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Cardiovascular Diseases

Cardiovascular Diseases group is a translational research group within the Cardiology Department of Vall d’Hebron Hospital that performs laboratory, clinical and epidemiological research. In the CIBERCV network we are within the topic of descriptor 2 “Arterial disease, thrombosis and myocardial ischemia-reperfusion injury”. Our contributions in these topics address the following lines: 

  • Myocardial ischemia-reperfusion injury (i.e. mechanisms of endogenous cardioprotection, ischemic conditioning and remodeling), 
  • Coronary artery disease (i.e. genetic factors involved in coronary artery disease, determinants of thrombotic complications and prognosis), 
  • Aortic diseases (i.e. determinants of aorta dilatation, aortic biomechanics abnormalities in Marfan´s syndrome, and new imaging methods), 
  • Congenital/familiar heart diseases (i.e. genetic determinants and prognosis factors). 

In the CIBERESP network, our group is interested in the study of effectiveness/cost-effectiveness of cardiovascular interventions, health outcome research and methods in clinical research. The group has 19 principal investigators, 32 active projects and clinical trial and has been done 142 publications in 2020.

Publications

CT or Invasive Coronary Angiography in Stable Chest Pain.

PMID: 35240010
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2022
Reference: N Engl J Med. 2022 Apr 28;386(17):1591-1602. doi: 10.1056/NEJMoa2200963. Epub 2022 Mar 4.
Impact factor: 91.253
Publication type: Paper in international publication
Authors: Rieckmann, Nina, Maurovich-Horvat, Pal, Bosserdt, Maria, Kofoed, Klaus F, Merkely, Bela, Knudsen, Andreas D, Benedek, Imre, Orr, Clare, Xavier Valente, Filipa, Zvaigzne, Ligita et al.
DOI: 10.1056/NEJMoa2200963

Defective dimerization of FoF1-ATP synthase secondary to glycation favors mitochondrial energy deficiency in cardiomyocytes during aging.

PMID: 35233924
Journal: AGING CELL
Year: 2022
Reference: Aging Cell. 2022 Mar;21(3):e13564. doi: 10.1111/acel.13564. Epub 2022 Mar 2.
Impact factor: 9.304
Publication type: Paper in international publication
Authors: Bou-Teen, Diana, Fernandez-Sanz, Celia, Miro-Casas, Elisabet, Nichtova, Zuzana, Bonzon-Kulichenko, Elena, Casos, Kelly, Inserte, Javier, Rodriguez-Sinovas, Antonio, Benito, Begona, Sheu, Shey-Shing et al.
DOI: 10.1111/acel.13564

Magnesium-based resorbable scaffold vs permanent metallic sirolimus-eluting stent in patients with ST-segment elevation myocardial infarction: 3-year results of the MAGSTEMI randomised controlled trial.

PMID: 35225793
Journal: EuroIntervention
Year: 2022
Reference: EuroIntervention. 2022 Feb 28. pii: EIJ-D-21-00651. doi: 10.4244/EIJ-D-21-00651.
Impact factor: 6.534
Publication type: Paper in international publication
Authors: Sabate, Manel, Cuesta, Javier, Ortega-Paz, Luis, Brugaletta, Salvatore, Gomez-Lara, Josep, Alfonso, Fernando, Cequier, Angel, Romani, Sebastian, Bordes, Pascual, Serra, Antonio et al.
DOI: 10.4244/EIJ-D-21-00651

Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation.

PMID: 35210032
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2022
Reference: J Am Coll Cardiol. 2022 Mar 1;79(8):772-785. doi: 10.1016/j.jacc.2021.11.056.
Impact factor: 24.093
Publication type: Paper in international publication
Authors: Kim, Won-Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L, Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C, Lisko, John et al.
DOI: 10.1016/j.jacc.2021.11.056

Temporal Trends, Characteristics, and Outcomes of Infective Endocarditis After Transcatheter Aortic Valve Replacement.

PMID: 33733675
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2021
Reference: Clin Infect Dis. 2021 Dec 6;73(11):e3750-e3758. doi: 10.1093/cid/ciaa1941.
Impact factor: 9.079
Publication type: Paper in international publication
Authors: Regueiro, Ander, Munoz-Garcia, Antonio, Herrmann, Howard C, Testa, Luca, Won-Keun, Kim, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio, Kapadia, Samir et al.
DOI: 10.1093/cid/ciaa1941

Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart.

