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Biomedical Research in Gynaecology

The Biomedical Research Group in Gynaecology is a multidisciplinary team made up of clinical specialists in gynaecology and pathology and basic and translational researchers. Our research is clearly translational. Although we take into account the obvious importance of understanding the mechanism at the cellular and molecular level and try to incorporate it into our research, our research is always focused on having a direct applicability to patients and their clinical benefit. On our way to transferring scientific results to clinical practice, we promote innovation and entrepreneurship.

Our group comprises four main research groups, which are closely connected: The clinical research group devoted mainly to clinical projects in all gynaecological cancers; and three translational research groups dedicated to ovarian cancer; endometrial cancer and endometriosis; diseases of the lower female genital tract.

Publications

Can We Reduce Overtreatment of Cervical High-Grade Squamous Intraepithelial Lesions?

PMID: 34928250
Journal: Journal of Lower Genital Tract Disease
Year: 2022
Reference: J Low Genit Tract Dis. 2022 Jan 1;26(1):20-26. doi: 10.1097/LGT.0000000000000635.
Impact factor:
Publication type: Paper in international publication
Authors: Bradbury, Melissa; Castellet, Cristina; Centeno, Cristina; Dinares, Maria Carme; Gil-Moreno, Antonio; Murcia, Maria Teresa; Perez-Benavente, Assumpcio; Rabasa, Jordi; Sainz, Alex et al.
DOI: 10.1097/LGT.0000000000000635

Uterine Inflammatory Myofibroblastic Neoplasms With Aggressive Behavior, Including an Epithelioid Inflammatory Myofibroblastic Sarcoma: A Clinicopathologic Study of 9 Cases.

PMID: 34138797
Journal: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
Year: 2022
Reference: Am J Surg Pathol. 2022 Jan 1;46(1):105-117. doi: 10.1097/PAS.0000000000001756.
Impact factor:
Publication type: Paper in international publication
Authors: Collins, Katrina; Euscher, Elizabeth D; Garcia, Angel; Malpica, Anais; Ramalingam, Preetha; Reques Llanos, Armando et al.
DOI: 10.1097/PAS.0000000000001756

SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.

PMID: 34428858
Journal: ANAESTHESIA
Year: 2022
Reference: Anaesthesia. 2022 Jan;77(1):28-39. doi: 10.1111/anae.15563. Epub 2021 Aug 24.
Impact factor:
Publication type: Paper in international publication
Authors: Bethurum, Alva; Bettamer, Nagat; Bettoni, Jeremie; Betz, Christian Stephan; Beuca, Alexandra; Bewarder, Julian; Beyene, Gaym; Beyer, Katharina; Beyrne, Carlos Daniel; Bezabih, Yoseph Solomon et al.
DOI: 10.1111/anae.15563

Vulvar Adenocarcinoma of Intestinal Type: A Case Report of an Uncommon Entity.

PMID: 33782341
Journal: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
Year: 2022
Reference: Int J Gynecol Pathol. 2022 Jan 1;41(1):98-103. doi: 10.1097/PGP.0000000000000784.
Impact factor:
Publication type: Letter or abstract
Authors: Castellvi, Josep; Garcia, Angel; Moscoso, Olivier; R Gomez-Hidalgo, Natalia; Ramon Y Cajal, Santiago; Reques, Armando; Saco, Adela et al.
DOI: 10.1097/PGP.0000000000000784

Robotic-Assisted Extraperitoneal Paraaortic Lymphadenectomy is Associated with Fewer Surgical Complications: A Post-hoc Analysis of the STELLA-2 randomized trial.

PMID: 34022445
Journal: Journal of Minimally Invasive Gynecology
Year: 2021
Reference: J Minim Invasive Gynecol. 2021 Dec;28(12):2004-2012.e1. doi: 10.1016/j.jmig.2021.05.009. Epub 2021 May 20.
Impact factor: 4.137
Publication type: Paper in international publication
Authors: Bradbury, Melissa, Perez-Benavente, Assumpcio, Diaz-Feijoo, Berta, Cabrera, Silvia, Chipirliu, Anca, Siegrist, Jaime, de la Torre, Javier, Bebia, Vicente, Gil-Moreno, Antonio, Hernandez, Alicia et al.
DOI: 10.1016/j.jmig.2021.05.009

Combined use of ICG and technetium does not improve sentinel lymph node detection in endometrial cancer: Results of the COMBITEC study.

