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Biomedical Research in Cancer Stem Cells

The work of the Biomedical Research in Cancer Stem Cell group focuses mainly on senescence (replicative or stress-induced oncoge). In our laboratory, we carry out several genetic screens based on the detection of new genes / small interfering RNA (siRNA) / microRNAs related to cell proliferation, which have a role in cancer. Therefore, we use different cell models: murine cells, human primary cells or immortalized cells capable of entering senescence.

The objectives of the group are:

  • Identification and characterization of genes / microRNAs in mammary tumors associated with a more aggressive character (triple negative).
  • Identification and characterization of markers in lung, laryngeal and pharyngeal cancer with diagnostic and prognostic value that help to target a more specific chemotherapy treatment.
  • Identification and characterization of populations of cancer stem cells (CSC) in tumors resistant to conventional therapies.
  • Early detection of breast cancer before it manifests itself clinically.
  • Study of new genes involved in cancer from their identification in massive genetic scans at the basic level.

Team

Juan Lorente Guerrero

Juan Lorente Guerrero

Senior researcher
Biomedical Research in Cancer Stem Cells
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Yoelsis Garcia Mayea

Yoelsis Garcia Mayea

Postdoctoral researcher
Biomedical Research in Cancer Stem Cells
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Mª jesus  Fernandez  Garcia

Mª jesus Fernandez Garcia

Biomedical Research in Cancer Stem Cells
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Almudena Sanchez Garcia

Almudena Sanchez Garcia

Predoctoral researcher
Biomedical Research in Cancer Stem Cells
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Ana María García Arumí

Ana María García Arumí

Biomedical Research in Cancer Stem Cells
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Ana Mª Moreno Perni

Ana Mª Moreno Perni

Research technician
Biomedical Research in Cancer Stem Cells
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Juan Lorente Guerrero

Juan Lorente Guerrero

Senior researcher
Biomedical Research in Cancer Stem Cells
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Yoelsis Garcia Mayea

Yoelsis Garcia Mayea

Postdoctoral researcher
Biomedical Research in Cancer Stem Cells
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Mª jesus  Fernandez  Garcia

Mª jesus Fernandez Garcia

Biomedical Research in Cancer Stem Cells
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Almudena Sanchez Garcia

Almudena Sanchez Garcia

Predoctoral researcher
Biomedical Research in Cancer Stem Cells
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Ana María García Arumí

Ana María García Arumí

Biomedical Research in Cancer Stem Cells
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Ana Mª Moreno Perni

Ana Mª Moreno Perni

Research technician
Biomedical Research in Cancer Stem Cells
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Research lines

Detección precoz de cáncer mamario antes de que éste se manifieste

A partir de datos preliminares de arrays, hemos caracterizado algunos microRNAs/mRNAs relevantes en tumores. Actualmente los estamos analizando a nivel de pacientes con cáncer en sangre como posible método predictivo antes de la aparición del tumor.

IP: Matilde Lleonart Pajarin

Estudio de proteínas de unión a RNA como nuevos factores pronóstico y diagnóstico en cáncer

En nuestro laboratorio hemos efectuado diversos “screenings” genéticos para detectar nuevos genes implicados en proliferación celular in vitro que además poséan un papel relevante en cáncer humano. De entre ellos descubrimos la proteínas CIRP, la cual hemos descrito como proteína oncogénica. Actualmente estamos valorando la función de CIRP en diversos tipos tumorales en correlación con la evolución clínica de los pacientes.

IP: Matilde Lleonart Pajarin

Gastroesophageal reflux prevalence in patients with obstructive sleep apnea syndrome.

Different studies suggest the association between gastroesophageal reflux disease (GERD) and OSAS, but GERD prevalence in OSAS and the severity influence of OSAS upon  GERD are not known yet. OBJECTIVES: The main objective of this study is to determine the prevalence of GERD in patients with obstructive sleep apnea syndrome using conventional polygraphic sleep. Wiht this study we also want to assess the efficacy of a symptom questionnaire in the diagnosis of gastroesophageal reflux in these patients. PURPOSE: Identifying patients with gastroesophageal reflux among patients affected by obstructive sleep apnea, in order to establish therapeutic measures to prevent GERD complications.

IP: Juan Lorente Guerrero, Juan Luis Quesada Martínez, Mª Jose Jurado Luque, Ana María Accarino Garaventa

Identificación y caracterización de genes/microRNAs en tumores humanos asociados a mal pronóstico

En base a arrays de microRNAs y mRNAs efectuados a partir de tumores humanos, identificamos los más desregulados entre tejidos normales y tumorales para caracterizarlos a nivel molecular.

IP: Matilde Lleonart Pajarin

Projects

Estudi de la resistència a fàrmacs en carcinoma de cèl·lules escamoses de cap i coll (HNSCC)

IP: Matilde Lleonart Pajarin
Collaborators: Cristina Mir Perez
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: IFI18/00046
Duration: 01/01/2019 - 31/05/2023

Drug-screen against novel proteins involved in cancer resistance

IP: Matilde Lleonart Pajarin
Collaborators: Almudena Sanchez Garcia, Miriam Izquierdo Sans
Funding agency: Fundació Institut de Recerca HUVH
Funding: 50649.27
Reference: VHIR/BEQUESPREDOC/2019/SANCHEZ
Duration: 14/09/2020 - 31/08/2023

Ayudas Margarita Salas

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Judit Álvarez González
Funding agency: Ministerio de Universidades
Funding: 0.01
Reference: MIU/M_SALAS/2021/GARCIA_UB
Duration: 01/04/2022 - 31/03/2022

GC16173720CARR Definición de mecanismos clave de la multiresistencia de tumores de cabeza y cuello a los tratamientos quimio- y radioterapéuticos. Identificación de nuevos antitumorales individualizados.