PMID: 33716106
Journal: FREE RADICAL BIOLOGY AND MEDICINE
Year: 2021
Reference: Free Radic Biol Med. 2021 May 1;167:109-124. doi: 10.1016/j.freeradbiomed.2021.02.043. Epub 2021 Mar 11.
Impact factor: 7.376
Publication type: Paper in international publication
Authors: Bou-Teen, Diana, Kaludercic, Nina, Weissman, David, Turan, Belma, Maack, Christoph, Di Lisa, Fabio, Ruiz-Meana, Marisol et al.
DOI: 10.1016/j.freeradbiomed.2021.02.043

[Restrictive cardiomyopathy: Importance of early diagnosis].

PMID: 33712406
Journal: ANALES DE PEDIATRIA
Year: 2021
Reference: An Pediatr (Engl Ed). 2021 Mar 9. pii: S1695-4033(20)30498-7. doi: 10.1016/j.anpedi.2020.11.012.
Impact factor: 1.5
Publication type: Letter whit IF
Authors: Brunet-Garcia, Laia, Roses-Noguer, Ferran, Betrian, Pedro, Balcells, Joan, Gran, Ferran et al.
DOI: 10.1016/j.anpedi.2020.11.012

Stratification and management of cardiovascular risk in cancer patients. A consensus document of the SEC, FEC, SEOM, SEOR, SEHH, SEMG, AEEMT, AEEC, and AECC.

PMID: 33712348
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2021
Reference: Rev Esp Cardiol (Engl Ed). 2021 May;74(5):438-448. doi: 10.1016/j.rec.2020.11.020. Epub 2021 Mar 10.
Impact factor: 4.753
Publication type: Paper in national publication
Authors: Garcia Sanz, Ramon, Martin Garcia, Ana, Mitroi, Cristina, Mazon Ramos, Pilar, Reinoso-Barbero, Luis, Rodriguez, Isabel, Serrano Antolin, Jose Maria, Toral, Belen, Torres Royo, Laura, Velasco Del Castillo, Sonia et al.
DOI: 10.1016/j.rec.2020.11.020

Mitral Regurgitation in Low-Flow, Low-Gradient Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Replacement: Insights From the TOPAS-TAVI Registry.

PMID: 32061600
Journal: JACC-Cardiovascular Interventions
Year: 2020
Reference: JACC Cardiovasc Interv. 2020 Mar 9;13(5):567-579. doi: 10.1016/j.jcin.2019.11.042. Epub 2020 Feb 12.
Impact factor: 8.432
Publication type: Paper in international publication
Authors: Dahou, Abdellaziz, Annabi, Mohamed-Salah, Pelletier-Beaumont, Emilie, Pibarot, Philippe, Rodes-Cabau, Josep, Schindler, John T, Serra, Vicenc, de Agustin, Alberto, Clavel, Marie-Annick, Freitas-Ferraz, Afonso B et al.
DOI: 10.1016/j.jcin.2019.11.042

Updating national diagnostic reference levels for interventional cardiology and methodological aspects.

PMID: 32032801
Journal: Physica Medica-European Journal of Medical Physics
Year: 2020
Reference: Phys Med. 2020 Feb;70:169-175. doi: 10.1016/j.ejmp.2020.01.014. Epub 2020 Feb 5.
Impact factor: 2.485
Publication type: Paper in international publication
Authors: Ten, Jose Ignacio, Sanchez, Roberto, Vano, Eliseo, Fernandez Soto, Jose M, Tobarra, Bonifacio, Perez, Armando, Garcia, Bruno, Carrera Magarino, Francisco, Fernandez, Jose Francisco Diaz, Luna, Rafael Jesus Martinez et al.
DOI: 10.1016/j.ejmp.2020.01.014

Sinus Superflex DS((c)) early collapse in systemic arterial duct.

PMID: 32014071
Journal: CARDIOLOGY IN THE YOUNG
Year: 2020
Reference: Cardiol Young. 2020 Mar;30(3):436-437. doi: 10.1017/S1047951120000189. Epub 2020 Feb 4.
Impact factor: 1
Publication type: Letter or abstract
Authors: Giralt-Garcia, Gemma, Marti-Aguasca, Gerard, Betrian-Blasco, Pedro et al.
DOI: 10.1017/S1047951120000189

Correction: Age-specific reference values for carotid arterial stiffness estimated by ultrasonic wall tracking.

