAS
Year: 2017
Reference: Pancreas. 2017 Aug;46(7):913-920. doi: 10.1097/MPA.0000000000000867.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, Helena; Balsells, Joaquim; Hernandez, Javier; Macarulla, Teresa; Merino, Xavier; Ramon Y Cajal Agueras, Santiago; Salcedo Allende, Maria Teresa; Tabernero, Josep; Zeron-Medina, Jorge et al.
DOI: 10.1097/MPA.0000000000000867

A 40-Year-Old Woman With Back Pain.

PMID: 27938773
Journal: CHEST
Year: 2016
Reference: Chest. 2016 Dec;150(6):e159-e165. doi: 10.1016/j.chest.2016.08.1449.
Impact factor:
Publication type: Paper in international publication
Authors: Aranda-Rodriguez, Santiago; Bujan-Rivas, Segundo; Deu-Martin, Maria; Fernandez-Codina, Andreu; Parra-Farinas, Carmen; Romagosa, Cleofe et al.
DOI: 10.1016/j.chest.2016.08.1449

Towards a new paradigm of microscopic colitis: Incomplete and variant forms.

PMID: 27784958
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2016
Reference: World J Gastroenterol. 2016 Oct 14;22(38):8459-8471.
Impact factor:
Publication type: Paper in international publication
Authors: Guagnozzi, Danila; Landolfi, Stefania; Vicario, Maria et al.
DOI: 10.3748/wjg.v22.i38.8459

Gap junctions and cancer: communicating for 50 years.

PMID: 27782134
Journal: NATURE REVIEWS CANCER
Year: 2016
Reference: Nat Rev Cancer. 2016 Dec;16(12):775-788. doi: 10.1038/nrc.2016.105. Epub 2016 Oct 21.
Impact factor:
Publication type: Paper in international publication
Authors: Aasen, Trond; Laird, Dale W; Lampe, Paul D; Mesnil, Marc; Naus, Christian C et al.
DOI: 10.1038/nrc.2016.105

Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-free and Overall Survival Times for Patients With Loco-regional Cancer.

PMID: 27521480
Journal: GASTROENTEROLOGY
Year: 2016
Reference: Gastroenterology. 2016 Nov;151(5):961-972. doi: 10.1053/j.gastro.2016.08.001. Epub 2016 Aug 10.
Impact factor:
Publication type: Paper in international publication
Authors: Arribas, Carles; Bock, Christoph; Elez, Elena; Esteller, Manel; Landolfi, Stefania; Lorden, Patricia; Manzano, Jose L; Martinez-Balibrea, Eva; Martinez-Cardus, Anna; Moran, Sebastian et al.
DOI: 10.1053/j.gastro.2016.08.001

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.

PMID: 26410082
Journal: CANCER DISCOV
Year: 2015
Reference: Cancer Discov. 2015 Nov;5(11):1164-77. doi: 10.1158/2159-8290.CD-15-0369. Epub 2015 Sep 26.
Impact factor:
Publication type: Paper in international publication
Authors: Barker, Frederick G 2nd; Baselga, Jose; Batchelor, Tracy T; Beroukhim, Rameen; Brastianos, Priscilla K; Cahill, Daniel P; Carter, Scott L; Chevalier, Aaron; Choueiri, Toni K; Cibulskis, Kristian et al.
DOI: 10.1158/2159-8290.CD-15-0369

Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study.

PMID: 26527776
Journal: J CLIN ONCOL
Year: 2015
Reference: J Clin Oncol. 2015 Dec 10;33(35):4176-87. doi: 10.1200/JCO.2015.63.4238. Epub 2015 Nov 2.
Impact factor:
Publication type: Paper in international publication
Authors: Andre, Thierry; Banzi, Maria; Bonnetain, Franck; Carlsson, Goran U; Chibaudel, Benoist; Colote, Soudhir; de Gramont, Aimery; de Gramont, Armand; Demetter, Pieter; Duval, Alex et al.
DOI: 10.1200/JCO.2015.63.4238

Pixel-by-Pixel Comparison of Volume Transfer Constant and Estimates of Cerebral Blood Volume from Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast-Enhanced MR Imaging in High-Grade Gliomas.

PMID: 25634715
Journal: AM J NEURORADIOL
Year: 2015
Reference: AJNR Am J Neuroradiol. 2015 May;36(5):871-6. doi: 10.3174/ajnr.A4231. Epub 2015 Jan 29.
Impact factor:
Publication type: Paper in international publication
Authors: Alcaide-Leon, P; Auger, C; Bharatha, A; Martinez-Saez, E; Pareto, D; Rovira, A et al.
DOI: 10.3174/ajnr.A4231

Sulfonylurea Receptor 1 in Humans with Post-Traumatic Brain Contusions.