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Juan Lorente Guerrero, GC16173720CARR Definición de mecanismos clave de la multiresistencia de tumores de cabeza y cuello a los tratamientos quimio- y , Josep Castellví Vives, Cristina Mir Perez, Vicente Peg Camara, Almudena Sanchez Garcia
Funding agency: Asociación Española Contra el Cáncer
Funding: 380000
Reference: AECC/GCE/2016/LLEONART
Duration: 01/10/2016 - 30/09/2022

Estudi de la resistència a fàrmacs en carcinoma de cèl·lules escamoses de cap i coll (HNSCC)

IP: Matilde Lleonart Pajarin
Collaborators: Cristina Mir Perez
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: IFI18/00046
Duration: 01/01/2019 - 31/05/2023

Drug-screen against novel proteins involved in cancer resistance

IP: Matilde Lleonart Pajarin
Collaborators: Almudena Sanchez Garcia, Miriam Izquierdo Sans
Funding agency: Fundació Institut de Recerca HUVH
Funding: 50649.27
Reference: VHIR/BEQUESPREDOC/2019/SANCHEZ
Duration: 14/09/2020 - 31/08/2023

GC16173720CARR Definición de mecanismos clave de la multiresistencia de tumores de cabeza y cuello a los tratamientos quimio- y radioterapéuticos. Identificación de nuevos antitumorales individualizados.

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Juan Lorente Guerrero, GC16173720CARR Definición de mecanismos clave de la multiresistencia de tumores de cabeza y cuello a los tratamientos quimio- y , Josep Castellví Vives, Cristina Mir Perez, Vicente Peg Camara, Almudena Sanchez Garcia
Funding agency: Asociación Española Contra el Cáncer
Funding: 380000
Reference: AECC/GCE/2016/LLEONART
Duration: 01/10/2016 - 30/09/2022

New therapeutic approaches in head and neck cancer

IP: Matilde Lleonart Pajarin
Collaborators: New therapeutic approaches in head and neck cancer , Yoelsis Garcia Mayea, Jordi Temprana Salvador, Angel García Jiménez, New therapeutic approaches in head and neck cancer , Josep Castellví Vives, Cristina Mir Perez, Laia Josa Culleré
Funding agency: Instituto de Salud Carlos III
Funding: 183920
Reference: PI20/00556
Duration: 01/01/2021 - 31/12/2023

Biomedical Research in Cancer Stem Cells

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: AGAUR
Funding: 0.01
Reference: 2017SGR01121
Duration: 01/01/2017 - 31/12/2020

Estudi de la resistència a fàrmacs en carcinoma de cèl·lules escamoses de cap i coll (HNSCC)

IP: Matilde Lleonart Pajarin
Collaborators: Cristina Mir Perez
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: IFI18/00046
Duration: 01/01/2019 - 31/05/2023

Drug-screen against novel proteins involved in cancer resistance

IP: Matilde Lleonart Pajarin
Collaborators: Almudena Sanchez Garcia, Miriam Izquierdo Sans
Funding agency: Fundació Institut de Recerca HUVH
Funding: 50649.27
Reference: VHIR/BEQUESPREDOC/2019/SANCHEZ
Duration: 14/09/2020 - 31/08/2023

Nuevas terapias aplicables a cánceres mamarios de naturaleza agresiva y metastática en base a aniquilar la población de células madre de cáncer.

IP: Matilde Lleonart Pajarin
Collaborators: Nuevas terapias aplicables a cánceres mamarios de naturaleza agresiva y metastática en base a aniquilar la población de células , Margarita Alberola Ferranti, Nuevas terapias aplicables a cánceres mamarios de naturaleza agresiva y metastática en base a aniquilar la población de células , Carmela Iglesias i Felip, Josep Castellví Vives, Nuevas terapias aplicables a cánceres mamarios de naturaleza agresiva y metastática en base a aniquilar la población de células
Funding agency: Instituto de Salud Carlos III
Funding: 195415
Reference: PI15/01262
Duration: 01/01/2016 - 30/11/2020

Biomedical Research in Cancer Stem Cells

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: AGAUR
Funding: 0.01
Reference: 2017SGR01121
Duration: 01/01/2017 - 31/12/2020

Estudi de la resistència a fàrmacs en carcinoma de cèl·lules escamoses de cap i coll (HNSCC)

IP: Matilde Lleonart Pajarin
Collaborators: Cristina Mir Perez
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: IFI18/00046
Duration: 01/01/2019 - 31/05/2023

Nuevas terapias aplicables a cánceres mamarios de naturaleza agresiva y metastática en base a aniquilar la población de células madre de cáncer.

IP: Matilde Lleonart Pajarin
Collaborators: Nuevas terapias aplicables a cánceres mamarios de naturaleza agresiva y metastática en base a aniquilar la población de células , Margarita Alberola Ferranti, Nuevas terapias aplicables a cánceres mamarios de naturaleza agresiva y metastática en base a aniquilar la población de células , Carmela Iglesias i Felip, Josep Castellví Vives, Nuevas terapias aplicables a cánceres mamarios de naturaleza agresiva y metastática en base a aniquilar la población de células
Funding agency: Instituto de Salud Carlos III
Funding: 195415
Reference: PI15/01262
Duration: 01/01/2016 - 30/11/2020

GC16173720CARR Definición de mecanismos clave de la multiresistencia de tumores de cabeza y cuello a los tratamientos quimio- y radioterapéuticos. Identificación de nuevos antitumorales individualizados.

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Juan Lorente Guerrero, GC16173720CARR Definición de mecanismos clave de la multiresistencia de tumores de cabeza y cuello a los tratamientos quimio- y , Josep Castellví Vives, Cristina Mir Perez, Vicente Peg Camara, Almudena Sanchez Garcia
Funding agency: Asociación Española Contra el Cáncer
Funding: 380000
Reference: AECC/GCE/2016/LLEONART
Duration: 01/10/2016 - 30/09/2022

Biomedical Research in Cancer Stem Cells

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: AGAUR
Funding: 0.01
Reference: 2017SGR01121
Duration: 01/01/2017 - 31/12/2020

Relevancia terapéutica de las Células Madre de Cáncer en carcinoma epidermoide Faringo-Laríngeo

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: PRED-VHIR-2014-12
Duration: 01/06/2015 - 31/05/2018

RNA binding proteins : Future markers for cancer progression

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 197196
Reference: PHD4MD/LLEONART/2015
Duration: 08/07/2015 - 08/07/2018

RedOx status of cancer stem cells and their resistance to chemo- and radio-therapy

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 40986
Reference: INCOMED - FELLOW 6
Duration: 08/06/2016 - 28/02/2018

Biomedical Research in Cancer Stem Cells

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: AGAUR
Funding: 0.01
Reference: 2017SGR01121
Duration: 01/01/2017 - 31/12/2020

Relevancia terapéutica de las Células Madre de Cáncer en carcinoma epidermoide Faringo-Laríngeo

