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19/06/2013

VHIR studies the most frequent viral infection in transplantations

2013_0171_2013_0171_IMATGE

19/06/2013

CMV in the most frequent viral infection in lung transplantation

Dr. Juliana Esperalba, researcher of the Microbiology group at Vall d’Hebron Institute of Research (VHIR), has obtained one of the grants for research projects awarded by "http://www.fundacionmutua.es/" Mutua Madrileña Foundation, worth 25.000 euros for the study ‘Three points to consider in the control of cytomegalovirus infection in lung transplantation: clinical, the virus and the immune system’. The objective of the project is to know and to better connect in a jointly and perspective way  three aspects: clinical, immune system involved in the control of the infection and genetic polymorphism of this virus that represents the more important viral infection in solid organ transplantation, specifically in lung transplantation. To carry it out, the Microbiology group will work together with specialists from researchers groups of Infectious Diseases and Pneumology from VHIR as well as the Group of Immune and Infection of the Instituto Hospital del Mar de Investigaciones Médicas (IMIM). This multidisciplinary group will study the kinetics of the virus and the immune response implicated from a year before the transplant to one year before it, to relate the behavior of this equilibrium virus-immunity response with the clinical evolution of the patient. CMV is a herpesvirus that infects the majority of population in an asymptomatic way, generally, and that persists in the organism in a latent state. The control of the infection/reactivation of the virus depends on factors both from the virus as well as from the host, but in immunodeficient patients the control of the infection by the host is weaken. In these cases the pathogenic role of the virus can be clear in a direct (for example, invasion of tissues) or indirect way (affecting the rejection of the graft, in opportunist infections or in mortality).

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