PMID: 26398596
Journal: J NEUROTRAUM
Year: 2015
Reference: J Neurotrauma. 2015 Oct 1;32(19):1478-87. doi: 10.1089/neu.2014.3706. Epub 2015 Jun 3.
Impact factor:
Publication type: Paper in international publication
Authors: Arikan, Fuat; Castro, Lidia; Cordero, Esteban; Martinez-Saez, Elena; Martinez-Valverde, Tamara; Poca, Maria-Antonia; Radoi, Andreea; Sahuquillo, Juan; Simard, J Marc; Vidal-Jorge, Marian et al.
DOI: 10.1089/neu.2014.3706

Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: retrospective testing of specimens from the EURTAC trial.

PMID: 24586842
Journal: PLoS One
Year: 2014
Reference: PLoS One. 2014 Feb 25;9(2):e89518. doi: 10.1371/journal.pone.0089518. eCollection 2014.
Impact factor:
Publication type: Paper in international publication
Authors: Beltran-Alamillo, Jordi; Benlloch, Susana; Bordogna, Walter; Botero, Maria Luisa; Cajal, Santiago Ramon Y; Chen, David; de Aguirre, Itziar; Gimenez-Capitan, Ana; Klughammer, Barbara; Kovach, Barbara et al.
DOI: 10.1371/journal.pone.0089518

Single intracoronary injection of encapsulated antagomir-92a promotes angiogenesis and prevents adverse infarct remodeling.

PMID: 25240056
Journal: Journal of the American Heart Association
Year: 2014
Reference: J Am Heart Assoc. 2014 Sep 19;3(5):e000946. doi: 10.1161/JAHA.114.000946.
Impact factor:
Publication type: Paper in international publication
Authors: Asin, Miguel Angel; Barba, Ignasi; Bellera, Neus; Esteves, Marielle; Ferret, Eulalia; Fonseca, Carla; Garcia Del Blanco, Bruno; Garcia-Dorado, David; Gonzalez-Alujas, M Teresa; Perez, Amadeo et al.
DOI: 10.1161/JAHA.114.000946

Internal translation of the connexin 43 transcript.

PMID: 24884945
Journal: Cell Communication and Signaling
Year: 2014
Reference: Cell Commun Signal. 2014 May 8;12:31. doi: 10.1186/1478-811X-12-31.
Impact factor:
Publication type: Letter or abstract
Authors: Aasen, Trond; Peula, Cristina; Ramon y Cajal, Santiago; Salat-Canela, Claudia; Sese, Marta et al.
DOI: 10.1186/1478-811X-12-31

Locally destructive mandibular pseudotumor as a manifestation of immunoglobulin G4-related disease.

PMID: 24618057
Journal: Oral Surgery Oral Medicine Oral Pathology Oral Radiology
Year: 2014
Reference: Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Aug;118(2):e40-3. doi: 10.1016/j.oooo.2014.01.023. Epub 2014 Jan 23.
Impact factor:
Publication type: Paper in international publication
Authors: Bescos Atin, Coro; Bordonaba Leiva, Sergio; Gutierrez Santamaria, Javier; Masia Gridilla, Jorge; Mogedas Vegara, Alfonso; Pamias Romero, Jorge; Romagosa Perez-Portabella, Cleofe et al.
DOI: 10.1016/j.oooo.2014.01.023

Clinical response to a lapatinib-based therapy of a Li-Fraumeni Syndrome patient with a novel HER2-V659E mutation.

PMID: 23950206
Journal: Cancer Discovery
Year: 2013
Reference: Cancer Discov. 2013 Nov;3(11):1238-44. doi: 10.1158/2159-8290.CD-13-0132. Epub 2013 Aug 15.
Impact factor:
Publication type: Paper in international publication
Authors: Arribas, Joaquin; Baselga, Jose; Caratu, Ginevra; De Mattos-Arruda, Leticia; Felip, Enriqueta; Grueso, Judit; Hernandez-Losa, Javier; Nuciforo, Paolo; Parra, Josep Lluis; Prudkin, Ludmila et al.
DOI: 10.1158/2159-8290.CD-13-0132

Reduction in neural injury with earlier delivery in a mouse model of congenital myelomeningocele.

