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Biomedical Research in Gynaecology

The Biomedical Research Group in Gynaecology is a multidisciplinary team made up of clinical specialists in gynaecology and pathology and basic and translational researchers. Our research is clearly translational. Although we take into account the obvious importance of understanding the mechanism at the cellular and molecular level and try to incorporate it into our research, our research is always focused on having a direct applicability to patients and their clinical benefit. On our way to transferring scientific results to clinical practice, we promote innovation and entrepreneurship.

Our group comprises four main research groups, which are closely connected: The clinical research group devoted mainly to clinical projects in all gynaecological cancers; and three translational research groups dedicated to ovarian cancer; endometrial cancer and endometriosis; diseases of the lower female genital tract.

Publications

Can We Reduce Overtreatment of Cervical High-Grade Squamous Intraepithelial Lesions?

PMID: 34928250
Journal: Journal of Lower Genital Tract Disease
Year: 2022
Reference: J Low Genit Tract Dis. 2022 Jan 1;26(1):20-26. doi: 10.1097/LGT.0000000000000635.
Impact factor: 1.925
Publication type: Paper in international publication
Authors: Bradbury, Melissa; Dinares, Maria Carme; Sainz, Alex; Castellet, Cristina; Perez-Benavente, Assumpcio; Gil-Moreno, Antonio; Centeno, Cristina; Murcia, Maria Teresa; Rabasa, Jordi et al.
DOI: 10.1097/LGT.0000000000000635

Clear Cell Carcinoma (CCC) of the Cervix Is a Human Papillomavirus (HPV)-independent Tumor Associated With Poor Outcome: A Comprehensive Analysis of 58 Cases.

PMID: 34985047
Journal: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
Year: 2022
Reference: Am J Surg Pathol. 2022 Jun 1;46(6):765-773. doi: 10.1097/PAS.0000000000001863. Epub 2022 Jan 5.
Impact factor: 6.394
Publication type: Paper in international publication
Authors: Park, Kay J; Stolnicu, Simona; Karpathiou, Georgia; Guerra, Esther; Mateoiu, Claudia; Reques, Armando; Bart, Joost; Felix, Ana; Fani, Daniela; Gama, Joao et al.
DOI: 10.1097/PAS.0000000000001863

Long-term outcomes of transobturator suburethral tapes for female stress urinary incontinence.

PMID: 34783388
Journal: NEUROUROLOGY AND URODYNAMICS
Year: 2022
Reference: Neurourol Urodyn. 2022 Jan;41(1):391-398. doi: 10.1002/nau.24835. Epub 2021 Nov 16.
Impact factor: 2.696
Publication type: Paper in international publication
Authors: Sabadell, Jordi; Montero-Armengol, Anabel; Salicru, Sabina; Catalan-Martinez, Marina; Gil-Moreno, Antonio; Poza, Jose L et al.
DOI: 10.1002/nau.24835

Fertility sparing treatment in patients with endometrial cancer (FERT-ENC): a multicentric retrospective study from the Spanish Investigational Network Gynecologic Oncology Group (SPAIN-GOG).

PMID: 35122158
Journal: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
Year: 2022
Reference: Arch Gynecol Obstet. 2022 Feb 4. pii: 10.1007/s00404-021-06375-2. doi: 10.1007/s00404-021-06375-2.
Impact factor: 2.344
Publication type: Paper in international publication
Authors: Arencibia Sanchez, Octavio; Sala Ferichola, Manuela; Munmanny, Merixell; Martin Salamanca, Belen; Iacoponi, Sara; Cabrera, Silvia; Coronado, Pluvio; Utrilla-Layna, Jesus; Bataller, Agueda; Fiol, Gabriel et al.
DOI: 10.1007/s00404-021-06375-2

Intraoperative Human Papillomavirus Test Predicts 24-Month High-Grade Squamous Intraepithelial Lesion Recurrence Saving Costs: A Prospective Cohort Study.

PMID: 32569022
Journal: Journal of Lower Genital Tract Disease
Year: 2020
Reference: J Low Genit Tract Dis. 2020 Oct;24(4):367-371. doi: 10.1097/LGT.0000000000000549.
Impact factor: 1.306
Publication type: Paper in international publication
Authors: Rabasa, Jordi, Alcalde, Ana, Bradbury, Melissa, Sanchez-Iglesias, Jose Luis, Guerrero, Diana, Forcada, Cristina, Perez-Benavente, Assumpcio, Cabrera, Silvia, Ramon Y Cajal, Santiago, Hernandez, Javier et al.
DOI: 10.1097/LGT.0000000000000549

Implications of extraperitoneal paraaortic lymphadenectomy to the left renal vein in locally advanced cervical cancer. A Spanish multicenter study.