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: PRED-VHIR-2014-12
Duration: 01/06/2015 - 31/05/2018

RNA binding proteins : Future markers for cancer progression

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 197196
Reference: PHD4MD/LLEONART/2015
Duration: 08/07/2015 - 08/07/2018

RedOx status of cancer stem cells and their resistance to chemo- and radio-therapy

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 40986
Reference: INCOMED - FELLOW 6
Duration: 08/06/2016 - 28/02/2018

Oncologia i Patologia Molecular

IP: Matilde Lleonart Pajarin
Collaborators: Oncologia i Patologia Molecular, Juan Lorente Guerrero, Margarita Alberola Ferranti, Marc Pellicer Sarasa, Oncologia i Patologia Molecular
Funding agency: AGAUR
Funding:
Reference: 2014 SGR 1617
Duration: 01/01/2014 - 31/12/2016

Relevancia terapéutica de las Células Madre de Cáncer en carcinoma epidermoide Faringo-Laríngeo

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: PRED-VHIR-2014-12
Duration: 01/06/2015 - 31/05/2018

RNA binding proteins : Future markers for cancer progression

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 197196
Reference: PHD4MD/LLEONART/2015
Duration: 08/07/2015 - 08/07/2018

RedOx status of cancer stem cells and their resistance to chemo- and radio-therapy

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 40986
Reference: INCOMED - FELLOW 6
Duration: 08/06/2016 - 28/02/2018

Oncologia i Patologia Molecular

IP: Matilde Lleonart Pajarin
Collaborators: Oncologia i Patologia Molecular, Juan Lorente Guerrero, Margarita Alberola Ferranti, Marc Pellicer Sarasa, Oncologia i Patologia Molecular
Funding agency: AGAUR
Funding:
Reference: 2014 SGR 1617
Duration: 01/01/2014 - 31/12/2016

Relevancia terapéutica de las Células Madre de Cáncer en carcinoma epidermoide Faringo-Laríngeo

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: PRED-VHIR-2014-12
Duration: 01/06/2015 - 31/05/2018

RNA binding proteins : Future markers for cancer progression

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 197196
Reference: PHD4MD/LLEONART/2015
Duration: 08/07/2015 - 08/07/2018

Identificación de nuevos factores pronóstico y diagnóstico en cáncer basados en microRNAs y sus proteínas diana que se asocian a tumores de carácter más agresivo

IP: Matilde Lleonart Pajarin
Collaborators: Identificación de nuevos factores pronóstico y diagnóstico en cáncer basados en microRNAs y sus proteínas diana que se asocian a, Angel García Jiménez, Teresa Moline Marimon, Carmela Iglesias i Felip, Vicente Peg Camara
Funding agency: Instituto de Salud Carlos III
Funding: 145200
Reference: PI12/01104
Duration: 01/01/2013 - 30/06/2017

Oncología y Patología Molecular

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: AGAUR
Funding: 39520
Reference: 2009 SGR 604
Duration: 01/01/2010 - 30/04/2014

Oncologia i Patologia Molecular

IP: Matilde Lleonart Pajarin
Collaborators: Oncologia i Patologia Molecular, Juan Lorente Guerrero, Margarita Alberola Ferranti, Marc Pellicer Sarasa, Oncologia i Patologia Molecular
Funding agency: AGAUR
Funding:
Reference: 2014 SGR 1617
Duration: 01/01/2014 - 31/12/2016

Desarrollo de dianas terapéuticas basadas en microRNAs sobreexpresados en cáncer de pulmón

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundación BBVA
Funding: 147000
Reference: BBVA/CONV.LLEONART/2010
Duration: 01/06/2010 - 01/06/2014

Identificación de nuevos factores pronóstico y diagnóstico en cáncer basados en microRNAs y sus proteínas diana que se asocian a tumores de carácter más agresivo

IP: Matilde Lleonart Pajarin
Collaborators: Identificación de nuevos factores pronóstico y diagnóstico en cáncer basados en microRNAs y sus proteínas diana que se asocian a, Angel García Jiménez, Teresa Moline Marimon, Carmela Iglesias i Felip, Vicente Peg Camara
Funding agency: Instituto de Salud Carlos III
Funding: 145200
Reference: PI12/01104
Duration: 01/01/2013 - 30/06/2017

Oncología y Patología Molecular

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: AGAUR
Funding: 39520
Reference: 2009 SGR 604
Duration: 01/01/2010 - 30/04/2014

Identificación de nuevas dianas terapéuticas basadas en micro-RNAs sobreexpresados en cáncer

IP: Matilde Lleonart Pajarin
Collaborators: Marc Pellicer Sarasa, Marta Garrido Pontnou, Carmela Iglesias i Felip
Funding agency: Instituto de Salud Carlos III
Funding: 147015
Reference: PI09/02193
Duration: 01/01/2010 - 30/04/2013

Desarrollo de dianas terapéuticas basadas en microRNAs sobreexpresados en cáncer de pulmón

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundación BBVA
Funding: 147000
Reference: BBVA/CONV.LLEONART/2010
Duration: 01/06/2010 - 01/06/2014

Identificación de nuevos factores pronóstico y diagnóstico en cáncer basados en microRNAs y sus proteínas diana que se asocian a tumores de carácter más agresivo

IP: Matilde Lleonart Pajarin
Collaborators: Identificación de nuevos factores pronóstico y diagnóstico en cáncer basados en microRNAs y sus proteínas diana que se asocian a, Angel García Jiménez, Teresa Moline Marimon, Carmela Iglesias i Felip, Vicente Peg Camara
Funding agency: Instituto de Salud Carlos III
Funding: 145200
Reference: PI12/01104
Duration: 01/01/2013 - 30/06/2017

Oncología y Patología Molecular

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: AGAUR
Funding: 39520
Reference: 2009 SGR 604
Duration: 01/01/2010 - 30/04/2014

Identificación de nuevas dianas terapéuticas basadas en micro-RNAs sobreexpresados en cáncer

IP: Matilde Lleonart Pajarin
Collaborators: Marc Pellicer Sarasa, Marta Garrido Pontnou, Carmela Iglesias i Felip
Funding agency: Instituto de Salud Carlos III
Funding: 147015
Reference: PI09/02193
Duration: 01/01/2010 - 30/04/2013

Desarrollo de dianas terapéuticas basadas en microRNAs sobreexpresados en cáncer de pulmón