PMID: 33992451
Journal: GYNECOLOGIC ONCOLOGY
Year: 2021
Reference: Gynecol Oncol. 2021 Jul;162(1):32-37. doi: 10.1016/j.ygyno.2021.05.002. Epub 2021 May 13.
Impact factor: 5.482
Publication type: Paper in international publication
Authors: Tejerizo-Garcia, Alvaro, Domingo, Santiago, Gil-Moreno, Antonio, Marti, Lola, Bebia, Vicente, Almansa-Gonzalez, Cristina, Cabrera, Silvia, Barahona-Orpinell, Marc, Padilla-Iserte, Pablo et al.
DOI: 10.1016/j.ygyno.2021.05.002

The cut-off for estrogen and progesterone receptor in endometrial cancer revisited: an ENITEC collaboration study.

PMID: 33338506
Journal: HUMAN PATHOLOGY
Year: 2021
Reference: Hum Pathol. 2021 Mar;109:80-91. doi: 10.1016/j.humpath.2020.12.003. Epub 2020 Dec 15.
Impact factor: 3.466
Publication type: Paper in international publication
Authors: Gil-Moreno, Antonio, Jan van Weelden, Willem, Reijnen, Casper, Kusters-Vandevelde, Heidi V N, Bulten, Johan, Bult, Peter, Leung, Samuel, Visser, Nicole C M, Santacana, Maria, Bronsert, Peter et al.
DOI: 10.1016/j.humpath.2020.12.003

Clinical Challenges in Managing Cervical Intraepithelial Neoplasia 2: A Report From a Cross-sectional Survey.

PMID: 33631780
Journal: Journal of Lower Genital Tract Disease
Year: 2021
Reference: J Low Genit Tract Dis. 2021 Apr 1;25(2):119-125. doi: 10.1097/LGT.0000000000000594.
Impact factor: 1.925
Publication type: Paper in international publication
Authors: Centeno, Cristina, Perez-Benavente, Assumpcio, Gil-Moreno, Antonio, Bradbury, Melissa et al.
DOI: 10.1097/LGT.0000000000000594

Technetium-99m-indocyanine green versus technetium-99m-methylene blue for sentinel lymph node biopsy in early-stage endometrial cancer.

PMID: 31992599
Journal: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Year: 2020
Reference: Int J Gynecol Cancer. 2020 Mar;30(3):311-317. doi: 10.1136/ijgc-2019-000923. Epub 2020 Jan 27.
Impact factor:
Publication type: Paper in international publication
Authors: Bebia, Vicente; Cabrera, Silvia; Forcada, Cristina; Franco-Camps, Silvia; Gil-Moreno, Antonio; Navales, Ignacio; Perez-Benavente, Assumpcio; Villasboas-Rosciolesi, Diego et al.
DOI: 10.1136/ijgc-2019-000923

Evaluation of the intraoperative human papilloma virus test as a marker of early cure at 12 months after electrosurgical excision procedure in patients with cervical High Grade Squamous Intraepithelial Lesion: a prospective cohort study.

PMID: 31502397
Journal: BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Year: 2020
Reference: BJOG. 2020 Jan;127(1):99-105. doi: 10.1111/1471-0528.15932. Epub 2019 Sep 25.
Impact factor:
Publication type: Paper in international publication
Authors: Alcalde, A; Bradbury, M; Cabrera, S; Centeno, C; Dinares, C; Forcada, C; Garcia, A; Gil-Moreno, A; Guerrero, D; Hernandez, J et al.
DOI: 10.1111/1471-0528.15932

Preoperative risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model: A development and validation study.