PMID: 32467055
Journal: GYNECOLOGIC ONCOLOGY
Year: 2020
Reference: Gynecol Oncol. 2020 Aug;158(2):287-293. doi: 10.1016/j.ygyno.2020.05.004. Epub 2020 May 26.
Impact factor: 4.623
Publication type: Paper in international publication
Authors: Gil-Ibanez, Blanca, Gil-Moreno, Antonio, Bebia, Vicente, Tejerizo, Alvaro, Perez-Regadera, Jose F, Benito, Virginia, Lubrano, Amina, Hernandez, Alicia, Gonzalez, Cristina, Domingo, Santiago et al.
DOI: 10.1016/j.ygyno.2020.05.004

Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer.

PMID: 32268485
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Apr 6;12(4). pii: cancers12040886. doi: 10.3390/cancers12040886.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Barber, Marta, Parrilla, Alfonso, Morote, Juan, Sanchez, Jose Luis, Perez-Benavente, Asuncion, Segura, Miguel F, Gil-Moreno, Antonio, Santamaria, Anna, Castellvi, Josep, Majem, Blanca et al.
DOI: 10.3390/cancers12040886

Prognostic Value and Therapeutic Implication of Laparoscopic Extraperitoneal Paraaortic Staging in Locally Advanced Cervical Cancer: A Spanish Multicenter Study.

PMID: 32152774
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2020
Reference: Ann Surg Oncol. 2020 Aug;27(8):2829-2839. doi: 10.1245/s10434-020-08329-5. Epub 2020 Mar 9.
Impact factor: 4.061
Publication type: Paper in international publication
Authors: Diaz-Feijoo, Berta, Torne, Aureli, Tejerizo, Alvaro, Benito, Virginia, Hernandez, Alicia, Ruiz, Ruben, Domingo, Santiago, Chipiriliu, Dra, Llueca, Antonio, Piquer, Lola et al.
DOI: 10.1245/s10434-020-08329-5

A giant superinfected uterine angioleiomyoma with distant septic metastases: an extremely rare presentation of a benign process and a systematic review of the literature.

PMID: 31435775
Journal: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
Year: 2019
Reference: Arch Gynecol Obstet. 2019 Oct;300(4):841-847. doi: 10.1007/s00404-019-05267-w. Epub 2019 Aug 21.
Impact factor: 2.199
Publication type: Review in international publication
Authors: Sanchez-Iglesias, Jose-Luis, Capote, Sira, Cubo-Abert, Montserrat, Cabrera, Silvia, Illan-Hernandez, Lidia, Perez-Benavente, Maria-Assumpcio, Monreal-Clua, Sonia, Gil-Moreno, Antonio, Carbonell-Socias, Melchor et al.
DOI: 10.1007/s00404-019-05267-w

Nerve-sparing versus non-nerve-sparing radical hysterectomy: surgical and long-term oncological outcomes.

PMID: 31360307
Journal: Oncotarget
Year: 2019
Reference: Oncotarget. 2019 Jul 16;10(44):4598-4608. doi: 10.18632/oncotarget.27078. eCollection 2019 Jul 16.
Impact factor: 0
Publication type: Paper in international publication
Authors: Gil-Moreno, Antonio, Carbonell-Socias, Melchor, Bradbury, Melissa, Garcia, Angel, Verges, Ramona, Puig, Oriol Puig, Sanchez-Iglesias, Jose Luis, Cabrera-Diaz, Silvia, de la Torre, Javier, Gomez-Hidalgo, Natalia R et al.
DOI: 10.18632/oncotarget.27078

MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways.

PMID: 31278368
Journal: ONCOGENE
Year: 2019
Reference: Oncogene. 2019 Aug;38(32):6035-6050. doi: 10.1038/s41388-019-0860-0. Epub 2019 Jul 5.
Impact factor: 6.634
Publication type: Paper in international publication
Authors: Majem, Blanca, Parrilla, Alfonso, Jimenez, Carlos, Suarez-Cabrera, Leticia, Barber, Marta, Marin, Andrea, Castellvi, Josep, Tamayo, Gabriel, Moreno-Bueno, Gema, Ponce, Jordi et al.
DOI: 10.1038/s41388-019-0860-0

Poor outcome in hypoxic endometrial carcinoma is related to vascular density.

PMID: 31011231
Journal: BRITISH JOURNAL OF CANCER
Year: 2019
Reference: Br J Cancer. 2019 May;120(11):1037-1044. doi: 10.1038/s41416-019-0461-2. Epub 2019 Apr 23.
Impact factor: 5.416
Publication type: Paper in international publication
Authors: Bronsert, Peter, Reijnen, Casper, van Weelden, Willem Jan, Arts, Martijn S J P, Peters, Johan P, Rijken, Paul F, van de Vijver, Koen, Santacana, Maria, Colas, Eva, Gil-Moreno, Antonio et al.
DOI: 10.1038/s41416-019-0461-2

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

From 6th to 7th March, more than 60 European researchers have shared the advances in translational research in endometrial cancer