Speaker:  Prof. Jesús Francisco Bermejo Martín. MD PhD Professor (PPL), Medicine Dept, Universidad de Salamanca (USAL). Principal Investigator, BioSepsis (Translational Research in Severe Infections) - IBSAL / USAL / CIBERES / EGIS.

Classical perspectives approaching the understanding of sepsis physiopathogenesis propose over-simplified models depicting the existence of “phases” (inflammatory / immunosuppression) occurring in either a sequential or a simultaneous manner. These “one-size-fits-all” models do not capture the complexity of sepsis, which is characterised by a large variety of clinical presentations, responding probably to different biological events in each individual patient. In our view, the “original sin” of sepsis is the inability of the host to control the pathogen using balanced responses which prevent damage to the tissues. The severity of sepsis at presentation would be determined indeed by the interplay between the performance of the immune system to control the pathogen and the degree of tissue damage caused  to do so. This balance is heavily influenced by the existence of prior comorbidities, basal immunosuppression, aging and sepsis treatment. This talk will propose thus a new provocative perspective on how sepsis pathogenesis should be approached, a new perspective that moves beyond the “phases” based models to a more personalised model considering together microbial, host response and tissue damage parameters to define the true individual biological status of each case of sepsis at presentation and along its clinical course. This new model should be taken into account to personalise treatment in this severe condition. 

Host: Dr. Juan Carlos Ruiz, Shock, Organ Dysfunction and Resuscitation. VHIR. Intensive Care Medicine, General Hospital 

Online assistance: https://gencat.zoom.us/j/88449511660