For the third consecutive year, the European Researchers' Night is held in Catalonia, which will take place on November 27 and 28. More than fifty scientific entities will participate in this dissemination event, with the main objective of bringing science, research, technology and innovation to the public in a simple and fun way, through talks, workshops, games, experiments and many others activities. The Vall d'Hebron researchers have decided to join this initiative.Every year the European Researchers' Night is held on the last Friday in September. But this edition, due to the pandemic, has been postponed for two months. For the same reason, most of the activities have been adapted to the online format to reach everyone in the safest and most comfortable way. However, the organized face-to-face activities will be carried out following the security measures established against COVID-19.The activities offered by the program are organized from different locations in all the provinces. The Vall d'Hebron researchers will collaborate by giving talks with the same objective of bringing science to the public, which will be published on the https://www.youtube.com/channel/UCeyJlvim_W9aNSWhFYGU78A/featured YouTube channel of the European Researchers' Night. In the following list you will find the talks that the Vall d'Hebron professionals will give.Autoimmunity after pathogen infectionsThis talk, conducted by Dr. Francesc Miró, a researcher from the VHIR's Systemic Diseases group, will explain what happens when the immune defense system attacks its own components that are recognized as foreign and how the autoimmunity is generated.Clinical research in a COVID-19 pandemic scenario. Learned lessonsDr. Adrián Sánchez, principal investigator from the VHIR Infectious Diseases group, will give a talk in which he will explain how research is managed in a pandemic period such as COVID-19 and how coordination, speed and preparation are fundamental.SARS-CoV-2 genomic variabilityThis talk will be given by Dr. Josep Quer, principal investigator of the VHIR Hepatic Diseases group, of the CIBER of Hepatic Diseases (CIBEREHD), member of the Spanish Society for Virology (SEV) and coordinator of the Translational Biomedical Research master's degree of the UAB. In it, the strategy of "not burning the house" will be explained, which allows the SARS-CoV-2 to maintain its very high specificity to bind to the human ACE-2 receptor, and transmit itself with high efficiency, while controlling its capacity to infect, favouring its persistence and transmission.Advances that represent small important steps in the development of new ways to treat Parkinson's diseaseDr. Ariadna Laguna, principal investigator from the VHIR Neurodegenerative Diseases group and with a Junior Leader La Caixa scholarship, will give this talk about Parkinson's disease, which is the second most frequent neurodegenerative disorder and which affects the nervous system in a chronic and disabling way. She will explain what have been the most important and encouraging advances that have been obtained in the last ten years to understand why neurons in the brain die, especially those related to the protein synuclein and the pigment neuromelanin, and also how microbes of the guts communicate with the brain. These advances represent small, but important steps in the development of new ways to treat this disease.Unmasking rheumatic diseases in childhood through single cell sequencing technologyDr. Mireia López, specialist in Rheumatology at the Vall d'Hebron Pediatric Rheumatology Unit, will give an introduction on rheumatic diseases that affect the population and, especially, those that affect infants. Through the functioning of the cells of the immune system, a pillar in the development of these diseases, we delve into their unknowns and learn how current technology can help us to decipher some of them. The genome of these cells, their instruction manual, can be studied individually with the single cell sequencing technique, allowing a better characterization of them and helping us to understand their role in juvenile idiopathic arthritis.Discovering clinical trialsThe project manager of the VHIR Hepatic Diseases group, Dr. Lada Murcia, will give an introductory talk on the operation of clinical trials to better understand the world around us. In addition, she will present the European project EU-PEARL and comment its role in improving clinical trials.Building bridges between diseases: the relationship and implication of the GBA gene in healthIn this talk, conducted by Dr. Maria Camprodon, internist at the Minority Diseases Unit of Vall d'Hebron, the GBA gene, which causes Gaucher disease, and its relationship with Parkinson's disease will be discussed. In addition, she will also talk about lines of research that are being developed in the Vall d'Hebron.Migraine Adaptive BrainFinally, Dr. Edoardo Caronna, neurologist of the VHIR Headache and Neurological Pain group, and Dr. Patricia Pozo-Rosich, head of the VHIR Headache and Neurological Pain group, specialist of the Vall d'Hebron Neurology Service and Head of the Migraine Adaptive Brain Center in Vall d'Hebron, will give a talk about migraine. This disease allows us to better understand the adaptive functions of the brain, specifically how it communicates and how it adapts to change through the processing of internal and external stimuli. These skills are essential to guarantee adequate cognitive performance, optimize our survival and improve health. In addition, understanding how the cognitive and sensory circuits communicate will also allow us to understand how the brain adapts to the environment.