08/06/2012 Alterations in the intestinal epithelium associated with the severity of irritable bowel syndrome 08/06/2012 A team of researchers at Vall d'Hebron Research Institute (VHIR), coordinated by Dr. Maria Vicario, member of the Digestive Physiology and Physiopathology group, has identified for the first time that the small intestine presents alterations of structural proteins associated with the severity of irritable bowel syndrome."We have verified that proteins that form the tight junctions in the epithelial cells of the jejunum are altered", affirms Dr. Vicario. One of the big innovations of the research, published in the last issue of Gut, is that "we have identified, by means of gene and protein expression and by electron microscopy, that these proteins are altered at two levels: they are less expressed and some are distributed in an abnormal location. Importantly, these alterations correlate with mucosal immune activation and with clinical symptoms", explains Dr. Vicario. A team of researchers at Vall d'Hebron Research Institute (VHIR), coordinated by Dr. Maria Vicario, member of the Digestive Physiology and Physiopathology group, has identified for the first time that the small intestine presents alterations of structural proteins associated with the severity of irritable bowel syndrome."We have verified that proteins that form the tight junctions in the epithelial cells of the jejunum are altered", affirms Dr. Vicario. One of the big innovations of the research, published in the last issue of Gut, is that "we have identified, by means of gene and protein expression and by electron microscopy, that these proteins are altered at two levels: they are less expressed and some are distributed in an abnormal location. Importantly, these alterations correlate with mucosal immune activation and with clinical symptoms", explains Dr. Vicario. Twitter LinkedIn Facebook Whatsapp
