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Gema Ariceta Iraola

Institutions of which they are part

Kidney Physiopathology
Vall Hebron Institut de Recerca
Gema Ariceta Iraola

Research lines

Mechanisms of chronic renal disease progression and cardiovascular risk in pediatric patients with chronic renal disease

Pediatric patients with chronic kidney disease (CKD) constitude a high risk group for cardiovascular disease (CVD) related to traditional and non-traditional risk factors. We are interested in studying the relationship between traditional CVD risk factors (obesity, overweight, anemia, dyslipemia, malnutrition, hypertension, and non-traditional CVD risk factors (homocysteine, asymmetric dymethylarginine (ADMA), FGF23, ultraselective protein C (PCR) and carotid intima-media thickness (cIMT) in children and adolescents with CKD, based on its severity and duration. Further, we are also interested in finding a biomarker to identify early in the disease, those patients with increased CVD risk and poor outcome.

IP: Gema Ariceta Iraola

Rare inhirited renal diseases

Our group is focused in research in primary or inherited tubular renal diseases, such as Dent’s Disease, Bartter syndrome, Tubular Acidosis, Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis, among others. Currently we are collaborating with other groups in Spain, within a research project named Renaltube the main purpose of which is to build a database while facilitating access to genotyping in order to improve the clinical and molecular knowledge of primary tubulopathies. Renaltube has a web-based approach with multilateral collaboration scheme that enhances the recruitment of data and promotes the understanding of underlying mechanisms of rare inherited diseases, defines more accurate diagnostic and follow-up criteria, develops new molecular techniques and will improve the overall care of the patients. Currently we are offering the analysis of 22 genes corresponding to 23 primary tubulopathies. After two years of activity Renaltube has collected data from 222 patients, the mayority from Spain and Latin America (85.3%). The most common tubulopathies are distal renal tubular acidosis (22.5%), and classical Bartter syndrome (19.3%) followed by familial hypomagesemia with hipercalciuria and nephrocalcinosis (15.7%), and Gitelman syndrome (15%).

IP: Gema Ariceta Iraola, Anna Meseguer Navarro

Projects

ADQUISICIÓN DE UN MICROSCOPIO MULTIDIMENSIONAL WIDEFIELD EQUIPADO PARA REALIZAR EXPERIMENTOS IN VIVO, DESTINADO A LA PLATAFORMA DE MICROSCOPÍA DE LA UNIDAD DE ALTA TECNOLOGÍA (UAT)

IP: Inmaculada Fuentes Camps
Collaborators: Maria Vicario Perez, Soledad Gallego Melcón, Fco Javier Santos Vicente, Diego Arango Corro, Gema Ariceta Iraola, Santiago Ramon y Cajal Agüeras, Marta Martínez Vicente, Anna Meseguer Navarro, Manuel Comabella Lopez, Ricardo Pujol Borrell, Joan Sahuquillo Barris, Joan Xavier Comella Carnicé, Miguel Segura Ginard, Simon Schwartz Navarro, Anna Rosell Novel, Meritxell Genesca Ferrer
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 177204.2
Reference: EQC2019-006309-P
Duration: 01/01/2019 - 31/12/2020

Ministerio de Ciencia

Biología de sistemas para el descubrimiento de mecanismos fisiopatológicos y dianas terapéuticas en la hipomagnesemia familiar primaria con hipercalciuria y nefrocalcinosis

IP: Gema Ariceta Iraola
Collaborators: -
Funding agency:
Funding:
Reference: PR(AMI)51/2019
Duration: -

OxalEurope Primary Hyperoxaluria Registry/ Registro Europeo de Hiperoxaluria Primaria.

IP: Gema Ariceta Iraola
Collaborators: -
Funding agency:
Funding:
Reference: PR(AMI)157/2019
Duration: -

AGORA: Investigación etiológica de los factores de riesgo genéticos y ambientales para el desarrollo de anomalías en niños. AGORA: Aetiologic research into genetic and Occupational /environmental Risk factors for Anomalies in children.

IP: Gema Ariceta Iraola
Collaborators: -
Funding agency:
Funding:
Reference: PR(AMI)209/2018
Duration: -

Related news

The association renews its commitment to the research of the Renal Pathophysiology group of VHIR in this rare disease that affects the kidneys.

The head of the Renal Pathophysiology group at VHIR was part of a round table on how research can help to meet the needs of patients with rare diseases.

The research describes the clinical characteristics and management of patients with this rare kidney disease in 55 hospitals in 21 European countries.

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