PMID: 32001827
Journal: JOURNAL OF HUMAN HYPERTENSION
Year: 2020
Reference: J Hum Hypertens. 2020 Mar;34(3):258. doi: 10.1038/s41371-020-0304-x.
Impact factor: 2.26
Publication type: Letter or abstract
Authors: Uejima, Tokuhisa, Dunstan, Frank D, Arbustini, Eloisa, Loboz-Grudzien, Krystyna, Hughes, Alun D, Carerj, Scipione, Favalli, Valentina, Antonini-Canterin, Francesco, Vriz, Olga, Vinereanu, Dragos et al.
DOI: 10.1038/s41371-020-0304-x

Comentarios a la guia ESC 2018 sobre el tratamiento de las enfermedades cardiovasculares durante el embarazo.

PMID: 30704722
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2019
Reference: Rev Esp Cardiol (Engl Ed). 2019 Feb;72(2):109-114. doi: 10.1016/j.rec.2018.12.002.
Impact factor: 5.078
Publication type: Editorial in national publication
Authors: Manso, Begona, Rosillo, Sandra, Zabala, J Ignacio, Alfonso, Fernando, Ibanez, Borja, Arribas, Fernando, Berga Congost, Gemma, Bueno, Hector, Evangelista, Arturo, Ferreira-Gonzalez, Ignacio et al.
DOI: 10.1016/j.rec.2018.12.002

Comments on the 2018 ESC/ESH Guidelines for the Management of Arterial Hypertension.

PMID: 30704721
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2019
Reference: Rev Esp Cardiol (Engl Ed). 2019 Feb;72(2):104-108. doi: 10.1016/j.rec.2018.12.001.
Impact factor: 5.078
Publication type: Editorial in national publication
Authors: Mazon, Pilar, Marin, Francisco, Cosin-Sales, Juan, Cordero, Alberto, Roldan, Inmaculada, Garcia-Moll, Xavier, Vazquez, Rafael, Coca, Antonio, Escobar, Carlos, Barrios, Vivencio et al.
DOI: 10.1016/j.rec.2018.12.001

Invasive Versus Conservative Strategy in Frail Patients With NSTEMI: The MOSCA-FRAIL Clinical Trial Study Design.

PMID: 29525724
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2019
Reference: Rev Esp Cardiol (Engl Ed). 2019 Feb;72(2):154-159. doi: 10.1016/j.rec.2018.02.007. Epub 2018 Mar 7.
Impact factor: 5.078
Publication type: Paper in international publication
Authors: Sanchis, Juan, Ariza-Sole, Albert, Abu-Assi, Emad, Alegre, Oriol, Alfonso, Fernando, Barrabes, Jose Antonio, Baz, Jose Antonio, Carol, Antonio, Diez Villanueva, Pablo, Garcia Del Blanco, Bruno et al.
DOI: 10.1016/j.recesp.2018.01.028

Colchicine Administered in the First Episode of Acute Idiopathic Pericarditis: A Randomized Multicenter Open-label Study.

PMID: 30683494
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2019
Reference: Rev Esp Cardiol (Engl Ed). 2019 Sep;72(9):709-716. doi: 10.1016/j.rec.2018.11.016. Epub 2019 Jan 22.
Impact factor: 5.078
Publication type: Paper in national publication
Authors: Sambola, Antonia, Roca Luque, Ivo, Merce, Jordi, Alguersuari, Joan, Francisco-Pascual, Jaume, Garcia-Dorado, David, Sagrista-Sauleda, Jaume et al.
DOI: 10.1016/j.rec.2018.11.016

Long-Term Outcomes in Patients With New Permanent Pacemaker Implantation Following Transcatheter Aortic Valve Replacement.

PMID: 29413244
Journal: JACC-Cardiovascular Interventions
Year: 2018
Reference: JACC Cardiovasc Interv. 2018 Feb 12;11(3):301-310. doi: 10.1016/j.jcin.2017.10.032.
Impact factor: 9.881
Publication type: Paper in international publication
Authors: Rodes-Cabau, Josep, Cote, Melanie, Chamandi, Chekrallah, Barbanti, Marco, Munoz-Garcia, Antonio, Latib, Azeem, Nombela-Franco, Luis, Gutierrez-Ibanez, Enrique, Veiga-Fernandez, Gabriela, Cheema, Asim N et al.
DOI: 10.1016/j.jcin.2017.10.032

Intra-atrial re-entrant tachycardia in congenital heart disease: types and relation of isthmus to atrial voltage.

