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23/09/2015

VHIR's researcher wins the L'ORÉAL-UNESCO 'For Women in Science' prize for an AIDS project

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23/09/2015

Dr. María José Buzón will carry out the research with the group of Infectious Diseases during 2016.

Textbody Dr. María José Buzón, researcher from the Infectious Diseases group at Vall d'Hebron Institute of Research (VHIR), has been one of the winners of the X Edición de las Bolsas de Investigación 2015 contest of the programme http://www.loreal.es/Foundation/Article.aspx?topcode=Foundation_AccessibleScience_WomenExcellence_W" L'ORéAL-UNESCO "For Women in Science" in Spain. Textbody The researcher, who has been granted with 15,000 euros, will lead a study about the use of viral latency reactivators as a therapy to treat human immunodeficiency virus (HIV) infection, responsible for AIDS. Textbody Current antiretroviral therapy for AIDS manages to suppresses viral load until this is not noticeable by diagnostic techniques, but it is not able to completely eliminate the virus from the body. This happens mainly because there are long-lasting and latently infected CD4+ T cells which are not sensitive to treatment. As a consequence, when the treatment is suspended, HIV reappears from latent reservoirs in just a few weeks' time. Textbody For this study, VHIR's researcher decided to extensively identify and analise which are the viral latency reactivators and their combinations that are able to reactivate viral genome expression specifically in long-lasting CD4+ cells. Furthermore, she will analise the contribution of the intrinsic features of induced genomes and the role of the integration sites of HIV in viral reactivation. Textbody With this research, Dr. Buzón trusts that "the effective identification and characterisation of the compounds able to reactive HIV in the true latent reservoirs and the features of these induced genomes will give us objective information about the development of new targeted strategies to treat AIDS".The national edition of the L'ORéAL-UNESCO "For Women in Science" programme in Spain is aimed at giving visibility to the work of Spanish scientists and to encourage the vocation for science among the youngest people. Dr. Buzón now aims for the international edition of this prize.

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