PMID: 23931768
Journal: Journal of Neurosurgery-Pediatrics
Year: 2013
Reference: J Neurosurg Pediatr. 2013 Oct;12(4):390-4. doi: 10.3171/2013.7.PEDS1351. Epub 2013 Aug 9.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Shanafey, Saud N; Canyadell, Marius Aguirre; Conesa, Xavier J; Fontecha, Cesar G; Ibanez, Vicenc M; Peiro, Jose L; Rojo, Alejandro A; Soldado, Francisco C; Toran, Nuria T et al.
DOI: 10.3171/2013.7.PEDS1351

SPECT/CT sentinel lymph node identification in papillary thyroid cancer: lymphatic staging and surgical management improvement.

PMID: 23907326
Journal: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Year: 2013
Reference: Eur J Nucl Med Mol Imaging. 2013 Oct;40(11):1645-55. doi: 10.1007/s00259-013-2476-x. Epub 2013 Aug 2.
Impact factor:
Publication type: Paper in international publication
Authors: Armengol, Manuel; Castell-Conesa, Joan; Castellvi, Josep; Caubet, Enric; Fort, Jose Manuel; Garcia-Burillo, Amparo; Gonzalez, Oscar; Iglesias, Carmela; Mesa, Jordi; Roca Bielsa, Isabel et al.
DOI: 10.1007/s00259-013-2476-x

Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy.

PMID: 23847097
Journal: JOURNAL OF LEUKOCYTE BIOLOGY
Year: 2013
Reference: J Leukoc Biol. 2013 Oct;94(4):779-89. doi: 10.1189/jlb.0213094. Epub 2013 Jul 11.
Impact factor:
Publication type: Paper in international publication
Authors: Bielanska, Joanna; Castellvi, Josep; Comes, Nuria; Condom, Enric; Felipe, Antonio; Ferreres, Joan Carles; Hernandez-Losa, Javier; Manils, Joan; Ramon Y Cajal, Santiago; Ruiz-Marcellan, M Carmen et al.
DOI: 10.1189/jlb.0213094

Association of ventricular noncompaction and histiocytoid cardiomyopathy: case report and review of the literature.

PMID: 22758650
Journal: PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
Year: 2012
Reference: Pediatr Dev Pathol. 2012 Sep-Oct;15(5):397-402. doi: 10.2350/12-05-1193-CR.1. Epub 2012 Jul 3.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.2350/12-05-1193-CR.1

Adult onset leukodystrophy with neuroaxonal spheroids and demyelinating plaque-like lesions.

PMID: 22007734
Journal: NEUROPATHOLOGY
Year: 2012
Reference: Neuropathology. 2012 Jun;32(3):285-92. doi: 10.1111/j.1440-1789.2011.01257.x. Epub 2011 Oct 18.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1111/j.1440-1789.2011.01257.x

Molecular profiling of patients with colorectal cancer and matched targeted therapy in Phase 1 clinical trials.

PMID: 22723336
Journal: MOLECULAR CANCER THERAPEUTICS
Year: 2012
Reference: Mol Cancer Ther. 2012 Sep;11(9):2062-71. doi: 10.1158/1535-7163.MCT-12-0290. Epub 2012 Jun 21.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1158/1535-7163.MCT-12-0290

Molecular bases of endometrial cancer: New roles for new actors in the diagnosis and the therapy of the disease.

PMID: 22037169
Journal: MOLECULAR AND CELLULAR ENDOCRINOLOGY
Year: 2012
Reference: Mol Cell Endocrinol. 2012 Jul 25;358(2):244-55. Epub 2011 Oct 20.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.mce.2011.10.003

Thoracic Findings of Systemic Diseases at High-Resolution CT in Children.

PMID: 21415192
Journal: RADIOGRAPHICS
Year: 2011
Reference: Radiographics. 2011 Mar-Apr;31(2):465-82.
Impact factor:
Publication type: Paper in international publication
Authors: Barber, Ignasi; Boixadera, Helena; Enriquez, Goya; Garcia-Pena, Pilar; Lucaya, Javier; Toran, Nuria et al.
DOI: 10.1148/rg.312095160

Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors.

PMID: 21040949
Journal: HUMAN PATHOLOGY
Year: 2011
Reference: Hum Pathol. 2011 Feb;42(2):194-203. Epub 2010 Oct 30.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1016/j.humpath.2010.04.020

Brain perihematoma genomic profile following spontaneous human intracerebral hemorrhage.

PMID: 21311749
Journal: PLoS One
Year: 2011
Reference: PLoS One. 2011 Feb 2;6(2):e16750.
Impact factor:
Publication type: Paper in international publication
Authors: Cuadrado, Eloy; Delgado, Pilar; Domingues-Montanari, Sophie; Fernandez-Cadenas, Israel; Garcia-Berrocoso, Teresa; Martinez-Saez, Elena; Montaner, Joan; Ortega-Aznar, Arantxa; Ribo, Marc; Rosell, Anna et al.
DOI: 10.1371/journal.pone.0016750

p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.