PMID: 29016802
Journal: EUROPACE
Year: 2018
Reference: Europace. 2018 Feb 1;20(2):353-361. doi: 10.1093/europace/eux250.
Impact factor: 5.231
Publication type: Paper in international publication
Authors: Mitjans, Angel Moya, Garcia-Dorado Garcia, David, Roca-Luque, Ivo, Dos Subira, Laura, Pascual, Jaume Francisco, Domenech, Antonia Pijuan, Perez-Rodon, Jordi, Subirana, M Teresa, Santos Ortega, Alba, Miranda, Berta et al.
DOI: 10.1093/europace/eux250

Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size.

PMID: 29402957
Journal: Scientific Reports
Year: 2018
Reference: Sci Rep. 2018 Feb 5;8(1):2442. doi: 10.1038/s41598-018-20866-4.
Impact factor: 4.122
Publication type: Paper in international publication
Authors: Miro-Casas, Elisabet, Ruiz-Meana, Marisol, Rodriguez-Sinovas, Antonio, Garcia-Dorado, David, Barba, Ignasi, Valls-Lacalle, Laura et al.
DOI: 10.1038/s41598-018-20866-4

A pragmatic approach for mortality prediction after surgery in infective endocarditis: Optimizing and refining EuroSCORE.

PMID: 29408350
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2018
Reference: Clin Microbiol Infect. 2018 Oct;24(10):1102.e7-1102.e15. doi: 10.1016/j.cmi.2018.01.019. Epub 2018 Mar 3.
Impact factor: 5.394
Publication type: Paper in international publication
Authors: Aznar, Maria L, de Alarcon, Aristides, Garcia-Cabrera, Emilio, Galvez-Acebal, Juan, Sanchez-Espin, Gemma, Reguera-Iglesias, Jose M, De La Torre-Lima, Javier, Lomas, Jose M, Hidalgo-Tenorio, Carmen, Vallejo, Nuria et al.
DOI: 10.1016/j.cmi.2018.01.019

Effects of Triple Therapy in Patients With Non-Valvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention Regarding Thromboembolic Risk Stratification.

PMID: 26725763
Journal: CIRCULATION JOURNAL
Year: 2016
Reference: Circ J. 2016 Jan 25;80(2):354-62. doi: 10.1253/circj.CJ-15-0923. Epub 2015 Dec 25.
Impact factor: 4.124
Publication type: Paper in international publication
Authors: Barrabes, Jose A, Alfonso, Fernando, Bueno, Hector, Cequier, Angel, Zueco, Javier, Rodriguez-Leor, Oriol, Bosch, Eduard, Tornos, Pilar, Garcia-Dorado, David, Alonso, Albert et al.
DOI: 10.1253/circj.CJ-15-0923

Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition.

PMID: 26705364
Journal: CARDIOVASCULAR RESEARCH
Year: 2016
Reference: Cardiovasc Res. 2016 Mar 1;109(3):374-84. doi: 10.1093/cvr/cvv279. Epub 2015 Dec 23.
Impact factor: 5.465
Publication type: Paper in international publication
Authors: Valls-Lacalle, Laura, Barba, Ignasi, Miro-Casas, Elisabet, Alburquerque-Bejar, Juan Jose, Ruiz-Meana, Marisol, Fuertes-Agudo, Marina, Rodriguez-Sinovas, Antonio, Garcia-Dorado, David et al.
DOI: 10.1093/cvr/cvv279

Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside.

PMID: 26667317
Journal: BASIC RESEARCH IN CARDIOLOGY
Year: 2016
Reference: Basic Res Cardiol. 2016 Jan;111(1):7. doi: 10.1007/s00395-015-0527-0. Epub 2015 Dec 14.
Impact factor: 6.008
Publication type: Paper in international publication
Authors: Boisvert, William A, Cabrera-Fuentes, Hector A, Alba-Alba, Corina, Aragones, Julian, Bernhagen, Jurgen, Fleming, Ingrid, Garcia-Dorado, David, Lecour, Sandrine, Liehn, Elisa, Marber, Michael S et al.
DOI: 10.1007/s00395-015-0527-0

Differential Diagnosis and Clinical Implications of Remnants of the Right Valve of the Sinus Venosus.