PMID: 32413043
Journal: PLOS MEDICINE
Year: 2020
Reference: PLoS Med. 2020 May 15;17(5):e1003111. doi: 10.1371/journal.pmed.1003111. eCollection 2020 May.
Impact factor: 10.5
Publication type: Paper in international publication
Authors: Reijnen, Casper, Gogou, Evangelia, Visser, Nicole C M, Engerud, Hilde, Pijnenborg, Johanna M A, Lucas, Peter J F, Kusters-Vandevelde, Heidi V N, Snijders, Marc P L M, Massuger, Leon F A G, Ramjith, Jordache et al.
DOI: 10.1371/journal.pmed.1003111

Prognostic Biomarkers in Endometrial Cancer: A Systematic Review and Meta-Analysis.

PMID: 32560580
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Jun 17;9(6). pii: jcm9061900. doi: 10.3390/jcm9061900.
Impact factor: 3.303
Publication type: Review in international publication
Authors: Gil-Moreno, Antonio, Cabrera, Silvia, Colas, Eva, Dittmar, Gunnar, Martinez-Garcia, Elena, Coll-de la Rubia, Eva et al.
DOI: 10.3390/jcm9061900

Percutaneous ultrasound guided vacuum-assisted excision of benign breast lesions: A learning curve to assess outcomes.

PMID: 30359092
Journal: BRITISH JOURNAL OF RADIOLOGY
Year: 2019
Reference: Br J Radiol. 2019 Feb;92(1094):20180626. doi: 10.1259/bjr.20180626. Epub 2018 Nov 29.
Impact factor:
Publication type: Paper in international publication
Authors: de Torres, Juan; Esgueva, Antonio; Espinosa-Bravo, Martin; Miranda, Ignacio; Rubio, Isabel T; Rus, Maria N; Salazar, Juan Pablo; Salvador, Rafael et al.
DOI: 10.1259/bjr.20180626

Surgical approaches in women with endometrial cancer with a body mass index greater than 35 kg/m(2).

PMID: 30191628
Journal: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
Year: 2019
Reference: J Obstet Gynaecol Res. 2019 Jan;45(1):195-202. doi: 10.1111/jog.13789. Epub 2018 Sep 6.
Impact factor:
Publication type: Paper in international publication
Authors: de la Torre-Fernandez de Vega, Javier; Diaz-Feijoo, Berta; Gil-Moreno, Antonio; Perez-Benavente, Maria A; Raventos-Tato, Rut M; Sabadell, Jordi; Sanchez-Iglesias, Jose L et al.
DOI: 10.1111/jog.13789

Vaginal Intraepithelial Neoplasia: Clinical Presentation, Management, and Outcomes in Relation to HIV Infection Status.

PMID: 30161052
Journal: Journal of Lower Genital Tract Disease
Year: 2019
Reference: J Low Genit Tract Dis. 2019 Jan;23(1):7-12. doi: 10.1097/LGT.0000000000000431.
Impact factor:
Publication type: Paper in international publication
Authors: Bradbury, Melissa; Cabrera, Silvia; Centeno-Mediavilla, Cristina; De La Torre, Javier; Diaz-Feijoo, Berta; Franco-Camps, Silvia; Garcia-Jimenez, Angel; Gil-Moreno, Antonio; Perez-Benavente, Asuncion; Sanchez-Iglesias, Jose Luis et al.
DOI: 10.1097/LGT.0000000000000431

Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B.

PMID: 31086659
Journal: Cancer & Metabolism
Year: 2019
Reference: Cancer Metab. 2019 May 9;7:5. doi: 10.1186/s40170-019-0196-9. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Besso, Maria Jose; Canals, Francesc; Lapyckyj, Lara; Matos, Maria Laura; Monge, Marta; Quevedo Cuenca, Jorge Oswaldo; Reventos, Jaume; Rosso, Marina; Vazquez-Levin, Monica Hebe et al.
DOI: 10.1186/s40170-019-0196-9

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

From 6th to 7th March, more than 60 European researchers have shared the advances in translational research in endometrial cancer