PMID: 21297668
Journal: ONCOGENE
Year: 2011
Reference: Oncogene. 2011 May 5;30(18):2087-97. Epub 2011 Feb 7.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1038/onc.2010.614

Between Bench and Bed Side: PI3K Inhibitors.

PMID: 20302563
Journal: CURRENT MOLECULAR MEDICINE
Year: 2010
Reference: Curr Mol Pharmacol. 2010 Jun;3(2):79-90.
Impact factor:
Publication type: Letter or abstract
Authors: ; et al.
DOI:

Cyclo-oxygenase type 2 is dysregulated in breast ductal carcinoma in situ and correlates with poor outcome.

PMID: 20227160
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology
Year: 2010
Reference: Eur J Obstet Gynecol Reprod Biol. 2010 Jul;151(1):72-6. Epub 2010 Mar 12.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.ejogrb.2010.02.033

Risk factors for positive findings in patients with high-grade T1 bladder cancer treated with transurethral resection of bladder tumour (TUR) and bacille Calmette-Guerin therapy and the decision for a repeat TUR.

PMID: 19558557
Journal: BJU INTERNATIONAL
Year: 2010
Reference: BJU Int. 2010 Jan;105(2):202-7. Epub 2009 Jun 24.
Impact factor:
Publication type: Paper in international publication
Authors: Cecchini, Lluis; de Torres, Ines; Landolfi, Stefania; Morote, Juan; Orsola, Anna; Planas, Jacques; Raventos, Carles X; Trilla, Enric et al.
DOI: 10.1111/j.1464-410X.2009.08694.x

Intraoperative assessment of sentinel lymph nodes after neoadjuvant chemotherapy in patients with breast cancer.

PMID: 19777186
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2010
Reference: Ann Surg Oncol. 2010 Jan;17(1):235-9. Epub 2009 Sep 24.
Impact factor:
Publication type: Paper in international publication
Authors: Aznar, Fernando; Lirola, Jose; Peg, Vicente; Rubio, Isabel T; Xercavins, Jordi et al.
DOI: 10.1245/s10434-009-0695-y

Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation.

PMID: 19158277
Journal: MOLECULAR AND CELLULAR BIOLOGY
Year: 2009
Reference: Mol Cell Biol. 2009 Apr;29(7):1855-68.
Impact factor:
Publication type: Paper in international publication
Authors: Artero-Castro, Ana; Callejas, Francisco B; Carnero, Amancio; Castellvi, Josep; Fernandez-Marcos, Pablo J; Kondoh, Hiroshi; Lleonart, Matilde E; Ramon y Cajal, Santiago; Serrano, Manuel et al.
DOI: 10.1128/MCB.01386-08

Lipoma of the uterine corpus: exceptional eventuality combined with an ovarian thecoma.

PMID: 19718431
Journal: Case Report Med
Year: 2009
Reference: Case Report Med. 2009;2009:340603.
Impact factor:
Publication type: Letter or abstract
Authors: Armengol, M; Castellvi, J; Fort, J M; Garcia, A; Vilallonga, R; Y Cajal, S Ramon et al.
DOI: 10.1155/2009/340603

Subtractive proteomic approach to the endometrial carcinoma invasion front.

PMID: 19691290
Journal: JOURNAL OF PROTEOME RESEARCH
Year: 2009
Reference: J Proteome Res. 2009 Oct;8(10):4676-84.
Impact factor:
Publication type: Paper in international publication
Authors: Abal, Miguel; Canals, Francesc; Castellvi, Josep; Colas, Eva; Colome, Nuria; Dolcet, Xavier; Doll, Andreas; Garcia, Angel; Gil-Moreno, Antonio; Lopez-Lopez, Rafael et al.
DOI: 10.1021/pr900390t

Epstein-Barr virus-associated lymphoma in patients with dermatomyositis. Be aware of double immunosuppression.

PMID: 19696063
Journal: RHEUMATOLOGY
Year: 2009
Reference: Rheumatology (Oxford). 2009 Nov;48(11):1462-3.
Impact factor:
Publication type: Letter or abstract
Authors: Labirua, Anne; Palacios, Andres; Salcedo-Allende, Teresa; Selva-O'Callaghan, Albert; Solans-Laque, Roser; Vilardell-Tarres, Miquel et al.
DOI: 10.1093/rheumatology/kep247

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The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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