Speaker: Dr. Ling Peng, Research director in the Interdisciplinary Center on Nanoscience in Marseille (CINaM) at the French National Scientific Research Center (CNRS) France.

Abstract: The application of nanotechnology is widely expected to bring breakthrough in medicine for disease treatment and diagnosis. Dendrimers are ideal precision materials for elaborating nanomedicine by virtue of their well-defined structure, multivalent cooperativity and nanosize per se. We have pioneered modular and adaptive self-assembling dendrimer nanosystems1 for the delivery of anticancer drugs,2 nucleic acid therapeutics3 and imaging agents4 for cancer detection and treatment. Remarkably, these supramolecular dendrimer nanosystems are able to exploit the in situ tumor-secreted extracellular vesicles for effective delivery and deep penetration in tumor tissue, while overcoming tumor heterogeneity and dynamic evolution.2 Also, we have recently developed self-assembling dendrimers against infectious diseases caused by multidrug-resistant pathogens.5 Our findings offer a fresh perspective for exploiting the advantageous features of supramolecular dendrimers to reach the ultimate goal of nanomedicine.

Host: Dr. Fernanda Raquel da Silva Andrade, Main researcher Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT).

Online attendance: https://gencat.zoom.us/j/86581646343