23/05/2012

Jesus Planagumà i Valls has been awarded with the PhD extraordinary prize for the thesis 'Analysis of the differential gene expression in the endometrial cancer', developed as member of the Research Unit in Biomedicine and Translational and Pediatric Oncology at Vall d'Hebron Research Institute (VHIR). Directed by Dr. Jaume Reventós, head of the unit, the thesis proved for the first time with results the overexpression of two new genes (RUNX1 and ETV5) in the endometrial carcinoma of endometrioide type.The endometrial carcinoma is the most frequent femenine genital malignant tumor of the industrialized countries and approximately 80% of the cases correspond to the endometrioide endometrial carcinoma.The study revealed a correlation of the overexpression of the RUNX1 and ETV5 genes with the initial process of miometrial infiltration, the moment in which the dissemination of the carcinoma begins to the contiguous tissue, it means the genesis of the endometrial metastasis. These results have allowed to start understanding, on the one hand, the complex molecular mechanism of tumour evolution of the endometrial cancer, and on the other hand, the origin of several projects of analysis of these genes in the endometrial and ovarian carcinoma published in numerous international prestige magazines.