Researchers from the Institut de Recerca de la Sida IrsiCaixa and the Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol have identified a group of 8 molecules of the immunological system which are associated to a worse immunological response of patients with Chronic Fatigue Syndrome (CFS). Scientists from the research group in CFS at Vall d’Hebron Research Institute (VHIR), the Clínica SCF in Tarragona, the Clínica Delfos, as well as several associations of patients with CFS and the foundation against AIDS in Catalonia, have also participated in this study done with 22 diagnosed individuals fulfilling Fukuda criteria. “The alterations of these molecules in patients with CFS could improve the reliability and the early diagnosis of this complex disorder which has been wrongly defined in the molecular field”, assures Julià Blanco, Miguel Servet senior researcher of the Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol at Irsi Caixa, coordinator of the study and responsible of the Virology and Cellular Immunology group. At present, the diagnosis of CFC is only focused in the evaluation of the clinical symptoms, after ruling out other diseases. Moreover, the diagnosis is not very quantitative, and requires effort and neurological tests which can be more unpleasant than a blood draw. The study was recently published in "http://www.translational-medicine.com/content/11/1/68/abstract" Journal of Translational Medicine and could also explain the higher effect of some infections caused by virus in these patients. Nonetheless, scientists stress the need of proving these results with larger studies. The Chronic Fatigue Syndrome is a complex disorder which affects the immunological, neurological, cardiovascular and endocrinal systems. In Spain, it is estimated that 1 of 1,000 people suffer CFS.