‘Critical Care Medicine’, the official magazine of Critical Care Society, has published the "http://www.sccm.org/Documents/SSC-Guidelines.pdf" third edition of the International Guidelines for Management of Severe Sepsis and Septic Shock. Dr. Jordi Rello, responsible of the Clinical Research/Innovation in Pneumonia & Sepsis (CRIPS) group at VHIR, has participated in these new standards agreed by 30 international professional organizations. The guidelines pursue the early application of the antibiotic treatment and the hemodynamic resuscitation. Specifically, professionals are asked to apply the therapeutic measures in two periods: during the first three and six hours. The recommendations insist on the need of starting the antibiotic treatment in the first hour after recognition. The new advances in the sepsis treatment, especially the therapeutic ones, don’t arrive easily to the professionals. For that reason, the third edition of these guidelines proposes educational sessions for medical staff. Finally, the agreed document also highlights the importance of following a protocol to detect sepsis in critically ill patients, because sometimes the disorder appears atypically and it is not identified until it is too late.