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundación BBVA
Funding: 147000
Reference: BBVA/CONV.LLEONART/2010
Duration: 01/06/2010 - 01/06/2014

Oncología y Patología Molecular

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: AGAUR
Funding: 39520
Reference: 2009 SGR 604
Duration: 01/01/2010 - 30/04/2014

Identificación y caracterización de nuevos genes que inmortalizan células primarias y su papel en tumores humanos

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 86052
Reference: FI06/00608
Duration: 08/02/2007 - 07/02/2011

Identificación de nuevas dianas terapéuticas basadas en micro-RNAs sobreexpresados en cáncer

IP: Matilde Lleonart Pajarin
Collaborators: Marc Pellicer Sarasa, Marta Garrido Pontnou, Carmela Iglesias i Felip
Funding agency: Instituto de Salud Carlos III
Funding: 147015
Reference: PI09/02193
Duration: 01/01/2010 - 30/04/2013

Desarrollo de dianas terapéuticas basadas en microRNAs sobreexpresados en cáncer de pulmón

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundación BBVA
Funding: 147000
Reference: BBVA/CONV.LLEONART/2010
Duration: 01/06/2010 - 01/06/2014

Oncología y Patología Molecular

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: AGAUR
Funding: 39520
Reference: 2009 SGR 604
Duration: 01/01/2010 - 30/04/2014

Identificación y caracterización de nuevos genes que inmortalizan células primarias y su papel en tumores humanos

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 86052
Reference: FI06/00608
Duration: 08/02/2007 - 07/02/2011

Desarrollo de dianas terapéuticas basadas en micro-RNAs sobreexpresados en cáncer

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundación Caja Navarra
Funding: 9463.18
Reference: CAN2009-16708
Duration: 01/01/2010 - 31/12/2010

Identificación de nuevas dianas terapéuticas basadas en micro-RNAs sobreexpresados en cáncer

IP: Matilde Lleonart Pajarin
Collaborators: Marc Pellicer Sarasa, Marta Garrido Pontnou, Carmela Iglesias i Felip
Funding agency: Instituto de Salud Carlos III
Funding: 147015
Reference: PI09/02193
Duration: 01/01/2010 - 30/04/2013

Identificación y caracterización de nuevos genes que inmortalizan células primarias y su papel en tumores humanos

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 86052
Reference: FI06/00608
Duration: 08/02/2007 - 07/02/2011

Imiten les cèl·lules canceroses l'estratègia de les cèl·lules mare embrionàries per ser immortals?

IP: Matilde Lleonart Pajarin
Collaborators: Santiago Ramon y Cajal Agüeras
Funding agency: Fundació La Marató de TV3
Funding: 221100
Reference: TV3/052130
Duration: 01/01/2006 - 31/12/2009

Identificación y caracterización de nuevos genes que inmortalizan células primarias y su papel en tumores humanos

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 86052
Reference: FI06/00608
Duration: 08/02/2007 - 07/02/2011

Identificación y caracterización de nuevos genes que inmortalicen células primarias y su papel en tumores humanos

IP: Matilde Lleonart Pajarin
Collaborators: Santiago Ramon y Cajal Agüeras, Carmela Iglesias i Felip, Javier Hernandez Losa
Funding agency: Instituto de Salud Carlos III
Funding: 94300
Reference: PI040530
Duration: 01/01/2005 - 30/08/2008

Imiten les cèl·lules canceroses l'estratègia de les cèl·lules mare embrionàries per ser immortals?

IP: Matilde Lleonart Pajarin
Collaborators: Santiago Ramon y Cajal Agüeras
Funding agency: Fundació La Marató de TV3
Funding: 221100
Reference: TV3/052130
Duration: 01/01/2006 - 31/12/2009

Identificación y caracterización de nuevos genes que inmortalizan células primarias y su papel en tumores humanos

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 86052
Reference: FI06/00608
Duration: 08/02/2007 - 07/02/2011

Búsqueda de genes existentes en células embrionarias murinas que estén implicados en la inmortalización

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 42070
Reference: CP03/00101
Duration: 01/03/2004 - 28/02/2007

Identificación y caracterización de nuevos genes que inmortalicen células primarias y su papel en tumores humanos

IP: Matilde Lleonart Pajarin
Collaborators: Santiago Ramon y Cajal Agüeras, Carmela Iglesias i Felip, Javier Hernandez Losa
Funding agency: Instituto de Salud Carlos III
Funding: 94300
Reference: PI040530
Duration: 01/01/2005 - 30/08/2008

Imiten les cèl·lules canceroses l'estratègia de les cèl·lules mare embrionàries per ser immortals?

IP: Matilde Lleonart Pajarin
Collaborators: Santiago Ramon y Cajal Agüeras
Funding agency: Fundació La Marató de TV3
Funding: 221100
Reference: TV3/052130
Duration: 01/01/2006 - 31/12/2009

Búsqueda de genes existentes en células embrionarias murinas que estén implicados en la inmortalización

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 42070
Reference: CP03/00101
Duration: 01/03/2004 - 28/02/2007

Identificación y caracterización de nuevos genes que inmortalicen células primarias y su papel en tumores humanos

IP: Matilde Lleonart Pajarin
Collaborators: Santiago Ramon y Cajal Agüeras, Carmela Iglesias i Felip, Javier Hernandez Losa
Funding agency: Instituto de Salud Carlos III
Funding: 94300
Reference: PI040530
Duration: 01/01/2005 - 30/08/2008

Imiten les cèl·lules canceroses l'estratègia de les cèl·lules mare embrionàries per ser immortals?

IP: Matilde Lleonart Pajarin
Collaborators: Santiago Ramon y Cajal Agüeras
Funding agency: Fundació La Marató de TV3
Funding: 221100
Reference: TV3/052130
Duration: 01/01/2006 - 31/12/2009

Genetic screen for detecting genes expressed in embryonic stem cells that bypass immortalisation in primary cells

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 31959
Reference: MERG-510300
Duration: 01/02/2004 - 31/01/2005

Búsqueda de genes existentes en células embrionarias murinas que estén implicados en la inmortalización

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 42070
Reference: CP03/00101
Duration: 01/03/2004 - 28/02/2007

Identificación y caracterización de nuevos genes que inmortalicen células primarias y su papel en tumores humanos

IP: Matilde Lleonart Pajarin
Collaborators: Santiago Ramon y Cajal Agüeras, Carmela Iglesias i Felip, Javier Hernandez Losa
Funding agency: Instituto de Salud Carlos III
Funding: 94300
Reference: PI040530
Duration: 01/01/2005 - 30/08/2008

Globo faríngeo, laringitis crónica y reflujo faringo laríngeo.

