Santiago Ramon y Cajal Agüeras Institutions of which they are part Head of group Translational Molecular Pathology Vall Hebron Institut de Recerca Email Santiago Ramon y Cajal Agüeras Email Institutions of which they are part Head of group Translational Molecular Pathology Vall Hebron Institut de Recerca
Research lines Study of gene expression of senescence in human tumors The expression of mARN genes identified by Dr.R. Bernards has been studied in normal and tumor tissue of cancer patients. This study identifies for the first time, RSK4 and KIAA0828 genes as genes whose role may be relevant in cancer. The expression of these genes is being studied in protein by Western blot and immunohistochemistry. Also are characterizing the biochemical pathways where these genes may be involved. IP: Santiago Ramon y Cajal Agüeras Identification of molecular targets associated with tumor progression and therapy resistance in colorectal carcinoma. Studying in colorectal cancer mechanisms of action of the central signal transduction pathways, identify potential molecular alterations that can be used as therapeutic targets and characterize the degree of genetic inestability. IP: Santiago Ramon y Cajal Agüeras Study of Cell Signalling pathway in human tumors. Identification of funnel factors. We have characterized the levels of activation in Cell Signalling in a spectrum of solid tumors and correlated the levels of various factors, including mTOR and downstream proteins (p70S6K, S6, 4EBP1, eIF4E) with prognosis and grade of malignancy. Also, are being characterized, at the molecular level, the factors involved in controlling the translation cap dependent and independent in malignant tumors. IP: Santiago Ramon y Cajal Agüeras Projects The MNK inhibitor EB1: a novel opportunity to combat therapy resistance in cancer treatment IP: Santiago Ramon y Cajal Agüeras Collaborators: Inés de Torres Ramirez, Sara Garcia Ortega, Elena Muro Blanc, Marta Cano Galietero, Vicente Peg Camara, Stefan Hummer Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 149347 Reference: 2024 PROD 00056 Duration: 02/12/2024 - 01/06/2026 inhibición de la comunicación celular para la prevención del desarrollo de metástasis y la resistencia a terapias antitumorales. Desarrollo de dos nuevas aproximaciones terapéuticas IP: Santiago Ramon y Cajal Agüeras Collaborators: Maria Rosa Somoza Lopez de Haro, Josep Castellví Vives, Sara Garcia Ortega, Elena Muro Blanc, Marta Cano Galietero, Javier Hernandez Losa, Marta Sese Faustino, Stefan Hummer, Lourdes Elena Salazar Huayna Funding agency: Instituto de Salud Carlos III Funding: 240000 Reference: PI23/01754 Duration: 01/01/2024 - 31/12/2026 INtegrative GENomic, digital Imaging and clinical information towars Precision Oncology Optimization – INGENIO IP: Santiago Ramon y Cajal Agüeras Collaborators: Jordi Temprana Salvador, Josep Castellví Vives, Joaquim Mateo Valderrama, Javier Hernandez Losa, Vicente Peg Camara, Irene Sansano Valero Funding agency: Instituto de Salud Carlos III Funding: 80400 Reference: PMP21/00107 Duration: 01/01/2022 - 31/12/2025 MnkImmunOnco) - Overcoming therapy resistance and immune evasion with a novel MNK inhibibtor IP: Santiago Ramon y Cajal Agüeras Collaborators: Inés de Torres Ramirez, Jordi Temprana Salvador, Vicente Peg Camara, Stefan Hummer Funding agency: Fundació Institut Bioenginyeria de Catalunya Funding: 0.01 Reference: M6871 Duration: 02/01/2023 - 31/12/2024 Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 … Next page › Last page »
