Dr. Juanjo González, Principal Investigator in the http://en.vhir.org/portal1/grup-equip.asp?t=microbiologia&s=recerca&contentid=186961 Microbiology group in VHIR received the grant to further develop the project named "Drug discovery and repurposing of nucleoside analogues as promising new antibacterial drugs".This grants are given by http://agaur.gencat.cat/ca/inici" AGAUR, the Business and Knowledge Department and the University and Research secretary. They are given to innovative and translational projects, which aim to reach industrial implementation. This project is co-financed by the European Funding for regional Development (FEDER) from the EU, within the Operative Program FEDER in Catalonia 2014-2020.Since its introduction in clinical practice, antibiotics have changed our tools to treat and control infectious diseases, reducing drastically mortality and morbidity. However, in the last decades the massive usage of antibiotics has promoted the appearance and dissemination of multidrug-resistant bacteria. Thus, common illnesses that were easily treated with antibiotics are starting to become challenging. It is thought that around 50.000 people die each year in Europe and UE due to infections caused by these resistant bacteria. This situation, combined with the reduced discovery of new antibiotic drugs, makes urgent to identify new molecules, therapeutic alternatives or approaches to treat infections related to multidrug-resistant bacteria. Nucleoside analogues and nucleobases are being used as anti-proliferative therapies against different cancer types and for certain viral infections, due to their ability to interfere in essential cellular processes. The project will evaluate the antibacterial capacity of nucleoside analogues for treating multidrug-resistant bacteria. The results will allow the development of novel and effective therapeutic strategies to treat infections that currently do not have any other viable approach.