IP: Juan Luis Quesada Martínez
Collaborators: Joan Piñas Massó, Jorge Serra Pueyo
Funding agency: Instituto de Salud Carlos III
Funding: 14490
Reference: PI021292
Duration: 06/11/2002 - 06/11/2005

Genetic screen for detecting genes expressed in embryonic stem cells that bypass immortalisation in primary cells

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 31959
Reference: MERG-510300
Duration: 01/02/2004 - 31/01/2005

Búsqueda de genes existentes en células embrionarias murinas que estén implicados en la inmortalización

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 42070
Reference: CP03/00101
Duration: 01/03/2004 - 28/02/2007

Globo faríngeo, laringitis crónica y reflujo faringo laríngeo.

IP: Juan Luis Quesada Martínez
Collaborators: Joan Piñas Massó, Jorge Serra Pueyo
Funding agency: Instituto de Salud Carlos III
Funding: 14490
Reference: PI021292
Duration: 06/11/2002 - 06/11/2005

Globo faríngeo, laringitis crónica y reflujo faringo laríngeo.

IP: Juan Luis Quesada Martínez
Collaborators: Joan Piñas Massó, Jorge Serra Pueyo
Funding agency: Instituto de Salud Carlos III
Funding: 14490
Reference: PI021292
Duration: 06/11/2002 - 06/11/2005

Globo faríngeo, laringitis crónica y reflujo faringo laríngeo.

IP: Juan Luis Quesada Martínez
Collaborators: Joan Piñas Massó, Jorge Serra Pueyo
Funding agency: Instituto de Salud Carlos III
Funding: 14490
Reference: PI021292
Duration: 06/11/2002 - 06/11/2005

Alteraciones del metabolismo proteico y producción de heat shock proteins en el estrés quirúrgico. Influencia del soporte nutricional y de la edad del paciente.

IP: Ana María García Arumí
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 21510.22
Reference: 97/0932
Duration: 01/11/1997 - 01/11/1998

Alteraciones del metabolismo proteico y producción de heat shock proteins en el estrés quirúrgico. Influencia del soporte nutricional y de la edad del paciente.

IP: Ana María García Arumí
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 21510.22
Reference: 97/0932
Duration: 01/11/1997 - 01/11/1998

Publications

TSPAN1, a novel tetraspanin member highly involved in carcinogenesis and chemoresistance.

PMID: 34979155
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Year: 2022
Reference: Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188674. doi: 10.1016/j.bbcan.2021.188674. Epub 2021 Dec 31.
Impact factor: 10.68
Publication type: Review in international publication
Authors: Mir, Cristina; Carballo, Laia; Sanchez-Garcia, Almudena; Bataller, Marina; LLeonart, Matilde E; Garcia-Mayea, Yoelsis et al.
DOI: 10.1016/j.bbcan.2021.188674

RNA-binding proteins: underestimated contributors in tumorigenesis.

PMID: 35124196
Journal: SEMINARS IN CANCER BIOLOGY
Year: 2022
Reference: Semin Cancer Biol. 2022 Feb 3. pii: S1044-579X(22)00020-7. doi: 10.1016/j.semcancer.2022.01.010.
Impact factor: 15.707
Publication type: Paper in international publication
Authors: LLeonart, M E; Kondoh, H; Garcia-Mayea, Y; Zhao, Y; Mir, C; Paciucci, R et al.
DOI: 10.1016/j.semcancer.2022.01.010

Targeting the "undruggable": RNA-binding proteins in the spotlight in cancer therapy.

PMID: 35772609
Journal: SEMINARS IN CANCER BIOLOGY
Year: 2022
Reference: Semin Cancer Biol. 2022 Jun 27. pii: S1044-579X(22)00152-3. doi: 10.1016/j.semcancer.2022.06.008.
Impact factor: 15.707
Publication type: Review in international publication
Authors: Garcia-Mayea, Y; LLeonart, M E; Mir, C et al.
DOI: 10.1016/j.semcancer.2022.06.008

Liver, Renal, and Cardiovascular Failure After Unintentional Overdose of Tizanidine in a 2-Year-Old Child.

PMID: 34421416
Journal: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Year: 2021
Reference: J Pediatr Pharmacol Ther. 2021;26(6):643-646. doi: 10.5863/1551-6776-26.6.643. Epub 2021 Aug 16.
Impact factor: 0
Publication type: Paper in international publication
Authors: Danés, Imma, Ortega, Juan, Vila, Jorgina, Morgenstern, Andrés, Vendrell, Lourdes et al.
DOI: 10.5863/1551-6776-26.6.643

Antibody cooperative adsorption onto AuNPs and its exploitation to force natural killer cells to kill HIV-infected T cells.

PMID: 34394703
Journal: Nano Today
Year: 2021
Reference: Nano Today. 2021 Feb;36. doi: 10.1016/j.nantod.2020.101056. Epub 2020 Dec 20.
Impact factor: 20.722
Publication type: Paper in international publication
Authors: Buzon, Maria J, Puntes, Victor, Genesca, Meritxell, Astorga-Gamaza, Antonio, Vitali, Michele, Borrajo, Mireya L, Jaime, Carlos, Bastus, Neus, Serra-Peinado, Carla, Luque-Ballesteros, Laura et al.
DOI: 10.1016/j.nantod.2020.101056

Enhanced DNA damage response through RAD50 in triple negative breast cancer resistant and cancer stem-like cells contributes to chemoresistance.

PMID: 33090711
Journal: FEBS Journal
Year: 2021
Reference: FEBS J. 2021 Apr;288(7):2184-2202. doi: 10.1111/febs.15588. Epub 2020 Nov 3.
Impact factor: 5.542
Publication type: Paper in international publication
Authors: Abad, Etna, Civit, Laia, Potesil, David, Zdrahal, Zbynek, Lyakhovich, Alex et al.
DOI: 10.1111/febs.15588

Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells.

