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17/08/2010

Described for the first time a key protein in cell mitosis

2010_0186_2010_0186_IMATGE

17/08/2010

A study led by Dr. Rosanna Paciucci, member of the Biomedical Research and traslational Oncology Unit at VHIR, and published in the Journal of Biological Chemistry, describes for the first time how key is Flotilina 1 for the correct separation of chromosomes during cell mitosis. This protein, present in cell membranes, can penetrate to the cell nucleus, where it interacts with the activity of protein Aurora Kinase B, which allows the proper segregation of chromosomes during cell division. The absence of Flotilina 1 does not allow the correct separation of chromosomes.

A study led by Dr. Rosanna Paciucci, member of the Biomedical Research and traslational Oncology Unit at VHIR, and published in the Journal of Biological Chemistry, describes for the first time how key is Flotilina 1 for the correct separation of chromosomes during cell mitosis. This protein, present in cell membranes, can penetrate to the cell nucleus, where it interacts with the activity of protein Aurora Kinase B, which allows the proper segregation of chromosomes during cell division. The absence of Flotilina 1 does not allow the correct separation of chromosomes.

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