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Ariadna Laguna Tuset

I am a neuroscientist with extensive experience in the molecular mechanisms underlying both neurodevelopmental and neurodegenerative diseases of the nervous system. My current research is aimed at identifying new therapeutic targets and biomarkers to improve the diagnosis and treatment of Parkinson's disease.

Institutions of which they are part

Main researcher
Neurodegenerative Diseases
Vall Hebron Institut de Recerca

Ariadna Laguna Tuset

Institutions of which they are part

Main researcher
Neurodegenerative Diseases
Vall Hebron Institut de Recerca

I am a neuroscientist with extensive experience in the molecular mechanisms underlying both neurodevelopmental and neurodegenerative diseases of the nervous system. My current research is aimed at identifying new therapeutic targets and biomarkers to improve the diagnosis and treatment of Parkinson's disease.

I received my Biology degree, Health and Life Sciences specialization, in 2003 at the Universitat Pompeu Fabra (Barcelona, Spain). I got my Ph.D. in 2008 in the laboratory of Dr. Mariona Arbonés at the Center for Genomic Regulation (CRG, Barcelona, Spain). My Ph.D. was devoted to study the molecular basis of Down Syndrome neurological alterations. In 2009, I joined the group of Professor Thomas Perlmann at the Ludwig Institute for Cancer Research – Karolinska Institutet (Stockholm, Sweden) as a post-doctoral Marie Curie researcher to work on the transcriptional regulation of dopamine neurons during development and in pathological conditions such as Parkinson’s disease.

In 2014, I moved back to Barcelona and joined the Neurodegenerative Diseases Research Group at the Vall d’Hebron Research Institute (VHIR) as a Beatriu de Pinós post-doctoral researcher funded by AGAUR-FP7 Marie Curie Actions. Afterwards, I received a Young Investigator contract from the Spanish government (Ministry of Economy and Competitiveness (MINECO)) and a Junior Leader fellowship from the La Caixa Foundation to establish my own research lines within the group. In addition, I am an associate researcher at the Neuroscience Institute of the Autonomous University of Barcelona (UAB) and Scientific Ambassador of the World Parkinson Coalition.

The research from my team is devoted to elucidate the molecular mechanisms of inter-organ communication in Parkinson’s disease and how this contributes to the pathophysiology and symptoms of this neurodegenerative disorder. Our research contributes to: (i) identify biomarkers for early detection, disease progression or response to treatment, (ii) identify new molecular targets and develop novel therapeutic strategies with disease-modifying potential, (iii) unravel molecular pathways common to other neurodegenerative or metabolic diseases. Researcher ID: F-9561-2016; Orcid: 0000-0002-9732-6677.

Projects

Modulation of age-dependent neuromelanin accumulation as a novel therapeutic strategy for Parkinson’s disease and brain aging

IP: Miquel Vila Bover
Collaborators: Ariadna Laguna Tuset, Thais Cuadros Arasa, Marta González Sepúlveda, Annabelle Parent
Funding agency: Fundació "La Caixa"
Funding: 466004
Reference: FBLC/HR17-00513/VILA
Duration: 01/09/2018 - 05/01/2022

Rol de la neuromelanina en la enfermedad de Parkinson y del envejecimiento cerebral: estudio `ptemcoañ terpéutico en nuevos modelos preclínicos "humanizados" in vivo.

IP: Miquel Vila Bover
Collaborators: Ariadna Laguna Tuset, Thais Cuadros Arasa
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 363000
Reference: SAF2016-77541-R
Duration: 30/12/2016 - 29/12/2020

Targeting the transcriptional regulator of autophagy LMX1B for Parkinson’s disease therapeutic development

IP: Ariadna Laguna Tuset
Collaborators: -
Funding agency: Michael J. Fox Foundation
Funding: 91400.31
Reference: TARGET.ADV_MJFF_2015_DR.LAGUNA
Duration: 05/11/2015 - 21/06/2017

Transcriptional profiling by Next-Generation Sequencing in pre-symptomatic, early and advanced phases of Parkinson's Disease

IP: Miquel Vila Bover
Collaborators: Ariadna Laguna Tuset, Laia Perez Lasarte
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 91022.4
Reference: 2013 BP_B 00113
Duration: 01/10/2014 - 30/09/2016

Related news

Vall d'Hebron has participated in a phase III clinical trial which confirmed the efficacy and safety of subcutaneous infusion of levodopa therapy.

This initiative is part of a pioneering study that seeks to assess how the relationship between different age groups can influence the quality of life and mental health of patients.

Dr. Miquel Vila, head of the Neurodegenerative Diseases research group at VHIR, is the co-chair of the local organising committee. And Dr. Ariadna Laguna, principal investigator of the same group, is a scientific ambassador.

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