PMID: 33316348
Journal: CANCER LETTERS
Year: 2021
Reference: Cancer Lett. 2021 Apr 10;503:185-196. doi: 10.1016/j.canlet.2020.12.010. Epub 2020 Dec 11.
Impact factor: 8.679
Publication type: Paper in international publication
Authors: Potesil, David, Zdrahal, Zbynek, OscarYanes, Lyakhovich, Alex, Graifer, Dmitry, Trifuoggi, Marco, Pagano, Giovanni, Grodzicki, Robert L, Abad, Etna, Samino, Sara et al.
DOI: 10.1016/j.canlet.2020.12.010

TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance.

PMID: 33167355
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Nov 5;12(11). pii: cancers12113269. doi: 10.3390/cancers12113269.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Garcia-Mayea, Yoelsis, Mir, Cristina, Carballo, Laia, Castellvi, Josep, Temprana-Salvador, Jordi, Lorente, Juan, Benavente, Sergi, Garcia-Pedrero, Juana M, Allonca, Eva, Rodrigo, Juan P et al.
DOI: 10.3390/cancers12113269

Drug-induced sleep endoscopy.

PMID: 31174844
Journal: Acta otorrinolaringologica espanola
Year: 2020
Reference: Acta Otorrinolaringol Esp. 2020 Sep-Oct;71(5):316-320. doi: 10.1016/j.otorri.2019.02.007. Epub 2019 Jun 4.
Impact factor: 0
Publication type: Paper in national publication
Authors: Carrasco Llatas, Marina, Martinez Ruiz de Apodaca, Paula, Baptista Jardin, Peter, O'Connor Reina, Carlos, Plaza Mayor, Guillermo, Vicente Gonzalez, Eugenio, Vilaseca Gonzalez, Isabel, Navazo Egia, Ana Isabel, Samara Pinol, Laura, Alvarez Garcia, Irene et al.
DOI: 10.1016/j.otorri.2019.02.007

Mandibular movement analisys by means of a kinematic model applied to the design of oral appliances for the treatment of obstructive sleep apnea.

PMID: 32769030
Journal: SLEEP MEDICINE
Year: 2020
Reference: Sleep Med. 2020 Sep;73:29-37. doi: 10.1016/j.sleep.2020.04.016. Epub 2020 Apr 30.
Impact factor: 3.038
Publication type: Paper in international publication
Authors: Garcia, Marcos, Cabrera, Juan A, Bataller, Alex, Vila, Javier, Mayoral, Pedro et al.
DOI: 10.1016/j.sleep.2020.04.016

Insights into new mechanisms and models of cancer stem cell multidrug resistance.

PMID: 31369817
Journal: SEMINARS IN CANCER BIOLOGY
Year: 2020
Reference: Semin Cancer Biol. 2020 Feb;60:166-180. doi: 10.1016/j.semcancer.2019.07.022. Epub 2019 Jul 29.
Impact factor: 11.09
Publication type: Review in international publication
Authors: Garcia-Mayea, Y, Mir, C, Masson, F, Paciucci, R, LLeonart, M E et al.
DOI: 10.1016/j.semcancer.2019.07.022

A quick guide for using Microsoft OneNote as an electronic laboratory notebook.

PMID: 31071077
Journal: PLoS Computational Biology
Year: 2019
Reference: PLoS Comput Biol. 2019 May 9;15(5):e1006918. doi: 10.1371/journal.pcbi.1006918. eCollection 2019 May.
Impact factor: 4.428
Publication type: Paper in international publication
Authors: Garcia-Cardenas, Jennyfer M, Saa, Pablo, Indacochea, Alberto, Armendariz-Castillo, Isaac, Zambrano, Ana Karina, Yumiceba, Veronica, Perez-Villa, Andy, Guevara-Ramirez, Patricia, Moscoso-Zea, Oswaldo, Paredes, Joel et al.
DOI: 10.1371/journal.pcbi.1006918

Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer.

PMID: 30373788
Journal: MOLECULAR & CELLULAR PROTEOMICS
Year: 2019
Reference: Mol Cell Proteomics. 2019 Feb;18(2):231-244. doi: 10.1074/mcp.RA118.001102. Epub 2018 Oct 29.
Impact factor: 4.828
Publication type: Paper in international publication
Authors: Abad, Etna, Garcia-Mayea, Yoelsis, Mir, Cristina, Sebastian, David, Zorzano, Antonio, Potesil, David, Zdrahal, Zbynek, Lyakhovich, Alex, Lleonart, Matilde et al.
DOI: 10.1074/mcp.RA118.001102

Clinical Practice Guideline recommendations on examination of the upper airway for adults with suspected obstructive sleep apnoea-hypopnoea syndrome.

PMID: 30616837
Journal: Acta otorrinolaringologica espanola
Year: 2019
Reference: Acta Otorrinolaringol Esp. 2019 Nov - Dec;70(6):364-372. doi: 10.1016/j.otorri.2018.06.008. Epub 2019 Jan 5.
Impact factor: 0
Publication type: Paper in national publication
Authors: Esteller, Eduard, Carrasco, Marina, Diaz-Herrera, Miguel Angel, Sampol, Gabriel, Juvanteny, Joan, Sieira, Ramon, Farre, Alex, Vilaseca, Isabel, Vila, Javier et al.
DOI: 10.1016/j.otorri.2018.06.008

Reactive Oxygen Species-Mediated Autophagy Defines the Fate of Cancer Stem Cells

PMID: 28683561
Journal: ANTIOXIDANTS & REDOX SIGNALING
Year: 2018
Reference: Antioxidants & Redox Signaling. 2018 Apr 10;28(11):1066-79. doi:10.1089/ars.2017.7223
Impact factor: 6.53
Publication type: Review in international publication
Authors: Lleonart Pajarin, Matilde, Abad Cortel, Etna, Graifer, Dmitry, Lyakhovich, Alex et al.
DOI: 10.1089/ars.2017.7223

Analysis of Racial/Ethnic Representation in Select Basic and Applied Cancer Research Studies.

PMID: 30228363
Journal: Scientific Reports
Year: 2018
Reference: Sci Rep. 2018 Sep 18;8(1):13978. doi: 10.1038/s41598-018-32264-x.
Impact factor: 4.122
Publication type: Paper in international publication
Authors: Gonzalez, Diana Abigail, Leone, Paola E, Paz-Y-Mino, Cesar, Guevara-Ramirez, Patricia, Cabrera-Andrade, Alejandro, Garcia-Cardenas, Jennyfer M, Guerrero, Santiago, Lopez-Cortes, Andres, Indacochea, Alberto, Zambrano, Ana Karina et al.
DOI: 10.1038/s41598-018-32264-x

The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy.

