About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Speaker: Dr. Fátima Valdés Mora. Head research group Cancer Epigenetic Biology and Therapeutics, Children’s Cancer Institute. Sydney
Abstract: Diffuse midline glioma (DMG) is the most aggressive brain tumour in children, with a median survival of less than one year and with no cure. DMG is an epigenetically driven cancer, where more than 85% of the cases are characterised by a global loss of the repressive epigenetic mark, histone 3 trimethylation at the lysine 27 (H3K27me3). This is caused by a single somatic mutation in the histone H3, called H3K27M, or by the overexpression of the developmental gene EZHIP, a natural mimic of H3K27M, and subclassifies these DMGs as “H3K27-altered”. Unfortunately, the epigenomic landscape of H3K27-altered DMG is far from been completed and thus epigenetic therapies tested in DMG to date have not been rationalized based on such information. Valdes Mora group’s mission is to complete the epigenomic landscapes on H3K27-altered DMGs, not only in the cancer cells but also in the cells from the tumour microenvironment (TME). Ultimately, we aim to use research-informed epigenetic therapy to target both the cancer cells and the cells from the TME as a novel therapeutic strategy for H3K27-altered DMG.
Host: Dr. Aroa Soriano Fernández. Main researcher. Childhood Cancer and Blood Disorders (VHIR)
enllaç online:
