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Gema Ariceta Iraola

Institutions of which they are part

Main researcher
Kidney Physiopathology
Vall Hebron Institut de Recerca

Gema Ariceta Iraola

Institutions of which they are part

Main researcher
Kidney Physiopathology
Vall Hebron Institut de Recerca

Research lines

Mechanisms of chronic renal disease progression and cardiovascular risk in pediatric patients with chronic renal disease

Pediatric patients with chronic kidney disease (CKD) constitude a high risk group for cardiovascular disease (CVD) related to traditional and non-traditional risk factors. We are interested in studying the relationship between traditional CVD risk factors (obesity, overweight, anemia, dyslipemia, malnutrition, hypertension, and non-traditional CVD risk factors (homocysteine, asymmetric dymethylarginine (ADMA), FGF23, ultraselective protein C (PCR) and carotid intima-media thickness (cIMT) in children and adolescents with CKD, based on its severity and duration.  Further, we are also interested in finding a biomarker to identify early in the disease, those patients with increased CVD risk and poor outcome.

IP: Gema Ariceta Iraola

Rare inhirited renal diseases

Our group is focused in research in primary or inherited tubular renal diseases, such as Dent’s Disease, Bartter syndrome, Tubular Acidosis, Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis, among others. Currently we are collaborating  with other groups in Spain, within a research project named Renaltube the main purpose of which is to build a database while facilitating access to genotyping in order to improve the clinical and molecular knowledge of primary tubulopathies. Renaltube has a web-based approach with multilateral collaboration scheme that enhances the recruitment of data and promotes the understanding of underlying mechanisms of rare inherited diseases, defines more accurate diagnostic and follow-up criteria, develops new molecular techniques and will improve the overall care of the patients. Currently we are offering the analysis of 22 genes corresponding to 23 primary tubulopathies. After two years of activity Renaltube has collected data from 222 patients, the mayority from Spain and Latin America (85.3%). The most common tubulopathies are distal renal tubular acidosis (22.5%), and classical Bartter syndrome (19.3%) followed by familial hypomagesemia with hipercalciuria and nephrocalcinosis (15.7%), and Gitelman syndrome (15%).

IP: Gema Ariceta Iraola, Anna Meseguer Navarro

Projects

Caracterización de la respuesta inmune celular específica frente al virus Epstein-Barr en receptores de trasplante renal pediátrico (CRICE-VEB)).

IP: Caracterización de la respuesta inmune celular específica frente al virus Epstein-Barr en receptores de trasplante renal pediátr
Collaborators: Gema Ariceta Iraola, Laura Donadeu Casassas, Delphine Kervella
Funding agency: Sociedad Española de Trasplantes
Funding: 20000
Reference: SET/AYUDAS.PROYECTOS/2023/LOPEZ
Duration: 01/01/2024 - 31/12/2025

La variabilidad fenotípica en pacientes afectados de Hipomagnesemia Familiar con Hipercalciuria y Nefrocalcinosis (HFHNC) como oportunidad para entender las bases fisiopatológicas de la enfermedad y para la búsqueda de soluciones terapéuticas

IP: Anna Meseguer Navarro
Collaborators: Gema Ariceta Iraola, Gerard Cantero Recasens
Funding agency: Sociedad Española de Nefrología (S.E.N.)
Funding: 24000
Reference: SENEFRO/PROJECTES/2023/MESEGUER
Duration: 27/11/2023 - 26/11/2025

RED NACIONAL DE LABORATORIOS DE FUNCION RENAL

IP: Francesc Moreso Mateos
Collaborators: Gema Ariceta Iraola, Joan López Hellin
Funding agency: Instituto de Salud Carlos III
Funding: 42900
Reference: PMP22/00119
Duration: 01/01/2023 - 31/12/2025

Biomarcadores, dianas y soluciones terapéuticas para mejorar el cuidado de pacientes afectados de Hipomagnesemia Familiar con Hipercalciuria y Nefrocalcinosis (HFHNC).

IP: Gema Ariceta Iraola
Collaborators: Hector Rios Duro, Mónica Durán Fernández, Gloria Mª Fraga Rodriguez, Julieta Torchia
Funding agency: Instituto de Salud Carlos III
Funding: 202070
Reference: PI22/01946
Duration: 01/01/2023 - 31/12/2025

Related news

Researchers at the VHIR have carried out a study showing that the ClC-5 protein regulates collagen levels through the β-catenin pathway and lysosomal degradation.

The research will perform a functional analysis of phenotype-modifying genetic variants in patients affected by familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (HFHNC).

The project, which has received funding from the Association for Genetic Kidney Disease Information and Research, aims to help develop new therapies for familial hypomagnesemia with hypercalciuria and nephrocalcinosis.

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