PMID: 28464404
Journal: BIOLOGICAL REVIEWS
Year: 2018
Reference: Biol Rev Camb Philos Soc. 2018 Feb;93(1):152-165. doi: 10.1111/brv.12337. Epub 2017 May 2.
Impact factor: 11.7
Publication type: Paper in international publication
Authors: Lorente, Juan, Velandia, Carolina, Leal, Jose A, Garcia-Mayea, Yoelsis, Lyakhovich, Alex, Kondoh, Hiroshi, LLeonart, Matilde E et al.
DOI: 10.1111/brv.12337

Efficacy and Safety of Ciprofloxacin Plus Fluocinolone in Otitis Media With Tympanostomy Tubes in Pediatric Patients: A Randomized Clinical Trial.

PMID: 28006041
Journal: JAMA Otolaryngology-Head & Neck Surgery
Year: 2017
Reference: JAMA Otolaryngol Head Neck Surg. 2017 Apr 1;143(4):341-349. doi: 10.1001/jamaoto.2016.3537.
Impact factor: 2.951
Publication type: Paper in international publication
Authors: Hernandez, F Javier, Lansford, Bryan, Douglis, Franklin, Esterhuizen, Kenneth, Spektor, Zorik, Pumarola, Felix, Ismail, Khaleed, Lanier, Brent, Hussain, Iftikhar, Ansley, John et al.
DOI: 10.1001/jamaoto.2016.3537

Targeting cancer cells through antibiotics-induced mitochondrial dysfunction requires autophagy inhibition.

PMID: 27693455
Journal: CANCER LETTERS
Year: 2017
Reference: Cancer Lett. 2017 Jan 1;384:60-69. doi: 10.1016/j.canlet.2016.09.023. Epub 2016 Sep 28.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Lyakhovich, Alex, Lleonart, Matilde E, Graifer, Dmitry, Esner, Milan et al.
DOI: 10.1016/j.canlet.2016.09.023

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

PMID: 29072692
Journal: Cell Death & Disease
Year: 2017
Reference: Cell Death Dis. 2017 Oct 26;8(10):e3141. doi: 10.1038/cddis.2017.544.
Impact factor: 5.965
Publication type: Paper in international publication
Authors: Mir, Cristina, Feliciano, Andrea, Garcia-Mayea, Yoelsis, Jubierre, Luz, Hernandez-Losa, Javier, Paciucci, Rosanna, Sansano, Irene, Sun, Yilin, Cajal, Santiago Ramon Y, Kondon, Hiroshi et al.
DOI: 10.1038/cddis.2017.544

Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss.

PMID: 28757873
Journal: International journal of otolaryngology
Year: 2017
Reference: Int J Otolaryngol. 2017;2017:5185268. doi: 10.1155/2017/5185268. Epub 2017 Jul 3.
Impact factor: 0
Publication type: Paper in international publication
Authors: Graterol, D, Mir, C, Garcia-Vaquero, C, Brana, I, Pardo, A N, Rochera-Villach, M I, Lyakhovich, A, LLeonart, M E, Lorente, J et al.
DOI: 10.1155/2017/5185268

Outcome prognostic factors in inoperable malignant bowel obstruction.

PMID: 27286874
Journal: SUPPORTIVE CARE IN CANCER
Year: 2016
Reference: Support Care Cancer. 2016 Nov;24(11):4577-86. doi: 10.1007/s00520-016-3299-7. Epub 2016 Jun 10.
Impact factor: 2.535
Publication type: Paper in international publication
Authors: Romeo, Margarita, de Los LLanos Gil, Maria, Cuadra Urteaga, Jose Luis, Vila, Laia, Ahlal, Sara, Indacochea, Alberto, Pardo, Nuria, Radua, Joaquim, Font, Albert, Tuca, Albert et al.
DOI: 10.1007/s00520-016-3299-7

[Bacterial etiology of acute otitis media in Spain in the post-pneumococcal conjugate vaccine era].

PMID: 26969247
Journal: ANALES DE PEDIATRIA
Year: 2016
Reference: An Pediatr (Barc). 2016 Nov;85(5):224-231. doi: 10.1016/j.anpedi.2015.10.016. Epub 2016 Mar 9.
Impact factor: 0.773
Publication type: Paper in national publication
Authors: Devadiga, Raghavendra, Rosell Ferrer, Rosa, Pumarola, Felix, Salamanca de la Cueva, Ignacio, Sistiaga-Hernando, Alessandra, Garcia-Corbeira, Pilar, Moraga-Llop, Fernando A, Cardelus, Sara, McCoig, Cynthia, Gomez Martinez, Justo Ramon et al.
DOI: 10.1016/j.anpedi.2015.10.016

Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission.

PMID: 27517150
Journal: Oncotarget
Year: 2016
Reference: Oncotarget. 2016 Sep 6;7(36):58065-58074. doi: 10.18632/oncotarget.11161.
Impact factor: 5.008
Publication type: Paper in international publication
Authors: Shyamsunder, Pavithra, Esner, Milan, Barvalia, Maunish, Wu, Yu Jun, Loja, Tomas, Verma, Rama S, Krejci, Lumir, Lyakhovich, Alex, Lleonart, Matilde E, Boon, Huat Bay et al.
DOI: 10.18632/oncotarget.11161

Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy.

PMID: 26697128
Journal: Oxidative Medicine and Cellular Longevity
Year: 2016
Reference: Oxid Med Cell Longev. 2016;2016:1716341. doi: 10.1155/2016/1716341. Epub 2015 Nov 30.
Impact factor: 4.492
Publication type: Review in national publication
Authors: Lyakhovich, Alex, Lleonart, Matilde E et al.
DOI: 10.1155/2016/1716341

[Laryngotracheal traumatic injuries (LTI) in children: when to operate?]

PMID: 27775292
Journal: Cirugia pediatrica : organo oficial de la Sociedad
Year: 2015
Reference: Cir Pediatr. 2015 Oct 10;28(4):165-171.
Impact factor: 0
Publication type: Letter or abstract
Authors: Lloret, J, Seidler, L, Lopez-Fernandez, S, Santiago-Martinez, S, Lain, A, Guillen, G, Gander, R, Pumarola, F et al.
DOI:

[Recurrent meningitis due to anatomical defects: The bacteria indicates its origin.]

PMID: 25446794
Journal: ANALES DE PEDIATRIA
Year: 2015
Reference: An Pediatr (Barc). 2015 Jun;82(6):388-96. doi: 10.1016/j.anpedi.2014.09.008. Epub 2014 Oct 29.
Impact factor: 0.722
Publication type: Paper in national publication
Authors: Morgenstern Isaak, A, Bach Faig, A, Martinez, S, Martin-Nalda, A, Vazquez Mendez, E, Pumarola Segura, F, Soler-Palacin, P et al.
DOI: 10.1016/j.anpedi.2014.09.008

Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs.

PMID: 26219394
Journal: CURRENT MEDICINAL CHEMISTRY
Year: 2015
Reference: Curr Med Chem. 2015;22(26):3040-53.
Impact factor: 3.853
Publication type: Review in national publication
Authors: Lyakhovich, Alex, Graifer, Dmitri et al.
DOI:

ROMO1 regulates RedOx states and serves as an inducer of NF-kappaB-driven EMT factors in Fanconi anemia.

PMID: 25687884
Journal: CANCER LETTERS
Year: 2015
Reference: Cancer Lett. 2015 May 28;361(1):33-8. doi: 10.1016/j.canlet.2015.02.020. Epub 2015 Feb 14.
Impact factor: 5.621
Publication type: Paper in international publication
Authors: Shyamsunder, Pavithra, Verma, Rama S, Lyakhovich, Alex et al.
DOI: 10.1016/j.canlet.2015.02.020

Frequent carriage of resistance mechanisms to beta-lactams and biofilm formation in Haemophilus influenzae causing treatment failure and recurrent otitis media in young children.

PMID: 24891432
Journal: J ANTIMICROB CHEMOTH
Year: 2014
Reference: J Antimicrob Chemother. 2014 Sep;69(9):2394-9. doi: 10.1093/jac/dku158. Epub 2014 Jun 2.
Impact factor: 5.439
Publication type: Paper in international publication
Authors: Campos, Jose, Garcia, Ernesto, Garcia-Cobos, Silvia, Moscoso, Miriam, Pumarola, Felix, Arroyo, Margarita, Lara, Noelia, Perez-Vazquez, Maria, Aracil, Belen, Oteo, Jesus et al.
DOI: 10.1093/jac/dku158

[Usefulness of the basic exploration of the upper airways and neighbor structures in patients with adult obstructive sleep apnea-hypopnea syndrome.]

PMID: 23830550
Journal: MED CLIN-BARCELONA
Year: 2014
Reference: Med Clin (Barc). 2014 Apr 7;142(7):310-6. doi: 10.1016/j.medcli.2013.04.035. Epub 2013 Jul 3.
Impact factor: 1.252
Publication type: Paper in national publication
Authors: Ferre, Alex, Vila, Javier, Arcalis, Nuria et al.
DOI: 10.1016/j.medcli.2013.04.035

Microbiology of bacteria causing recurrent acute otitis media (AOM) and AOM treatment failure in young children in Spain: shifting pathogens in the post-pneumococcal conjugate vaccination era.

PMID: 23746414
Journal: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
Year: 2013
Reference: Int J Pediatr Otorhinolaryngol. 2013 Aug;77(8):1231-6. doi: 10.1016/j.ijporl.2013.04.002. Epub 2013 Jun 6.
Impact factor: 1.35
Publication type: Paper in international publication
Authors: Hausdorff, William P, Marano, Cinzia, Pircon, Jean-Yves, Pumarola, Felix, Mares, Josep, Losada, Isabel, Minguella, Isabel, Moraga, Fernando, Tarrago, David, Aguilera, Ulla et al.
DOI: 10.1016/j.ijporl.2013.04.002

[Postoperative nausea and vomiting in major trauma surgery].

PMID: 23183147
Journal: Enfermeria clinica
Year: 2012
Reference: Enferm Clin. 2012 Nov-Dec;22(6):293-8. doi: 10.1016/j.enfcli.2012.10.002. Epub 2012 Nov 24.
Impact factor: 0
Publication type: Paper in national publication
Authors: Biarnes-Sune, Alfons, Malpartida-Obon, Mercedes, Moreno-Montes, Olga, Garcia-Gomez, Laura, Aige-Cristofol, M Mireya, Rejon-Vallverdu, M Merce, Gonzalez-Perez, M Gloria, Perich-Torrens, Elisenda, Alonso-Vicente, M Rosa, Albertos-Riera, M Amparo et al.
DOI: 10.1016/j.enfcli.2012.10.002

Thesis

Papel de los exosomas en la comunicación entre las células tumorales y los macrófagos en el carcinoma laríngeo

PhD student: Angela maria Bellmunt Fontanet
Director/s: Juan Lorente Guerrero
University: Universitat Autònoma de Barcelona
Year: 2018

Identificación y caracterización funcional de microRNAS en cáncer de mama

PhD student: Andrea F Feliciano Aguirre
Director/s: Matilde Lleonart Pajarin
University: Universitat Autònoma de Barcelona
Year: 2017

In vivo elucidation of the role of Pim kinases in tumorigenesis

PhD student: Maja Narlik
Director/s: Amancio Carnero Moya
University: Universitat Autònoma de Barcelona
Year: 2012

Espinofilina, un tumor supresor dependiente de la ausencia de p53

PhD student: Irene Ferrer
Director/s: Amancio Carnero Moya
University: Universitat Autònoma de Barcelona
Year: 2009

Generación de herramientas celulares para validación de drogas antitumorales

PhD student: María Victoria Moneo
Director/s: Amancio Carnero Moya
University: Universitat Autònoma de Barcelona
Year: 2009

Blog

News

On World Cancer Research Day, we highlight the impact of VHIR projects in the field of oncology.

The team led by Dr. Matilde E. LLeonart has observed the presence of elevated levels of syntenin-1 in chemotherapy-resistant cells and cancer stem cells.

Job offers

Postdoctoral Basic Researcher-Sarcoma Laboratory, Translational Research in paediatric and Adolescent Cancer, VHIR
Start date:
03/03/2022
End date:
17/03/2022
Document: Download
Predoctoral Researcher-Biomedical Research in Cancer Stem Cells.
Start date:
02/08/2021
End date:
17/08/2021
Document: Download
oferta_predoctoral_biomedicalresearch_CancerStemCells.
Start date:
03/10/2016
End date:
10/10/2016
Document: Download