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19/12/2018

New study between the VHIR and the UB on autonomic dysfunction in patients with CFG and other CSS, with support of the ACAF

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19/12/2018

The VHIR and the UB jointly carry out a study on dysautonomia and circadian rhythms in patients with chronic fatigue syndrome and other central sensitization syndromes, with the support of the ACAF.

The Catalan Association of Fibromyalgia Affected by Fibromyalgia and other Central Sensitization Syndromes (ACAF, in its Catalan acronym), contributes to a study on chronical fatigue and circadian rhythms. The association contribute with the acquisition of several actigraphs to study autonomic dysfunction and circadian rhythms in patients with Chronic Fatigue Syndrome (CFG) and other Central Sensitivity Syndromes (CSS). The study is carried out by the http://en.vhir.org/web_vhir/portal1/grup-presentacio.asp?s=recerca&contentid=9328&idrefer= Chronic Fatigue group of the Vall d'Hebron Research Institute (Dr. José Alegre and Dr. Jesús Castro) and the Chronobiology group of the University of Barcelona (Dr. Trinitat Cambras and Dr. Antoni Díez).In patients with chronic fatigue syndrome, fibromyalgia and other central sensitivity syndromes, suffer alterations in the sleeping rhythm and in the body temperature regulation. Both variables are linked to circadian rhythms (existing variations in activity between day and night), for that reason, the project considers whether the circadian system could present functional alterations too. A recent pilot study evaluated the association of circadian rhythm and automatic dysfunction in patients with chronic fatigue syndrome, which has been published in https://www.ncbi.nlm.nih.gov/pubmed/29874259" PLoSOne.The main objective of this project is to study the circadian rhythmicity and peripheral temperature of patients with CFS and other SSC. Motor activity and temperature would be record with actigraphs, devices that are fixed on the wrist, such as a wristwatch. The device measures the number of movements, the cutaneous temperature and the amount of ambient light every minute.The study of circadian rhythms in these patients would allow to identify individual treatment patterns, which would help to establish behavioral guidelines for each person based on their circadian rhythms. The determination of the rhythmic pattern could be used as a diagnostic aid and contribute to an improvement in the treatment of the disease, improving the quality of life of patients.This collaboration between the Chronic Fatigue group of the VHIR, the Chronobiology group of the UB and the ACAF becomes one more step in the way of promoting and supporting research, for a better understanding of the central sensitization syndromes.

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