PMID: 26787493
Journal: JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
Year: 2016
Reference: J Am Soc Echocardiogr. 2016 Mar;29(3):183-94. doi: 10.1016/j.echo.2015.11.018. Epub 2016 Jan 16.
Impact factor: 4.254
Publication type: Paper in international publication
Authors: Moral, Sergio, Ballesteros, Esther, Huguet, Marina, Panaro, Alejandro, Palet, Jordi, Evangelista, Arturo et al.
DOI: 10.1016/j.echo.2015.11.018

Implantable Cardioverter-defibrillator Therapy for Hypertrophic Cardiomyopathy: Usefulness in Primary and Secondary Prevention.

PMID: 25449813
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2015
Reference: Rev Esp Cardiol (Engl Ed). 2015 Jun;68(6):492-6. doi: 10.1016/j.rec.2014.06.025. Epub 2014 Nov 20.
Impact factor: 3.792
Publication type: Paper in national publication
Authors: Sarrias, Axel, Galve, Enrique, Sabate, Xavier, Moya, Angel, Anguera, Ignacio, Nunez, Elaine, Villuendas, Roger, Garcia-Dorado, David, Alcalde, Oscar et al.
DOI: 10.1016/j.rec.2014.06.025

Warranty periods for normal myocardial perfusion stress SPECT.

PMID: 25116906
Journal: JOURNAL OF NUCLEAR CARDIOLOGY
Year: 2015
Reference: J Nucl Cardiol. 2015 Feb;22(1):44-54. doi: 10.1007/s12350-014-9957-6. Epub 2014 Aug 13.
Impact factor: 2.942
Publication type: Paper in international publication
Authors: Romero-Farina, Guillermo, Candell-Riera, Jaume, Aguade-Bruix, Santiago, Ferreira-Gonzalez, Ignacio, Cuberas-Borros, Gemma, Pizzi, Nazarena, Garcia-Dorado, David et al.
DOI: 10.1007/s12350-014-9957-6

[Diagnosis and treatment of familial hypercholesterolemia in Spain: Consensus document.]

PMID: 24704195
Journal: Atencion Primaria
Year: 2015
Reference: Aten Primaria. 2015 Jan;47(1):56-65. doi: 10.1016/j.aprim.2013.12.015. Epub 2014 Apr 3.
Impact factor: 0.953
Publication type: Paper in national publication
Authors: Mata, Pedro, Alonso, Rodrigo, Ruiz, Antonio, Gonzalez-Juanatey, Jose R, Badimon, Lina, Diaz-Diaz, Jose L, Munoz, Maria Teresa, Muniz, Ovidio, Galve, Enrique, Irigoyen, Luis et al.
DOI: 10.1016/j.aprim.2013.12.015

Door-to-balloon time and mortality.

PMID: 24401062
Journal: NEW ENGL J MED
Year: 2014
Reference: N Engl J Med. 2014 Jan 9;370(2):179. doi: 10.1056/NEJMc1313113#SA3.
Impact factor: 54.42
Publication type: Letter whit IF
Authors: Garcia-Dorado, David, Garcia del Blanco, Bruno et al.
DOI: 10.1056/NEJMc1313113#SA3

An in vitro phantom study on the influence of tear size and configuration on the hemodynamics of the lumina in chronic type B aortic dissections.

PMID: 23141674
Journal: JOURNAL OF VASCULAR SURGERY
Year: 2013
Reference: J Vasc Surg. 2013 Feb;57(2):464-474.e5. doi: 10.1016/j.jvs.2012.07.008. Epub 2012 Nov 7.
Impact factor: 2.879
Publication type: Paper in international publication
Authors: Rudenick, Paula A, Bijnens, Bart H, Garcia-Dorado, David, Evangelista, Arturo et al.
DOI: 10.1016/j.jvs.2012.07.008

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News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

The study on the effects of diesel particles on the heart has been recognized as the best research work from Spain at the association’s Scientific Sessions.

Extracorporeal Cardiopulmonary Resuscitation (ECPR) offers therapeutic options for patients in whom conventional cardiopulmonary resuscitation techniques fail to restore the heartbeat.